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\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\"><style>#nxe-nr-gcri-editions-xt-04-lenses-and-readings.nxe{display:block;box-sizing:border-box;max-width:1180px;margin:0 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8px;text-align:left;vertical-align:top;border-bottom:1px solid;border-color:inherit}#nxe-nr-gcri-editions-xt-04-lenses-and-readings.nxe svg{display:none}#nxe-nr-gcri-editions-xt-04-lenses-and-readings.nxe svg.nx-i{display:inline-block;width:18px;height:18px;vertical-align:-3px}#nxe-nr-gcri-editions-xt-04-lenses-and-readings.nxe :where([role=\"tablist\"],[role=\"toolbar\"],[hidden],button,.nx-theme-toggle,.nx-live-slot){display:none}#nxe-nr-gcri-editions-xt-04-lenses-and-readings.nxe img{max-width:100%;height:auto}<\/style><svg class=\"nx-defs\" aria-hidden=\"true\" focusable=\"false\" width=\"0\" height=\"0\"><defs><linearGradient id=\"nx-gi\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"1\"><stop offset=\"0\" class=\"nx-gi-a\"\/><stop offset=\"0.55\" class=\"nx-gi-b\"\/><stop offset=\"1\" class=\"nx-gi-c\"\/><\/linearGradient><linearGradient id=\"nx-giu\" gradientUnits=\"userSpaceOnUse\" x1=\"0\" y1=\"0\" x2=\"800\" y2=\"0\"><stop offset=\"0\" class=\"nx-gi-a\"\/><stop offset=\"0.55\" class=\"nx-gi-b\"\/><stop offset=\"1\" class=\"nx-gi-c\"\/><\/linearGradient><linearGradient id=\"nx-gp\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"1\"><stop offset=\"0\" class=\"nx-gp-a\"\/><stop offset=\"1\" class=\"nx-gp-b\"\/><\/linearGradient><\/defs><\/svg><div class=\"nrp\"><div class=\"nrp-wrap\"><p class=\"nrj-draft\" data-nrj-shared=\"draft\" role=\"note\"><strong>Draft, not yet released.<\/strong> In stewardship review. Not indexed until the first approved release.<\/p><div class=\"nrp-reader\"><nav class=\"nrp-rail\" aria-label=\"Contents of Synthetic Biology and Bioengineering 2026\"><p class=\"nf-ui-eyebrow\">Contents<\/p><ol class=\"nrp-toc\"><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Edition home<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/summary\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Executive summary<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/coupled-system\/\"><span class=\"nrp-toc-n\">1<\/span><span>Synthetic biology is a build capability and a governance test<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/findings\/\"><span class=\"nrp-toc-n\">2<\/span><span>Key findings<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-and-sectors\/\"><span class=\"nrp-toc-n\">3<\/span><span>Systems and sectors at baseline<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/risk-and-capability\/\"><span class=\"nrp-toc-n\">4<\/span><span>Risks and capability<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/scenario\/\"><span class=\"nrp-toc-n\">5<\/span><span>Design capability outpaces screening and oversight<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/lenses-and-readings\/\" aria-current=\"page\"><span class=\"nrp-toc-n\">6<\/span><span>Readings from the other desks<\/span><\/a><ol class=\"nrp-toc-sub\"><li><a href=\"#nx-nrp-xt-04-c6-s1\">6.1 The other desks&#8217; editions of this subject<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c6-s2\">6.2 Three lenses<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c6-s3\">6.3 Standards, Academy and steward contributions<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c6-s4\">6.4 <abbr title=\"The Global Centre for Risk and Innovation\">GCRI<\/abbr> reading: the model card<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c6-s5\">6.5 Global Risks Forum reading: editorial essays<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c6-s6\">6.6 Global Risks Alliance reading: 2027 synthetic biology readiness pack<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c6-s7\">6.7 Nexus Standards reading: standards and regulatory watch<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c6-s8\">6.8 