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:where([role=\"tablist\"],[role=\"toolbar\"],[hidden],button,.nx-theme-toggle,.nx-live-slot){display:none}#nxe-n29s6wdr.nxe img{max-width:100%;height:auto}<\/style><svg class=\"nx-defs\" aria-hidden=\"true\" focusable=\"false\" width=\"0\" height=\"0\"><defs><linearGradient id=\"nx-gi\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"1\"><stop offset=\"0\" class=\"nx-gi-a\"\/><stop offset=\"0.55\" class=\"nx-gi-b\"\/><stop offset=\"1\" class=\"nx-gi-c\"\/><\/linearGradient><linearGradient id=\"nx-giu\" gradientUnits=\"userSpaceOnUse\" x1=\"0\" y1=\"0\" x2=\"800\" y2=\"0\"><stop offset=\"0\" class=\"nx-gi-a\"\/><stop offset=\"0.55\" class=\"nx-gi-b\"\/><stop offset=\"1\" class=\"nx-gi-c\"\/><\/linearGradient><linearGradient id=\"nx-gp\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"1\"><stop offset=\"0\" class=\"nx-gp-a\"\/><stop offset=\"1\" class=\"nx-gp-b\"\/><\/linearGradient><\/defs><\/svg><section class=\"nx-scene nx-es-scene\" data-scene=\"text\" data-ground=\"none\" data-es-org=\"gcri\" aria-labelledby=\"nx-scene-title\"><div class=\"nx-scene-intro nx-es-intro\"><p class=\"nx-eyebrow\"><abbr title=\"The Global Centre for Risk and Innovation\">GCRI<\/abbr> \u00b7 Health Nexus<\/p><span class=\"nx-scene-rule\" aria-hidden=\"true\"><\/span><h1 id=\"nx-scene-title\" class=\"nx-scene-title\">Biotechnology for health countermeasures<\/h1><p class=\"nx-scene-lede\">Biotechnology platforms determine how quickly diagnostics, vaccines and therapeutics can be developed, manufactured and delivered when a new threat appears. In this field the concern is capacity and dependency: which platforms exist, where manufacturing sits, what inputs it needs, and the biosafety and biosecurity oversight that must accompany it.<\/p><div class=\"nx-actions\"><a class=\"nx-btn\" data-variant=\"primary\" href=\"https:\/\/therisk.global\/health-nexus\/write-to-us\/contact\/\">Make an enquiry <svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/a><a class=\"nx-btn\" data-variant=\"secondary\" href=\"https:\/\/therisk.global\/health-nexus\/stem\/\">Back to STEM foundation of Health Nexus<\/a><\/div><\/div><\/section><section id=\"nx-s-1-sec\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" aria-labelledby=\"nx-s-1\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">01<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Contents<\/span><\/div><h2 id=\"nx-s-1\" class=\"nx-section-title\">Biotechnology for health countermeasures in five parts.<\/h2><\/div><div class=\"nx-section-body\"><div class=\"nx-es-fig\" data-es-layout=\"protocol\"><div class=\"nx-hero-panel\"><div class=\"nx-lv-steps\"><div class=\"nx-register-head\"><span class=\"nx-eyebrow\"><strong>Protocol<\/strong><\/span><span class=\"nx-eyebrow\">5 steps<\/span><\/div><ol><li><a href=\"#nx-sec-application\"><span class=\"nx-lv-steps-n\">01<\/span><span class=\"nx-lv-steps-t\">Application<\/span><span class=\"nx-lv-steps-d\">What biotechnology platforms does here<\/span><\/a><\/li><li><a href=\"#nx-sec-data\"><span class=\"nx-lv-steps-n\">02<\/span><span class=\"nx-lv-steps-t\">Data<\/span><span class=\"nx-lv-steps-d\">What the method consumes<\/span><\/a><\/li><li><a href=\"#nx-sec-checks\"><span class=\"nx-lv-steps-n\">03<\/span><span class=\"nx-lv-steps-t\">Validation<\/span><span class=\"nx-lv-steps-d\">How results are checked<\/span><\/a><\/li><li><a href=\"#nx-sec-connections\"><span class=\"nx-lv-steps-n\">04<\/span><span class=\"nx-lv-steps-t\">Connections<\/span><span class=\"nx-lv-steps-d\">Topics that rely on this method<\/span><\/a><\/li><li><a href=\"#nx-sec-stewardship\"><span class=\"nx-lv-steps-n\">05<\/span><span class=\"nx-lv-steps-t\">Stewardship<\/span><span class=\"nx-lv-steps-d\">Who maintains the method<\/span><\/a><\/li><\/ol><\/div><\/div><\/div><\/div><\/div><\/section><section id=\"nx-sec-application\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" data-variant=\"split\" aria-labelledby=\"nx-s-2\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">02<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Application<\/span><\/div><h2 id=\"nx-s-2\" class=\"nx-section-title\">What biotechnology platforms does here.