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\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Not indexed until the first approved release.<\/p><div class=\"nrp-reader\"><nav class=\"nrp-rail\" aria-label=\"Contents of Global Science and Engineering Frontier 2026\"><p class=\"nf-ui-eyebrow\">Contents<\/p><ol class=\"nrp-toc\"><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Edition home<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/summary\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Executive summary<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/coupled-system\/\"><span class=\"nrp-toc-n\">1<\/span><span>Science is where the frontier is made<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/findings\/\"><span class=\"nrp-toc-n\">2<\/span><span>Key findings<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/systems-and-sectors\/\"><span class=\"nrp-toc-n\">3<\/span><span>Systems and sectors at baseline<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/risk-and-capability\/\"><span class=\"nrp-toc-n\">4<\/span><span>Risks and capability<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/scenario\/\"><span class=\"nrp-toc-n\">5<\/span><span>Loss of trust in the research record during a fast-moving emergency<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/lenses-and-readings\/\"><span class=\"nrp-toc-n\">6<\/span><span>Readings from the other desks<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/agenda\/\"><span class=\"nrp-toc-n\">7<\/span><span>The 2027 agenda<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/systems-in-depth\/\" aria-current=\"page\"><span class=\"nrp-toc-n\">8<\/span><span>Systems in depth<\/span><\/a><ol class=\"nrp-toc-sub\"><li><a href=\"#nx-nrp-gs-15-c8-s1\">8.1 Science and health<\/a><\/li><li><a href=\"#nx-nrp-gs-15-c8-s2\">8.2 Science and nature<\/a><\/li><li><a href=\"#nx-nrp-gs-15-c8-s3\">8.3 Science, compute and the digital layer<\/a><\/li><li><a href=\"#nx-nrp-gs-15-c8-s4\">8.4 Science, finance and talent<\/a><\/li><li><a href=\"#nx-nrp-gs-15-c8-s5\">8.5 Integrity, openness and governance<\/a><\/li><\/ol><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/methodology\/\"><span class=\"nrp-toc-n\">A<\/span><span>Methodology<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/data\/\"><span class=\"nrp-toc-n\">B<\/span><span>Data appendix<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/references\/\"><span class=\"nrp-toc-n\">C<\/span><span>References and record<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/full\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Complete edition, for print<\/span><\/a><\/li><\/ol><div class=\"nrp-actions\"><a class=\"nf-ui-btn\" data-variant=\"secondary\" href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/full\/\"><svg class=\"nrp-i\" viewBox=\"0 0 24 24\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2\"\/><path d=\"M6 9V3a1 1 0 0 1 1-1h10a1 1 0 0 1 1 1v6\"\/><rect x=\"6\" y=\"14\" width=\"12\" height=\"8\" rx=\"1\"\/><\/svg>Print or save as PDF<\/a><\/div><\/nav><article class=\"nrp-flow\" aria-labelledby=\"nx-nrp-gs-15-c8-top\"><header class=\"nrp-chap-head\" id=\"nx-nrp-gs-15-c8-top\"><ul class=\"nrp-eyerow\"><li class=\"nf-ui-eyebrow\"><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/\">Global Science and Engineering Frontier 2026<\/a><\/li><li class=\"nf-ui-eyebrow\">Chapter 8<\/li><\/ul><span class=\"nrp-rule\" aria-hidden=\"true\"><\/span><h1 class=\"pp-hero-title\">Systems in depth<\/h1><p class=\"nrp-lede\">One section per system: its state at evidence close, its exposures and what the operational series will watch.<\/p><p class=\"nrp-chap-meta\"><span>8 min read<\/span><span>0 figures<\/span><span>5 tables<\/span><span>18 notes<\/span><span>NR-SECTOR-SCIENCE-GLOBAL-2026-BASELINE<\/span><\/p><details class=\"nrp-toc-m\"><summary>Contents<\/summary><ol class=\"nrp-toc\"><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Edition home<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/summary\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Executive summary<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/coupled-system\/\"><span class=\"nrp-toc-n\">1<\/span><span>Science is where the frontier is made<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/findings\/\"><span class=\"nrp-toc-n\">2<\/span><span>Key findings<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/systems-and-sectors\/\"><span