Risk Academy reading: literature and evidence review, science and assessments<\/a><\/li><\/ol><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/agenda\/\"><span class=\"nrp-toc-n\">7<\/span><span>The 2027 agenda<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-in-depth\/\"><span class=\"nrp-toc-n\">8<\/span><span>Systems in depth<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/methodology\/\"><span class=\"nrp-toc-n\">A<\/span><span>Methodology<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/data\/\"><span class=\"nrp-toc-n\">B<\/span><span>Data appendix<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/references\/\"><span class=\"nrp-toc-n\">C<\/span><span>References and record<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/full\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Complete edition, for print<\/span><\/a><\/li><\/ol><div class=\"nrp-actions\"><a class=\"nf-ui-btn\" data-variant=\"secondary\" href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/full\/\"><svg class=\"nrp-i\" viewBox=\"0 0 24 24\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2\"\/><path d=\"M6 9V3a1 1 0 0 1 1-1h10a1 1 0 0 1 1 1v6\"\/><rect x=\"6\" y=\"14\" width=\"12\" height=\"8\" rx=\"1\"\/><\/svg>Print or save as PDF<\/a><\/div><\/nav><article class=\"nrp-flow\" aria-labelledby=\"nx-nrp-xt-04-c6-top\"><header class=\"nrp-chap-head\" id=\"nx-nrp-xt-04-c6-top\"><ul class=\"nrp-eyerow\"><li class=\"nf-ui-eyebrow\"><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/\">Synthetic Biology and Bioengineering 2026<\/a><\/li><li class=\"nf-ui-eyebrow\">Chapter 6<\/li><\/ul><span class=\"nrp-rule\" aria-hidden=\"true\"><\/span><h1 class=\"pp-hero-title\">Readings from the other desks<\/h1><p class=\"nrp-lede\">The synthetic biology baseline is read through each steward\u2019s lens, then once as a whole. Each lens is a projection of reviewed findings, not a separate argument. The other desks&#8217; own editions of this subject are listed first, as cross-references, not copies.<\/p><p class=\"nrp-chap-meta\"><span>16 min read<\/span><span>0 figures<\/span><span>8 tables<\/span><span>40 notes<\/span><span>NR-XTECH-SYNBIO-GLOBAL-2026-BASELINE<\/span><\/p><details class=\"nrp-toc-m\"><summary>Contents<\/summary><ol class=\"nrp-toc\"><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Edition home<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/summary\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Executive summary<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/coupled-system\/\"><span class=\"nrp-toc-n\">1<\/span><span>Synthetic biology is a build capability and a governance test<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/findings\/\"><span class=\"nrp-toc-n\">2<\/span><span>Key findings<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-and-sectors\/\"><span class=\"nrp-toc-n\">3<\/span><span>Systems and sectors at baseline<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/risk-and-capability\/\"><span class=\"nrp-toc-n\">4<\/span><span>Risks and capability<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/scenario\/\"><span class=\"nrp-toc-n\">5<\/span><span>Design capability outpaces screening and oversight<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/lenses-and-readings\/\" aria-current=\"page\"><span class=\"nrp-toc-n\">6<\/span><span>Readings from the other desks<\/span><\/a><ol class=\"nrp-toc-sub\"><li><a href=\"#nx-nrp-xt-04-c6-s1\">6.1 The other desks&#8217; editions of this subject<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c6-s2\">6.2 Three lenses<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c6-s3\">6.3 Standards, Academy and steward contributions<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c6-s4\">6.4 GCRI reading: the model card<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c6-s5\">6.5 Global Risks Forum reading: editorial essays<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c6-s6\">6.6 