<\/h2><p class=\"nx-lede\">Biotechnology platforms apply biological <a class=\"nx-link nx-term\" href=\"https:\/\/docs.therisk.global\/organization\/systems\" data-tc=\"Systems\" data-tk=\"Nexus Standards\" data-td=\"The twenty Nexus systems, NXS-CMD to NXS-LAB\">systems<\/a> to produce medicines, diagnostics, materials and agricultural products. They expand response capacity for health threats while introducing dual-use and biosafety concerns. In health and biosecurity, biotechnology capacity shapes how quickly countermeasures can be produced in a crisis. Its supply chains and dual-use potential are part of biosecurity planning. The canonical description is on <a class=\"nx-link\" href=\"https:\/\/therisk.global\/stem\/technology\/biotechnology\/\">the STEM Commons<\/a>.<\/p><\/div><div class=\"nx-section-body\"><div class=\"nx-cols\"><article><div class=\"nx-glyph-row\"><span class=\"nx-glyph\" data-tone=\"accent\" data-size=\"lg\"><svg class=\"nx-i\" viewBox=\"0 0 24 24\" aria-hidden=\"true\" focusable=\"false\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M2 15c6.67-6 13.33 0 20-6\"\/><path d=\"M9 22c1.8-2 2.52-3.99 2.81-5.99\"\/><path d=\"M15 2c-1.8 2-2.52 4-2.81 5.99\"\/><path d=\"m17 6-2.5-2.5\"\/><path d=\"m14 8-1-1\"\/><path d=\"m7 18 2.5 2.5\"\/><path d=\"m3.5 14.5.5.5\"\/><path d=\"m20 9 .5.5\"\/><path d=\"m6.5 12.5 1 1\"\/><path d=\"m16.5 10.5 1 1\"\/><path d=\"m10 16 1.5 1.5\"\/><\/svg><\/span><\/div><h3 class=\"nx-h3 nx-mt-2\">Countermeasure manufacturing capacity<\/h3><p class=\"nx-p nx-mt-1\">Manufacturing sites, platform technologies and their input dependencies are mapped by region, so surge scenarios can state where capacity exists and what would constrain it.<\/p><\/article><article><div class=\"nx-glyph-row\"><span class=\"nx-glyph\" data-tone=\"accent\" data-size=\"lg\"><svg class=\"nx-i\" viewBox=\"0 0 24 24\" aria-hidden=\"true\" focusable=\"false\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M6 18h8\"\/><path d=\"M3 22h18\"\/><path d=\"M14 22a7 7 0 1 0 0-14h-1\"\/><path d=\"M9 14h2\"\/><path d=\"M9 12a2 2 0 0 1-2-2V6h6v4a2 2 0 0 1-2 2Z\"\/><path d=\"M12 6V3a1 1 0 0 0-1-1H9a1 1 0 0 0-1 1v3\"\/><\/svg><\/span><\/div><h3 class=\"nx-h3 nx-mt-2\">Diagnostic readiness<\/h3><p class=\"nx-p nx-mt-1\">The availability, regulatory status and independent performance evaluations of diagnostic assays for priority pathogens are compiled, so gaps in testing capacity can be seen before an event.<\/p><\/article><article><div class=\"nx-glyph-row\"><span class=\"nx-glyph\" data-tone=\"accent\" data-size=\"lg\"><svg class=\"nx-i\" viewBox=\"0 0 24 24\" aria-hidden=\"true\" focusable=\"false\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M20 13c0 5-3.5 7.5-7.66 8.95a1 1 0 0 1-.67-.01C7.5 20.5 4 18 4 13V6a1 1 0 0 1 1-1c2 0 4.5-1.2 6.24-2.72a1.17 1.17 0 0 1 1.52 0C14.51 3.81 17 5 19 5a1 1 0 0 1 1 1z\"\/><path d=\"m9 12 2 2 4-4\"\/><\/svg><\/span><\/div><h3 class=\"nx-h3 nx-mt-2\">Biosafety and biosecurity oversight<\/h3><p class=\"nx-p nx-mt-1\">Laboratory containment, oversight arrangements and dual-use review processes are documented against the WHO Laboratory Biosafety Manual and national regulation.<\/p><\/article><\/div><\/div><\/div><\/section><section id=\"nx-s-3-sec\" class=\"nx-section\" data-hue=\"health\" aria-labelledby=\"nx-s-3\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">03<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Monitor<\/span><\/div><h2 id=\"nx-s-3\" class=\"nx-section-title\">Oversight register.<\/h2><p class=\"nx-lede\">The screen a team would use to follow this method: its measures, states and decisions. Names are examples and values are illustrative.<\/p><\/div><div class=\"nx-section-body\"><figure class=\"nx-fk nx-cx\" data-fk=\"cx-health-method-oversight\" data-cx=\"health.method-oversight\" data-variant=\"section\" aria-label=\"Oversight register: illustrative console with example names and values\"><div class=\"nx-fk-head\"><div class=\"nx-fk-heading\"><h3 class=\"nx-fk-title\">Oversight register<\/h3><p class=\"nx-fk-sub\">Health \u00b7 Biotechnology for health \u00b7 Run R-6512<\/p><\/div><div class=\"nx-fk-actions\"><button type=\"button\" class=\"nx-fk-btn\" data-fk-act=\"menu\" aria-haspopup=\"true\" aria-expanded=\"false\" hidden><svg viewBox=\"0 0 24 24\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M12 4v11\"\/><path d=\"m7 10 5 5 5-5\"\/><path d=\"M5 20h14\"\/><\/svg>Export<\/button><ul class=\"nx-fk-menu\" data-fk-menu=\"true\" hidden><li><button type=\"button\" data-fk-act=\"export-png\">Image<small>PNG of the map or chart<\/small><\/button><\/li><li><button type=\"button\" data-fk-act=\"export-csv\">Data<small>CSV of the