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3f8CIwreJoKRwHHRNXfc3DNWM71mKy3t5exrop26P5rHHY0mUqm1lVsbKWnnDQTlzxbGV59ZITZ8usdKDHBDQ2iK9F6vfUB0grpmGa91nasCvrC6\/WM5U8ZNsoPOE9M9PzwMr016N2kvY8ZRIAMURhHkVJtB4N1b2Bpu5pnaPicwDWxQ6W04JQ8TcOCpylEWZXqobIrxvvIA0g+9sasM6amltxQL1HJloG6A0S61Ub664U1cqXwJeQqFLw6oWZiOVL1dQX6EzeKferZKHeDeaIhnycb4A2x0HQsQCeYK1i4SkVrsGZl5S4CmlJcX39kfiyGmG6vNsWrwsoV0aS2zbZITV5hLyeNQJXk6oO4qPcEy6krNhbUDDnmsRSf+mf26wvePVfpj1F0ydqrPjgZcyx0Air4vlAmKn3EciYw3pqRbDuy154olvl5p64Tw2oXgVZxmjxWvQwbHYLisLJtn3Z1erc4TLEyQPLFDlfa9IoRQIRBxn3s3hz5EO6cIdL7SnhflkOSfmtg+STpJ7mDuwBNOvFH7Df6mCEHQoizA88oPitjjNQx26tuy9\/RlhBtotD8wCEuvYFBJYNXo7yH586+EGrAtsMHdMjMBGTmW1EP0pYu4h5mVmEjzY+b7cqJzPrmvGFWDaTX7swykGP8f9RDvrZ1aGXbyap2g\/+XkUhOyp5NR3LVU4mA6OdFUZE6ZSjHSHUKJkuqSKXu88WBlUhpFe8CYDRj1THd3C+ZeiJ6hQOxp\/OneL0GSvZhWzbU0RwtIapaJ1YRNV\/GmKqhngj13dv7gFeP1PxQkVqBn5UzWhs3PVbGkFwJegEx8Bfs6CxjxC94FLxZBY4KzlU12fwmw21399wcOVPJSIycKQTrJU\/XCfyUGcdG4CPAUruHEUp2w69ttsTJZJAYgfLtyFdgGHF5pD8aFCTRTWXUZmkMLguEcAgpH7arz8FKV0g1IaIZaI\/acyeYUakBLvrOgNvJAwxRDhfCCL7lXrLflPb6K0n63wbWe7K3WK\/Nr1VH5ZtSiyuXoAU+brZ7e\/P1urL8yJlyNmguU0F8zQL+3neFy\/RDo7GR4edOQVB5aJgPhJB2DwlbVUf8BTvhRuAkWnEQuKSJrCXOfGZj0urGeVRODLMN+\/FzwuAUeMFgVju77pzMCSEL8AhbZDAGeD\/kvT6IXh8q4y7jhFuOkGXOe7zM04DE5QBNnrQCWEjzjPYv2EATI2+fCIGFDRjQMQ0949gA67xUpQ8so+YTG2SCeeV2Hvk08KQOXiGH9Xqb3y\/kF3JMRTmfZ\/EBdWKdV7i0S2SrsSSt7vJorlZjqXZ8rKVw2BOOfXgFisj+cvAjhqHsOMy4dM+9zJo8C0mMV7yxCoWl50\/zFFhcyOUlq82BUFhzBOcBTLkGZJGFJi8GVfaWAKwt\/OOu7adA0JO+V3Q78Em1BlFpolCCcb4J8wEKCxktWMjotqu7NJZIzx\/c5UWyMONWt6JKccy8QJWFCW0dEdHY06d+BlF1s1L46aa2+ragMONrMcujPxlN0HqdvTAgHrcq7HOrUz2SfZS1Wz1dsaPhVFR9p0ni+GEzGo3EuZzj2iwehbIq4UdaKVJn5fJUboUTRwsnjm\/Q5aB2\/HT7oBQXe76F9TaF\/Eqzmt3aTfLdSgiJezzXmLTDxrjrmNVRDyoC3BFFsqVIi9l7cqLVVUZKnkDPfNH\/2xv0\/\/Yse\/DPF7ha5wGB3kLJIceT5K6ulvBwFTWzVF8OLrThEzNRFmcb4X57IPCTig7h\/EmS+\/BaCAJiZfT+jGhOvNL1RmLXzJFXvG4ofkHZnovYO4b4R8FcPNgsOveX1INUFULY+ka+5bP6+63ZI+bf3urlBjfM3t7fHsYwUSvP7fFNc56AhiFslCj8vCQPMjwyszm1LfOhucQvIKasK1iZdpN\/jaOF2W5+s15C\/IfOXswasen88ytuzHm6zKM2ALUqVGkhz0CxOlcW1xTnNwJUpyAS5ClOInAW8cOxpLEPsZ+KXyxxXCp+cioqfk4pS3xXVHYhl\/ogew9pXES+xd6OQDNdNL2nzwg3Y3m4WVV2JC6P9+l2tFmmcc\/zJ0lhrluJRPw8DaRQWVQgBz5jQBAppMDd3FMtoXDIZRk2SWg6iQKvYx+81nIEfwAR5QM7mmaj\/8BFlHuaxbNNWf8D20oV\/B4qvtcrvucVp6z\/ng2emIimk\/bC3bxXMYxaoo8nUpAIbPGcyHWeqWR3+i+sgqRE6PIKOJwO1LPk1ug4m10ZTHyBBwSWoaBTyvWwOXaYAacPZT6S93oB0GDKjG\/C8+ijbtLGK\/XxquBh1LL09433tVn1uNvSx92fD17p6zWHgYJgApqlXConXFrZew9qI21ErYzcfSSt7sec3f+Y5T74CJtF2U3fgwzwcWADkKsInaT++YnQ69dl4S\/XmZlZH4p6Z31WWyZVE6X+6m8wUOX164Jk3kNfQxzv4QzlQHmfAeW9DhSoMYd6eVSqgGi23pA\/02rhxsErK5DeLydk20ugUUyceEyel8zxoFuIq83He6sO2w0JIbBWwWVHDkfYJTdH5CNE3RYqZVrMk97N0fbQ\/2kfKgxdrriZmwHDG11a0WijjLMHoYVbqXcG3WpyrWpKSo13TBz\/xTNUTIst1dGTodUL\/Kwc9A\/1dGmh4\/h+y2oPNCwv9BlhQZ\/xkCH4sP8tX7sKYbWYEXC91ssLzCcH\/pHPpjjkr3zIxS8Axa9Z91W5crkYyzREiDcLaVd5qFbBMTClZw5vU4cl\/lIXcL8DvfrOjh4yUvGd06ufqPlA+9+BwPEECLu4koqsYUNodsiO3mVkcMhk5rB3rD9kIneY\/CnuxXnO+EH3nSp6Nwszszo\/RJe3N5JZxxlr2m7lY\/oEY\/rEjk6zqX5i6qR+YeSU9j+xQdUQEsk\/cZ2yPssFtLhgR1+yWS6yFq8o+cL6C1YpCIumBOdyRXtX9GiWmWJkLd3BVWb1qFey7kihrMb6Gcb6mR19y2b\/mY\/VC81vtP9ZLcMjIygEd2WbTofUA5P8lGqqQzf3aahOMa\/GRJuTCLLSWVRnS8DbMMxZwlBBKyGsHw60e3nWa3iRWXErj4LgQKhkQCAfQSexwiXlnMf2PQV3XJ1VuC5hC79XCKscABZT+bgoZK3j1wBAigtrBDPiM2M\/mETdheCwZupC+x3Dc5IHrEwU0N6vjIh8tVoeWS1uzQATlijQC1kvZCr1eg9BU6iDAm7myf7qKaa5v8Ov4BUORMBlWLQp\/b2uZQbsOih16zgKCSqKa0vANUkAS+jX5de8DGee97hEagShlg1VsBEm94Dgc+qJuYhWOvyd+I0L9RzPK1TKy3X0Bupt+UM5UJF5sXIuqohFi3cGQLJWoa\/IBoALH0vjlPNv8jEK+OEuJ\/l1tSRUqipqTNVXvsR8x8tVhYNbOoa0cAwpHMBwSXceAukyz8vCgauzd0D5JovG44AamY5uR7INnmtjp4oRClSslVgo7jZZVvHwbV68HuWpxH2A+DpysiuPMscPOuJuL7bZZCn5fIUCEpnqnl+bmZ1\/SE8V3LIoccbco+SS0an5mCEQOMIysTpoj\/kpEGe0Jx7EthW\/RcZtPd216pNTtOqE+jr0Ja38rXBZ1x3\/dDuJFqFIZZQps\/d+Y3hVtjzL9O7C8rwL60uUtvABEyWWYbvBsLn1Uu5c8YYvoGXYsS\/3MjzLbwgXDKQqXQ\/kq0oiiA18BBf7NA4ciFbiEbgW8qdxlDCHSxmCpF3S2ttQ+IJzBo4minBOsntVMqh86l1m2cY\/FZw7P\/3omLqfsqXf+9Tb+4319i5pMZ85jPlfNXclTGgSGcdchSNNwqDGgastqhhUl4Z099emD6nIasskzpR3CUqKmjK0PBgA2L8YXv2LVd2tpV+jZW0Ff+kbtz4C7CSOqZM4oUuNaCSC0mJnDFFcMk64IioYtpU6Z4aOWrLo6Sv4lkfuPtkWP6bVTb1zkocfaIkf8uqWbvldRFpbMkQN9tG\/2NOHn4shn3q\/sZrtm23GT6V7VTMEQbLbPSZhWYz8k+282UPS2L0Sf1F3GEvog\/v1lt41p9HQD2ju3gv26xqxOmelEhL2wizzuQg8OGoftHpb7uq0mLBuBMpotJ31vCv8Yyv5ReB6m7DxQbMCPfGMsRVYogkMkV6aqy1c6gemjJJotA9F6ECmSK7JRpU3gjebP5+VAP1PVsiH\/yez2q9BBw7rpW8E2E1vE98b0+IGyd\/LyKPMmW7bGJJT1SafaJWbhyC2PfXD5kRX+etwZkrSSI6ZNfYuf+bHSDD4VZQ4zSgxRG5l95ptvoKD0kbcr\/SpN1FyWPGgKC3MJ+0Eia3w6b98Y4M46P0MPZSi5LSTBOaiWo6o+wwwhAoMiQBDqCjmTzvP809yOiNWryirzvzqCZOl4lfVlWh7I3C6LjC8BVpIanhh6\/cfG0HG13MSpd22IPZmNPE5JdS\/LOKm\/hGPGNE\/c45FiHBgNi5IXtme+Z1lu3W9Fg+iBLT2O8vKVfYrmaU4qei9QgSoG0Nl20BqQuY7PBNpqW3Fj5UBogldpb74zjlhJIFMQ\/xL96ddEvUJw907ap5IoeKv+qs3dksTZ6DYOGNHf2VahTNQbPzF+mdst0whi+ySKk62xIoyhryIUnYXxfUX+NXxmKXra7S2BMrhimW4SMa6h4hNRrXI7XlI9MuamXZ3UZfX6T6povnHIna8qR8OncQy4FwZx8Y\/81\/bT+KNmIdl9Pkp\/CcRzxDX63vZk7Y6u29IESK47ryv1EYCr4f6ZWq3px8vP9yhqi\/8jmOsTIiS6NfdihXmRJ4T8pzSi6YT7V4vfCsV3KDR5e1+pDros1WB1LD5ZUH37Bio6TyUvsTsWZGYFtV87YSIflulKrvlurI6Z1V+B51gdtg\/7dc9Hq9\/RF61esov9ZhmP48ODlvb\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Not indexed until the first approved release.