Global Risks Alliance reading: 2027 synthetic biology readiness pack<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c6-s7\">6.7 Nexus Standards reading: standards and regulatory watch<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c6-s8\">6.8 Risk Academy reading: literature and evidence review, science and assessments<\/a><\/li><\/ol><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/agenda\/\"><span class=\"nrp-toc-n\">7<\/span><span>The 2027 agenda<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-in-depth\/\"><span class=\"nrp-toc-n\">8<\/span><span>Systems in depth<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/methodology\/\"><span class=\"nrp-toc-n\">A<\/span><span>Methodology<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/data\/\"><span class=\"nrp-toc-n\">B<\/span><span>Data appendix<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/references\/\"><span class=\"nrp-toc-n\">C<\/span><span>References and record<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/full\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Complete edition, for print<\/span><\/a><\/li><\/ol><\/details><\/header><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c6-s1\" aria-labelledby=\"nx-nrp-xt-04-c6-s1-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c6-s1-h\"><span class=\"nrp-num\">6.1<\/span><span>The other desks&#8217; editions of this subject<\/span><\/h2><p class=\"nrp-stand\">Federation: each desk writes its own edition for the subjects in its remit. Until a desk releases, its edition shows its frame and the reading this edition printed for it.<\/p><div class=\"nrp-tblw\"><table class=\"nrp-tbl\"><thead><tr><th scope=\"col\">Desk<\/th><th scope=\"col\">Edition<\/th><th scope=\"col\">State<\/th><th scope=\"col\">Identifier<\/th><\/tr><\/thead><tbody><tr data-host=\"true\"><th scope=\"row\">GCRI Systems Evidence<\/th><td>No edition of this subject at this desk in the 2026 Baseline cycle<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Not in this cycle<\/span><\/td><td class=\"nrp-mono\"><\/td><\/tr><tr><th scope=\"row\">GRF Public Deliberation<\/th><td>Outside this desk&#8217;s remit<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Not in remit<\/span><\/td><td class=\"nrp-mono\"><\/td><\/tr><tr><th scope=\"row\">GRA Capital Readiness<\/th><td>Outside this desk&#8217;s remit<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Not in remit<\/span><\/td><td class=\"nrp-mono\"><\/td><\/tr><tr><th scope=\"row\">Standards Progress<\/th><td>No edition of this subject at this desk in the 2026 Baseline cycle<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Not in this cycle<\/span><\/td><td class=\"nrp-mono\"><\/td><\/tr><tr><th scope=\"row\">Academy Capability<\/th><td>No edition of this subject at this desk in the 2026 Baseline cycle<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Not in this cycle<\/span><\/td><td class=\"nrp-mono\"><\/td><\/tr><tr><th scope=\"row\">Index Measurement<\/th><td>Outside this desk&#8217;s remit<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Not in remit<\/span><\/td><td class=\"nrp-mono\"><\/td><\/tr><\/tbody><\/table><\/div><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c6-s2\" aria-labelledby=\"nx-nrp-xt-04-c6-s2-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c6-s2-h\"><span class=\"nrp-num\">6.2<\/span><span>Three lenses<\/span><\/h2><p class=\"nrp-stand\">One edition, read by each steward. The lens of this site comes first.<\/p><div class=\"nrp-cards\" data-n=\"3\"><article class=\"nf-ui-card nrp-card\" data-host=\"true\"><p class=\"nf-ui-eyebrow\">GCRI \u00b7 KEY T<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">Technical Truth<\/h3><p>The evidence supports reading synthetic biology as a build capability, a manufacturing base and a governance test. Build results are strong on single organisms, risk evidence is newer, and the physical footprint is unmeasured. Evidence is strongest for peer-reviewed results and weakest for energy, capacity and screening coverage.