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:where([role=\"tablist\"],[role=\"toolbar\"],[hidden],button,.nx-theme-toggle,.nx-live-slot){display:none}#nxe-n1467qc4.nxe img{max-width:100%;height:auto}<\/style><svg class=\"nx-defs\" aria-hidden=\"true\" focusable=\"false\" width=\"0\" height=\"0\"><defs><linearGradient id=\"nx-gi\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"1\"><stop offset=\"0\" class=\"nx-gi-a\"\/><stop offset=\"0.55\" class=\"nx-gi-b\"\/><stop offset=\"1\" class=\"nx-gi-c\"\/><\/linearGradient><linearGradient id=\"nx-giu\" gradientUnits=\"userSpaceOnUse\" x1=\"0\" y1=\"0\" x2=\"800\" y2=\"0\"><stop offset=\"0\" class=\"nx-gi-a\"\/><stop offset=\"0.55\" class=\"nx-gi-b\"\/><stop offset=\"1\" class=\"nx-gi-c\"\/><\/linearGradient><linearGradient id=\"nx-gp\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"1\"><stop offset=\"0\" class=\"nx-gp-a\"\/><stop offset=\"1\" class=\"nx-gp-b\"\/><\/linearGradient><\/defs><\/svg><section class=\"nx-scene nx-es-scene\" data-scene=\"text\" data-ground=\"none\" data-es-org=\"gcri\" aria-labelledby=\"nx-scene-title\"><div class=\"nx-scene-intro nx-es-intro\"><p class=\"nx-eyebrow\"><abbr title=\"The Global Centre for Risk and Innovation\">GCRI<\/abbr> \u00b7 Health Nexus<\/p><span class=\"nx-scene-rule\" aria-hidden=\"true\"><\/span><h1 id=\"nx-scene-title\" class=\"nx-scene-title\">Molecular and life sciences for health threats<\/h1><p class=\"nx-scene-lede\">Molecular and life sciences characterise the pathogens, hosts and vectors behind health threats: their genomes, how they evolve, how they resist drugs and how they move between species. In this field they supply the laboratory and genomic evidence that confirms an event, links cases and tracks resistance across human, animal and environmental samples.<\/p><div class=\"nx-actions\"><a class=\"nx-btn\" data-variant=\"primary\" href=\"https:\/\/therisk.global\/health-nexus\/write-to-us\/contact\/\">Make an enquiry <svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/a><a class=\"nx-btn\" data-variant=\"secondary\" href=\"https:\/\/therisk.global\/health-nexus\/stem\/\">Back to STEM foundation of Health Nexus<\/a><\/div><\/div><\/section><section id=\"nx-s-1-sec\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" aria-labelledby=\"nx-s-1\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">01<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Register<\/span><\/div><h2 id=\"nx-s-1\" class=\"nx-section-title\">Molecular and life sciences for health threats on the record.<\/h2><\/div><div class=\"nx-section-body\"><div class=\"nx-es-fig\" data-es-layout=\"console\"><div class=\"nx-hero-panel\"><div class=\"nx-register\"><div class=\"nx-register-head\"><span class=\"nx-eyebrow\"><strong>Method record<\/strong><\/span><span class=\"nx-eyebrow\">STEM method<\/span><\/div><ol class=\"nx-register-rows\"><li><div><span class=\"nx-register-k\">Method<\/span><span class=\"nx-register-v\">Molecular and life sciences<\/span><\/div><\/li><li><div><span class=\"nx-register-k\">Steward<\/span><span class=\"nx-register-v\"><a class=\"nx-link\" href=\"https:\/\/therisk.global\/biotechnology-biosecurity\/\">Biotechnology and Biosecurity<\/a><\/span><\/div><\/li><li><div><span class=\"nx-register-k\">Applied in<\/span><span class=\"nx-register-v\">Health Nexus<\/span><\/div><\/li><li><div><span class=\"nx-register-k\">Data<\/span><span class=\"nx-register-v\"><a class=\"nx-link\" href=\"#nx-sec-data\">4 inputs<\/a><\/span><\/div><\/li><li><div><span class=\"nx-register-k\">Checks<\/span><span class=\"nx-register-v\"><a class=\"nx-link\" href=\"#nx-sec-checks\">3 validation steps<\/a><\/span><\/div><\/li><li><div><span class=\"nx-register-k\">Canonical page<\/span><span class=\"nx-register-v\"><a class=\"nx-link\" href=\"https:\/\/therisk.global\/stem\/science\/life-sciences\/\">STEM Commons<\/a><\/span><\/div><\/li><\/ol><\/div><\/div><\/div><\/div><\/div><\/section><section id=\"nx-sec-application\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" data-variant=\"split\" aria-labelledby=\"nx-s-2\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">02<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Application<\/span><\/div><h2 id=\"nx-s-2\" class=\"nx-section-title\">What molecular and life sciences does here.