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:where([role=\"tablist\"],[role=\"toolbar\"],[hidden],button,.nx-theme-toggle,.nx-live-slot){display:none}#nxe-n1467qc4.nxe img{max-width:100%;height:auto}<\/style><svg class=\"nx-defs\" aria-hidden=\"true\" focusable=\"false\" width=\"0\" height=\"0\"><defs><linearGradient id=\"nx-gi\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"1\"><stop offset=\"0\" class=\"nx-gi-a\"\/><stop offset=\"0.55\" class=\"nx-gi-b\"\/><stop offset=\"1\" class=\"nx-gi-c\"\/><\/linearGradient><linearGradient id=\"nx-giu\" gradientUnits=\"userSpaceOnUse\" x1=\"0\" y1=\"0\" x2=\"800\" y2=\"0\"><stop offset=\"0\" class=\"nx-gi-a\"\/><stop offset=\"0.55\" class=\"nx-gi-b\"\/><stop offset=\"1\" class=\"nx-gi-c\"\/><\/linearGradient><linearGradient id=\"nx-gp\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"1\"><stop offset=\"0\" class=\"nx-gp-a\"\/><stop offset=\"1\" class=\"nx-gp-b\"\/><\/linearGradient><\/defs><\/svg><section class=\"nx-hero\" data-layout=\"console\" aria-labelledby=\"nx-title-1\"><div class=\"nx-container\"><div class=\"nx-theme-toggle\" role=\"group\" aria-label=\"Appearance of this page\" hidden><button type=\"button\" data-mode=\"light\" aria-pressed=\"false\">Light<\/button><button type=\"button\" data-mode=\"dark\" aria-pressed=\"false\">Dark<\/button><button type=\"button\" data-mode=\"auto\" aria-pressed=\"true\">Auto<\/button><\/div><div class=\"nx-folio\" aria-label=\"Document reference\"><strong>G04 \u00b7 METHOD \u00b7 life-sciences<\/strong>GCRI dossier \u00b7 service level R0<\/div><div class=\"nx-hero-grid\"><div class=\"nx-hero-text\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">GCRI<\/span><span class=\"nx-eyebrow\" aria-hidden=\"true\">\u00b7<\/span><span class=\"nx-eyebrow\">Health Nexus<\/span><span class=\"nx-eyebrow\" aria-hidden=\"true\">\u00b7<\/span><span class=\"nx-eyebrow\">Established<\/span><\/div><div class=\"nx-accent-row\"><span class=\"nx-accent-rule\" aria-hidden=\"true\"><\/span><span>Method page \u00b7 Molecular and life sciences<\/span><\/div><h1 id=\"nx-title-1\" class=\"nx-hero-title\">Molecular and life sciences for health threats<\/h1><p class=\"nx-tagline\">Molecular and life sciences characterise the pathogens, hosts and vectors behind health threats: their genomes, how they evolve, how they resist drugs and how they move between species. In this field they supply the laboratory and genomic evidence that confirms an event, links cases and tracks resistance across human, animal and environmental samples.<\/p><div class=\"nx-actions\"><a class=\"nx-btn\" data-variant=\"primary\" href=\"https:\/\/therisk.global\/health-nexus\/contact\/\">Make an enquiry <svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/a><a class=\"nx-btn\" data-variant=\"secondary\" href=\"https:\/\/therisk.global\/health-nexus\/stem\/\">Back to STEM foundation of Health Nexus<\/a><\/div><\/div><div class=\"nx-hero-panel\"><div class=\"nx-register\"><div class=\"nx-register-head\"><span class=\"nx-eyebrow\"><strong>Method record<\/strong><\/span><span class=\"nx-eyebrow\">life-sciences<\/span><\/div><ol class=\"nx-register-rows\"><li><div><span class=\"nx-register-k\">Method<\/span><span class=\"nx-register-v\">Molecular and life sciences<\/span><\/div><\/li><li><div><span class=\"nx-register-k\">Steward<\/span><span class=\"nx-register-v\"><a class=\"nx-link\" href=\"https:\/\/therisk.global\/biotechnology-biosecurity\/\">Biotechnology and Biosecurity<\/a><\/span><\/div><\/li><li><div><span class=\"nx-register-k\">Applied in<\/span><span class=\"nx-register-v\">Health Nexus<\/span><\/div><\/li><li><div><span class=\"nx-register-k\">Data<\/span><span class=\"nx-register-v\"><a class=\"nx-link\" href=\"#nx-sec-data\">4 inputs<\/a><\/span><\/div><\/li><li><div><span class=\"nx-register-k\">Checks<\/span><span class=\"nx-register-v\"><a class=\"nx-link\" href=\"#nx-sec-checks\">3 validation steps<\/a><\/span><\/div><\/li><li><div><span class=\"nx-register-k\">Canonical page<\/span><span class=\"nx-register-v\"><a class=\"nx-link\" href=\"https:\/\/therisk.global\/stem\/science\/life-sciences\/\">STEM