class=\"nrp-toc-n\">3<\/span><span>Systems and sectors at baseline<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/risk-and-capability\/\"><span class=\"nrp-toc-n\">4<\/span><span>Risks and capability<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/scenario\/\"><span class=\"nrp-toc-n\">5<\/span><span>Loss of trust in the research record during a fast-moving emergency<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/lenses-and-readings\/\"><span class=\"nrp-toc-n\">6<\/span><span>Readings from the other desks<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/agenda\/\"><span class=\"nrp-toc-n\">7<\/span><span>The 2027 agenda<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/systems-in-depth\/\" aria-current=\"page\"><span class=\"nrp-toc-n\">8<\/span><span>Systems in depth<\/span><\/a><ol class=\"nrp-toc-sub\"><li><a href=\"#nx-nrp-gs-15-c8-s1\">8.1 Science and health<\/a><\/li><li><a href=\"#nx-nrp-gs-15-c8-s2\">8.2 Science and nature<\/a><\/li><li><a href=\"#nx-nrp-gs-15-c8-s3\">8.3 Science, compute and the digital layer<\/a><\/li><li><a href=\"#nx-nrp-gs-15-c8-s4\">8.4 Science, finance and talent<\/a><\/li><li><a href=\"#nx-nrp-gs-15-c8-s5\">8.5 Integrity, openness and governance<\/a><\/li><\/ol><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/methodology\/\"><span class=\"nrp-toc-n\">A<\/span><span>Methodology<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/data\/\"><span class=\"nrp-toc-n\">B<\/span><span>Data appendix<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/references\/\"><span class=\"nrp-toc-n\">C<\/span><span>References and record<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/full\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Complete edition, for print<\/span><\/a><\/li><\/ol><\/details><\/header><section class=\"nrp-block\" id=\"nx-nrp-gs-15-c8-s1\" aria-labelledby=\"nx-nrp-gs-15-c8-s1-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-gs-15-c8-s1-h\"><span class=\"nrp-num\">8.1<\/span><span>Science and health<\/span><\/h2><p class=\"nrp-stand\">Health depends on discovery: structures, trials, treatments and the rules that govern risky research. The 2023 genome-editing authorisation and the open structure archives show the link; the WHO framework shows the governance side.<\/p><div class=\"pp-cells nrp-cells-3\"><div class=\"nrp-cell\"><span class=\"pp-metric\">214<\/span><span class=\"nrp-cell-u\">million<\/span><p>predicted protein structures in the AlphaFold database, 2024<sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n12\" id=\"nx-nrp-gs-15-c8-r12\" aria-label=\"Note 12\">12<\/a><\/sup><\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">8 Dec<\/span><span class=\"nrp-cell-u\">2023<\/span><p>first FDA authorisation of a novel genome-editing treatment<sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n17\" id=\"nx-nrp-gs-15-c8-r17\" aria-label=\"Note 17\">17<\/a><\/sup><\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">174<\/span><span class=\"nrp-cell-u\">pages<\/span><p>WHO framework on dual-use life science research, 2022<sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n18\" id=\"nx-nrp-gs-15-c8-r18\" aria-label=\"Note 18\">18<\/a><\/sup><\/p><\/div><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-gs-15-c8-tab1\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 8.1<\/span><span class=\"nrp-tbl-t\">State at baseline<\/span><\/caption><thead><tr><th scope=\"col\">Component<\/th><th scope=\"col\">State<\/th><th scope=\"col\">Evidence<\/th><th scope=\"col\">Status<\/th><\/tr><\/thead><tbody><tr><td>Structure prediction<\/td><td>a diffusion-based model predicts complexes of proteins, nucleic acids, ligands and ions<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n11\" id=\"nx-nrp-gs-15-c8-r11\" aria-label=\"Note 11\">11<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>Predicted structures<\/td><td>over 214 million sequences covered by the database<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n12\" aria-label=\"Note 12\">12<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>Genome editing<\/td><td>first cell-based therapies for sickle cell disease, one using genome editing<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n17\" aria-label=\"Note 17\">17<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>Dual-use governance<\/td><td>values, principles and tools for Member States and research institutions<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n18\" aria-label=\"Note 18\">18<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-split\"><div><h3 class=\"nrp-h3\">Couplings<\/h3><ul class=\"nrp-list\"><li>BIO \u2192 HLT sequences and structures<\/li><li>DAT \u2192 HLT open archives<\/li><li>GOV \u2192 HLT dual-use governance<\/li><\/ul><\/div><div><h3 class=\"nrp-h3\">Evidence to bind in 2027<\/h3><ul class=\"nrp-list\"><li>dual-use governance in practice<\/li><li>time from discovery to access in low-income regions<\/li><\/ul><\/div><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">WHAT TO WATCH<\/p><p>Further genome-editing authorisations; updates to structure models; national uptake of the WHO framework.