<\/p><p class=\"nrp-note\">BLD-001 \u00b7 SEC-005 \u00b7 GOV-007 \u00b7 SYS-012<\/p><\/article><article class=\"nf-ui-card nrp-card\"><p class=\"nf-ui-eyebrow\">GRF \u00b7 KEY M<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">Public Meaning<\/h3><p>For most people synthetic biology arrives as a medicine, a food label or a warning about misuse. The baseline asks that public debate separate peer-reviewed results from company statements and plans, and keep oversight of both benefit and risk in view.<\/p><p class=\"nrp-note\">CLN-004 \u00b7 SEC-005 \u00b7 SEC-006<\/p><\/article><article class=\"nf-ui-card nrp-card\"><p class=\"nf-ui-eyebrow\">GRA \u00b7 KEY F<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">Capital Meaning<\/h3><p>Readiness implications only. Company results are mixed and public programmes are at the planning stage<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n16\" id=\"nx-nrp-xt-04-c6-r16\" aria-label=\"Note 16\">16<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n17\" id=\"nx-nrp-xt-04-c6-r17\" aria-label=\"Note 17\">17<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n24\" id=\"nx-nrp-xt-04-c6-r24\" aria-label=\"Note 24\">24<\/a><\/sup>. These show where finance-readiness evidence will matter. Nothing here is advice, a rating or an approval.<\/p><p class=\"nrp-note\">FIN-011 \u00b7 GOV-008<\/p><\/article><article class=\"nf-ui-card nrp-card\"><p class=\"nf-ui-eyebrow\">NEXUS<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">Synthesis<\/h3><p>Synthetic biology is well described by single results and thinly measured as a system. The 2027 programme should count screening coverage, publish a comparable footprint and test the design and screening gap before the next framework revision.<\/p><p class=\"nrp-note\">SYS-012 \u00b7 Q-01 \u00b7 Q-02<\/p><\/article><\/div><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c6-s3\" aria-labelledby=\"nx-nrp-xt-04-c6-s3-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c6-s3-h\"><span class=\"nrp-num\">6.3<\/span><span>Standards, Academy and steward contributions<\/span><\/h2><p class=\"nrp-stand\">How the <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/\" data-tc=\"Nexus Standards\" data-tk=\"Nexus Standards\" data-td=\"The foundation standards\">Nexus Standards<\/a> drafts, the Risk Academy and the three stewards feed each quarterly edition for synthetic biology. The standards are a preparatory working draft (2026) and are cited as drafts, never as adopted standards.<\/p><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-c6-tab1\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 6.1<\/span><span class=\"nrp-tbl-t\">The quarterly rhythm every edition follows<\/span><\/caption><thead><tr><th scope=\"col\">Quarter<\/th><th scope=\"col\">Edition<\/th><th scope=\"col\">Question<\/th><th scope=\"col\">Boundary<\/th><\/tr><\/thead><tbody><tr><td>Q1<\/td><td>State and Agenda<\/td><td>What matters this year, and what is the starting position?<\/td><td>observed baseline stays distinct from planned work<\/td><\/tr><tr><td>Q2<\/td><td>Evidence and Build<\/td><td>What new evidence and capability exist?<\/td><td>a configured capability is not a validated result<\/td><\/tr><tr><td>Q3<\/td><td><a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-c1\" data-tc=\"NRS-C1 stress-test\" data-tk=\"Nexus risk vocabulary\" data-td=\"An assessment of how a system, portfolio or institution would perform under severe but plausible adverse scenarios, to find weaknesses before they are revealed by events.\" data-ts=\"NRS-C1\" data-tr=\"draft\">Stress Test<\/a> and Readiness<\/td><td>What do scenarios and tests show?<\/td><td>simulated loss or performance is not observed impact<\/td><\/tr><tr><td>Q4<\/td><td>Annual Synthesis and Renewal<\/td><td>What changed in the year, and what renews?