figure&#8217;s values<\/small><\/button><\/li><\/ul><\/div><\/div><div class=\"nx-cx-status\"><span class=\"nx-fk-pill\" data-state=\"info\"><i aria-hidden=\"true\"><\/i>Reviews current<\/span><span class=\"nx-cx-prod\">GCRI \u00b7 Health Nexus<\/span><\/div><div class=\"nx-cx-grid\"><div class=\"nx-fk-panel nx-cx-p\" data-w=\"4\" data-t=\"table\"><div class=\"nx-fk-panel-head\"><div><h4 class=\"nx-fk-panel-title\">Institutional reviews<\/h4><p class=\"nx-fk-panel-sub\">capacity and oversight only<\/p><\/div><\/div><div class=\"nx-fk-tablewrap\" data-fk-view=\"table:cx-health-method-oversight-t0\"><table class=\"nx-fk-table\" data-fk-table=\"cx-health-method-oversight-t0\" aria-label=\"Institutional reviews\"><thead><tr><th scope=\"col\" data-col=\"c0\" aria-sort=\"none\"><button type=\"button\" data-fk-sort=\"c0\">Project<\/button><\/th><th scope=\"col\" data-col=\"c1\" aria-sort=\"none\"><button type=\"button\" data-fk-sort=\"c1\">Review body<\/button><\/th><th scope=\"col\" data-col=\"c2\" aria-sort=\"none\"><button type=\"button\" data-fk-sort=\"c2\">Containment level<\/button><\/th><th scope=\"col\" data-col=\"c3\" aria-sort=\"none\"><button type=\"button\" data-fk-sort=\"c3\">Next review<\/button><\/th><th scope=\"col\" data-col=\"c4\" aria-sort=\"none\"><button type=\"button\" data-fk-sort=\"c4\">State<\/button><\/th><\/tr><\/thead><tbody><tr data-fk-key=\"cx-health-method-oversight:r0-0\" tabindex=\"0\" role=\"row\" aria-selected=\"false\"><td>Project P-517<\/td><td>Institutional committee<\/td><td>Level 1<\/td><td>Q3<\/td><td><span class=\"nx-fk-pill\" data-state=\"met\"><i aria-hidden=\"true\"><\/i>Approved<\/span><\/td><\/tr><tr data-fk-key=\"cx-health-method-oversight:r0-1\" tabindex=\"0\" role=\"row\" aria-selected=\"false\"><td>Project P-056<\/td><td>Institutional committee<\/td><td>Level 1<\/td><td>Q3<\/td><td><span class=\"nx-fk-pill\" data-state=\"info\"><i aria-hidden=\"true\"><\/i>Pending<\/span><\/td><\/tr><tr data-fk-key=\"cx-health-method-oversight:r0-2\" tabindex=\"0\" role=\"row\" aria-selected=\"false\"><td>Project P-843<\/td><td>Institutional committee<\/td><td>Level 2<\/td><td>Q1<\/td><td><span class=\"nx-fk-pill\" data-state=\"near\"><i aria-hidden=\"true\"><\/i>Conditions<\/span><\/td><\/tr><tr data-fk-key=\"cx-health-method-oversight:r0-3\" tabindex=\"0\" role=\"row\" aria-selected=\"false\"><td>Project P-111<\/td><td>Institutional committee<\/td><td>Level 1<\/td><td>Q2<\/td><td><span class=\"nx-fk-pill\" data-state=\"near\"><i aria-hidden=\"true\"><\/i>Conditions<\/span><\/td><\/tr><\/tbody><\/table><\/div><\/div><div class=\"nx-fk-panel nx-cx-p\" data-w=\"2\" data-t=\"bullets\"><div class=\"nx-fk-panel-head\"><div><h4 class=\"nx-fk-panel-title\">Training coverage<\/h4><\/div><\/div><div class=\"nx-fk-chart\"><svg class=\"nx-fk-svg\" viewBox=\"0 0 360 92\" width=\"360\" height=\"92\" role=\"img\" focusable=\"false\" preserveAspectRatio=\"xMidYMid meet\" aria-label=\"Training coverage\" data-fk-chart=\"bars\"><g data-m=\"row\" data-k=\"r-b0\"><text data-m=\"rlabel\" x=\"104\" y=\"17\" text-anchor=\"end\">Biosafety<\/text><rect data-m=\"bar\" data-k=\"b-b0-v\" data-c=\"acc\" x=\"112\" y=\"4\" width=\"102.3\" height=\"18\"\/><rect data-m=\"bar\" data-k=\"b-b0-r\" data-c=\"rule\" x=\"215.3\" y=\"4\" width=\"6.9\" height=\"18\"\/><text data-m=\"vlabel\" data-k=\"v-b0\" x=\"228.2\" y=\"17\">89 of 95 required<\/text><rect data-m=\"hit\" x=\"0\" y=\"-1\" width=\"360\" height=\"28\"\/><\/g><g data-m=\"row\" data-k=\"r-b1\"><text data-m=\"rlabel\" x=\"104\" y=\"45\" text-anchor=\"end\">Biosecurity awareness<\/text><rect data-m=\"bar\" data-k=\"b-b1-v\" data-c=\"acc\" x=\"112\" y=\"32\" width=\"78.6\" height=\"18\"\/><rect data-m=\"bar\" data-k=\"b-b1-r\" data-c=\"rule\" x=\"191.6\" y=\"32\" width=\"24.8\" height=\"18\"\/><text data-m=\"vlabel\" data-k=\"v-b1\" x=\"222.4\" y=\"45\">69 of 90 required<\/text><rect data-m=\"hit\" x=\"0\" y=\"27\" width=\"360\" height=\"28\"\/><\/g><g data-m=\"row\" data-k=\"r-b2\"><text data-m=\"rlabel\" x=\"104\" y=\"73\" text-anchor=\"end\">Incident reporting<\/text><rect data-m=\"bar\" data-k=\"b-b2\" data-c=\"acc\" x=\"112\" y=\"60\" width=\"104.7\" height=\"18\"\/><text data-m=\"vlabel\" data-k=\"v-b2\" x=\"222.7\" y=\"73\">90 of 90 required<\/text><rect data-m=\"hit\" x=\"0\" y=\"55\" width=\"360\" height=\"28\"\/><\/g><\/svg><\/div><\/div><\/div><div class=\"nx-fk-tip\" aria-hidden=\"true\" hidden><\/div><figcaption class=\"nx-fk-cap\"><span>Oversight register: the screen&#8217;s structure, terms and states for Health.