<\/h2><p class=\"nx-lede\">Molecular and life sciences study the structure and function of living <a class=\"nx-link nx-term\" href=\"https:\/\/docs.therisk.global\/organization\/systems\" data-tc=\"Systems\" data-tk=\"Nexus Standards\" data-td=\"The twenty Nexus systems, NXS-CMD to NXS-LAB\">systems<\/a> from genes and proteins to cells and organisms. They underpin the understanding of pathogens, resistance, toxicity and biological innovation. In health and biosecurity, life sciences support pathogen characterisation, <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/health\/biological-hazard-standards\/\" data-tc=\"NHS-1 health.systemic-bio.antimicrobial-resistance\" data-tk=\"Health and biosecurity \u00b7 Systemic biological risks\" data-td=\"Spread of microbes that no longer respond to medicines, making routine infections and surgery dangerous.\" data-ts=\"NRS-H45\" data-tr=\"draft\">antimicrobial resistance<\/a> tracking and biosecurity assessment. They inform how biological threats might spread through health, agriculture and trade. The canonical description is on <a class=\"nx-link\" href=\"https:\/\/therisk.global\/stem\/science\/life-sciences\/\">the STEM Commons<\/a>.<\/p><\/div><div class=\"nx-section-body\"><div class=\"nx-cols\"><article><div class=\"nx-glyph-row\"><span class=\"nx-glyph\" data-tone=\"accent\" data-size=\"lg\"><svg class=\"nx-i\" viewBox=\"0 0 24 24\" aria-hidden=\"true\" focusable=\"false\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M6 18h8\"\/><path d=\"M3 22h18\"\/><path d=\"M14 22a7 7 0 1 0 0-14h-1\"\/><path d=\"M9 14h2\"\/><path d=\"M9 12a2 2 0 0 1-2-2V6h6v4a2 2 0 0 1-2 2Z\"\/><path d=\"M12 6V3a1 1 0 0 0-1-1H9a1 1 0 0 0-1 1v3\"\/><\/svg><\/span><\/div><h3 class=\"nx-h3 nx-mt-2\">Genomic surveillance of pathogens<\/h3><p class=\"nx-p nx-mt-1\">Sequences from clinical, animal and environmental samples are assembled, assigned to lineages and placed on phylogenies to identify variants and assess relatedness, with sampling coverage reported beside every tree.<\/p><\/article><article><div class=\"nx-glyph-row\"><span class=\"nx-glyph\" data-tone=\"accent\" data-size=\"lg\"><svg class=\"nx-i\" viewBox=\"0 0 24 24\" aria-hidden=\"true\" focusable=\"false\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M7 20h10\"\/><path d=\"M10 20c5.5-2.5.8-6.4 3-10\"\/><path d=\"M9.5 9.4c1.1.8 1.8 2.2 2.3 3.7-2 .4-3.5.4-4.8-.3-1.2-.6-2.3-1.9-3-4.2 2.8-.5 4.4 0 5.5.8z\"\/><path d=\"M14.1 6a7 7 0 0 0-1.1 4c1.9-.1 3.3-.6 4.3-1.4 1-1 1.6-2.3 1.7-4.6-2.7.1-4 1-4.9 2z\"\/><\/svg><\/span><\/div><h3 class=\"nx-h3 nx-mt-2\">Cross-species linkage in One Health<\/h3><p class=\"nx-p nx-mt-1\">Pathogen and resistance-gene sequences from people, livestock and the environment are compared to assess whether they share a source, under agreed sampling and metadata standards.<\/p><\/article><article><div class=\"nx-glyph-row\"><span class=\"nx-glyph\" data-tone=\"accent\" data-size=\"lg\"><svg class=\"nx-i\" viewBox=\"0 0 24 24\" aria-hidden=\"true\" focusable=\"false\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M7 16.3c2.2 0 4-1.83 4-4.05 0-1.16-.57-2.26-1.71-3.19S7.29 6.75 7 5.3c-.29 1.45-1.14 2.84-2.29 3.76S3 11.1 3 12.25c0 2.22 1.8 4.05 4 4.05z\"\/><path d=\"M12.56 6.6A10.97 10.97 0 0 0 14 3.02c.5 2.5 2 4.9 4 6.5s3 3.5 3 5.5a6.98 6.98 0 0 1-11.91 4.97\"\/><\/svg><\/span><\/div><h3 class=\"nx-h3 nx-mt-2\">Wastewater and environmental surveillance<\/h3><p class=\"nx-p nx-mt-1\">Nucleic acid targets in wastewater are measured and normalised for flow and population markers to follow community infection trends independently of who seeks testing.