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\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solid;border-color:inherit}#nxe-nr-gcri-editions-xt-04-findings.nxe svg{display:none}#nxe-nr-gcri-editions-xt-04-findings.nxe svg.nx-i{display:inline-block;width:18px;height:18px;vertical-align:-3px}#nxe-nr-gcri-editions-xt-04-findings.nxe :where([role=\"tablist\"],[role=\"toolbar\"],[hidden],button,.nx-theme-toggle,.nx-live-slot){display:none}#nxe-nr-gcri-editions-xt-04-findings.nxe img{max-width:100%;height:auto}<\/style><svg class=\"nx-defs\" aria-hidden=\"true\" focusable=\"false\" width=\"0\" height=\"0\"><defs><linearGradient id=\"nx-gi\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"1\"><stop offset=\"0\" class=\"nx-gi-a\"\/><stop offset=\"0.55\" class=\"nx-gi-b\"\/><stop offset=\"1\" class=\"nx-gi-c\"\/><\/linearGradient><linearGradient id=\"nx-giu\" gradientUnits=\"userSpaceOnUse\" x1=\"0\" y1=\"0\" x2=\"800\" y2=\"0\"><stop offset=\"0\" class=\"nx-gi-a\"\/><stop offset=\"0.55\" class=\"nx-gi-b\"\/><stop offset=\"1\" class=\"nx-gi-c\"\/><\/linearGradient><linearGradient id=\"nx-gp\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"1\"><stop offset=\"0\" class=\"nx-gp-a\"\/><stop offset=\"1\" class=\"nx-gp-b\"\/><\/linearGradient><\/defs><\/svg><div class=\"nrp\"><div class=\"nrp-wrap\"><p class=\"nrj-draft\" data-nrj-shared=\"draft\" role=\"note\"><strong>Draft, not yet released.<\/strong> In stewardship review. Not indexed until the first approved release.<\/p><div class=\"nrp-reader\"><nav class=\"nrp-rail\" aria-label=\"Contents of Synthetic Biology and Bioengineering 2026\"><p class=\"nf-ui-eyebrow\">Contents<\/p><ol class=\"nrp-toc\"><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Edition home<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/summary\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Executive summary<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/coupled-system\/\"><span class=\"nrp-toc-n\">1<\/span><span>Synthetic biology is a build capability and a governance test<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/findings\/\" aria-current=\"page\"><span class=\"nrp-toc-n\">2<\/span><span>Key findings<\/span><\/a><ol class=\"nrp-toc-sub\"><li><a href=\"#nx-nrp-xt-04-c2-s1\">2.1 Headline finding<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c2-s2\">2.2 BLD<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c2-s3\">2.3 CLN<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c2-s4\">2.4 Security<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c2-s5\">2.5 Governance<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c2-s6\">2.6 Finance<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c2-s7\">2.7 Systemic<\/a><\/li><\/ol><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-and-sectors\/\"><span class=\"nrp-toc-n\">3<\/span><span>Systems and sectors at baseline<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/risk-and-capability\/\"><span class=\"nrp-toc-n\">4<\/span><span>Risks and capability<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/scenario\/\"><span class=\"nrp-toc-n\">5<\/span><span>Design capability outpaces screening and oversight<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/lenses-and-readings\/\"><span class=\"nrp-toc-n\">6<\/span><span>Readings from the other desks<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/agenda\/\"><span class=\"nrp-toc-n\">7<\/span><span>The 2027 agenda<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-in-depth\/\"><span class=\"nrp-toc-n\">8<\/span><span>Systems in depth<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/methodology\/\"><span class=\"nrp-toc-n\">A<\/span><span>Methodology<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/data\/\"><span class=\"nrp-toc-n\">B<\/span><span>Data appendix<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/references\/\"><span class=\"nrp-toc-n\">C<\/span><span>References and record<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/full\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Complete edition, for print<\/span><\/a><\/li><\/ol><div class=\"nrp-actions\"><a class=\"nf-ui-btn\" data-variant=\"secondary\" href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/full\/\"><svg class=\"nrp-i\" viewBox=\"0 0 24 24\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2\"\/><path d=\"M6 9V3a1 1 0 0 1 1-1h10a1 1 0 0 1 1 1v6\"\/><rect x=\"6\" y=\"14\" width=\"12\" height=\"8\" rx=\"1\"\/><\/svg>Print or save as PDF<\/a><\/div><\/nav><article class=\"nrp-flow\" aria-labelledby=\"nx-nrp-xt-04-c2-top\"><header class=\"nrp-chap-head\" id=\"nx-nrp-xt-04-c2-top\"><ul class=\"nrp-eyerow\"><li class=\"nf-ui-eyebrow\"><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/\">Synthetic Biology and Bioengineering 2026<\/a><\/li><li class=\"nf-ui-eyebrow\">Chapter 2<\/li><\/ul><span class=\"nrp-rule\" aria-hidden=\"true\"><\/span><h1 class=\"pp-hero-title\">Key findings<\/h1><p class=\"nrp-lede\">Twelve findings carry the synthetic biology baseline. They are grouped by coupling and never ranked. Each resolves to its source or, where Nexus analysis is involved, to its stated method.