<\/p><\/aside><h3 class=\"nrp-h3\">Related editions<\/h3><ul class=\"nrp-chips\"><li class=\"nf-ui-chip\">GLB Global Systems<\/li><li class=\"nf-ui-chip\">GS-04 Health and One Health<\/li><li class=\"nf-ui-chip\">GS-12 Earth Observation and Planetary Intelligence<\/li><li class=\"nf-ui-chip\">GS-13 Cyber and Digital Systems<\/li><li class=\"nf-ui-chip\">GS-14 Policy, Institutions and Governance<\/li><li class=\"nf-ui-chip\">XT-02 Quantum Technologies<\/li><\/ul><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">boundary<\/p><p>This chapter describes research couplings. It assesses no laboratory or company. Health-system planning rests with national authorities and WHO, and no personal health data are used or shown in <a class=\"nx-link\" href=\"https:\/\/docs.therisk.global\/organization\/programme\/reports\">Reports<\/a>.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-gs-15-c8-s2\" aria-labelledby=\"nx-nrp-gs-15-c8-s2-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-gs-15-c8-s2-h\"><span class=\"nrp-num\">8.2<\/span><span>Science and nature<\/span><\/h2><p class=\"nrp-stand\">Nature is measured through shared archives of records and structures. Their size is a strength, and their coverage and bias are the open questions.<\/p><div class=\"pp-cells nrp-cells-3\"><div class=\"nrp-cell\"><span class=\"pp-metric\">3.89<\/span><span class=\"nrp-cell-u\">billion<\/span><p>GBIF occurrence records at access<sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n23\" id=\"nx-nrp-gs-15-c8-r23\" aria-label=\"Note 23\">23<\/a><\/sup><\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">306<\/span><span class=\"nrp-cell-u\">million<\/span><p>GBIF records dated 2025<sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n23\" aria-label=\"Note 23\">23<\/a><\/sup><\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">262,922<\/span><span class=\"nrp-cell-u\">entries<\/span><p>Protein Data Bank holdings at access<sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n22\" id=\"nx-nrp-gs-15-c8-r22\" aria-label=\"Note 22\">22<\/a><\/sup><\/p><\/div><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-gs-15-c8-tab2\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 8.2<\/span><span class=\"nrp-tbl-t\">State at baseline<\/span><\/caption><thead><tr><th scope=\"col\">Component<\/th><th scope=\"col\">State<\/th><th scope=\"col\">Evidence<\/th><th scope=\"col\">Status<\/th><\/tr><\/thead><tbody><tr><td>Species records<\/td><td>occurrence records published through one open network<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n23\" aria-label=\"Note 23\">23<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>Structure archive<\/td><td>experimental structures held in one open archive<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n22\" aria-label=\"Note 22\">22<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>Predicted structures<\/td><td>model predictions integrated with primary databases<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n12\" aria-label=\"Note 12\">12<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>Coverage and bias<\/td><td>record density by place and taxon not consolidated here<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n23\" aria-label=\"Note 23\">23<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Expert input<\/span><\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-split\"><div><h3 class=\"nrp-h3\">Couplings<\/h3><ul class=\"nrp-list\"><li>DAT \u2192 BIO open records<\/li><li>AIC \u2192 BIO structure models<\/li><li>BIO \u2192 DAT new sequences and records<\/li><\/ul><\/div><div><h3 class=\"nrp-h3\">Evidence to bind in 2027<\/h3><ul class=\"nrp-list\"><li>spatial and taxonomic bias of records<\/li><li>reuse of archives in decisions<\/li><\/ul><\/div><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">WHAT TO WATCH<\/p><p>Growth of the archives; funding of curation; new data standards for species records.