<\/p><div class=\"nrp-reader\"><nav class=\"nrp-rail\" aria-label=\"Contents of Synthetic Biology and Bioengineering 2026\"><p class=\"nf-ui-eyebrow\">Contents<\/p><ol class=\"nrp-toc\"><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Edition home<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/summary\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Executive summary<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/coupled-system\/\"><span class=\"nrp-toc-n\">1<\/span><span>Synthetic biology is a build capability and a governance test<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/findings\/\"><span class=\"nrp-toc-n\">2<\/span><span>Key findings<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-and-sectors\/\" aria-current=\"page\"><span class=\"nrp-toc-n\">3<\/span><span>Systems and sectors at baseline<\/span><\/a><ol class=\"nrp-toc-sub\"><li><a href=\"#nx-nrp-xt-04-c3-s1\">3.1 Where each system stood at evidence close<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c3-s2\">3.2 Domain posture<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c3-s3\">3.3 Sector screens<\/a><\/li><\/ol><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/risk-and-capability\/\"><span class=\"nrp-toc-n\">4<\/span><span>Risks and capability<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/scenario\/\"><span class=\"nrp-toc-n\">5<\/span><span>Design capability outpaces screening and oversight<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/lenses-and-readings\/\"><span class=\"nrp-toc-n\">6<\/span><span>Readings from the other desks<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/agenda\/\"><span class=\"nrp-toc-n\">7<\/span><span>The 2027 agenda<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-in-depth\/\"><span class=\"nrp-toc-n\">8<\/span><span>Systems in depth<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/methodology\/\"><span class=\"nrp-toc-n\">A<\/span><span>Methodology<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/data\/\"><span class=\"nrp-toc-n\">B<\/span><span>Data appendix<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/references\/\"><span class=\"nrp-toc-n\">C<\/span><span>References and record<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/full\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Complete edition, for print<\/span><\/a><\/li><\/ol><div class=\"nrp-actions\"><a class=\"nf-ui-btn\" data-variant=\"secondary\" href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/full\/\"><svg class=\"nrp-i\" viewBox=\"0 0 24 24\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2\"\/><path d=\"M6 9V3a1 1 0 0 1 1-1h10a1 1 0 0 1 1 1v6\"\/><rect x=\"6\" y=\"14\" width=\"12\" height=\"8\" rx=\"1\"\/><\/svg>Print or save as PDF<\/a><\/div><\/nav><article class=\"nrp-flow\" aria-labelledby=\"nx-nrp-xt-04-c3-top\"><header class=\"nrp-chap-head\" id=\"nx-nrp-xt-04-c3-top\"><ul class=\"nrp-eyerow\"><li class=\"nf-ui-eyebrow\"><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/\">Synthetic Biology and Bioengineering 2026<\/a><\/li><li class=\"nf-ui-eyebrow\">Chapter 3<\/li><\/ul><span class=\"nrp-rule\" aria-hidden=\"true\"><\/span><h1 class=\"pp-hero-title\">Systems and sectors at baseline<\/h1><p class=\"nrp-chap-meta\"><span>7 min read<\/span><span>0 figures<\/span><span>2 tables<\/span><span>18 notes<\/span><span>NR-XTECH-SYNBIO-GLOBAL-2026-BASELINE<\/span><\/p><details class=\"nrp-toc-m\"><summary>Contents<\/summary><ol class=\"nrp-toc\"><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Edition home<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/summary\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Executive summary<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/coupled-system\/\"><span class=\"nrp-toc-n\">1<\/span><span>Synthetic biology is a build capability and a governance test<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/findings\/\"><span class=\"nrp-toc-n\">2<\/span><span>Key findings<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-and-sectors\/\" aria-current=\"page\"><span class=\"nrp-toc-n\">3<\/span><span>Systems and sectors