<\/p><p class=\"nrp-chap-meta\"><span>9 min read<\/span><span>1 figure<\/span><span>0 tables<\/span><span>28 notes<\/span><span>NR-XTECH-SYNBIO-GLOBAL-2026-BASELINE<\/span><\/p><details class=\"nrp-toc-m\"><summary>Contents<\/summary><ol class=\"nrp-toc\"><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Edition home<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/summary\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Executive summary<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/coupled-system\/\"><span class=\"nrp-toc-n\">1<\/span><span>Synthetic biology is a build capability and a governance test<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/findings\/\" aria-current=\"page\"><span class=\"nrp-toc-n\">2<\/span><span>Key findings<\/span><\/a><ol class=\"nrp-toc-sub\"><li><a href=\"#nx-nrp-xt-04-c2-s1\">2.1 Headline finding<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c2-s2\">2.2 BLD<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c2-s3\">2.3 CLN<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c2-s4\">2.4 Security<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c2-s5\">2.5 Governance<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c2-s6\">2.6 Finance<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c2-s7\">2.7 Systemic<\/a><\/li><\/ol><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-and-sectors\/\"><span class=\"nrp-toc-n\">3<\/span><span>Systems and sectors at baseline<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/risk-and-capability\/\"><span class=\"nrp-toc-n\">4<\/span><span>Risks and capability<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/scenario\/\"><span class=\"nrp-toc-n\">5<\/span><span>Design capability outpaces screening and oversight<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/lenses-and-readings\/\"><span class=\"nrp-toc-n\">6<\/span><span>Readings from the other desks<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/agenda\/\"><span class=\"nrp-toc-n\">7<\/span><span>The 2027 agenda<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-in-depth\/\"><span class=\"nrp-toc-n\">8<\/span><span>Systems in depth<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/methodology\/\"><span class=\"nrp-toc-n\">A<\/span><span>Methodology<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/data\/\"><span class=\"nrp-toc-n\">B<\/span><span>Data appendix<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/references\/\"><span class=\"nrp-toc-n\">C<\/span><span>References and record<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/full\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Complete edition, for print<\/span><\/a><\/li><\/ol><\/details><\/header><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c2-s1\" aria-labelledby=\"nx-nrp-xt-04-c2-s1-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c2-s1-h\"><span class=\"nrp-num\">2.1<\/span><span>Headline finding<\/span><\/h2><p class=\"nrp-find-m\"><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 4<\/span><a class=\"nrp-find-id\" href=\"#nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-BLD-001\">NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-BLD-001<\/a><\/p><p class=\"nrp-km-t\">A bacterium with a 57-codon genetic code was reported in Science in 2025, seven codons fewer than the standard 64, with over 101,000 codon changes in a synthetic genome of about 4 million base pairs.<\/p><figure class=\"nrp-fig\" id=\"nx-nrp-xt-04-c2-fig1\" aria-labelledby=\"nx-nrp-xt-04-c2-fig1-t\"><figcaption class=\"nrp-figcap\"><span class=\"nf-ui-eyebrow\">Figure 2.1<\/span><span class=\"nf-ui-title\" data-level=\"card\" id=\"nx-nrp-xt-04-c2-fig1-t\">Codons in the genetic code<\/span><\/figcaption><div class=\"nrp-tblw\"><table class=\"nrp-tbl nrp-bars\"><thead><tr><th scope=\"col\">Item<\/th><th scope=\"col\"><span class=\"nrp-sr\">Bar, scaled to the largest value<\/span><\/th><th scope=\"col\">Value<\/th><\/tr><\/thead><tbody><tr><th scope=\"row\">Standard genetic code<\/th><td class=\"nrp-barc\"><svg class=\"nrp-svg nrp-barsvg\" viewBox=\"0 0 100 8\" preserveAspectRatio=\"none\" aria-hidden=\"true\" focusable=\"false\"><rect class=\"nrp-track\" x=\"0\" y=\"0\" width=\"100\" height=\"8\"\/><rect class=\"nrp-bar\" x=\"0\" y=\"0\" width=\"100.0\" height=\"8\"\/><\/svg><\/td><td class=\"nrp-mono\">64<\/td><\/tr><tr><th scope=\"row\">Syn61 strain (2019)<\/th><td class=\"nrp-barc\"><svg class=\"nrp-svg nrp-barsvg\" viewBox=\"0 0 100 8\" preserveAspectRatio=\"none\" aria-hidden=\"true\" focusable=\"false\"><rect class=\"nrp-track\" x=\"0\" y=\"0\" width=\"100\" height=\"8\"\/><rect class=\"nrp-bar\" x=\"0\" y=\"0\" width=\"95.3\" height=\"8\"\/><\/svg><\/td><td class=\"nrp-mono\">61<\/td><\/tr><tr><th scope=\"row\">Syn57 strain (2025)<\/th><td class=\"nrp-barc\"><svg class=\"nrp-svg nrp-barsvg\" viewBox=\"0 0 100 8\" preserveAspectRatio=\"none\" aria-hidden=\"true\" focusable=\"false\"><rect class=\"nrp-track\" x=\"0\" y=\"0\" width=\"100\" height=\"8\"\/><rect class=\"nrp-bar\" x=\"0\" y=\"0\" width=\"89.1\" height=\"8\"\/><\/svg><\/td><td class=\"nrp-mono\">57<\/td><\/tr><\/tbody><\/table><\/div><p class=\"nrp-fig-src\">Sources: MRC Laboratory of Molecular Biology<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n2\" id=\"nx-nrp-xt-04-c2-r2\" aria-label=\"Note 2\">2<\/a><\/sup>; Nature 569 (2019)<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n3\" id=\"nx-nrp-xt-04-c2-r3\" aria-label=\"Note 3\">3<\/a><\/sup>. Each bar counts codons in the code of that organism.