<\/p><\/aside><h3 class=\"nrp-h3\">Related editions<\/h3><ul class=\"nrp-chips\"><li class=\"nf-ui-chip\">GLB Global Systems<\/li><li class=\"nf-ui-chip\">GS-04 Health and One Health<\/li><li class=\"nf-ui-chip\">GS-12 Earth Observation and Planetary Intelligence<\/li><li class=\"nf-ui-chip\">GS-13 Cyber and Digital Systems<\/li><li class=\"nf-ui-chip\">GS-14 Policy, Institutions and Governance<\/li><li class=\"nf-ui-chip\">XT-02 Quantum Technologies<\/li><\/ul><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">boundary<\/p><p>Biodiversity is not reduced to a single number. Where valuation is used later, it will never be presented as the whole value.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-gs-15-c8-s3\" aria-labelledby=\"nx-nrp-gs-15-c8-s3-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-gs-15-c8-s3-h\"><span class=\"nrp-num\">8.3<\/span><span>Science, compute and the digital layer<\/span><\/h2><p class=\"nrp-stand\">The frontier is increasingly computational. Exascale machines, quantum memories and AI <a class=\"nx-link nx-term\" href=\"https:\/\/docs.therisk.global\/organization\/systems\" data-tc=\"Systems\" data-tk=\"Nexus Standards\" data-td=\"The twenty Nexus systems, NXS-CMD to NXS-LAB\">systems<\/a> change who can do what, and how fast the record grows.<\/p><div class=\"pp-cells nrp-cells-3\"><div class=\"nrp-cell\"><span class=\"pp-metric\">5<\/span><span class=\"nrp-cell-u\">systems<\/span><p>exascale on the TOP500 list, June 2026<sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n4\" id=\"nx-nrp-gs-15-c8-r4\" aria-label=\"Note 4\">4<\/a><\/sup><\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">6<\/span><span class=\"nrp-cell-u\">months<\/span><p><a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-c1\" data-tc=\"NRS-C1 doubling-time\" data-tk=\"Nexus risk vocabulary\" data-td=\"The time a quantity growing at a constant proportional rate takes to double; short doubling times compress the window for action.\" data-ts=\"NRS-C1\" data-tr=\"draft\">doubling time<\/a> of training compute since the early 2010s<sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n13\" id=\"nx-nrp-gs-15-c8-r13\" aria-label=\"Note 13\">13<\/a><\/sup><\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">2.14<\/span><span class=\"nrp-cell-u\">factor<\/span><p>logical error suppression per step in code distance<sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n10\" id=\"nx-nrp-gs-15-c8-r10\" aria-label=\"Note 10\">10<\/a><\/sup><\/p><\/div><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-gs-15-c8-tab3\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 8.3<\/span><span class=\"nrp-tbl-t\">State at baseline<\/span><\/caption><thead><tr><th scope=\"col\">Component<\/th><th scope=\"col\">State<\/th><th scope=\"col\">Evidence<\/th><th scope=\"col\">Status<\/th><\/tr><\/thead><tbody><tr><td>Exascale systems<\/td><td>LineShine 2.198 Eflop\/s; El Capitan 1.809; Frontier 1.353; Aurora 1.012; JUPITER Booster 1.000<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n4\" aria-label=\"Note 4\">4<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>Training compute<\/td><td>doubling about every six months in the deep learning era, to 2022<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n13\" aria-label=\"Note 13\">13<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>Quantum memory<\/td><td>a 101-qubit distance-7 code, 0.143% error per cycle, 2.4 times beyond break-even<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n10\" aria-label=\"Note 10\">10<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>AI in research<\/td><td>agents reach 38.8% against 83.5% for PhD experts on a research-task benchmark<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n9\" id=\"nx-nrp-gs-15-c8-r9\" aria-label=\"Note 9\">9<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-split\"><div><h3 class=\"nrp-h3\">Couplings<\/h3><ul class=\"nrp-list\"><li>INF \u2192 AIC compute<\/li><li>AIC \u2192 DAT research output<\/li><li>INF \u2192 DAT quantum and exascale methods<\/li><\/ul><\/div><div><h3 class=\"nrp-h3\">Evidence to bind in 2027<\/h3><ul class=\"nrp-list\"><li>private compute not on the list<\/li><li>confirmed AI discoveries<\/li><\/ul><\/div><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">WHAT TO WATCH<\/p><p>The November 2026 TOP500 list; second-generation error-corrected devices; independent replication of AI research claims.