at baseline<\/span><\/a><ol class=\"nrp-toc-sub\"><li><a href=\"#nx-nrp-xt-04-c3-s1\">3.1 Where each system stood at evidence close<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c3-s2\">3.2 Domain posture<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c3-s3\">3.3 Sector screens<\/a><\/li><\/ol><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/risk-and-capability\/\"><span class=\"nrp-toc-n\">4<\/span><span>Risks and capability<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/scenario\/\"><span class=\"nrp-toc-n\">5<\/span><span>Design capability outpaces screening and oversight<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/lenses-and-readings\/\"><span class=\"nrp-toc-n\">6<\/span><span>Readings from the other desks<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/agenda\/\"><span class=\"nrp-toc-n\">7<\/span><span>The 2027 agenda<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-in-depth\/\"><span class=\"nrp-toc-n\">8<\/span><span>Systems in depth<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/methodology\/\"><span class=\"nrp-toc-n\">A<\/span><span>Methodology<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/data\/\"><span class=\"nrp-toc-n\">B<\/span><span>Data appendix<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/references\/\"><span class=\"nrp-toc-n\">C<\/span><span>References and record<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/full\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Complete edition, for print<\/span><\/a><\/li><\/ol><\/details><\/header><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c3-s1\" aria-labelledby=\"nx-nrp-xt-04-c3-s1-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c3-s1-h\"><span class=\"nrp-num\">3.1<\/span><span>Where each system stood at evidence close<\/span><\/h2><div class=\"pp-cells nrp-cells-3\"><article class=\"nrp-cell\"><p class=\"nf-ui-eyebrow\">BLD \u00b7 Genomes<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">Codons in the genetic code of the Syn57 strain<\/h3><span class=\"pp-metric\">57<\/span><span class=\"nrp-cell-u\">codons<\/span><p>down from 64; over 101,000 codon changes.<\/p><p class=\"nrp-cell-foot\"><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><span>2025<\/span><span>Science<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n1\" id=\"nx-nrp-xt-04-c3-r1\" aria-label=\"Note 1\">1<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n2\" id=\"nx-nrp-xt-04-c3-r2\" aria-label=\"Note 2\">2<\/a><\/sup><\/span><\/p><\/article><article class=\"nrp-cell\"><p class=\"nf-ui-eyebrow\">BLD \u00b7 Yeast<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">Synthetic yeast chromosomes combined in one strain<\/h3><span class=\"pp-metric\">6.5<\/span><span class=\"nrp-cell-u\">chromosomes<\/span><p>over half of the synthetic genome in one strain.<\/p><p class=\"nrp-cell-foot\"><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><span>2023<\/span><span>Cell<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n4\" id=\"nx-nrp-xt-04-c3-r4\" aria-label=\"Note 4\">4<\/a><\/sup><\/span><\/p><\/article><article class=\"nrp-cell\"><p class=\"nf-ui-eyebrow\">CLN \u00b7 Therapy<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">Patients free of severe crises for 12 months, exa-cel trial<\/h3><span class=\"pp-metric\">97<\/span><span class=\"nrp-cell-u\">%<\/span><p>29 of 30 evaluable patients.<\/p><p class=\"nrp-cell-foot\"><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><span>2024<\/span><span>NEJM<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n8\" id=\"nx-nrp-xt-04-c3-r8\" aria-label=\"Note 8\">8<\/a><\/sup><\/span><\/p><\/article><article class=\"nrp-cell\"><p class=\"nf-ui-eyebrow\">GOV \u00b7 Governance<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">Minimum federal funding recommended by a US commission<\/h3><span class=\"pp-metric\">15<\/span><span class=\"nrp-cell-u\">USD billion<\/span><p>over five years; a recommendation, not spending.<\/p><p class=\"nrp-cell-foot\"><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><span>2025<\/span><span>CRS<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n14\" id=\"nx-nrp-xt-04-c3-r14\" aria-label=\"Note 14\">14<\/a><\/sup><\/span><\/p><\/article><article class=\"nrp-cell\"><p class=\"nf-ui-eyebrow\">FIN \u00b7 Finance<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">Ginkgo Bioworks revenue<\/h3><span class=\"pp-metric\">170.2<\/span><span class=\"nrp-cell-u\">USD million<\/span><p>down from USD 227.0 million in 2024; company filing.