<\/p><\/figure><h3 class=\"nrp-h3\">Implication<\/h3><p class=\"nrp-p\">Whole-genome design and writing now works at the scale of a bacterial genome. The authors state aims such as further compression and tests of viral resistance; those are plans, not results<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n1\" id=\"nx-nrp-xt-04-c2-r1\" aria-label=\"Note 1\">1<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n2\" aria-label=\"Note 2\">2<\/a><\/sup>. The result shows capability on one organism and says nothing about industrial use, cost or safety in the field.<\/p><h3 class=\"nrp-h3\">What would move it<\/h3><p class=\"nrp-p\">Peer-reviewed tests of viral resistance, independent replication and any published cost of whole-genome synthesis would each move this finding.<\/p><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c2-s2\" aria-labelledby=\"nx-nrp-xt-04-c2-s2-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c2-s2-h\"><span class=\"nrp-num\">2.2<\/span><span>BLD<\/span><\/h2><ol class=\"nrp-find\"><li id=\"nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-BLD-001\"><p class=\"nrp-find-m\"><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 4<\/span><a class=\"nrp-find-id\" href=\"#nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-BLD-001\">NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-BLD-001<\/a><\/p><p class=\"nrp-find-t\">A bacterium with a 57-codon genetic code was reported in 2025. Its synthetic genome of about 4 million base pairs carries over 101,000 codon changes and was built from 38 fragments of about 100,000 base pairs; an earlier strain recoded 18,214 codons and uses 61 codons.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n1\" aria-label=\"Note 1\">1<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n2\" aria-label=\"Note 2\">2<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n3\" aria-label=\"Note 3\">3<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n44\" id=\"nx-nrp-xt-04-c2-r44\" aria-label=\"Note 44\">44<\/a><\/sup><\/p><\/li><li id=\"nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-BLD-002\"><p class=\"nrp-find-m\"><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 4<\/span><a class=\"nrp-find-id\" href=\"#nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-BLD-002\">NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-BLD-002<\/a><\/p><p class=\"nrp-find-t\">By 2023 a single yeast strain carried six and a half synthetic chromosomes, over half of the synthetic yeast genome design; in 2010 the first cell run by a chemically synthesised genome had a 1.08 million base pair genome.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n4\" id=\"nx-nrp-xt-04-c2-r4\" aria-label=\"Note 4\">4<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n5\" id=\"nx-nrp-xt-04-c2-r5\" aria-label=\"Note 5\">5<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n43\" id=\"nx-nrp-xt-04-c2-r43\" aria-label=\"Note 43\">43<\/a><\/sup><\/p><\/li><li id=\"nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-BLD-003\"><p class=\"nrp-find-m\"><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 4<\/span><a class=\"nrp-find-id\" href=\"#nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-BLD-003\">NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-BLD-003<\/a><\/p><p class=\"nrp-find-t\">A 2016 design automation tool built 60 genetic circuits in E. coli, 45 worked in every output state and 92% of output states matched predictions; a 2023 generative method designed protein binders, and one binder to influenza hemagglutinin matched its design model in a cryo-EM structure.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n6\" id=\"nx-nrp-xt-04-c2-r6\" aria-label=\"Note 6\">6<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n7\" id=\"nx-nrp-xt-04-c2-r7\" aria-label=\"Note 7\">7<\/a><\/sup><\/p><\/li><\/ol><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c2-s3\" aria-labelledby=\"nx-nrp-xt-04-c2-s3-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c2-s3-h\"><span class=\"nrp-num\">2.3<\/span><span>CLN<\/span><\/h2><ol class=\"nrp-find\"><li id=\"nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-CLN-004\"><p class=\"nrp-find-m\"><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 4<\/span><a class=\"nrp-find-id\" href=\"#nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-CLN-004\">NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-CLN-004<\/a><\/p><p class=\"nrp-find-t\">A CRISPR-edited cell therapy was authorised by the US regulator on 8 December 2023; in a phase 3 study 29 of 30 evaluable patients (97%) were free of severe crises for 12 months, and in 2025 a patient-specific base-editing therapy was given to one infant.