<\/td><td>release follows review, not event publicity deadlines<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-c6-tab2\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 6.2<\/span><span class=\"nrp-tbl-t\">Who contributes what each quarter<\/span><\/caption><thead><tr><th scope=\"col\">Steward or body<\/th><th scope=\"col\">Role<\/th><th scope=\"col\">Contribution route<\/th><\/tr><\/thead><tbody><tr><td>The Global Centre for Risk and Innovation (GCRI Canada)<\/td><td>Lead Institution and Consortium Secretariat; publisher of record; technical truth (key T)<\/td><td>science and practice communities \u00b7 GCRI gateway<\/td><\/tr><tr><td>The Global Risks Forum (GRF)<\/td><td>leadership, dialogue and the <a class=\"nx-link\" href=\"https:\/\/docs.therisk.global\/organization\/programme\/universe\">Universe<\/a> programme; public meaning (key M)<\/td><td>policy, Universe and national adoption \u00b7 GRF gateway<\/td><\/tr><tr><td>The Global Risks Alliance (GRA)<\/td><td>finance, insurance and development readiness; capital meaning (key F)<\/td><td>finance and insurance \u00b7 GRA gateway<\/td><\/tr><tr><td>Nexus Standards<\/td><td>preparatory drafts on vocabulary, hazards, indicators and methods<\/td><td>Standards site \u00b7 working groups HAZ, IND, MTH, FIN, AI<\/td><\/tr><tr><td>Risk Academy<\/td><td>learning pathways tied to the agenda questions<\/td><td>Academy gateway \u00b7 learning by review<\/td><\/tr><tr><td>Nexus Standards and Academy<\/td><td>technology chapter inputs: GCRI evidence, NXS standards, RA capability<\/td><td>technology editorial board<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-split\"><div><h3 class=\"nrp-h3\">Standards drafts used in this edition<\/h3><ul class=\"nrp-list\"><li>Risk vocabulary NRS-C1 (424 terms) for terms in the glossary<\/li><li>Hazard atlas NHS-1 1.1.0 (905 hazards in 120 families) for risk objects<\/li><li>Seven risk classes: global, catastrophic, existential, emerging, planetary, exponential, frontier-tech<\/li><\/ul><\/div><div><h3 class=\"nrp-h3\">Standards calendar to watch<\/h3><ul class=\"nrp-list\"><li>Founding calls from 20 October 2026; working groups meet from 5 November 2026<\/li><li>Inaugural Global Standards Council session, 12 January 2027<\/li><li>Quarterly reviews in March, June, September and December, aligned with each edition<\/li><\/ul><\/div><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">boundary<\/p><p>Nothing here certifies. A Nexus attestation records an evaluation under a mandate; it confers no certification, endorsement or approval. Adoption of any standard is a decision of the competent standards body.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c6-s4\" aria-labelledby=\"nx-nrp-xt-04-c6-s4-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c6-s4-h\"><span class=\"nrp-num\">6.4<\/span><span>GCRI reading: the model card<\/span><\/h2><p class=\"nrp-p\">GCRI&#8217;s reading of this edition is its model card: what the national model is, what it computes and where it stops. It is printed in full in Annex A, with the methods it belongs to. <a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/methodology\/\">Annex A, methodology<\/a><\/p><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c6-s5\" aria-labelledby=\"nx-nrp-xt-04-c6-s5-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c6-s5-h\"><span class=\"nrp-num\">6.5<\/span><span>Global Risks Forum reading: editorial essays<\/span><\/h2><p class=\"nrp-stand\">Four signed essays by the <a class=\"nx-link\" href=\"https:\/\/docs.therisk.global\/organization\/programme\/reports\">Reports<\/a> editorial team set out the positions this edition takes. They are interpretation, labelled as such; the evidence they draw on is in the findings register.<\/p><div class=\"nrp-cards\"><article class=\"nf-ui-card nrp-card\"><p class=\"nf-ui-eyebrow\">Synthetic biology is a build capability, a manufacturing base and a governance test. The first is advancing fast, the second is thinly measured and the third is unevenly implemented. Keeping them apart avoids both hype and alarm.