<\/p><p class=\"nrp-cell-foot\"><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><span>2025<\/span><span>company filing<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n17\" id=\"nx-nrp-xt-04-c3-r17\" aria-label=\"Note 17\">17<\/a><\/sup><\/span><\/p><\/article><article class=\"nrp-cell\"><p class=\"nf-ui-eyebrow\">SYS \u00b7 Cross-system<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">Awards in the US distributed bioindustrial manufacturing programme<\/h3><span class=\"pp-metric\">25<\/span><span class=\"nrp-cell-u\">awards<\/span><p>USD 42 million in total by September 2024.<\/p><p class=\"nrp-cell-foot\"><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><span>2024<\/span><span>programme page<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n24\" id=\"nx-nrp-xt-04-c3-r24\" aria-label=\"Note 24\">24<\/a><\/sup><\/span><\/p><\/article><\/div><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c3-s2\" aria-labelledby=\"nx-nrp-xt-04-c3-s2-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c3-s2-h\"><span class=\"nrp-num\">3.2<\/span><span>Domain posture<\/span><\/h2><p class=\"nrp-stand\">Each of the twelve coupled domains is read through synthetic biology, in words, not scored. The coupling column names the dependency that carries synthetic biology risk into each domain.<\/p><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-c3-tab1\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 3.1<\/span><span class=\"nrp-tbl-t\">Each domain read in words, not scored<\/span><\/caption><thead><tr><th scope=\"col\">Domain<\/th><th scope=\"col\">Posture at baseline<\/th><th scope=\"col\">Coupling<\/th><th scope=\"col\">Status<\/th><\/tr><\/thead><tbody><tr><td><span class=\"nrp-mono\">WAT<\/span><\/td><td>Process water use of fermentation and facilities is not published on a common basis.<\/td><td><span class=\"nrp-mono\">WAT \u2192 BIO<\/span><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Expert input<\/span> <span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 1<\/span><\/td><\/tr><tr><td><span class=\"nrp-mono\">ENE<\/span><\/td><td>Energy use of biomanufacturing at scale is not bound; no figure used.<\/td><td><span class=\"nrp-mono\">ENE \u2194 BIO<\/span><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Expert input<\/span> <span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 1<\/span><\/td><\/tr><tr><td><span class=\"nrp-mono\">FOO<\/span><\/td><td>No coupling documented at baseline in the sources read; precision fermentation and crop work are not evidenced here.<\/td><td><span class=\"nrp-mono\">none documented<\/span><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Expert input<\/span> <span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 1<\/span><\/td><\/tr><tr><td><span class=\"nrp-mono\">HLT<\/span><\/td><td>A CRISPR therapy was authorised in 2023 and 29 of 30 evaluable trial patients had no severe crises for 12 months.<\/td><td><span class=\"nrp-mono\">BIO \u2192 HLT<\/span><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span> <span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 4<\/span><\/td><\/tr><tr><td><span class=\"nrp-mono\">BIO<\/span><\/td><td>The core system: recoded genomes, synthetic yeast chromosomes, designed circuits and proteins.<\/td><td><span class=\"nrp-mono\">the core system<\/span><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span> <span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 4<\/span><\/td><\/tr><tr><td><span class=\"nrp-mono\">CLI<\/span><\/td><td>Bio-based production could change emissions; no figure bound here.<\/td><td><span class=\"nrp-mono\">none documented<\/span><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Expert input<\/span> <span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 1<\/span><\/td><\/tr><tr><td><span class=\"nrp-mono\">INF<\/span><\/td><td>US planning awards and an institute for bioindustrial manufacturing; capacity itself is not counted.<\/td><td><span class=\"nrp-mono\">FIN \u2192 INF<\/span><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span> <span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 3<\/span><\/td><\/tr><tr><td><span class=\"nrp-mono\">FIN<\/span><\/td><td>Company revenue is mixed: Ginkgo fell to USD 170.2 million, Twist guided to USD 456 to 457 million.<\/td><td><span class=\"nrp-mono\">FIN \u2192 BIO<\/span><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span> <span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 2<\/span><\/td><\/tr><tr><td><span class=\"nrp-mono\">DAT<\/span><\/td><td>Design tools and sequence data couple to screening; the 2025 study tested that link.