<\/span><span data-honesty=\"true\">Example names and illustrative values; a design, not a record or a live system.<\/span><\/figcaption><\/figure><\/div><\/div><\/section><section id=\"nx-sec-data\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" aria-labelledby=\"nx-s-4\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">04<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Data<\/span><\/div><h2 id=\"nx-s-4\" class=\"nx-section-title\">What the method consumes.<\/h2><p class=\"nx-lede\">Datasets and records used by biotechnology platforms on this platform, with the role each plays and the label its values carry. Sources are listed in <a class=\"nx-link\" href=\"https:\/\/therisk.global\/health-nexus\/research\/sources\/\">the source register<\/a>.<\/p><\/div><div class=\"nx-section-body\" data-lv=\"register\"><div class=\"nx-table-wrap\"><table class=\"nx-table\" data-stack=\"true\"><thead><tr><th scope=\"col\">Data<\/th><th scope=\"col\">Role<\/th><th scope=\"col\">Label<\/th><\/tr><\/thead><tbody><tr><td data-label=\"Data\">WHO Prequalification and Emergency Use Listing records<\/td><td data-label=\"Role\">Regulatory status of products<\/td><td data-label=\"Label\"><span class=\"nx-chip\">Published statistics<\/span><\/td><\/tr><tr><td data-label=\"Data\">WHO International Clinical Trials Registry Platform<\/td><td data-label=\"Role\">Countermeasure development pipeline<\/td><td data-label=\"Label\"><span class=\"nx-chip\">REPORTED<\/span><\/td><\/tr><tr><td data-label=\"Data\">Manufacturer and regulatory site registers<\/td><td data-label=\"Role\">Manufacturing capacity and location<\/td><td data-label=\"Label\"><span class=\"nx-chip\">DECLARED<\/span><\/td><\/tr><tr><td data-label=\"Data\">Independent diagnostic evaluations<\/td><td data-label=\"Role\">Assay performance<\/td><td data-label=\"Label\"><span class=\"nx-chip\">OBSERVED<\/span><\/td><\/tr><\/tbody><\/table><\/div><div class=\"nx-live-slot\" data-nxf-slot=\"data\" data-nxf-kind=\"data\" data-nxf-resource=\"nexus:\/\/gcri\/G04\/stem\/biotechnology\/#data\" data-nxf-title=\"Method record\" data-nxf-height=\"520\" hidden><\/div><div class=\"nx-live-slot\" data-nxf-slot=\"evidence\" data-nxf-kind=\"evidence\" data-nxf-resource=\"nexus:\/\/gcri\/G04\/stem\/biotechnology\/#evidence\" data-nxf-title=\"Evidence\" data-nxf-height=\"520\" hidden><\/div><\/div><\/div><\/section><section id=\"nx-sec-signature\" class=\"nx-section\" data-hue=\"health\" aria-labelledby=\"nx-s-5\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">05<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Sector signature<\/span><\/div><h2 id=\"nx-s-5\" class=\"nx-section-title\">The sector signature of biotechnology for health countermeasures.<\/h2><p class=\"nx-lede\">The sectors biotechnology for health countermeasures touches and how strongly they depend on each other: what a study has to observe and model together.<\/p><\/div><div class=\"nx-section-body\"><div class=\"nx-canvas-wrap\"><figure class=\"nx-nsig\" data-nx-sig=\"WIFH\" data-sig-name=\"Health and its partners\" data-sig-line=\"Health gives workforce for operations to infrastructure (0.3), farm labour to food (0.3) and utility workforce to water (0.2).\" data-sig-inst=\"The Global Centre for Risk and Innovation\"><div class=\"nx-nsig-plate\"><div class=\"nx-nsig-strip\" role=\"group\" aria-label=\"Signatures in context\" hidden><\/div><div class=\"nx-nsig-stage\"><div class=\"nx-nsig-top\"><span>Select corners \u00b7 hover lines<\/span><span class=\"nx-nsig-pairs\">6 \/ 15 relations<\/span><\/div><div class=\"nx-nsig-tilt\"><svg class=\"nx-nsig-svg\" viewBox=\"-370 -290 740 580\" role=\"img\" aria-label=\"Sector signature hexagon: Water, Infrastructure, Food and Health selected, 6 of 15 relations in play, coupling 0.42. Teaching values.\" focusable=\"false\" data-nx-z=\"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\"><\/svg><\/div><\/div><div class=\"nx-nsig-read\"><div><p class=\"nx-nsig-k\">Signature<\/p><p class=\"nx-nsig-name\">Health and its partners<\/p><p class=\"nx-nsig-line\">Health gives workforce for operations to infrastructure (0.3), farm labour to food (0.3) and utility workforce to water (0.2).