Commons<\/a><\/span><\/div><\/li><\/ol><p class=\"nx-register-foot\">GCRI \u00b7 Established \u00b7 service level R0<\/p><\/div><\/div><\/div><\/div><\/section> <nav class=\"nx-index-strip\" data-nx-spy=\"true\" aria-label=\"On this page\"><div class=\"nx-container\"><a href=\"#nx-sec-brief-answer\"><span>01<\/span>The short answer<\/a><a href=\"#nx-sec-application\"><span>02<\/span>What molecular and life sciences\u2026<\/a><a href=\"#nx-sec-terms\"><span>03<\/span>Terms used on this page<\/a><a href=\"#nx-sec-field\"><span>04<\/span>Access to care in the Caribbean<\/a><a href=\"#nx-sec-canvas\"><span>05<\/span>The method as a run graph<\/a><a href=\"#nx-sec-data\"><span>06<\/span>What the method consumes<\/a><a href=\"#nx-sec-checks\"><span>07<\/span>How results are checked<\/a><a href=\"#nx-sec-connections\"><span>08<\/span>Topics that rely on this method<\/a><\/div><\/nav> <section id=\"nx-sec-brief-answer\" class=\"nx-section\" data-hue=\"health\" data-variant=\"split\" aria-labelledby=\"nx-s-2\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">01<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">In brief<\/span><\/div><h2 id=\"nx-s-2\" class=\"nx-section-title\">The short answer.<\/h2><p class=\"nx-lede\">Genomic surveillance is the routine sequencing and analysis of pathogen genomes to detect, characterise and track infections. With other molecular methods it confirms events, links cases, follows how pathogens evolve and resist drugs, and traces movement between people, animals and the environment, including through wastewater.<\/p><\/div><\/div><\/section><section id=\"nx-sec-application\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" data-variant=\"stack\" aria-labelledby=\"nx-s-3\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">02<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Application<\/span><\/div><h2 id=\"nx-s-3\" class=\"nx-section-title\">What molecular and life sciences does here.<\/h2><p class=\"nx-lede\">Molecular and life sciences study the structure and function of living systems from genes and proteins to cells and organisms. They underpin the understanding of pathogens, resistance, toxicity and biological innovation. In health and biosecurity, life sciences support pathogen characterisation, antimicrobial resistance tracking and biosecurity assessment. They inform how biological threats might spread through health, agriculture and trade. The canonical description is on <a class=\"nx-link\" href=\"https:\/\/therisk.global\/stem\/science\/life-sciences\/\">the STEM Commons<\/a>.<\/p><\/div><div class=\"nx-section-body\"><div class=\"nx-cols\"><article><div class=\"nx-glyph-row\"><span class=\"nx-glyph\" data-tone=\"accent\" data-size=\"lg\"><svg class=\"nx-i\" viewBox=\"0 0 24 24\" aria-hidden=\"true\" focusable=\"false\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M6 18h8\"\/><path d=\"M3 22h18\"\/><path d=\"M14 22a7 7 0 1 0 0-14h-1\"\/><path d=\"M9 14h2\"\/><path d=\"M9 12a2 2 0 0 1-2-2V6h6v4a2 2 0 0 1-2 2Z\"\/><path d=\"M12 6V3a1 1 0 0 0-1-1H9a1 1 0 0 0-1 1v3\"\/><\/svg><\/span><\/div><h3 class=\"nx-h3 nx-mt-2\">Genomic surveillance of pathogens<\/h3><p class=\"nx-p nx-mt-1\">Sequences from clinical, animal and environmental samples are assembled, assigned to lineages and placed on phylogenies to identify variants and assess relatedness, with sampling coverage reported beside every tree.<\/p><\/article><article><div class=\"nx-glyph-row\"><span class=\"nx-glyph\" data-tone=\"accent\" data-size=\"lg\"><svg class=\"nx-i\" viewBox=\"0 0 24 24\" aria-hidden=\"true\" focusable=\"false\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M7 20h10\"\/><path d=\"M10 20c5.5-2.5.8-6.4 3-10\"\/><path d=\"M9.5 9.4c1.1.8 1.8 2.2 2.3 3.7-2 .4-3.5.4-4.8-.3-1.2-.6-2.3-1.9-3-4.2 2.8-.5 4.4 0 5.5.8z\"\/><path d=\"M14.1 6a7 7 0 0 0-1.1 4c1.9-.1 3.3-.6 4.3-1.4 1-1 1.6-2.3 1.7-4.6-2.7.1-4 1-4.9 2z\"\/><\/svg><\/span><\/div><h3 class=\"nx-h3 nx-mt-2\">Cross-species linkage in One Health<\/h3><p class=\"nx-p nx-mt-1\">Pathogen and resistance-gene sequences from people, livestock and the environment are compared to assess whether they share a source, under agreed sampling and metadata standards.