<\/td><td><span class=\"nrp-mono\">DAT \u2192 BIO<\/span><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span> <span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 4<\/span><\/td><\/tr><tr><td><span class=\"nrp-mono\">AIC<\/span><\/td><td>Machine-learning design tools are part of the build capability and of the screening problem.<\/td><td><span class=\"nrp-mono\">AIC \u2192 BIO<\/span><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span> <span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 4<\/span><\/td><\/tr><tr><td><span class=\"nrp-mono\">MIN<\/span><\/td><td>Reagent, instrument and feedstock dependence is not documented in the sources read.<\/td><td><span class=\"nrp-mono\">none documented<\/span><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Expert input<\/span> <span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 1<\/span><\/td><\/tr><tr><td><span class=\"nrp-mono\">TRD<\/span><\/td><td>Export controls and biosecurity rules shape access to tools and materials; text not bound.<\/td><td><span class=\"nrp-mono\">BIO \u2194 TRD<\/span><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Inferred<\/span> <span class=\"nrp-eql\" title=\"Evidence-quality level, 1 to 5\">EQL 2<\/span><\/td><\/tr><\/tbody><\/table><\/div><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c3-s3\" aria-labelledby=\"nx-nrp-xt-04-c3-s3-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c3-s3-h\"><span class=\"nrp-num\">3.3<\/span><span>Sector screens<\/span><\/h2><p class=\"nrp-stand\">All sixteen sectors are screened for their dependence on synthetic biology, on the same grammar as every national edition. The evidence column describes coverage of the baseline evidence, not the performance of the sector.<\/p><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-c3-tab2\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 3.2<\/span><span class=\"nrp-tbl-t\">Sectors: baseline evidence and the exposure to watch<\/span><\/caption><thead><tr><th scope=\"col\">Code<\/th><th scope=\"col\">Sector<\/th><th scope=\"col\">Baseline evidence<\/th><th scope=\"col\">Exposure to watch<\/th><th scope=\"col\">Evidence coverage<\/th><\/tr><\/thead><tbody><tr><td><span class=\"nrp-mono\">GS-00<\/span><\/td><td>Cross-system<\/td><td>synthetic biology couples to health, food, finance and biosecurity<\/td><td>design and screening gap<\/td><td>THIN<\/td><\/tr><tr><td><span class=\"nrp-mono\">GS-01<\/span><\/td><td>Water<\/td><td>process water use not published<\/td><td>facility siting<\/td><td>THIN<\/td><\/tr><tr><td><span class=\"nrp-mono\">GS-02<\/span><\/td><td>Energy<\/td><td>energy footprint of manufacturing not bound<\/td><td>load from large facilities<\/td><td>THIN<\/td><\/tr><tr><td><span class=\"nrp-mono\">GS-03<\/span><\/td><td>Food<\/td><td>no documented coupling in the sources read<\/td><td>none documented<\/td><td>THIN<\/td><\/tr><tr><td><span class=\"nrp-mono\">GS-04<\/span><\/td><td>Health<\/td><td>authorised CRISPR therapy and trial results<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n8\" aria-label=\"Note 8\">8<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n9\" id=\"nx-nrp-xt-04-c3-r9\" aria-label=\"Note 9\">9<\/a><\/sup><\/td><td>access and cost<\/td><td>PARTIAL<\/td><\/tr><tr><td><span class=\"nrp-mono\">GS-05<\/span><\/td><td>Finance<\/td><td>company filings give a <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-c1\" data-tc=\"NRS-C1 weak-signal\" data-tk=\"Nexus risk vocabulary\" data-td=\"An early, fragmentary indication of a possible change that is not yet clearly recognised or understood.\" data-ts=\"NRS-C1\" data-tr=\"draft\">weak signal<\/a><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n16\" id=\"nx-nrp-xt-04-c3-r16\" aria-label=\"Note 16\">16<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n17\" aria-label=\"Note 17\">17<\/a><\/sup><\/td><td>funding gaps<\/td><td>PARTIAL<\/td><\/tr><tr><td><span class=\"nrp-mono\">GS-06<\/span><\/td><td>Development<\/td><td>access to tools and skills<\/td><td>widening gaps<\/td><td>THIN<\/td><\/tr><tr><td><span class=\"nrp-mono\">GS-07<\/span><\/td><td>Climate<\/td><td>footprint at scale not bound<\/td><td>energy and feedstock demand<\/td><td>THIN<\/td><\/tr><tr><td><span class=\"nrp-mono\">GS-08<\/span><\/td><td>Disaster<\/td><td>no documented coupling<\/td><td>none documented<\/td><td>THIN<\/td><\/tr><tr><td><span class=\"nrp-mono\">GS-09<\/span><\/td><td>Infrastructure<\/td><td>manufacturing planning awards<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n23\" id=\"nx-nrp-xt-04-c3-r23\" aria-label=\"Note 23\">23<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n24\" aria-label=\"Note 24\">24<\/a><\/sup><\/td><td>capacity not