<\/p><\/div><p class=\"nx-nsig-code\" aria-live=\"polite\"><span>W<\/span> \u00b7 <span class=\"nx-nsig-off\">E<\/span> \u00b7 <span>I<\/span> \u00b7 <span>F<\/span> \u00b7 <span>H<\/span> \u00b7 <span class=\"nx-nsig-off\">B<\/span><\/p><dl class=\"nx-nsig-stats\"><div><dt>Sectors<\/dt><dd><strong>4<\/strong> <small>of 6<\/small><\/dd><\/div><div><dt>Relations<\/dt><dd><strong>6<\/strong> <small>of 15<\/small><\/dd><\/div><div><dt>Coupling<\/dt><dd><strong>0.42<\/strong> <small>share of total<\/small><\/dd><\/div><\/dl><div class=\"nx-nsig-detail\"><h3 class=\"nx-nsig-dh\">Strongest relations in play<\/h3><ul class=\"nx-nsig-rel\"><li><span class=\"nx-nsig-rt\"><b>Water \u2192 Food<\/b> \u00b7 irrigation<\/span><span class=\"nx-nsig-bar\" data-v=\"8\" aria-hidden=\"true\"><i><\/i><\/span><span class=\"nx-nsig-v\">0.8<\/span><\/li><li><span class=\"nx-nsig-rt\"><b>Food \u2192 Health<\/b> \u00b7 nutrition<\/span><span class=\"nx-nsig-bar\" data-v=\"7\" aria-hidden=\"true\"><i><\/i><\/span><span class=\"nx-nsig-v\">0.7<\/span><\/li><li><span class=\"nx-nsig-rt\"><b>Infrastructure \u2192 Water<\/b> \u00b7 pipes, dams and treatment works<\/span><span class=\"nx-nsig-bar\" data-v=\"6\" aria-hidden=\"true\"><i><\/i><\/span><span class=\"nx-nsig-v\">0.6<\/span><\/li><li><span class=\"nx-nsig-rt\"><b>Water \u2192 Health<\/b> \u00b7 drinking water and sanitation<\/span><span class=\"nx-nsig-bar\" data-v=\"7\" aria-hidden=\"true\"><i><\/i><\/span><span class=\"nx-nsig-v\">0.7<\/span><\/li><\/ul><\/div><div class=\"nx-nsig-actions\" hidden><button type=\"button\" class=\"nx-nsig-btn\" data-sig-act=\"all\">Select all<\/button><button type=\"button\" class=\"nx-nsig-btn\" data-sig-act=\"clear\">Clear<\/button><button type=\"button\" class=\"nx-nsig-btn nx-nsig-pri\" data-sig-act=\"copy\">Copy signature<\/button><\/div><\/div><\/div><figcaption class=\"nx-nsig-note\">Teaching values for a typical city-region, not measurements for any place. Coupling is the summed strength of the relations in play, as a share of all fifteen.<\/figcaption><\/figure><\/div><\/div><\/div><\/section><section id=\"nx-sec-checks\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" data-variant=\"stack\" aria-labelledby=\"nx-s-6\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">06<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Validation<\/span><\/div><h2 id=\"nx-s-6\" class=\"nx-section-title\">How results are checked.<\/h2><p class=\"nx-lede\">Products are evaluated through staged preclinical and clinical testing and manufacturing quality controls. Regulatory review and independent replication check claims.<\/p><\/div><div class=\"nx-section-body\"><div class=\"nx-table-wrap\"><table class=\"nx-table\" data-stack=\"true\"><thead><tr><th scope=\"col\">Check<\/th><th scope=\"col\">How it is done<\/th><\/tr><\/thead><tbody><tr><td data-label=\"Check\">Regulatory status verification<\/td><td data-label=\"How it is done\"><a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-c1\" data-tc=\"NRS-C1 product-status\" data-tk=\"Nexus risk vocabulary\" data-td=\"The Nexus label on a risk product saying whether it is usable: OK, no data, insufficient evidence, degraded or withheld. A status is never upgraded to hide a gap.\" data-ts=\"NRS-C1\" data-tr=\"draft\">Product status<\/a> is confirmed against the regulator&#8217;s public register, not company statements<\/td><\/tr><tr><td data-label=\"Check\">Input dependency tracing<\/td><td data-label=\"How it is done\">Critical inputs such as raw materials, consumables and fill-finish capacity are traced for each platform<\/td><\/tr><tr><td data-label=\"Check\">Biosecurity review<\/td><td data-label=\"How it is done\">Published material describes capacity and oversight without detailing hazardous methods<\/td><\/tr><\/tbody><\/table><\/div><p class=\"nx-note nx-mt-3\">Scale-up from laboratory to production often fails or takes time. Containment and oversight can lag behind technical capability.<\/p><\/div><\/div><\/section><section id=\"nx-sec-audience\" class=\"nx-section\" data-hue=\"health\" aria-labelledby=\"nx-s-7\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">07<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Methods and evidence<\/span><\/div><h2 id=\"nx-s-7\" class=\"nx-section-title\">How biotechnology for health countermeasures is modelled, measured and tested.<\/h2><p class=\"nx-lede\">The model, its assumptions, its data and its uncertainty, in the form a scientist or engineer would check. Structures follow published methods. The values drawn are illustrative, not findings.