<\/p><\/article><article><div class=\"nx-glyph-row\"><span class=\"nx-glyph\" data-tone=\"accent\" data-size=\"lg\"><svg class=\"nx-i\" viewBox=\"0 0 24 24\" aria-hidden=\"true\" focusable=\"false\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M7 16.3c2.2 0 4-1.83 4-4.05 0-1.16-.57-2.26-1.71-3.19S7.29 6.75 7 5.3c-.29 1.45-1.14 2.84-2.29 3.76S3 11.1 3 12.25c0 2.22 1.8 4.05 4 4.05z\"\/><path d=\"M12.56 6.6A10.97 10.97 0 0 0 14 3.02c.5 2.5 2 4.9 4 6.5s3 3.5 3 5.5a6.98 6.98 0 0 1-11.91 4.97\"\/><\/svg><\/span><\/div><h3 class=\"nx-h3 nx-mt-2\">Wastewater and environmental surveillance<\/h3><p class=\"nx-p nx-mt-1\">Nucleic acid targets in wastewater are measured and normalised for flow and population markers to follow community infection trends independently of who seeks testing.<\/p><\/article><\/div><\/div><\/div><\/section><section id=\"nx-sec-terms\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" data-variant=\"split\" aria-labelledby=\"nx-s-4\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">03<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Key terms<\/span><\/div><h2 id=\"nx-s-4\" class=\"nx-section-title\">Terms used on this page.<\/h2><p class=\"nx-lede\">Each term as this page uses it. Where a standard-setting body defines the term, the wording follows that body.<\/p><\/div><div class=\"nx-section-body\"><div class=\"nx-table-wrap\"><table class=\"nx-table\" data-stack=\"true\"><thead><tr><th scope=\"col\">Term<\/th><th scope=\"col\">Definition<\/th><\/tr><\/thead><tbody><tr><td data-label=\"Term\">Phylogenetic analysis<\/td><td data-label=\"Definition\">Reconstructing the evolutionary relationships among pathogen genomes to infer how cases are linked.<\/td><\/tr><tr><td data-label=\"Term\">Wastewater surveillance<\/td><td data-label=\"Definition\">Testing sewage for pathogen genetic material to track infection trends in the community it drains.<\/td><\/tr><tr><td data-label=\"Term\">Variant<\/td><td data-label=\"Definition\">A pathogen lineage with genetic changes that distinguish it from others, which may alter spread or severity.<\/td><\/tr><\/tbody><\/table><\/div><\/div><\/div><\/section><section id=\"nx-sec-field\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" aria-labelledby=\"nx-s-5\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">04<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Geography<\/span><\/div><h2 id=\"nx-s-5\" class=\"nx-section-title\">Access to care in the Caribbean.<\/h2><p class=\"nx-lede\">How far each division sits from a large city, with the roads and airports that carry patients and supplies, shown for the Caribbean as an example geography for this subject.<\/p><\/div><div class=\"nx-section-body\"><div class=\"nx-canvas-wrap\"><div class=\"nx-map nx-cmap\" data-nx-map=\"ctx\" data-cmap=\"caribbean:health\" data-ramp=\"red\" data-basis=\"case\" data-focus=\"0 0 2000 1110|210 137 881 375|1015 373 1250 533|857 363 1039 501|610 463 748 519\"><figure class=\"nx-fk\" data-fk=\"map-caribbean-health\" data-ramp=\"red\" 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\"><figcaption class=\"nx-fk-cap\"><span>How far each division sits from a large city, with the roads and airports that carry patients and supplies.<\/span><span data-honesty=\"true\">Indicator derived from Natural Earth at map scale; a screening view, not an assessment.<\/span><\/figcaption><\/figure><div class=\"nx-live-slot nx-live-slot--map\" data-nxf-slot=\"map\" data-nxf-kind=\"map\" data-nxf-resource=\"nexus:\/\/gcri\/G04\/stem\/life-sciences\/#map\" data-nxf-title=\"Health Nexus live map\" data-nxf-height=\"560\" hidden><\/div><div class=\"nx-map-hud\"><span class=\"nx-eyebrow\">GCRI \u00b7 Health Nexus \u00b7 field<\/span><span class=\"nx-eyebrow nx-map-hud-right\">DESIGN FIGURE<\/span><\/div><\/div><\/div><\/div><\/div><\/section><section id=\"nx-sec-canvas\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" aria-labelledby=\"nx-s-6\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">05<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Canvas<\/span><\/div><h2 id=\"nx-s-6\" class=\"nx-section-title\">The method as a run graph.