counted<\/td><td>THIN<\/td><\/tr><tr><td><span class=\"nrp-mono\">GS-10<\/span><\/td><td>Cities<\/td><td>no documented coupling<\/td><td>none documented<\/td><td>THIN<\/td><\/tr><tr><td><span class=\"nrp-mono\">GS-11<\/span><\/td><td>Biodiversity<\/td><td>gene drive and release questions<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n11\" id=\"nx-nrp-xt-04-c3-r11\" aria-label=\"Note 11\">11<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n20\" id=\"nx-nrp-xt-04-c3-r20\" aria-label=\"Note 20\">20<\/a><\/sup><\/td><td>release and oversight<\/td><td>PARTIAL<\/td><\/tr><tr><td><span class=\"nrp-mono\">GS-12<\/span><\/td><td>Earth observation<\/td><td>no documented coupling<\/td><td>none documented<\/td><td>THIN<\/td><\/tr><tr><td><span class=\"nrp-mono\">GS-13<\/span><\/td><td>Cyber and digital<\/td><td>screening of machine-designed sequences<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n13\" id=\"nx-nrp-xt-04-c3-r13\" aria-label=\"Note 13\">13<\/a><\/sup><\/td><td>sequence data handling<\/td><td>PARTIAL<\/td><\/tr><tr><td><span class=\"nrp-mono\">GS-14<\/span><\/td><td>Policy<\/td><td>US, EU, OECD and CBD instruments<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n14\" aria-label=\"Note 14\">14<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n18\" id=\"nx-nrp-xt-04-c3-r18\" aria-label=\"Note 18\">18<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n20\" aria-label=\"Note 20\">20<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n22\" id=\"nx-nrp-xt-04-c3-r22\" aria-label=\"Note 22\">22<\/a><\/sup><\/td><td>uneven implementation<\/td><td>PARTIAL<\/td><\/tr><tr><td><span class=\"nrp-mono\">GS-15<\/span><\/td><td>Science<\/td><td>strong peer-reviewed base<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n1\" aria-label=\"Note 1\">1<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n3\" id=\"nx-nrp-xt-04-c3-r3\" aria-label=\"Note 3\">3<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n4\" aria-label=\"Note 4\">4<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n6\" id=\"nx-nrp-xt-04-c3-r6\" aria-label=\"Note 6\">6<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c3-n7\" id=\"nx-nrp-xt-04-c3-r7\" aria-label=\"Note 7\">7<\/a><\/sup><\/td><td>common benchmarks<\/td><td>GOOD<\/td><\/tr><\/tbody><\/table><\/div><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c3-notes\" aria-labelledby=\"nx-nrp-xt-04-c3-notes-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c3-notes-h\"><span>Notes<\/span><\/h2><p class=\"nrp-note\">Numbers are the edition&#8217;s reference numbers, so a note reads the same in every chapter. The full list, with every source and its licence, is in Annex C. <a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/references\/\">Annex C, references<\/a><\/p><ol class=\"nrp-notes\"><li id=\"nx-nrp-xt-04-c3-n1\"><span class=\"nrp-notes-n\">1<\/span><span>Robertson, W.E. et al., Escherichia coli with a 57-codon genetic code, Science 390 (6771), eady4368, published 23 October 2025 (record read via PubMed, PMID 40743368; the record gives a 4 megabase synthetic genome and six replaced sense codons). American Association for the Advancement of Science, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c3-r1\" aria-label=\"Back to the first call of note 1\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c3-n2\"><span class=\"nrp-notes-n\">2<\/span><span>MRC Laboratory of Molecular Biology (ed.), Syn57 represents a new chapter in the genetic code of life (news page, 1 August 2025; over 101,000 codons recoded; 64 to 57 codons; genome of about 4 megabases built from 38 fragments of about 100 kilobases). MRC Laboratory of Molecular Biology, Cambridge. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c3-r2\" aria-label=\"Back to the first call of note 2\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c3-n4\"><span class=\"nrp-notes-n\">4<\/span><span>Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions, Cell 186 (24), 5220 to 5236, 2023 (record read via Europe PMC: 6.5 synthetic chromosomes in one strain; over half of the Sc2.0 genome). Cell Press, Cambridge, Massachusetts. Observation year 2023. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c3-r4\" aria-label=\"Back to the first call of note 4\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c3-n8\"><span class=\"nrp-notes-n\">8<\/span><span>Frangoul, H. et al., Exagamglogene autotemcel for severe sickle cell disease, New England Journal of Medicine 390 (18), 1649 to 1662, 2024 (record read via Europe PMC: 44 treated; 29 of 30 evaluable free of severe crises for 12 months; median follow-up 19.3 months). Massachusetts Medical Society, Waltham. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c3-r8\" aria-label=\"Back to the first call of note 8\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c3-n14\"><span class=\"nrp-notes-n\">14<\/span><span>Congressional Research Service (ed.), National Security Commission on Emerging Biotechnology: Final Report and Options for Congress, CRS Insight IN12546, 17 April 2025 (report of 8 April 2025; 49 recommendations; at least USD 15 billion over five years; National Biotechnology Coordination Office). Library of Congress, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c3-r14\" aria-label=\"Back to the first call of note 14\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c3-n17\"><span class=\"nrp-notes-n\">17<\/span><span>Ginkgo Bioworks Holdings, Inc. (ed.), Form 8-K exhibit 99.1, fourth quarter and full year 2025 results (company filing of 26 February 2026; revenue USD 170.155 million against USD 227.043 million; net loss USD 312.763 million; company statements are weak evidence). US Securities and Exchange Commission, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c3-r17\" aria-label=\"Back to the first call of note 17\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c3-n24\"><span class=\"nrp-notes-n\">24<\/span><span>US Manufacturing Program (ed.), Bioindustrial (programme topic page; Distributed Bioindustrial Manufacturing Program awards announced 10 July to 13 September 2024; 25 awards; USD 42 million cumulative). Manufacturing USA, Gaithersburg. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c3-r24\" aria-label=\"Back to the first call of note 24\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c3-n9\"><span class=\"nrp-notes-n\">9<\/span><span>US Food and Drug Administration (ed.), FDA approves first gene therapies to treat patients with sickle cell disease (press announcement, 8 December 2023; Casgevy and Lyfgenia; ages 12 and over; 29 of 31 evaluable Casgevy patients free of severe crises for at least 12 months). FDA, Silver Spring. Observation year 2023. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c3-r9\" aria-label=\"Back to the first call of note 9\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c3-n16\"><span class=\"nrp-notes-n\">16<\/span><span>Twist Bioscience Corporation (ed.), Form 8-K exhibit 99.1, results for the fiscal third quarter ended 30 June 2026 (company filing; revenue USD 118.4 million; nine months USD 332.8 million; fiscal 2026 guidance USD 456 to 457 million; company statements and guidance are weak evidence). US Securities and Exchange Commission, Washington. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c3-r16\" aria-label=\"Back to the first call of note 16\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c3-n23\"><span class=\"nrp-notes-n\">23<\/span><span>BioMADE (ed.), DoD approves USD 87 million for newest bioindustrial manufacturing innovation institute (news page; seven years; the page shows Oct 20 and a 2023 footer, the press release is dated 2020 in search listings). BioMADE, Saint Paul. Observation year 2020. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c3-r23\" aria-label=\"Back to the first call of note 23\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c3-n11\"><span class=\"nrp-notes-n\">11<\/span><span>Kyrou, K. et al., A CRISPR-Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes, Nature Biotechnology 36, 1062 to 1066, 2018 (record read via Europe PMC; laboratory cages only). Springer Nature, London. Observation year 2018. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c3-r11\" aria-label=\"Back to the first call of note 11\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c3-n20\"><span class=\"nrp-notes-n\">20<\/span><span>Secretariat of the Convention on Biological Diversity (ed.), Synthetic biology (programme page; decisions X\/13 to 16\/21; AHTEG; <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-c1\" data-tc=\"NRS-C1 horizon-scanning\" data-tk=\"Nexus risk vocabulary\" data-td=\"Systematic searching for early signs of potentially important developments, threats and opportunities at the margins of current thinking.\" data-ts=\"NRS-C1\" data-tr=\"draft\" data-tg=\"https:\/\/globalriskforum.com\/glossary\/horizon-scanning\/\" data-tgl=\"Global Risks Forum glossary\">horizon scanning<\/a>; thematic action plan). CBD Secretariat, Montreal. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c3-r20\" aria-label=\"Back to the first call of note 20\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c3-n13\"><span class=\"nrp-notes-n\">13<\/span><span>Strengthening nucleic acid biosecurity screening against generative protein design tools, Science 390 (6768), 82 to 87, 2025 (record read via Europe PMC; abstract only; no method detail used). American Association for the Advancement of Science, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c3-r13\" aria-label=\"Back to the first call of note 13\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c3-n18\"><span class=\"nrp-notes-n\">18<\/span><span>OECD (ed.), Anticipatory governance for responsible innovation in synthetic biology, OECD Science, Technology and Industry Policy Papers No. 193, 21 May 2026 (record read via a bibliographic database; abstract only). OECD Publishing, Paris. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c3-r18\" aria-label=\"Back to the first call of note 18\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c3-n22\"><span class=\"nrp-notes-n\">22<\/span><span>Baker McKenzie (ed.), EU Biotech Act unveiled: Commission proposal to turn Europe into a biotech powerhouse (law firm summary, 19 December 2025; proposal of 16 December 2025; health focus; investment pilot with the European Investment Bank Group; 12-month certificate extension; biodefence measures; second act expected in Q3 2026). Secondary source, not the Commission text. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c3-r22\" aria-label=\"Back to the first call of note 22\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c3-n3\"><span class=\"nrp-notes-n\">3<\/span><span>Fredens, J. et al., Total synthesis of Escherichia coli with a recoded genome, Nature 569 (7757), 514 to 518, 2019 (record read via Europe PMC: 18,214 codons recoded; 61-codon genome). Springer Nature, London. Observation year 2019. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c3-r3\" aria-label=\"Back to the first call of note 3\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c3-n6\"><span class=\"nrp-notes-n\">6<\/span><span>Nielsen, A.A.K. et al., Genetic circuit design automation, Science 352 (6281), 2016 (record read via Europe PMC: 60 circuits; 45 correct in all output states; 92% of output states as predicted). American Association for the Advancement of Science, Washington. Observation year 2016. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c3-r6\" aria-label=\"Back to the first call of note 6\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c3-n7\"><span class=\"nrp-notes-n\">7<\/span><span>Watson, J.L. et al., De novo design of protein structure and function with RFdiffusion, Nature 620, 1089 to 1100, 2023 (record read via Europe PMC). Springer Nature, London. Observation year 2023. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c3-r7\" aria-label=\"Back to the first call of note 7\">back<\/a><\/span><\/li><\/ol><\/section><section class=\"nrp-block nrp-noprint\" id=\"nx-nrp-xt-04-c3-cite\" aria-labelledby=\"nx-nrp-xt-04-c3-cite-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c3-cite-h\"><span>Cite this chapter<\/span><\/h2><pre class=\"nrp-pre\">Valadbaygi, S. (Ed.). (2026). Chapter 3: Systems and sectors at baseline. In Exponential Technology Report 2026: Synthetic Biology and Bioengineering (Baseline Edition 2026, Report No. NR-XTECH-SYNBIO-GLOBAL-2026-BASELINE) [Draft under review]. The Global Centre for Risk and Innovation (GCRI).<\/pre><p class=\"nrp-note\">Every citation form of the whole report, BibTeX and RIS included, is on the edition home. <a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/#nx-nrp-xt-04-land-cite\">Cite this report<\/a><\/p><\/section><nav class=\"nrp-pager\" aria-label=\"Previous and next\"><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/findings\/\" rel=\"prev\"><span class=\"nf-ui-eyebrow\">Previous \u00b7 Chapter 2<\/span><span class=\"nrp-pager-t\">Key findings<\/span><\/a><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/risk-and-capability\/\" rel=\"next\"><span class=\"nf-ui-eyebrow\">Next \u00b7 Chapter 4<\/span><span class=\"nrp-pager-t\">Risks and capability<\/span><\/a><\/nav><\/article><\/div><\/div><\/div><div class=\"nrp-noprint\"><section id=\"nx-sec-nr-gateway\" class=\"nx-section\" data-hue=\"systemic\" data-tone=\"alt\" aria-labelledby=\"nx-nr-gateway-h\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">Reports<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Contribute<\/span><\/div><h2 id=\"nx-nr-gateway-h\" class=\"nx-section-title\">Send evidence or a correction on Synthetic Biology and Bioengineering.<\/h2><p class=\"nx-lede\"><a class=\"nx-link\" href=\"https:\/\/docs.therisk.global\/organization\/programme\/reports\">Reports<\/a> is the Consortium&#8217;s quarterly publication, written by six desks. 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