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n8\" id=\"nx-nrp-xt-04-c2-r8\" aria-label=\"Note 8\">8<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n9\" id=\"nx-nrp-xt-04-c2-r9\" aria-label=\"Note 9\">9<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n10\" id=\"nx-nrp-xt-04-c2-r10\" aria-label=\"Note 10\">10<\/a><\/sup><\/p><\/li><\/ol><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c2-s4\" aria-labelledby=\"nx-nrp-xt-04-c2-s4-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c2-s4-h\"><span class=\"nrp-num\">2.4<\/span><span>Security<\/span><\/h2><ol class=\"nrp-find\"><li id=\"nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-SEC-005\"><p class=\"nrp-find-m\"><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 4<\/span><a class=\"nrp-find-id\" href=\"#nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-SEC-005\">NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-SEC-005<\/a><\/p><p class=\"nrp-find-t\">A 2025 Science study found that current screening tools often failed to detect sequences redesigned with open machine-learning protein design software, and reported patches that substantially improved detection.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n13\" id=\"nx-nrp-xt-04-c2-r13\" aria-label=\"Note 13\">13<\/a><\/sup><\/p><\/li><li id=\"nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-SEC-006\"><p class=\"nrp-find-m\"><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 3<\/span><a class=\"nrp-find-id\" href=\"#nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-SEC-006\">NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-SEC-006<\/a><\/p><p class=\"nrp-find-t\">A 2024 Science policy forum on <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-h101\" data-tc=\"NHS-1 tech.biotech.mirror-life\" data-tk=\"Frontier and exponential technology \u00b7 Biotechnology and synthetic biology\" data-td=\"Creation and escape of organisms built from mirror-image molecules, which could evade immune defences, predators and decay in people, animals and plants and spread unchecked through ecosystems.\" data-ts=\"NRS-H101\" data-tr=\"draft\" data-tx=\"https:\/\/risksindex.com\/hazards\/tech\/\" data-txl=\"Frontier and exponential technology\">mirror life<\/a> called for broad discussion on a path forward.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n12\" id=\"nx-nrp-xt-04-c2-r12\" aria-label=\"Note 12\">12<\/a><\/sup><\/p><\/li><\/ol><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c2-s5\" aria-labelledby=\"nx-nrp-xt-04-c2-s5-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c2-s5-h\"><span class=\"nrp-num\">2.5<\/span><span>Governance<\/span><\/h2><ol class=\"nrp-find\"><li id=\"nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-GOV-007\"><p class=\"nrp-find-m\"><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 2<\/span><a class=\"nrp-find-id\" href=\"#nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-GOV-007\">NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-GOV-007<\/a><\/p><p class=\"nrp-find-t\">Executive Order 14292 of May 2025 gave OSTP 90 days to revise or replace the 2024 US framework for nucleic acid synthesis screening; a Congressional Research Service note found in July 2026 that it could not determine whether either had been revised, and sources differ on whether the framework is in force.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n25\" id=\"nx-nrp-xt-04-c2-r25\" aria-label=\"Note 25\">25<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n26\" id=\"nx-nrp-xt-04-c2-r26\" aria-label=\"Note 26\">26<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n27\" id=\"nx-nrp-xt-04-c2-r27\" aria-label=\"Note 27\">27<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n30\" id=\"nx-nrp-xt-04-c2-r30\" aria-label=\"Note 30\">30<\/a><\/sup><\/p><\/li><li id=\"nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-GOV-008\"><p class=\"nrp-find-m\"><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 3<\/span><a class=\"nrp-find-id\" href=\"#nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-GOV-008\">NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-GOV-008<\/a><\/p><p class=\"nrp-find-t\">The US National Security Commission on Emerging Biotechnology delivered its final report on 8 April 2025 with 49 recommendations and a call for at least USD 15 billion over five years.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n14\" id=\"nx-nrp-xt-04-c2-r14\" aria-label=\"Note 14\">14<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n15\" id=\"nx-nrp-xt-04-c2-r15\" aria-label=\"Note 15\">15<\/a><\/sup><\/p><\/li><li id=\"nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-GOV-009\"><p class=\"nrp-find-m\"><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 2<\/span><a class=\"nrp-find-id\" href=\"#nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-GOV-009\">NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-GOV-009<\/a><\/p><p class=\"nrp-find-t\">The European Commission proposed a Biotech Act on 16 December 2025, centred on health biotechnology, with an investment pilot with the European Investment Bank Group, a 12-month certificate extension and biodefence measures; a second act on the wider ecosystem was expected in the third quarter of 2026.