<\/h2><p class=\"nx-lede\">Data from the source register feeds the methods; calibration and an independent test gate the estimate and its limits; the decision stays with the competent authority.<\/p><\/div><div class=\"nx-section-body\"><div class=\"nx-plate\" data-wide=\"true\"><div class=\"nx-plate-label\"><span class=\"nx-eyebrow\"><strong>Method canvas<\/strong> \u00b7 Molecular and life sciences as applied here<\/span><span class=\"nx-eyebrow\">Design, not a record<\/span><\/div><div class=\"nx-figure-frame\" data-scene=\"true\"><svg class=\"nx-figure nx-ui nx-dag\" viewBox=\"0 0 1200 564\" data-nx-dag=\"true\" data-w=\"1200\" data-h=\"564\" role=\"img\" aria-labelledby=\"nx-dag-g04-stem-life-sciences-biosec-oversight-t nx-dag-g04-stem-life-sciences-biosec-oversight-d\" data-nx-z=\"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\"><title id=\"nx-dag-g04-stem-life-sciences-biosec-oversight-t\">Molecular and life sciences in Health Nexus: institutional oversight of research<\/title><desc id=\"nx-dag-g04-stem-life-sciences-biosec-oversight-d\">Capacity and oversight only: proposals go to an institutional committee, reviewed under national rules, approved with conditions, supported by training, audited, and incidents are reported to the national body. Design of the process, not a record of a run.<\/desc><\/svg><\/div><\/div><p class=\"nx-caption\"><strong>Fig. 01<\/strong><span>Nodes carry their type, metrics and state; connectors show what feeds what; the gates are the validation steps; the timeline is one application. Design of the method's use, not a record of a run.<\/span><\/p><\/div><\/div><\/section><section id=\"nx-sec-data\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" aria-labelledby=\"nx-s-7\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">06<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Data<\/span><\/div><h2 id=\"nx-s-7\" class=\"nx-section-title\">What the method consumes.<\/h2><p class=\"nx-lede\">Datasets and records used by molecular and life sciences on this platform, with the role each plays and the label its values carry. Sources are listed in <a class=\"nx-link\" href=\"https:\/\/therisk.global\/health-nexus\/research\/sources\/\">the source register<\/a>.<\/p><\/div><div class=\"nx-section-body\" data-lv=\"register\"><div class=\"nx-table-wrap\"><table class=\"nx-table\" data-stack=\"true\"><thead><tr><th scope=\"col\">Data<\/th><th scope=\"col\">Role<\/th><th scope=\"col\">Label<\/th><\/tr><\/thead><tbody><tr><td data-label=\"Data\">INSDC archives (GenBank, ENA, DDBJ)<\/td><td data-label=\"Role\">Reference and outbreak sequences<\/td><td data-label=\"Label\"><span class=\"nx-chip\">OBSERVED<\/span><\/td><\/tr><tr><td data-label=\"Data\">GISAID<\/td><td data-label=\"Role\">Influenza and coronavirus genomes with metadata<\/td><td data-label=\"Label\"><span class=\"nx-chip\">OBSERVED<\/span><\/td><\/tr><tr><td data-label=\"Data\">WHO GLASS<\/td><td data-label=\"Role\">Resistance phenotypes from laboratory surveillance<\/td><td data-label=\"Label\"><span class=\"nx-chip\">REPORTED<\/span><\/td><\/tr><tr><td data-label=\"Data\">Wastewater sampling programmes<\/td><td data-label=\"Role\">Community trend signals<\/td><td data-label=\"Label\"><span class=\"nx-chip\">OBSERVED<\/span><\/td><\/tr><\/tbody><\/table><\/div><div class=\"nx-live-slot\" data-nxf-slot=\"data\" data-nxf-kind=\"data\" data-nxf-resource=\"nexus:\/\/gcri\/G04\/stem\/life-sciences\/#data\" data-nxf-title=\"Method record\" data-nxf-height=\"520\" hidden><\/div><div class=\"nx-live-slot\" data-nxf-slot=\"evidence\" data-nxf-kind=\"evidence\" data-nxf-resource=\"nexus:\/\/gcri\/G04\/stem\/life-sciences\/#evidence\" data-nxf-title=\"Evidence\" data-nxf-height=\"520\" hidden><\/div><\/div><\/div><\/section><section id=\"nx-sec-checks\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" data-variant=\"split\" aria-labelledby=\"nx-s-8\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">07<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Validation<\/span><\/div><h2 id=\"nx-s-8\" class=\"nx-section-title\">How results are checked.