<\/p><\/div><div class=\"nx-section-body\"><div class=\"nx-au\" data-au-voice=\"science\" data-au-n=\"1\"><figure class=\"nx-au-c\" data-au-fig=\"uncertainty-band\"><h3 class=\"nx-h4\">Uncertainty bands<\/h3><p class=\"nx-p nx-au-what\">How far the outlook for biotechnology for health countermeasures could spread, shown as ranges rather than a single line.<\/p><div class=\"nx-au-fig\"><svg class=\"nx-au-svg\" viewBox=\"0 0 560 240\" role=\"img\" aria-label=\"Central estimate with likely and very likely ranges for Biotechnology for health countermeasures\" focusable=\"false\"><line class=\"nx-au-ax\" x1=\"46\" y1=\"206\" x2=\"544\" y2=\"206\"\/><line class=\"nx-au-ax\" x1=\"46\" y1=\"18\" x2=\"46\" y2=\"206\"\/><path class=\"nx-au-band nx-au-band-w\" d=\"M46 142.1l83-18.8 83-18.8 83-22.6 83-20.7 83-18.8 83-18.8 0 124.1-83 0-83 0-83 1.9-83 3.8-83 0-83 3.7z\"\/><path class=\"nx-au-band\" d=\"M46 145.8l83-15 83-13.2 83-16.9 83-15 83-13.2 83-13.1 0 52.6-83 5.6-83 5.7-83 7.5-83 9.4-83 5.6-83 7.6z\"\/><path class=\"nx-au-ac\" d=\"M46 149.6l83-11.3 83-9.4 83-13.1 83-11.3 83-9.4 83-9.4\"\/><text class=\"nx-au-t\" x=\"46\" y=\"222\" text-anchor=\"middle\">Now<\/text><text class=\"nx-au-t\" x=\"129\" y=\"222\" text-anchor=\"middle\">+5<\/text><text class=\"nx-au-t\" x=\"212\" y=\"222\" text-anchor=\"middle\">+10<\/text><text class=\"nx-au-t\" x=\"295\" y=\"222\" text-anchor=\"middle\">+15<\/text><text class=\"nx-au-t\" x=\"378\" y=\"222\" text-anchor=\"middle\">+20<\/text><text class=\"nx-au-t\" x=\"461\" y=\"222\" text-anchor=\"middle\">+25<\/text><text class=\"nx-au-t\" x=\"544\" y=\"222\" text-anchor=\"middle\">+30 y<\/text><text class=\"nx-au-t\" x=\"40\" y=\"36.8\" text-anchor=\"end\">high<\/text><text class=\"nx-au-t\" x=\"40\" y=\"187.2\" text-anchor=\"end\">low<\/text><text class=\"nx-au-t\" x=\"540\" y=\"17.64\" text-anchor=\"end\">very likely range<\/text><text class=\"nx-au-t\" x=\"540\" y=\"73.36\" text-anchor=\"end\">likely range<\/text><\/svg><\/div><dl class=\"nx-au-kv\"><div><dt>Central estimate<\/dt><dd>median of the ensemble<\/dd><\/div><div><dt>Ranges<\/dt><dd>likely and very likely, in IPCC calibrated language<\/dd><\/div><div><dt>Ensemble<\/dt><dd>members, scenarios and initial conditions stated<\/dd><\/div><div><dt>Read with<\/dt><dd>the sensitivity of the result to each input<\/dd><\/div><\/dl><figcaption class=\"nx-caption\"><span>Illustrative ensemble spread on an index scale; the form follows IPCC uncertainty guidance. Not a projection.<\/span><\/figcaption><\/figure><\/div><div class=\"nx-chips nx-au-fw\" aria-label=\"Frameworks cited\"><span class=\"nx-chip\">FAIR guiding principles \u00b7 GO FAIR and FORCE11<\/span><span class=\"nx-chip\">W3C PROV \u00b7 World Wide Web Consortium<\/span><span class=\"nx-chip\">Guidance on consistent treatment of uncertainties \u00b7 IPCC<\/span><span class=\"nx-chip\">CEOS Analysis Ready Data \u00b7 Committee on Earth Observation Satellites<\/span><\/div><\/div><\/div><\/section><section id=\"nx-sec-connections\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" data-variant=\"stack\" aria-labelledby=\"nx-s-8\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">08<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Connections<\/span><\/div><h2 id=\"nx-s-8\" class=\"nx-section-title\">Topics that rely on this method.<\/h2><\/div><div class=\"nx-section-body\"><ul class=\"nx-list\"><li><a class=\"nx-link\" href=\"https:\/\/therisk.global\/health-nexus\/topics\/health-supply-chains\/\">Health supply chains<\/a><\/li><\/ul><\/div><\/div><\/section><section id=\"nx-s-9-sec\" class=\"nx-section\" data-hue=\"health\" aria-labelledby=\"nx-s-9\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">09<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Process<\/span><\/div><h2 id=\"nx-s-9\" class=\"nx-section-title\">How the process runs.<\/h2><\/div><div class=\"nx-section-body\"><div class=\"nx-canvas-wrap\"><div class=\"nx-pe\" id=\"nx-pe-biosec-oversight\" data-nx-pe=\"nx-pe-biosec-oversight\" data-active=\"oversight\"><div class=\"nx-pe-shell\"><p class=\"nx-pe-eb\">Process<\/p><h2 class=\"nx-pe-title\">Biotechnology for health countermeasures: Life-science research oversight<\/h2><p class=\"nx-pe-cap\">Capacity and oversight only, following the WHO Laboratory biosafety manual (4th edition) and WHO life sciences framework, with no methods, agents or protocols.