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n22\" id=\"nx-nrp-xt-04-c2-r22\" aria-label=\"Note 22\">22<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n28\" id=\"nx-nrp-xt-04-c2-r28\" aria-label=\"Note 28\">28<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n29\" id=\"nx-nrp-xt-04-c2-r29\" aria-label=\"Note 29\">29<\/a><\/sup><\/p><\/li><li id=\"nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-GOV-010\"><p class=\"nrp-find-m\"><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 3<\/span><a class=\"nrp-find-id\" href=\"#nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-GOV-010\">NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-GOV-010<\/a><\/p><p class=\"nrp-find-t\">The OECD found in May 2026 that governments are moving toward adaptive synthetic biology governance but that implementation remains uneven; the CBD asked in decision 16\/21 for a thematic action plan on capacity building and technology transfer.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n18\" id=\"nx-nrp-xt-04-c2-r18\" aria-label=\"Note 18\">18<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n19\" id=\"nx-nrp-xt-04-c2-r19\" aria-label=\"Note 19\">19<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n20\" id=\"nx-nrp-xt-04-c2-r20\" aria-label=\"Note 20\">20<\/a><\/sup><\/p><\/li><\/ol><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c2-s6\" aria-labelledby=\"nx-nrp-xt-04-c2-s6-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c2-s6-h\"><span class=\"nrp-num\">2.6<\/span><span>Finance<\/span><\/h2><ol class=\"nrp-find\"><li id=\"nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-FIN-011\"><p class=\"nrp-find-m\"><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 2<\/span><a class=\"nrp-find-id\" href=\"#nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-FIN-011\">NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-FIN-011<\/a><\/p><p class=\"nrp-find-t\">Ginkgo Bioworks reported revenue of USD 170.2 million for 2025 against USD 227.0 million for 2024, and Twist Bioscience reported USD 332.8 million for the nine months to 30 June 2026 with full-year guidance of USD 456 to 457 million. These are company statements.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n16\" id=\"nx-nrp-xt-04-c2-r16\" aria-label=\"Note 16\">16<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c2-n17\" id=\"nx-nrp-xt-04-c2-r17\" aria-label=\"Note 17\">17<\/a><\/sup><\/p><\/li><\/ol><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c2-s7\" aria-labelledby=\"nx-nrp-xt-04-c2-s7-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c2-s7-h\"><span class=\"nrp-num\">2.7<\/span><span>Systemic<\/span><\/h2><ol class=\"nrp-find\"><li id=\"nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-SYS-012\"><p class=\"nrp-find-m\"><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Expert input<\/span><span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 2<\/span><a class=\"nrp-find-id\" href=\"#nx-NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-SYS-012\">NRF-XTECH-SYNBIO-GLOBAL-2026-BASELINE-SYS-012<\/a><\/p><p class=\"nrp-find-t\">The leading compound pathway for 2027 testing is design capability and cheap DNA moving faster than screening practice and governance, while the footprint of the manufacturing base stays unmeasured. \u00a7 scenario<\/p><\/li><\/ol><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c2-notes\" aria-labelledby=\"nx-nrp-xt-04-c2-notes-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c2-notes-h\"><span>Notes<\/span><\/h2><p class=\"nrp-note\">Numbers are the edition&#8217;s reference numbers, so a note reads the same in every chapter. The full list, with every source and its licence, is in Annex C. <a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/references\/\">Annex C, references<\/a><\/p><ol class=\"nrp-notes\"><li id=\"nx-nrp-xt-04-c2-n2\"><span class=\"nrp-notes-n\">2<\/span><span>MRC Laboratory of Molecular Biology (ed.), Syn57 represents a new chapter in the genetic code of life (news page, 1 August 2025; over 101,000 codons recoded; 64 to 57 codons; genome of about 4 megabases built from 38 fragments of about 100 kilobases). MRC Laboratory of Molecular Biology, Cambridge. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r2\" aria-label=\"Back to the first call of note 2\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n3\"><span class=\"nrp-notes-n\">3<\/span><span>Fredens, J. et al., Total synthesis of Escherichia coli with a recoded genome, Nature 569 (7757), 514 to 518, 2019 (record read via Europe PMC: 18,214 codons recoded; 61-codon genome). Springer Nature, London. Observation year 2019. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r3\" aria-label=\"Back to the first call of note 3\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n1\"><span class=\"nrp-notes-n\">1<\/span><span>Robertson, W.E. et al., Escherichia coli with a 57-codon genetic code, Science 390 (6771), eady4368, published 23 October 2025 (record read via PubMed, PMID 40743368; the record gives a 4 megabase synthetic genome and six replaced sense codons). American Association for the Advancement of Science, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r1\" aria-label=\"Back to the first call of note 1\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n44\"><span class=\"nrp-notes-n\">44<\/span><span>UNVERIFIED, not opened: bioRxiv preprint of the Syn57 study, Escherichia coli with a 57-codon genetic code, 2025, identified from a search result; the page returned HTTP 429. Cold Spring Harbor Laboratory, New York. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r44\" aria-label=\"Back to the first call of note 44\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n4\"><span class=\"nrp-notes-n\">4<\/span><span>Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions, Cell 186 (24), 5220 to 5236, 2023 (record read via Europe PMC: 6.5 synthetic chromosomes in one strain; over half of the Sc2.0 genome). Cell Press, Cambridge, Massachusetts. Observation year 2023. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r4\" aria-label=\"Back to the first call of note 4\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n5\"><span class=\"nrp-notes-n\">5<\/span><span>Gibson, D.G. et al., Creation of a bacterial cell controlled by a chemically synthesised genome, Science 329 (5987), 52 to 56, 2010 (record read via Europe PMC: 1.08 million base pair genome). American Association for the Advancement of Science, Washington. Observation year 2010. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r5\" aria-label=\"Back to the first call of note 5\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n43\"><span class=\"nrp-notes-n\">43<\/span><span>UNVERIFIED, not opened: Richardson, S.M. et al., Design of a synthetic yeast genome, Science 355, 1040 to 1044, 2017, cited from memory. Observation year 2017. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r43\" aria-label=\"Back to the first call of note 43\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n6\"><span class=\"nrp-notes-n\">6<\/span><span>Nielsen, A.A.K. et al., Genetic circuit design automation, Science 352 (6281), 2016 (record read via Europe PMC: 60 circuits; 45 correct in all output states; 92% of output states as predicted). American Association for the Advancement of Science, Washington. Observation year 2016. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r6\" aria-label=\"Back to the first call of note 6\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n7\"><span class=\"nrp-notes-n\">7<\/span><span>Watson, J.L. et al., De novo design of protein structure and function with RFdiffusion, Nature 620, 1089 to 1100, 2023 (record read via Europe PMC). Springer Nature, London. Observation year 2023. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r7\" aria-label=\"Back to the first call of note 7\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n8\"><span class=\"nrp-notes-n\">8<\/span><span>Frangoul, H. et al., Exagamglogene autotemcel for severe sickle cell disease, New England Journal of Medicine 390 (18), 1649 to 1662, 2024 (record read via Europe PMC: 44 treated; 29 of 30 evaluable free of severe crises for 12 months; median follow-up 19.3 months). Massachusetts Medical Society, Waltham. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r8\" aria-label=\"Back to the first call of note 8\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n9\"><span class=\"nrp-notes-n\">9<\/span><span>US Food and Drug Administration (ed.), FDA approves first gene therapies to treat patients with sickle cell disease (press announcement, 8 December 2023; Casgevy and Lyfgenia; ages 12 and over; 29 of 31 evaluable Casgevy patients free of severe crises for at least 12 months). FDA, Silver Spring. Observation year 2023. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r9\" aria-label=\"Back to the first call of note 9\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n10\"><span class=\"nrp-notes-n\">10<\/span><span>Musunuru, K. et al., Patient-specific in vivo gene editing to treat a rare genetic disease, New England Journal of Medicine 392 (22), 2235 to 2243, 2025 (record read via Europe PMC: one infant; two infusions at about 7 and 8 months). Massachusetts Medical Society, Waltham. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r10\" aria-label=\"Back to the first call of note 10\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n13\"><span class=\"nrp-notes-n\">13<\/span><span>Strengthening nucleic acid biosecurity screening against generative protein design tools, Science 390 (6768), 82 to 87, 2025 (record read via Europe PMC; abstract only; no method detail used). American Association for the Advancement of Science, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r13\" aria-label=\"Back to the first call of note 13\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n12\"><span class=\"nrp-notes-n\">12<\/span><span>Confronting risks of <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-h101\" data-tc=\"NHS-1 tech.biotech.mirror-life\" data-tk=\"Frontier and exponential technology \u00b7 Biotechnology and synthetic biology\" data-td=\"Creation and escape of organisms built from mirror-image molecules, which could evade immune defences, predators and decay in people, animals and plants and spread unchecked through ecosystems.