<\/h2><p class=\"nx-lede\">Results are confirmed through biological replicates, independent laboratories and orthogonal assays. Reference standards and proficiency testing check analytical accuracy.<\/p><\/div><div class=\"nx-section-body\" data-lv=\"ledger\"><div class=\"nx-table-wrap\"><table class=\"nx-table\" data-stack=\"true\"><thead><tr><th scope=\"col\">Check<\/th><th scope=\"col\">How it is done<\/th><\/tr><\/thead><tbody><tr><td data-label=\"Check\">External quality assessment<\/td><td data-label=\"How it is done\">Laboratories take part in proficiency testing and use reference materials for each assay<\/td><\/tr><tr><td data-label=\"Check\">Sampling representativeness<\/td><td data-label=\"How it is done\">How sequenced samples were selected is reported, so lineage shares are not over-read<\/td><\/tr><tr><td data-label=\"Check\">Phylogenetic robustness<\/td><td data-label=\"How it is done\">Trees are tested with bootstrap or posterior support and alternative models before relatedness is described<\/td><\/tr><\/tbody><\/table><\/div><p class=\"nx-note nx-mt-3\">Laboratory findings do not always translate to organisms or populations. Sampling bias in sequence databases limits generalisation.<\/p><\/div><\/div><\/section><section id=\"nx-sec-connections\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" data-variant=\"stack\" aria-labelledby=\"nx-s-9\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">08<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Connections<\/span><\/div><h2 id=\"nx-s-9\" class=\"nx-section-title\">Topics that rely on this method.<\/h2><\/div><div class=\"nx-section-body\"><ul class=\"nx-list\" data-nav=\"true\"><li><a class=\"nx-link\" href=\"https:\/\/therisk.global\/health-nexus\/topics\/one-health\/\"><span>One Health<\/span><svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/a><\/li><li><a class=\"nx-link\" href=\"https:\/\/therisk.global\/health-nexus\/topics\/infectious-threats\/\"><span>Infectious threats<\/span><svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/a><\/li><\/ul><\/div><\/div><\/section><section id=\"nx-sec-stewardship\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" data-variant=\"split\" aria-labelledby=\"nx-s-10\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">09<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Stewardship<\/span><\/div><h2 id=\"nx-s-10\" class=\"nx-section-title\">Who maintains the method.<\/h2><p class=\"nx-lede\"><a class=\"nx-link\" href=\"https:\/\/therisk.global\/biotechnology-biosecurity\/\">Biotechnology and Biosecurity<\/a> stewards molecular and life sciences for the Consortium and reviews how it is applied across platforms.<\/p><\/div><div class=\"nx-section-body\"><p class=\"nx-p\"><a class=\"nx-link\" href=\"https:\/\/therisk.global\/stem\/science\/life-sciences\/\">Canonical page: Molecular and life sciences<\/a><\/p><\/div><\/div><\/section><section id=\"nx-s-11-sec\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" aria-labelledby=\"nx-s-11\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">10<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Connected<\/span><\/div><h2 id=\"nx-s-11\" class=\"nx-section-title\">Where this page leads across the Consortium.<\/h2><\/div><div class=\"nx-section-body\"><ul class=\"nx-dest\"><li><a class=\"nx-dest-card\" href=\"https:\/\/therisk.global\/stem\/science\/life-sciences\/\"><span class=\"nx-dest-top\"><span class=\"nx-dest-rel\">Canonical method page<\/span><span class=\"nx-dest-host\">GCRI<\/span><\/span><span class=\"nx-dest-title\">Molecular and life sciences<\/span><span class=\"nx-dest-why\">Platform application links to the canonical method page.<\/span><span class=\"nx-dest-go\" aria-hidden=\"true\"><svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/span><\/a><\/li><li><a class=\"nx-dest-card\" href=\"https:\/\/therisk.global\/biotechnology-biosecurity\/stem\/life-sciences\/\"><span class=\"nx-dest-top\"><span class=\"nx-dest-rel\">Steward platform<\/span><span class=\"nx-dest-host\">GCRI<\/span><\/span><span class=\"nx-dest-title\">Molecular and life sciences for biotechnology and biosecurity<\/span><span class=\"nx-dest-why\">Biotechnology and Biosecurity stewards this method.