<\/p><\/article><\/div><\/div><\/div><\/section><section id=\"nx-sec-signature\" class=\"nx-section\" data-hue=\"health\" aria-labelledby=\"nx-s-3\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">03<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Sector signature<\/span><\/div><h2 id=\"nx-s-3\" class=\"nx-section-title\">The sector signature of molecular and life sciences for health threats.<\/h2><p class=\"nx-lede\">The sectors molecular and life sciences for health threats touches and how strongly they depend on each other: what a study has to observe and model together.<\/p><\/div><div class=\"nx-section-body\"><div class=\"nx-canvas-wrap\"><figure class=\"nx-nsig\" data-nx-sig=\"WIFH\" data-sig-name=\"Health and its partners\" data-sig-line=\"Health gives workforce for operations to infrastructure (0.3), farm labour to food (0.3) and utility workforce to water (0.2).\" data-sig-inst=\"The Global Centre for Risk and Innovation\"><div class=\"nx-nsig-plate\"><div class=\"nx-nsig-strip\" role=\"group\" aria-label=\"Signatures in context\" hidden><\/div><div class=\"nx-nsig-stage\"><div class=\"nx-nsig-top\"><span>Select corners \u00b7 hover lines<\/span><span class=\"nx-nsig-pairs\">6 \/ 15 relations<\/span><\/div><div class=\"nx-nsig-tilt\"><svg class=\"nx-nsig-svg\" viewBox=\"-370 -290 740 580\" role=\"img\" aria-label=\"Sector signature hexagon: Water, Infrastructure, Food and Health selected, 6 of 15 relations in play, coupling 0.42. Teaching values.\" focusable=\"false\" data-nx-z=\"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\"><\/svg><\/div><\/div><div class=\"nx-nsig-read\"><div><p class=\"nx-nsig-k\">Signature<\/p><p class=\"nx-nsig-name\">Health and its partners<\/p><p class=\"nx-nsig-line\">Health gives workforce for operations to infrastructure (0.3), farm labour to food (0.3) and utility workforce to water (0.2).<\/p><\/div><p class=\"nx-nsig-code\" aria-live=\"polite\"><span>W<\/span> \u00b7 <span class=\"nx-nsig-off\">E<\/span> \u00b7 <span>I<\/span> \u00b7 <span>F<\/span> \u00b7 <span>H<\/span> \u00b7 <span class=\"nx-nsig-off\">B<\/span><\/p><dl class=\"nx-nsig-stats\"><div><dt>Sectors<\/dt><dd><strong>4<\/strong> <small>of 6<\/small><\/dd><\/div><div><dt>Relations<\/dt><dd><strong>6<\/strong> <small>of 15<\/small><\/dd><\/div><div><dt>Coupling<\/dt><dd><strong>0.42<\/strong> <small>share of total<\/small><\/dd><\/div><\/dl><div class=\"nx-nsig-detail\"><h3 class=\"nx-nsig-dh\">Strongest relations in play<\/h3><ul class=\"nx-nsig-rel\"><li><span class=\"nx-nsig-rt\"><b>Water \u2192 Food<\/b> \u00b7 irrigation<\/span><span class=\"nx-nsig-bar\" data-v=\"8\" aria-hidden=\"true\"><i><\/i><\/span><span class=\"nx-nsig-v\">0.8<\/span><\/li><li><span class=\"nx-nsig-rt\"><b>Food \u2192 Health<\/b> \u00b7 nutrition<\/span><span class=\"nx-nsig-bar\" data-v=\"7\" aria-hidden=\"true\"><i><\/i><\/span><span class=\"nx-nsig-v\">0.7<\/span><\/li><li><span class=\"nx-nsig-rt\"><b>Infrastructure \u2192 Water<\/b> \u00b7 pipes, dams and treatment works<\/span><span class=\"nx-nsig-bar\" data-v=\"6\" aria-hidden=\"true\"><i><\/i><\/span><span class=\"nx-nsig-v\">0.6<\/span><\/li><li><span class=\"nx-nsig-rt\"><b>Water \u2192 Health<\/b> \u00b7 drinking water and sanitation<\/span><span class=\"nx-nsig-bar\" data-v=\"7\" aria-hidden=\"true\"><i><\/i><\/span><span class=\"nx-nsig-v\">0.7<\/span><\/li><\/ul><\/div><div class=\"nx-nsig-actions\" hidden><button type=\"button\" class=\"nx-nsig-btn\" data-sig-act=\"all\">Select all<\/button><button type=\"button\" class=\"nx-nsig-btn\" data-sig-act=\"clear\">Clear<\/button><button type=\"button\" class=\"nx-nsig-btn nx-nsig-pri\" data-sig-act=\"copy\">Copy signature<\/button><\/div><\/div><\/div><figcaption class=\"nx-nsig-note\">Teaching values for a typical city-region, not measurements for any place. Coupling is the summed strength of the relations in play, as a share of all fifteen.