<\/p><\/aside><h3 class=\"nrp-h3\">Related editions<\/h3><ul class=\"nrp-chips\"><li class=\"nf-ui-chip\">GLB Global Systems<\/li><li class=\"nf-ui-chip\">GS-04 Health and One Health<\/li><li class=\"nf-ui-chip\">GS-12 Earth Observation and Planetary Intelligence<\/li><li class=\"nf-ui-chip\">GS-13 Cyber and Digital Systems<\/li><li class=\"nf-ui-chip\">GS-14 Policy, Institutions and Governance<\/li><li class=\"nf-ui-chip\">XT-02 Quantum Technologies<\/li><\/ul><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">boundary<\/p><p>This chapter describes technical couplings. It assesses no company, laboratory or state and makes no forecast of technology timelines.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-gs-15-c8-s4\" aria-labelledby=\"nx-nrp-gs-15-c8-s4-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-gs-15-c8-s4-h\"><span class=\"nrp-num\">8.4<\/span><span>Science, finance and talent<\/span><\/h2><p class=\"nrp-stand\">Money and people decide where the frontier is. Spending and researcher density are both concentrated, and mobility is changing who works where.<\/p><div class=\"pp-cells nrp-cells-3\"><div class=\"nrp-cell\"><span class=\"pp-metric\">3.48<\/span><span class=\"nrp-cell-u\">USD trillion<\/span><p>global R&amp;D expenditure, 2024<sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n1\" id=\"nx-nrp-gs-15-c8-r1\" aria-label=\"Note 1\">1<\/a><\/sup><\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">354<\/span><span class=\"nrp-cell-u\">USD billion<\/span><p>worldwide venture investment, 2024<sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n1\" aria-label=\"Note 1\">1<\/a><\/sup><\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">89<\/span><span class=\"nrp-cell-u\">%<\/span><p>fall since 2017 in AI researchers moving to the United States<sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n8\" id=\"nx-nrp-gs-15-c8-r8\" aria-label=\"Note 8\">8<\/a><\/sup><\/p><\/div><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-gs-15-c8-tab4\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 8.4<\/span><span class=\"nrp-tbl-t\">State at baseline<\/span><\/caption><thead><tr><th scope=\"col\">Component<\/th><th scope=\"col\">State<\/th><th scope=\"col\">Evidence<\/th><th scope=\"col\">Status<\/th><\/tr><\/thead><tbody><tr><td>Public and business R&amp;D<\/td><td>China 30%, United States 29%, EU-27 18% of global spending<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n1\" aria-label=\"Note 1\">1<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>Venture investment<\/td><td>USD 354 billion in 2024, about half the 2021 peak of USD 694 billion<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n1\" aria-label=\"Note 1\">1<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>Public programmes<\/td><td>Horizon Europe indicative funding of EUR 93.5 billion for 2021 to 2027<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n24\" id=\"nx-nrp-gs-15-c8-r24\" aria-label=\"Note 24\">24<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>Talent mobility<\/td><td>temporary visa holders earned 38% of US S&amp;E doctorates in 2024<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n1\" aria-label=\"Note 1\">1<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-split\"><div><h3 class=\"nrp-h3\">Couplings<\/h3><ul class=\"nrp-list\"><li>FIN \u2192 DAT funding and capacity<\/li><li>TRD \u2192 DAT mobility<\/li><li>FIN \u2192 AIC private AI investment<\/li><\/ul><\/div><div><h3 class=\"nrp-h3\">Evidence to bind in 2027<\/h3><ul class=\"nrp-list\"><li>funding changes in 2025 and 2026<\/li><li>mobility outside the United States<\/li><\/ul><\/div><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">WHAT TO WATCH<\/p><p>National budget decisions; visa rules; the next UNESCO release for emerging regions.<\/p><\/aside><h3 class=\"nrp-h3\">Related editions<\/h3><ul class=\"nrp-chips\"><li class=\"nf-ui-chip\">GLB Global Systems<\/li><li class=\"nf-ui-chip\">GS-04 Health and One Health<\/li><li class=\"nf-ui-chip\">GS-12 Earth Observation and Planetary Intelligence<\/li><li class=\"nf-ui-chip\">GS-13 Cyber and Digital Systems<\/li><li class=\"nf-ui-chip\">GS-14 Policy, Institutions and Governance<\/li><li class=\"nf-ui-chip\">XT-02 Quantum Technologies<\/li><\/ul><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">boundary<\/p><p>This chapter describes financial and labour couplings. It assesses no funder or institution and gives no investment advice.