\" data-ts=\"NRS-H101\" data-tr=\"draft\" data-tx=\"https:\/\/risksindex.com\/hazards\/tech\/\" data-txl=\"Frontier and exponential technology\">mirror life<\/a>, Science 386, 1351 to 1353, 2024 (record read via Europe PMC; the record gives only a one-line abstract calling for broad discussion). American Association for the Advancement of Science, Washington. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r12\" aria-label=\"Back to the first call of note 12\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n25\"><span class=\"nrp-notes-n\">25<\/span><span>UNVERIFIED, not opened: Office of Science and Technology Policy (ed.), Framework for Nucleic Acid Synthesis Screening, April 2024, taken from search-result summaries; a fetch of the page was refused by the fetch tool. OSTP, Washington. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r25\" aria-label=\"Back to the first call of note 25\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n26\"><span class=\"nrp-notes-n\">26<\/span><span>UNVERIFIED, not opened: Executive Order 14292, Improving the Safety and Security of Biological Research, 5 May 2025 (90 days to revise or replace the framework), taken from search-result summaries; a fetch of an explainer page was refused by the fetch tool. The White House, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r26\" aria-label=\"Back to the first call of note 26\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n27\"><span class=\"nrp-notes-n\">27<\/span><span>UNVERIFIED, not opened: Congressional Research Service (ed.), report on artificial intelligence and biosecurity risks (reported in July 2026 as unable to determine whether the 2024 framework or the 2025 policy had been revised), taken from a trade news summary. Library of Congress, Washington. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r27\" aria-label=\"Back to the first call of note 27\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n30\"><span class=\"nrp-notes-n\">30<\/span><span>UNVERIFIED, not opened: Engineering Biology Research Consortium (ed.), response on nucleic acid synthesis screening under Executive Order 14292, November 2025, listed in search results only. EBRC, Emeryville. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r30\" aria-label=\"Back to the first call of note 30\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n14\"><span class=\"nrp-notes-n\">14<\/span><span>Congressional Research Service (ed.), National Security Commission on Emerging Biotechnology: Final Report and Options for Congress, CRS Insight IN12546, 17 April 2025 (report of 8 April 2025; 49 recommendations; at least USD 15 billion over five years; National Biotechnology Coordination Office). Library of Congress, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r14\" aria-label=\"Back to the first call of note 14\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n15\"><span class=\"nrp-notes-n\">15<\/span><span>Federation of American Scientists (ed.), Translating Vision into Action: FAS commentary on the NSCEB final report (commentary page; six pillars; cites over USD 210 billion of US GDP and over 640,000 jobs for the bioeconomy; secondary and advocacy-leaning source). Federation of American Scientists, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r15\" aria-label=\"Back to the first call of note 15\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n22\"><span class=\"nrp-notes-n\">22<\/span><span>Baker McKenzie (ed.), EU Biotech Act unveiled: Commission proposal to turn Europe into a biotech powerhouse (law firm summary, 19 December 2025; proposal of 16 December 2025; health focus; investment pilot with the European Investment Bank Group; 12-month certificate extension; biodefence measures; second act expected in Q3 2026). Secondary source, not the Commission text. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r22\" aria-label=\"Back to the first call of note 22\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n28\"><span class=\"nrp-notes-n\">28<\/span><span>UNVERIFIED, not opened: European Commission (ed.), Proposal for a Biotech Act, COM(2025) 1022, 16 December 2025, taken from law firm and regulator summaries; the Commission page was not retrieved. European Commission, Brussels. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r28\" aria-label=\"Back to the first call of note 28\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n29\"><span class=\"nrp-notes-n\">29<\/span><span>UNVERIFIED, not opened: European Parliament (ed.), Legislative train entry for the European Biotech Act II (second act expected in the third quarter of 2026), taken from a search-result summary; the page returned no content. European Parliament, Brussels. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r29\" aria-label=\"Back to the first call of note 29\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n18\"><span class=\"nrp-notes-n\">18<\/span><span>OECD (ed.), Anticipatory governance for responsible innovation in synthetic biology, OECD Science, Technology and Industry Policy Papers No. 193, 21 May 2026 (record read via a bibliographic database; abstract only). OECD Publishing, Paris. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r18\" aria-label=\"Back to the first call of note 18\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n19\"><span class=\"nrp-notes-n\">19<\/span><span>OECD (ed.), Synthetic biology, AI and automation: a forward-looking technology assessment, OECD Science, Technology and Industry Policy Papers No. 187, 4 December 2025 (record read via a bibliographic database; abstract only). OECD Publishing, Paris. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r19\" aria-label=\"Back to the first call of note 19\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n20\"><span class=\"nrp-notes-n\">20<\/span><span>Secretariat of the Convention on Biological Diversity (ed.), Synthetic biology (programme page; decisions X\/13 to 16\/21; AHTEG; <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-c1\" data-tc=\"NRS-C1 horizon-scanning\" data-tk=\"Nexus risk vocabulary\" data-td=\"Systematic searching for early signs of potentially important developments, threats and opportunities at the margins of current thinking.\" data-ts=\"NRS-C1\" data-tr=\"draft\" data-tg=\"https:\/\/globalriskforum.com\/glossary\/horizon-scanning\/\" data-tgl=\"Global Risks Forum glossary\">horizon scanning<\/a>; thematic action plan). CBD Secretariat, Montreal. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r20\" aria-label=\"Back to the first call of note 20\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n16\"><span class=\"nrp-notes-n\">16<\/span><span>Twist Bioscience Corporation (ed.), Form 8-K exhibit 99.1, results for the fiscal third quarter ended 30 June 2026 (company filing; revenue USD 118.4 million; nine months USD 332.8 million; fiscal 2026 guidance USD 456 to 457 million; company statements and guidance are weak evidence). US Securities and Exchange Commission, Washington. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r16\" aria-label=\"Back to the first call of note 16\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c2-n17\"><span class=\"nrp-notes-n\">17<\/span><span>Ginkgo Bioworks Holdings, Inc. (ed.), Form 8-K exhibit 99.1, fourth quarter and full year 2025 results (company filing of 26 February 2026; revenue USD 170.155 million against USD 227.043 million; net loss USD 312.763 million; company statements are weak evidence). US Securities and Exchange Commission, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c2-r17\" aria-label=\"Back to the first call of note 17\">back<\/a><\/span><\/li><\/ol><\/section><section class=\"nrp-block nrp-noprint\" id=\"nx-nrp-xt-04-c2-cite\" aria-labelledby=\"nx-nrp-xt-04-c2-cite-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c2-cite-h\"><span>Cite this chapter<\/span><\/h2><pre class=\"nrp-pre\">Valadbaygi, S. (Ed.). (2026). Chapter 2: Key findings. In Exponential Technology Report 2026: Synthetic Biology and Bioengineering (Baseline Edition 2026, Report No. NR-XTECH-SYNBIO-GLOBAL-2026-BASELINE) [Draft under review]. The Global Centre for Risk and Innovation (GCRI).<\/pre><p class=\"nrp-note\">Every citation form of the whole report, BibTeX and RIS included, is on the edition home. <a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/#nx-nrp-xt-04-land-cite\">Cite this report<\/a><\/p><\/section><nav class=\"nrp-pager\" aria-label=\"Previous and next\"><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/coupled-system\/\" rel=\"prev\"><span class=\"nf-ui-eyebrow\">Previous \u00b7 Chapter 1<\/span><span class=\"nrp-pager-t\">Synthetic biology is a build capability and a governance test<\/span><\/a><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-and-sectors\/\" rel=\"next\"><span class=\"nf-ui-eyebrow\">Next \u00b7 Chapter 3<\/span><span class=\"nrp-pager-t\">Systems and sectors at baseline<\/span><\/a><\/nav><\/article><\/div><\/div><\/div><div class=\"nrp-noprint\"><section id=\"nx-sec-nr-gateway\" class=\"nx-section\" data-hue=\"systemic\" data-tone=\"alt\" aria-labelledby=\"nx-nr-gateway-h\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">Reports<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Contribute<\/span><\/div><h2 id=\"nx-nr-gateway-h\" class=\"nx-section-title\">Send evidence or a correction on Synthetic Biology and Bioengineering.<\/h2><p class=\"nx-lede\"><a class=\"nx-link\" href=\"https:\/\/docs.therisk.global\/organization\/programme\/reports\">Reports<\/a> is the Consortium&#8217;s quarterly publication, written by six desks. 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