<\/figcaption><\/figure><\/div><\/div><\/div><\/section><section id=\"nx-sec-data\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" data-variant=\"stack\" aria-labelledby=\"nx-s-4\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">04<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Data<\/span><\/div><h2 id=\"nx-s-4\" class=\"nx-section-title\">What the method consumes.<\/h2><p class=\"nx-lede\">Datasets and records used by molecular and life sciences on this platform, with the role each plays and the label its values carry. Sources are listed in <a class=\"nx-link\" href=\"https:\/\/therisk.global\/health-nexus\/research\/sources\/\">the source register<\/a>.<\/p><\/div><div class=\"nx-section-body\" data-lv=\"register\"><div class=\"nx-table-wrap\"><table class=\"nx-table\" data-stack=\"true\"><thead><tr><th scope=\"col\">Data<\/th><th scope=\"col\">Role<\/th><th scope=\"col\">Label<\/th><\/tr><\/thead><tbody><tr><td data-label=\"Data\">INSDC archives (GenBank, ENA, DDBJ)<\/td><td data-label=\"Role\">Reference and outbreak sequences<\/td><td data-label=\"Label\"><span class=\"nx-chip\">OBSERVED<\/span><\/td><\/tr><tr><td data-label=\"Data\">GISAID<\/td><td data-label=\"Role\">Influenza and coronavirus genomes with metadata<\/td><td data-label=\"Label\"><span class=\"nx-chip\">OBSERVED<\/span><\/td><\/tr><tr><td data-label=\"Data\">WHO GLASS<\/td><td data-label=\"Role\">Resistance phenotypes from laboratory surveillance<\/td><td data-label=\"Label\"><span class=\"nx-chip\">REPORTED<\/span><\/td><\/tr><tr><td data-label=\"Data\">Wastewater sampling programmes<\/td><td data-label=\"Role\">Community trend signals<\/td><td data-label=\"Label\"><span class=\"nx-chip\">OBSERVED<\/span><\/td><\/tr><\/tbody><\/table><\/div><div class=\"nx-live-slot\" data-nxf-slot=\"data\" data-nxf-kind=\"data\" data-nxf-resource=\"nexus:\/\/gcri\/G04\/stem\/life-sciences\/#data\" data-nxf-title=\"Method record\" data-nxf-height=\"520\" hidden><\/div><div class=\"nx-live-slot\" data-nxf-slot=\"evidence\" data-nxf-kind=\"evidence\" data-nxf-resource=\"nexus:\/\/gcri\/G04\/stem\/life-sciences\/#evidence\" data-nxf-title=\"Evidence\" data-nxf-height=\"520\" hidden><\/div><\/div><\/div><\/section><section id=\"nx-sec-audience\" class=\"nx-section\" data-hue=\"health\" aria-labelledby=\"nx-s-5\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">05<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Methods and evidence<\/span><\/div><h2 id=\"nx-s-5\" class=\"nx-section-title\">How molecular and life sciences for health threats is modelled, measured and tested.<\/h2><p class=\"nx-lede\">The model, its assumptions, its data and its uncertainty, in the form a scientist or engineer would check. Structures follow published methods. The values drawn are illustrative, not findings.<\/p><\/div><div class=\"nx-section-body\"><div class=\"nx-au\" data-au-voice=\"science\" data-au-n=\"1\"><figure class=\"nx-au-c\" data-au-fig=\"uncertainty-band\"><h3 class=\"nx-h4\">Uncertainty bands<\/h3><p class=\"nx-p nx-au-what\">How far the outlook for molecular and life sciences for health threats could spread, shown as ranges rather than a single line.