<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">EDITORIAL ESSAY \u00b7 01<\/h3><p>Three stories, one field<\/p><\/article><article class=\"nf-ui-card nrp-card\"><p class=\"nf-ui-eyebrow\">A peer-reviewed experiment, a policy proposal and a company announcement carry different weight. This edition labels each, and treats company revenue and guidance as weak evidence.<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">EDITORIAL ESSAY \u00b7 02<\/h3><p>Separate results, plans and statements<\/p><\/article><article class=\"nf-ui-card nrp-card\"><p class=\"nf-ui-eyebrow\">Feedstock, energy, water, DNA supply and capacity are rarely counted. A published footprint would show whether scale is limited by biology, supply or money.<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">EDITORIAL ESSAY \u00b7 03<\/h3><p>The footprint is the blind spot<\/p><\/article><article class=\"nf-ui-card nrp-card\"><p class=\"nf-ui-eyebrow\">Screening and dual-use frameworks were written before generative design tools. Evidence shows gaps and fixes, and the work is practice, coverage and shared text across jurisdictions.<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">EDITORIAL ESSAY \u00b7 04<\/h3><p>Oversight has to keep pace with design<\/p><\/article><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">boundary<\/p><p>Essays are signed views of the editorial team. Contributed articles from regional consortia, national pathways and invited experts begin with the 2027 global edition, each with its own review route and disclosures.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c6-s6\" aria-labelledby=\"nx-nrp-xt-04-c6-s6-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c6-s6-h\"><span class=\"nrp-num\">6.6<\/span><span>Global Risks Alliance reading: 2027 synthetic biology readiness pack<\/span><\/h2><p class=\"nrp-stand\">The registers that open the 2027 global cycle. At baseline each is initialised from this edition.<\/p><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-c6-tab3\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 6.3<\/span><span class=\"nrp-tbl-t\">2027 synthetic biology readiness pack<\/span><\/caption><thead><tr><th scope=\"col\">Item<\/th><th scope=\"col\">Register<\/th><th scope=\"col\">State at baseline<\/th><th scope=\"col\">First 2027 entry<\/th><\/tr><\/thead><tbody><tr><td>E1<\/td><td>Synthetic biology risk state delta<\/td><td>baseline set by this edition<\/td><td>changes against the baseline<\/td><\/tr><tr><td>E2<\/td><td>WEFH+B state delta<\/td><td>five global system readings set<\/td><td>indicator updates and freshness<\/td><\/tr><tr><td>E3<\/td><td>Agenda and Portfolio movement<\/td><td>eight agenda items \u00b7 6 proposed objects<\/td><td>admission decisions<\/td><\/tr><tr><td>E4<\/td><td>Federation delivery register<\/td><td>national chapters in preparation<\/td><td>national chapters<\/td><\/tr><tr><td>E5<\/td><td>Consortium capability register<\/td><td>national consortia forming<\/td><td>first contributions<\/td><\/tr><tr><td>E6<\/td><td>Leadership questions and challenges<\/td><td>none yet<\/td><td>first challenge log<\/td><\/tr><tr><td>E7<\/td><td>Foundry technical state<\/td><td>national environments prepared<\/td><td>first federation cut<\/td><\/tr><tr><td>E8<\/td><td>Publication candidates<\/td><td>twelve findings carried forward<\/td><td>PUBLISH \u00b7 HOLD dispositions<\/td><\/tr><tr><td>E9<\/td><td>Universe readiness<\/td><td>one candidate mission<\/td><td>admission and role spine<\/td><\/tr><tr><td>E10<\/td><td>Correction register<\/td><td>none<\/td><td>first federation-wide cycle<\/td><\/tr><\/tbody><\/table><\/div><h3 class=\"nrp-h3\">Publication dispositions<\/h3><ul class=\"nrp-chips\"><li class=\"nf-ui-chip\">Publish<\/li><li class=\"nf-ui-chip\">Hold<\/li><li class=\"nf-ui-chip\">Needs evidence<\/li><li class=\"nf-ui-chip\">Restricted<\/li><li class=\"nf-ui-chip\">Superseded<\/li><\/ul><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">boundary<\/p><p>Programme progress is not real-world risk improvement. These registers record the work of the Nexus programme; they report on no state or organisation.