<\/p><ol class=\"nx-pe-steps\"><li class=\"nx-pe-lane\"><h3 class=\"nx-pe-lane-t\">01 Institution<\/h3><ol><li class=\"nx-pe-step\"><span class=\"nx-pe-n\" translate=\"no\">01<\/span><span class=\"nx-pe-st\">Proposal<\/span><span class=\"nx-pe-k\">Dataset<\/span><span class=\"nx-pe-sm\">A research institution submits a proposal for review. The place is set by the page.<\/span><\/li><li class=\"nx-pe-step\"><span class=\"nx-pe-n\" translate=\"no\">02<\/span><span class=\"nx-pe-st\">Institutional committee<\/span><span class=\"nx-pe-k\">Gate \u00b7 The institution<\/span><span class=\"nx-pe-sm\">A biosafety committee is an independent institutional review group, reporting to senior management. Review follows national rules.<\/span><\/li><li class=\"nx-pe-step\"><span class=\"nx-pe-n\" translate=\"no\">03<\/span><span class=\"nx-pe-st\">Conditions: risk control measures<\/span><span class=\"nx-pe-k\">Step<\/span><span class=\"nx-pe-sm\">A <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-c1\" data-tc=\"NRS-C1 risk-assessment\" data-tk=\"Nexus risk vocabulary\" data-td=\"The overall process of identifying, analysing and evaluating risk to inform decisions.\" data-ts=\"NRS-C1\" data-tr=\"draft\">risk assessment<\/a> sets the measures: core requirements, heightened control measures or maximum containment, not one biosafety level.<\/span><\/li><li class=\"nx-pe-step\"><span class=\"nx-pe-n\" translate=\"no\">04<\/span><span class=\"nx-pe-st\">Training and competence<\/span><span class=\"nx-pe-k\">Step<\/span><span class=\"nx-pe-sm\">Actual risk depends on the agent, the procedure and staff competency. Training and personnel competence have their own section.<\/span><\/li><\/ol><\/li><li class=\"nx-pe-lane\"><h3 class=\"nx-pe-lane-t\">02 Assurance<\/h3><ol><li class=\"nx-pe-step\"><span class=\"nx-pe-n\" translate=\"no\">05<\/span><span class=\"nx-pe-st\">Audit and inspection<\/span><span class=\"nx-pe-k\">Gate<\/span><span class=\"nx-pe-sm\">Many <a class=\"nx-link nx-term\" href=\"https:\/\/docs.therisk.global\/organization\/programme\/labs\" data-tc=\"Labs\" data-tk=\"Nexus Standards\" data-td=\"The research pillar of the programme, one of six (OR-11, OR-12)\">labs<\/a> run cooperative inspections: periodic self-audits plus a rarer, deeper evaluation with the biosafety officer or committee.<\/span><\/li><li class=\"nx-pe-step\"><span class=\"nx-pe-n\" translate=\"no\">06<\/span><span class=\"nx-pe-st\">Emergency and incident response<\/span><span class=\"nx-pe-k\">Step<\/span><span class=\"nx-pe-sm\">The manual covers emergency and incident response at each level of measures. External reporting of incidents depends on national rules.<\/span><\/li><\/ol><\/li><li class=\"nx-pe-lane\"><h3 class=\"nx-pe-lane-t\">03 National<\/h3><ol><li class=\"nx-pe-step\"><span class=\"nx-pe-n\" translate=\"no\">07<\/span><span class=\"nx-pe-st\">National oversight<\/span><span class=\"nx-pe-k\">Decision \u00b7 National IHR focal point<\/span><span class=\"nx-pe-sm\">The WHO framework is for those who govern biorisks, such as policy makers and regulators. National bodies set national rules.<\/span><\/li><\/ol><\/li><\/ol><p class=\"nx-pe-foot\"><span>Neutral outline of a published external standard or method, from its issuing body. Not a record of operation. Nexus does not perform, certify or approve any step shown. A gate or decision belongs to the party the source names. The Biological Weapons Convention is not drawn in this flow. The framework is the WHO global guidance framework for the responsible use of the life sciences.<\/span><\/p><\/div><\/div><\/div><\/div><\/div><\/section><section id=\"nx-sec-stewardship\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" data-variant=\"split\" aria-labelledby=\"nx-s-10\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">10<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Stewardship<\/span><\/div><h2 id=\"nx-s-10\" class=\"nx-section-title\">Who maintains the method.<\/h2><p class=\"nx-lede\"><a class=\"nx-link\" href=\"https:\/\/therisk.global\/biotechnology-biosecurity\/\">Biotechnology and Biosecurity<\/a> stewards biotechnology platforms for the Consortium and reviews how it is applied across platforms.<\/p><\/div><div class=\"nx-section-body\"><p class=\"nx-p\"><a class=\"nx-link\" href=\"https:\/\/therisk.global\/stem\/technology\/biotechnology\/\">Canonical page: Biotechnology platforms<\/a><\/p><\/div><\/div><\/section><section id=\"nx-s-11-sec\" class=\"nx-section\" data-hue=\"health\" aria-labelledby=\"nx-s-11\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">11<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Connected<\/span><\/div><h2 id=\"nx-s-11\" class=\"nx-section-title\">Where this page leads across the Consortium.