<\/p><div class=\"nx-au-fig\"><svg class=\"nx-au-svg\" viewBox=\"0 0 560 240\" role=\"img\" aria-label=\"Central estimate with likely and very likely ranges for Molecular and life sciences for health threats\" focusable=\"false\"><line class=\"nx-au-ax\" x1=\"46\" y1=\"206\" x2=\"544\" y2=\"206\"\/><line class=\"nx-au-ax\" x1=\"46\" y1=\"18\" x2=\"46\" y2=\"206\"\/><path class=\"nx-au-band nx-au-band-w\" d=\"M46 142.1l83-18.8 83-18.8 83-22.6 83-20.7 83-18.8 83-18.8 0 124.1-83 0-83 0-83 1.9-83 3.8-83 0-83 3.7z\"\/><path class=\"nx-au-band\" d=\"M46 145.8l83-15 83-13.2 83-16.9 83-15 83-13.2 83-13.1 0 52.6-83 5.6-83 5.7-83 7.5-83 9.4-83 5.6-83 7.6z\"\/><path class=\"nx-au-ac\" d=\"M46 149.6l83-11.3 83-9.4 83-13.1 83-11.3 83-9.4 83-9.4\"\/><text class=\"nx-au-t\" x=\"46\" y=\"222\" text-anchor=\"middle\">Now<\/text><text class=\"nx-au-t\" x=\"129\" y=\"222\" text-anchor=\"middle\">+5<\/text><text class=\"nx-au-t\" x=\"212\" y=\"222\" text-anchor=\"middle\">+10<\/text><text class=\"nx-au-t\" x=\"295\" y=\"222\" text-anchor=\"middle\">+15<\/text><text class=\"nx-au-t\" x=\"378\" y=\"222\" text-anchor=\"middle\">+20<\/text><text class=\"nx-au-t\" x=\"461\" y=\"222\" text-anchor=\"middle\">+25<\/text><text class=\"nx-au-t\" x=\"544\" y=\"222\" text-anchor=\"middle\">+30 y<\/text><text class=\"nx-au-t\" x=\"40\" y=\"36.8\" text-anchor=\"end\">high<\/text><text class=\"nx-au-t\" x=\"40\" y=\"187.2\" text-anchor=\"end\">low<\/text><text class=\"nx-au-t\" x=\"540\" y=\"17.64\" text-anchor=\"end\">very likely range<\/text><text class=\"nx-au-t\" x=\"540\" y=\"73.36\" text-anchor=\"end\">likely range<\/text><\/svg><\/div><dl class=\"nx-au-kv\"><div><dt>Central estimate<\/dt><dd>median of the ensemble<\/dd><\/div><div><dt>Ranges<\/dt><dd>likely and very likely, in IPCC calibrated language<\/dd><\/div><div><dt>Ensemble<\/dt><dd>members, scenarios and initial conditions stated<\/dd><\/div><div><dt>Read with<\/dt><dd>the sensitivity of the result to each input<\/dd><\/div><\/dl><figcaption class=\"nx-caption\"><span>Illustrative ensemble spread on an index scale; the form follows IPCC uncertainty guidance. Not a projection.<\/span><\/figcaption><\/figure><\/div><div class=\"nx-chips nx-au-fw\" aria-label=\"Frameworks cited\"><span class=\"nx-chip\">FAIR guiding principles \u00b7 GO FAIR and FORCE11<\/span><span class=\"nx-chip\">W3C PROV \u00b7 World Wide Web Consortium<\/span><span class=\"nx-chip\">Guidance on consistent treatment of uncertainties \u00b7 IPCC<\/span><span class=\"nx-chip\">CEOS Analysis Ready Data \u00b7 Committee on Earth Observation Satellites<\/span><\/div><\/div><\/div><\/section><section id=\"nx-sec-checks\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" data-variant=\"split\" aria-labelledby=\"nx-s-6\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">06<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Validation<\/span><\/div><h2 id=\"nx-s-6\" class=\"nx-section-title\">How results are checked.<\/h2><p class=\"nx-lede\">Results are confirmed through biological replicates, independent laboratories and orthogonal assays. Reference standards and proficiency testing check analytical accuracy.<\/p><\/div><div class=\"nx-section-body\" data-lv=\"ledger\"><div class=\"nx-table-wrap\"><table class=\"nx-table\" data-stack=\"true\"><thead><tr><th scope=\"col\">Check<\/th><th scope=\"col\">How it is done<\/th><\/tr><\/thead><tbody><tr><td data-label=\"Check\">External quality assessment<\/td><td data-label=\"How it is done\">Laboratories take part in proficiency testing and use reference materials for each assay<\/td><\/tr><tr><td data-label=\"Check\">Sampling representativeness<\/td><td data-label=\"How it is done\">How sequenced samples were selected is reported, so lineage shares are not over-read<\/td><\/tr><tr><td data-label=\"Check\">Phylogenetic robustness<\/td><td data-label=\"How it is done\">Trees are tested with bootstrap or posterior support and alternative models before relatedness is described<\/td><\/tr><\/tbody><\/table><\/div><p class=\"nx-note nx-mt-3\">Laboratory findings do not always translate to organisms or populations. Sampling bias in sequence databases limits generalisation.<\/p><\/div><\/div><\/section><section id=\"nx-s-7-sec\" class=\"nx-section\" data-hue=\"health\" aria-labelledby=\"nx-s-7\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">07<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Process<\/span><\/div><h2 id=\"nx-s-7\" class=\"nx-section-title\">How the process runs.