<\/span><span class=\"nx-dest-go\" aria-hidden=\"true\"><svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/span><\/a><\/li><\/ul><\/div><\/div><\/section><section id=\"nx-s-12-sec\" class=\"nx-section\" data-hue=\"health\" aria-labelledby=\"nx-s-12\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">11<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Questions<\/span><\/div><h2 id=\"nx-s-12\" class=\"nx-section-title\">Questions and answers.<\/h2><\/div><div class=\"nx-section-body\"><div class=\"nx-faq\"><details><summary>What are the limits of molecular and life sciences in this field?<\/summary><div class=\"nx-answer\">Laboratory findings do not always translate to organisms or populations. Sampling bias in sequence databases limits generalisation.<\/div><\/details><details><summary>How are results checked?<\/summary><div class=\"nx-answer\">Results are confirmed through biological replicates, independent laboratories and orthogonal assays. Reference standards and proficiency testing check analytical accuracy.<\/div><\/details><details><summary>Are the values on this page real?<\/summary><div class=\"nx-answer\">The data names, roles and checks are real descriptions of practice. The canvas shows a design of the method's use, not a run; no result is reported here.<\/div><\/details><details><summary>Where else is this method applied?<\/summary><div class=\"nx-answer\">The <a class=\"nx-link\" href=\"https:\/\/therisk.global\/stem\/science\/life-sciences\/\">canonical method page<\/a> lists every platform that applies it.<\/div><\/details><\/div><\/div><\/div><\/section><section class=\"nx-section\" data-tone=\"alt\" aria-labelledby=\"nx-rel-13\"><div class=\"nx-container\"><span class=\"nx-eyebrow\">Related<\/span><h2 id=\"nx-rel-13\" class=\"nx-h3 nx-mt-2\">Around Health Nexus.<\/h2><nav class=\"nx-related nx-mt-3\" aria-label=\"Related\"><a href=\"https:\/\/therisk.global\/health-nexus\/stem\/epidemiology\/\">Epidemiology for health security <svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/a><a href=\"https:\/\/therisk.global\/health-nexus\/stem\/probability-statistics\/\">Statistics for health evidence <svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/a><a href=\"https:\/\/therisk.global\/health-nexus\/stem\/complex-systems\/\">Complex systems modelling for health <svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/a><a href=\"https:\/\/therisk.global\/health-nexus\/stem\/causal-inference\/\">Causal inference for public health <svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/a><a href=\"https:\/\/therisk.global\/health-nexus\/stem\/data-engineering\/\">Health data engineering and interoperability <svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/a><a href=\"https:\/\/therisk.global\/health-nexus\/stem\/biotechnology\/\">Biotechnology for health countermeasures <svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/a><a href=\"https:\/\/therisk.global\/health-nexus\/\">Health Nexus home <svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/a><a href=\"https:\/\/therisk.global\/health-nexus\/counterparts\/\">Counterparts across the Consortium <svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/a><a href=\"https:\/\/therisk.global\/\">The Global Centre for Risk and Innovation home <svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/a><a href=\"https:\/\/therisk.global\/trust\/\">GCRI governance and trust <svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/a><\/nav><\/div><\/section><section class=\"nx-closing\" aria-labelledby=\"nx-close-14\"><div class=\"nx-container\"><span class=\"nx-eyebrow\">Health Nexus<\/span><h2 id=\"nx-close-14\" class=\"nx-section-title\">Bring your expertise to this field.<\/h2><p class=\"nx-lede\">The current service level is R0: information and enquiries. 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