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-gs-15-c8-s5\" aria-labelledby=\"nx-nrp-gs-15-c8-s5-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-gs-15-c8-s5-h\"><span class=\"nrp-num\">8.5<\/span><span>Integrity, openness and governance<\/span><\/h2><p class=\"nrp-stand\">The record is shared infrastructure. Retractions, paper mills and low replication strain it, and open science and AI ethics recommendations set the rules around it.<\/p><div class=\"pp-cells nrp-cells-3\"><div class=\"nrp-cell\"><span class=\"pp-metric\">15,582<\/span><span class=\"nrp-cell-u\">notices<\/span><p>retraction notices registered with Crossref, 2023<sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n6\" id=\"nx-nrp-gs-15-c8-r6\" aria-label=\"Note 6\">6<\/a><\/sup><\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">36<\/span><span class=\"nrp-cell-u\">%<\/span><p>of 100 psychology replications significant, against 97% of originals<sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n16\" id=\"nx-nrp-gs-15-c8-r16\" aria-label=\"Note 16\">16<\/a><\/sup><\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">193<\/span><span class=\"nrp-cell-u\">countries<\/span><p>Member States that adopted the UNESCO open science recommendation<sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n25\" id=\"nx-nrp-gs-15-c8-r25\" aria-label=\"Note 25\">25<\/a><\/sup><\/p><\/div><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-gs-15-c8-tab5\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 8.5<\/span><span class=\"nrp-tbl-t\">State at baseline<\/span><\/caption><thead><tr><th scope=\"col\">Component<\/th><th scope=\"col\">State<\/th><th scope=\"col\">Evidence<\/th><th scope=\"col\">Status<\/th><\/tr><\/thead><tbody><tr><td>Retraction notices<\/td><td>1,678 in 2015; 15,582 in 2023; 7,632 in 2025<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n6\" aria-label=\"Note 6\">6<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>Paper mills<\/td><td>case studies show brokers and mills enabling fraud at scale<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n14\" id=\"nx-nrp-gs-15-c8-r14\" aria-label=\"Note 14\">14<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>Replication<\/td><td>replication effects half the size of the originals in 100 psychology studies<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n16\" aria-label=\"Note 16\">16<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>Open science and AI ethics<\/td><td>two UNESCO recommendations adopted in 2021<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n25\" aria-label=\"Note 25\">25<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-gs-15-c8-n26\" id=\"nx-nrp-gs-15-c8-r26\" aria-label=\"Note 26\">26<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-split\"><div><h3 class=\"nrp-h3\">Couplings<\/h3><ul class=\"nrp-list\"><li>AIC \u2192 DAT \u2192 GOV integrity<\/li><li>GOV \u2192 DAT recommendations<\/li><li>DAT \u2192 HLT reliance on the record<\/li><\/ul><\/div><div><h3 class=\"nrp-h3\">Evidence to bind in 2027<\/h3><ul class=\"nrp-list\"><li>share of the record affected<\/li><li>open-access share<\/li><\/ul><\/div><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">WHAT TO WATCH<\/p><p>Retraction notices for 2026; publisher data sharing; national plans for the UNESCO recommendations.<\/p><\/aside><h3 class=\"nrp-h3\">Related editions<\/h3><ul class=\"nrp-chips\"><li class=\"nf-ui-chip\">GLB Global Systems<\/li><li class=\"nf-ui-chip\">GS-04 Health and One Health<\/li><li class=\"nf-ui-chip\">GS-12 Earth Observation and Planetary Intelligence<\/li><li class=\"nf-ui-chip\">GS-13 Cyber and Digital Systems<\/li><li class=\"nf-ui-chip\">GS-14 Policy, Institutions and Governance<\/li><li class=\"nf-ui-chip\">XT-02 Quantum Technologies<\/li><\/ul><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">boundary<\/p><p>This chapter describes the research record. It assesses no journal, publisher or researcher and makes no finding of misconduct about any case.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-gs-15-c8-notes\" aria-labelledby=\"nx-nrp-gs-15-c8-notes-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-gs-15-c8-notes-h\"><span>Notes<\/span><\/h2><p class=\"nrp-note\">Numbers are the edition&#8217;s reference numbers, so a note reads the same in every chapter. The full list, with every source and its licence, is in Annex C. <a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/gs-15\/references\/\">Annex C, references<\/a><\/p><ol class=\"nrp-notes\"><li id=\"nx-nrp-gs-15-c8-n12\"><span class=\"nrp-notes-n\">12<\/span><span>Varadi, M. et al., AlphaFold Protein Structure Database in 2024: providing structure coverage for over 214 million protein sequences, Nucleic Acids Research 52 (database issue), 368 to 375, 2024 (abstract read through Europe PMC). Oxford University Press, Oxford. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-gs-15-c8-r12\" aria-label=\"Back to the first call of note 12\">back<\/a><\/span><\/li><li id=\"nx-nrp-gs-15-c8-n17\"><span class=\"nrp-notes-n\">17<\/span><span>US Food and Drug Administration (ed.), FDA Approves First Gene Therapies to Treat Patients with Sickle Cell Disease, press announcement of 8 December 2023. FDA, Silver Spring. Page read. Observation year 2023. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-gs-15-c8-r17\" aria-label=\"Back to the first call of note 17\">back<\/a><\/span><\/li><li id=\"nx-nrp-gs-15-c8-n18\"><span class=\"nrp-notes-n\">18<\/span><span>WHO (ed.), Global guidance framework for the responsible use of the life sciences: mitigating biorisks and governing <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-c1\" data-tc=\"NRS-C1 dual-use-research\" data-tk=\"Nexus risk vocabulary\" data-td=\"Legitimate research whose knowledge, methods or products could also be misused to cause serious harm.\" data-ts=\"NRS-C1\" data-tr=\"draft\">dual-use research<\/a>, 174 pages, 2022. World Health Organization, Geneva. Publication page and overview read; the full text was not opened. Observation year 2022. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-gs-15-c8-r18\" aria-label=\"Back to the first call of note 18\">back<\/a><\/span><\/li><li id=\"nx-nrp-gs-15-c8-n11\"><span class=\"nrp-notes-n\">11<\/span><span>Abramson, J. et al., Accurate structure prediction of biomolecular interactions with AlphaFold 3, Nature 630, 493 to 500, 2024 (abstract and open full text read through Europe PMC). Springer Nature, London. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-gs-15-c8-r11\" aria-label=\"Back to the first call of note 11\">back<\/a><\/span><\/li><li id=\"nx-nrp-gs-15-c8-n23\"><span class=\"nrp-notes-n\">23<\/span><span>GBIF (ed.), GBIF API, occurrence count and counts by year (3,890,294,224 records on the access date; 305,893,347 dated 2025). Global Biodiversity Information Facility, Copenhagen. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-gs-15-c8-r23\" aria-label=\"Back to the first call of note 23\">back<\/a><\/span><\/li><li id=\"nx-nrp-gs-15-c8-n22\"><span class=\"nrp-notes-n\">22<\/span><span>RCSB Protein Data Bank (ed.), Current holdings, list of entry identifiers (262,922 entries counted by the editors on the access date). Research Collaboratory for Structural Bioinformatics. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-gs-15-c8-r22\" aria-label=\"Back to the first call of note 22\">back<\/a><\/span><\/li><li id=\"nx-nrp-gs-15-c8-n4\"><span class=\"nrp-notes-n\">4<\/span><span>TOP500 project (ed.), TOP500 list, 67th edition, June 2026 (release text read in full for the leading <a class=\"nx-link nx-term\" href=\"https:\/\/docs.therisk.global\/organization\/systems\" data-tc=\"Systems\" data-tk=\"Nexus Standards\" data-td=\"The twenty Nexus systems, NXS-CMD to NXS-LAB\">systems<\/a>). TOP500, Prometeus GmbH. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-gs-15-c8-r4\" aria-label=\"Back to the first call of note 4\">back<\/a><\/span><\/li><li id=\"nx-nrp-gs-15-c8-n13\"><span class=\"nrp-notes-n\">13<\/span><span>Sevilla, J. et al., Compute Trends Across Three Eras of Machine Learning, arXiv 2202.05924, 2022 (abstract page read). Cornell University, Ithaca. Observation year 2022. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-gs-15-c8-r13\" aria-label=\"Back to the first call of note 13\">back<\/a><\/span><\/li><li id=\"nx-nrp-gs-15-c8-n10\"><span class=\"nrp-notes-n\">10<\/span><span>Google Quantum AI and collaborators, Quantum error correction below the surface code threshold, arXiv 2408.13687 (full text opened) and Nature 638, 920 to 926, 2024. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-gs-15-c8-r10\" aria-label=\"Back to the first call of note 10\">back<\/a><\/span><\/li><li id=\"nx-nrp-gs-15-c8-n9\"><span class=\"nrp-notes-n\">9<\/span><span>Stanford HAI (ed.), The 2026 AI Index Report, Chapter 5 Science, chapter page with its highlights. Stanford Institute for Human-Centered AI, Stanford. Page read; the chapter PDF was not opened. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-gs-15-c8-r9\" aria-label=\"Back to the first call of note 9\">back<\/a><\/span><\/li><li id=\"nx-nrp-gs-15-c8-n1\"><span class=\"nrp-notes-n\">1<\/span><span>NSB (ed.), Science and Engineering Indicators 2026: The State of U.S. Science and Engineering (NSB-SEP-2026-1), May 2026, National Science Board and National Center for Science and Engineering Statistics, US National Science Foundation, Alexandria. Full PDF opened; global R&amp;D, publications, collaboration, venture investment, semiconductor and doctoral-degree figures read from the text. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-gs-15-c8-r1\" aria-label=\"Back to the first call of note 1\">back<\/a><\/span><\/li><li id=\"nx-nrp-gs-15-c8-n8\"><span class=\"nrp-notes-n\">8<\/span><span>Stanford HAI (ed.), The 2026 AI Index Report, overview page with the ten top takeaways. Stanford Institute for Human-Centered AI, Stanford. Page read; the report PDF was not opened. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-gs-15-c8-r8\" aria-label=\"Back to the first call of note 8\">back<\/a><\/span><\/li><li id=\"nx-nrp-gs-15-c8-n24\"><span class=\"nrp-notes-n\">24<\/span><span>European Commission (ed.), Horizon Europe, programme page (indicative funding of EUR 93.5 billion for 2021 to 2027 after the mid-term review). European Commission, Brussels. Page read. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-gs-15-c8-r24\" aria-label=\"Back to the first call of note 24\">back<\/a><\/span><\/li><li id=\"nx-nrp-gs-15-c8-n6\"><span class=\"nrp-notes-n\">6<\/span><span>Crossref (ed.), Crossref REST API, work counts by type and publication year and counts of retraction notices (update-type filter), queried live on the access date. Crossref, Oxford. Counts are subject to later registration. Observation year 2025 (series 2015 to 2025). Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-gs-15-c8-r6\" aria-label=\"Back to the first call of note 6\">back<\/a><\/span><\/li><li id=\"nx-nrp-gs-15-c8-n16\"><span class=\"nrp-notes-n\">16<\/span><span>Open Science Collaboration, Estimating the reproducibility of psychological science, Science 349(6251), aac4716, 2015 (abstract read through Europe PMC; full text not opened). American Association for the Advancement of Science, Washington. Observation year 2015. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-gs-15-c8-r16\" aria-label=\"Back to the first call of note 16\">back<\/a><\/span><\/li><li id=\"nx-nrp-gs-15-c8-n25\"><span class=\"nrp-notes-n\">25<\/span><span>UNESCO (ed.), UNESCO Recommendation on Open Science, 2021, programme page (193 Member States). UNESCO, Paris. Page read; the Recommendation text itself returned an access error. Observation year 2021. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-gs-15-c8-r25\" aria-label=\"Back to the first call of note 25\">back<\/a><\/span><\/li><li id=\"nx-nrp-gs-15-c8-n14\"><span class=\"nrp-notes-n\">14<\/span><span>Richardson, R.A.K. et al., The entities enabling scientific fraud at scale are large, resilient, and growing rapidly, Proceedings of the National Academy of Sciences 122(32), 2025 (abstract and open full text record read through Europe PMC). National Academy of Sciences, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-gs-15-c8-r14\" aria-label=\"Back to the first call of note 14\">back<\/a><\/span><\/li><li id=\"nx-nrp-gs-15-c8-n26\"><span class=\"nrp-notes-n\">26<\/span><span>UNESCO (ed.), Recommendation on the Ethics of Artificial Intelligence, November 2021, programme page (193 Member States). UNESCO, Paris. Page read; the text itself was not opened. Observation year 2021. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-gs-15-c8-r26\" aria-label=\"Back to the first call of note 26\">back<\/a><\/span><\/li><\/ol><\/section><section class=\"nrp-block nrp-noprint\" id=\"nx-nrp-gs-15-c8-cite\" aria-labelledby=\"nx-nrp-gs-15-c8-cite-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-gs-15-c8-cite-h\"><span>Cite this chapter<\/span><\/h2><pre class=\"nrp-pre\">Valadbaygi, S. (Ed.). (2026). Chapter 8: Systems in depth. In Nexus Global Science and Engineering Frontier Risk and Resilience Report 2026: Baseline Edition, The State of the World\u2019s Science and Engineering Frontier. (Baseline Edition 2026, Report No. NR-SECTOR-SCIENCE-GLOBAL-2026-BASELINE) [Draft under review]. 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