<\/h2><\/div><div class=\"nx-section-body\"><div class=\"nx-canvas-wrap\"><div class=\"nx-pe\" id=\"nx-pe-biosec-oversight\" data-nx-pe=\"nx-pe-biosec-oversight\" data-active=\"oversight\"><div class=\"nx-pe-shell\"><p class=\"nx-pe-eb\">Process<\/p><h2 class=\"nx-pe-title\">Molecular and life sciences for health threats: Life-science research oversight<\/h2><p class=\"nx-pe-cap\">Capacity and oversight only, following the WHO Laboratory biosafety manual (4th edition) and WHO life sciences framework, with no methods, agents or protocols.<\/p><ol class=\"nx-pe-steps\"><li class=\"nx-pe-lane\"><h3 class=\"nx-pe-lane-t\">01 Institution<\/h3><ol><li class=\"nx-pe-step\"><span class=\"nx-pe-n\" translate=\"no\">01<\/span><span class=\"nx-pe-st\">Proposal<\/span><span class=\"nx-pe-k\">Dataset<\/span><span class=\"nx-pe-sm\">A research institution submits a proposal for review. The place is set by the page.<\/span><\/li><li class=\"nx-pe-step\"><span class=\"nx-pe-n\" translate=\"no\">02<\/span><span class=\"nx-pe-st\">Institutional committee<\/span><span class=\"nx-pe-k\">Gate \u00b7 The institution<\/span><span class=\"nx-pe-sm\">A biosafety committee is an independent institutional review group, reporting to senior management. Review follows national rules.<\/span><\/li><li class=\"nx-pe-step\"><span class=\"nx-pe-n\" translate=\"no\">03<\/span><span class=\"nx-pe-st\">Conditions: risk control measures<\/span><span class=\"nx-pe-k\">Step<\/span><span class=\"nx-pe-sm\">A <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-c1\" data-tc=\"NRS-C1 risk-assessment\" data-tk=\"Nexus risk vocabulary\" data-td=\"The overall process of identifying, analysing and evaluating risk to inform decisions.\" data-ts=\"NRS-C1\" data-tr=\"draft\">risk assessment<\/a> sets the measures: core requirements, heightened control measures or maximum containment, not one biosafety level.<\/span><\/li><li class=\"nx-pe-step\"><span class=\"nx-pe-n\" translate=\"no\">04<\/span><span class=\"nx-pe-st\">Training and competence<\/span><span class=\"nx-pe-k\">Step<\/span><span class=\"nx-pe-sm\">Actual risk depends on the agent, the procedure and staff competency. Training and personnel competence have their own section.<\/span><\/li><\/ol><\/li><li class=\"nx-pe-lane\"><h3 class=\"nx-pe-lane-t\">02 Assurance<\/h3><ol><li class=\"nx-pe-step\"><span class=\"nx-pe-n\" translate=\"no\">05<\/span><span class=\"nx-pe-st\">Audit and inspection<\/span><span class=\"nx-pe-k\">Gate<\/span><span class=\"nx-pe-sm\">Many <a class=\"nx-link nx-term\" href=\"https:\/\/docs.therisk.global\/organization\/programme\/labs\" data-tc=\"Labs\" data-tk=\"Nexus Standards\" data-td=\"The research pillar of the programme, one of six (OR-11, OR-12)\">labs<\/a> run cooperative inspections: periodic self-audits plus a rarer, deeper evaluation with the biosafety officer or committee.<\/span><\/li><li class=\"nx-pe-step\"><span class=\"nx-pe-n\" translate=\"no\">06<\/span><span class=\"nx-pe-st\">Emergency and incident response<\/span><span class=\"nx-pe-k\">Step<\/span><span class=\"nx-pe-sm\">The manual covers emergency and incident response at each level of measures. External reporting of incidents depends on national rules.<\/span><\/li><\/ol><\/li><li class=\"nx-pe-lane\"><h3 class=\"nx-pe-lane-t\">03 National<\/h3><ol><li class=\"nx-pe-step\"><span class=\"nx-pe-n\" translate=\"no\">07<\/span><span class=\"nx-pe-st\">National oversight<\/span><span class=\"nx-pe-k\">Decision \u00b7 District health office<\/span><span class=\"nx-pe-sm\">The WHO framework is for those who govern biorisks, such as policy makers and regulators. National bodies set national rules.