<\/h2><\/div><div class=\"nx-section-body\"><ul class=\"nx-dest\"><li><a class=\"nx-dest-card\" href=\"https:\/\/therisk.global\/biotechnology-biosecurity\/stem\/biotechnology\/\"><span class=\"nx-dest-top\"><span class=\"nx-dest-rel\">Steward platform<\/span><span class=\"nx-dest-host\">GCRI<\/span><\/span><span class=\"nx-dest-title\">Biotechnology platforms at Biotechnology and Biosecurity<\/span><span class=\"nx-dest-why\">Biotechnology and Biosecurity stewards this method.<\/span><span class=\"nx-dest-go\" aria-hidden=\"true\"><svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/span><\/a><\/li><\/ul><\/div><\/div><\/section><section id=\"nx-s-12-sec\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" aria-labelledby=\"nx-s-12\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">12<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Questions<\/span><\/div><h2 id=\"nx-s-12\" class=\"nx-section-title\">Questions and answers.<\/h2><\/div><div class=\"nx-section-body\"><div class=\"nx-faq\"><details><summary>What are the limits of biotechnology platforms in this field?<\/summary><div class=\"nx-answer\">Scale-up from laboratory to production often fails or takes time. Containment and oversight can lag behind technical capability.<\/div><\/details><details><summary>How are results checked?<\/summary><div class=\"nx-answer\">Products are evaluated through staged preclinical and clinical testing and manufacturing quality controls. Regulatory review and independent replication check claims.<\/div><\/details><details><summary>Are the values on this page real?<\/summary><div class=\"nx-answer\">The data names, roles and checks are real descriptions of practice. The canvas shows a design of the method&#8217;s use, not a run; no result is reported here.<\/div><\/details><details><summary>Where else is this method applied?<\/summary><div class=\"nx-answer\">The <a class=\"nx-link\" href=\"https:\/\/therisk.global\/stem\/technology\/biotechnology\/\">canonical method page<\/a> lists every platform that applies it.<\/div><\/details><\/div><\/div><\/div><\/section><section id=\"nx-sec-nr-gateway\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" aria-labelledby=\"nx-nr-gateway-h\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">Reports<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Contribute<\/span><\/div><h2 id=\"nx-nr-gateway-h\" class=\"nx-section-title\">Contribute evidence from this page.<\/h2><p class=\"nx-lede\"><a class=\"nx-link\" href=\"https:\/\/docs.therisk.global\/organization\/programme\/reports\">Reports<\/a> is the Consortium&#8217;s quarterly publication. What you know about this subject can become evidence, a case or a correction in the next edition, credited to you and published under CC BY 4.0 where it is your own work.<\/p><div class=\"nx-chips\"><span class=\"nx-chip\">GCRI<\/span><span class=\"nx-chip\">Health Nexus<\/span><span class=\"nx-chip\">Global Sector Risk and Resilience<\/span><span class=\"nx-chip\">Country Systems Risk and Resilience<\/span><span class=\"nx-chip\">Evidence Brief<\/span><\/div><\/div><div class=\"nx-section-body\"><ul class=\"nx-dest\"><li><a class=\"nx-dest-card\" href=\"https:\/\/therisk.global\/health-nexus\/write-to-us\/contact\/\"><span class=\"nx-dest-top\"><span class=\"nx-dest-rel\">Email<\/span><span class=\"nx-dest-host\">Gateway GW-GCRI<\/span><\/span><span class=\"nx-dest-title\">Send it from this page<\/span><span class=\"nx-dest-why\">Evidence, a correction, a case, a method, a review, a translation or profile input. It arrives tagged with this page, so the editor who owns it receives it.<\/span><span class=\"nx-dest-go\" aria-hidden=\"true\"><svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/span><\/a><\/li><li><a class=\"nx-dest-card\" href=\"https:\/\/therisk.global\/nexus-reports\/open-science\/#nx-sec-zenodo\"><span class=\"nx-dest-top\"><span class=\"nx-dest-rel\">Zenodo<\/span><span class=\"nx-dest-host\">Open deposit<\/span><\/span><span class=\"nx-dest-title\">Deposit it and submit to the community<\/span><span class=\"nx-dest-why\">Publish your own record on Zenodo with your ORCID iD, then submit it to the Reports community there. 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