<\/span><\/li><\/ol><\/li><\/ol><p class=\"nx-pe-foot\"><span>Neutral outline of a published external standard or method, from its issuing body. Not a record of operation. Nexus does not perform, certify or approve any step shown. A gate or decision belongs to the party the source names. The Biological Weapons Convention is not drawn in this flow. The framework is the WHO global guidance framework for the responsible use of the life sciences.<\/span><\/p><\/div><\/div><\/div><\/div><\/div><\/section><section id=\"nx-sec-connections\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" data-variant=\"split\" aria-labelledby=\"nx-s-8\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">08<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Connections<\/span><\/div><h2 id=\"nx-s-8\" class=\"nx-section-title\">Topics that rely on this method.<\/h2><\/div><div class=\"nx-section-body\"><ul class=\"nx-list\" data-nav=\"true\"><li><a class=\"nx-link\" href=\"https:\/\/therisk.global\/health-nexus\/topics\/one-health\/\"><span>One Health<\/span><svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/a><\/li><li><a class=\"nx-link\" href=\"https:\/\/therisk.global\/health-nexus\/topics\/infectious-threats\/\"><span>Infectious threats<\/span><svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/a><\/li><\/ul><\/div><\/div><\/section><section id=\"nx-sec-stewardship\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" aria-labelledby=\"nx-s-9\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">09<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Stewardship<\/span><\/div><h2 id=\"nx-s-9\" class=\"nx-section-title\">Who maintains the method.<\/h2><p class=\"nx-lede\"><a class=\"nx-link\" href=\"https:\/\/therisk.global\/biotechnology-biosecurity\/\">Biotechnology and Biosecurity<\/a> stewards molecular and life sciences for the Consortium and reviews how it is applied across platforms.<\/p><\/div><div class=\"nx-section-body\"><p class=\"nx-p\"><a class=\"nx-link\" href=\"https:\/\/therisk.global\/stem\/science\/life-sciences\/\">Canonical page: Molecular and life sciences<\/a><\/p><\/div><\/div><\/section><section id=\"nx-s-10-sec\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" aria-labelledby=\"nx-s-10\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">10<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Connected<\/span><\/div><h2 id=\"nx-s-10\" class=\"nx-section-title\">Where this page leads across the Consortium.<\/h2><\/div><div class=\"nx-section-body\"><ul class=\"nx-dest\"><li><a class=\"nx-dest-card\" href=\"https:\/\/therisk.global\/biotechnology-biosecurity\/stem\/life-sciences\/\"><span class=\"nx-dest-top\"><span class=\"nx-dest-rel\">Steward platform<\/span><span class=\"nx-dest-host\">GCRI<\/span><\/span><span class=\"nx-dest-title\">Molecular and life sciences for biotechnology and biosecurity<\/span><span class=\"nx-dest-why\">Biotechnology and Biosecurity stewards this method.<\/span><span class=\"nx-dest-go\" aria-hidden=\"true\"><svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/span><\/a><\/li><\/ul><\/div><\/div><\/section><section id=\"nx-s-11-sec\" class=\"nx-section\" data-hue=\"health\" aria-labelledby=\"nx-s-11\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">11<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Questions<\/span><\/div><h2 id=\"nx-s-11\" class=\"nx-section-title\">Questions and answers.<\/h2><\/div><div class=\"nx-section-body\"><div class=\"nx-faq\"><details><summary>What are the limits of molecular and life sciences in this field?<\/summary><div class=\"nx-answer\">Laboratory findings do not always translate to organisms or populations. Sampling bias in sequence databases limits generalisation.<\/div><\/details><details><summary>How are results checked?<\/summary><div class=\"nx-answer\">Results are confirmed through biological replicates, independent laboratories and orthogonal assays. Reference standards and proficiency testing check analytical accuracy.<\/div><\/details><details><summary>Are the values on this page real?<\/summary><div class=\"nx-answer\">The data names, roles and checks are real descriptions of practice. The canvas shows a design of the method&#8217;s use, not a run; no result is reported here.<\/div><\/details><details><summary>Where else is this method applied?<\/summary><div class=\"nx-answer\">The <a class=\"nx-link\" href=\"https:\/\/therisk.global\/stem\/science\/life-sciences\/\">canonical method page<\/a> lists every platform that applies it.<\/div><\/details><\/div><\/div><\/div><\/section><section id=\"nx-sec-nr-gateway\" class=\"nx-section\" data-hue=\"health\" data-tone=\"alt\" aria-labelledby=\"nx-nr-gateway-h\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">Reports<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Contribute<\/span><\/div><h2 id=\"nx-nr-gateway-h\" class=\"nx-section-title\">Contribute evidence from this page.<\/h2><p class=\"nx-lede\"><a class=\"nx-link\" href=\"https:\/\/docs.therisk.global\/organization\/programme\/reports\">Reports<\/a> is the Consortium&#8217;s quarterly publication. What you know about this subject can become evidence, a case or a correction in the next edition, credited to you and published under CC BY 4.0 where it is your own work.<\/p><div class=\"nx-chips\"><span class=\"nx-chip\">GCRI<\/span><span class=\"nx-chip\">Health Nexus<\/span><span class=\"nx-chip\">Global Sector Risk and Resilience<\/span><span class=\"nx-chip\">Country Systems Risk and Resilience<\/span><span class=\"nx-chip\">Evidence Brief<\/span><\/div><\/div><div class=\"nx-section-body\"><ul class=\"nx-dest\"><li><a class=\"nx-dest-card\" href=\"https:\/\/therisk.global\/health-nexus\/write-to-us\/contact\/\"><span class=\"nx-dest-top\"><span class=\"nx-dest-rel\">Email<\/span><span class=\"nx-dest-host\">Gateway GW-GCRI<\/span><\/span><span class=\"nx-dest-title\">Send it from this page<\/span><span class=\"nx-dest-why\">Evidence, a correction, a case, a method, a review, a translation or profile input. It arrives tagged with this page, so the editor who owns it receives it.<\/span><span class=\"nx-dest-go\" aria-hidden=\"true\"><svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/span><\/a><\/li><li><a class=\"nx-dest-card\" href=\"https:\/\/therisk.global\/nexus-reports\/open-science\/#nx-sec-zenodo\"><span class=\"nx-dest-top\"><span class=\"nx-dest-rel\">Zenodo<\/span><span class=\"nx-dest-host\">Open deposit<\/span><\/span><span class=\"nx-dest-title\">Deposit it and submit to the community<\/span><span class=\"nx-dest-why\">Publish your own record on Zenodo with your ORCID iD, then submit it to the Reports community there. Curators review it; the DOI stays yours.<\/span><span class=\"nx-dest-go\" aria-hidden=\"true\"><svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/span><\/a><\/li><li><a class=\"nx-dest-card\" href=\"https:\/\/therisk.global\/nexus-reports\/contribute\/\"><span class=\"nx-dest-top\"><span class=\"nx-dest-rel\">Reports<\/span><span class=\"nx-dest-host\">GCRI<\/span><\/span><span class=\"nx-dest-title\">See every way to contribute<\/span><span class=\"nx-dest-why\">The contribution types, how each is reviewed, what credit you receive, the licence and what is never accepted.<\/span><span class=\"nx-dest-go\" aria-hidden=\"true\"><svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/span><\/a><\/li><\/ul><div class=\"nx-live-slot\" data-nxf-slot=\"contribute\" data-nxf-kind=\"workflow\" data-nxf-resource=\"nexus:\/\/gcri\/health-nexus\/stem\/life-sciences#contribute\" data-nxf-title=\"Contribute evidence\" data-nxf-height=\"480\" hidden><\/div><p class=\"nx-note nx-mt-3\">Never send personal data, sensitive infrastructure detail or anything you have no right to share. 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