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c6-s7\" aria-labelledby=\"nx-nrp-xt-04-c6-s7-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c6-s7-h\"><span class=\"nrp-num\">6.7<\/span><span>Nexus Standards reading: standards and regulatory watch<\/span><\/h2><p class=\"nrp-stand\">Instruments and published guidance that shape the <a class=\"nx-link nx-term\" href=\"https:\/\/docs.therisk.global\/organization\/systems\" data-tc=\"Systems\" data-tk=\"Nexus Standards\" data-td=\"The twenty Nexus systems, NXS-CMD to NXS-LAB\">systems<\/a> in this edition, by status on the retrieval date. The edition assesses no one\u2019s compliance.<\/p><ul class=\"nrp-chips\"><li class=\"nf-ui-chip\">IN FORCE<\/li><li class=\"nf-ui-chip\">PUBLISHED<\/li><li class=\"nf-ui-chip\">DRAFT<\/li><li class=\"nf-ui-chip\">PUBLISHED \u00b7 VOLUNTARY<\/li><\/ul><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-c6-tab4\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 6.4<\/span><span class=\"nrp-tbl-t\">Standards and regulatory watch<\/span><\/caption><thead><tr><th scope=\"col\">Instrument<\/th><th scope=\"col\">Body<\/th><th scope=\"col\">Scope<\/th><th scope=\"col\">Status<\/th><th scope=\"col\">Relevance<\/th><\/tr><\/thead><tbody><tr><td>Global guidance framework for the life sciences<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n21\" id=\"nx-nrp-xt-04-c6-r21\" aria-label=\"Note 21\">21<\/a><\/sup><\/td><td>WHO<\/td><td>global<\/td><td>PUBLISHED 2022<\/td><td>dual-use governance<\/td><\/tr><tr><td>Framework for nucleic acid synthesis screening<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n25\" id=\"nx-nrp-xt-04-c6-r25\" aria-label=\"Note 25\">25<\/a><\/sup><\/td><td>OSTP<\/td><td>US<\/td><td>PUBLISHED 2024<\/td><td>screening; status after 2025 order unclear<\/td><\/tr><tr><td>Executive Order 14292<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n26\" id=\"nx-nrp-xt-04-c6-r26\" aria-label=\"Note 26\">26<\/a><\/sup><\/td><td>US President<\/td><td>US<\/td><td>IN FORCE 2025<\/td><td>research safety and framework revision<\/td><\/tr><tr><td>Harmonised screening protocol<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n31\" id=\"nx-nrp-xt-04-c6-r31\" aria-label=\"Note 31\">31<\/a><\/sup><\/td><td>IGSC<\/td><td>industry, global<\/td><td>PUBLISHED \u00b7 VOLUNTARY<\/td><td>screening practice<\/td><\/tr><tr><td>Screening guidance for synthetic nucleic acids<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n32\" id=\"nx-nrp-xt-04-c6-r32\" aria-label=\"Note 32\">32<\/a><\/sup><\/td><td>UK Government<\/td><td>UK<\/td><td>PUBLISHED \u00b7 VOLUNTARY<\/td><td>screening practice<\/td><\/tr><tr><td>ISO 20688-2 on gene synthesis<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n36\" id=\"nx-nrp-xt-04-c6-r36\" aria-label=\"Note 36\">36<\/a><\/sup><\/td><td>ISO<\/td><td>global<\/td><td>PUBLISHED \u00b7 VOLUNTARY<\/td><td>production requirements<\/td><\/tr><tr><td>Biotech Act proposal<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n22\" id=\"nx-nrp-xt-04-c6-r22\" aria-label=\"Note 22\">22<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n28\" id=\"nx-nrp-xt-04-c6-r28\" aria-label=\"Note 28\">28<\/a><\/sup><\/td><td>European Commission<\/td><td>EU<\/td><td>DRAFT<\/td><td>health biotechnology and biodefence<\/td><\/tr><tr><td>CBD decisions 15\/31 and 16\/21<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n20\" id=\"nx-nrp-xt-04-c6-r20\" aria-label=\"Note 20\">20<\/a><\/sup><\/td><td>CBD parties<\/td><td>global<\/td><td>PUBLISHED<\/td><td><a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-c1\" data-tc=\"NRS-C1 horizon-scanning\" data-tk=\"Nexus risk vocabulary\" data-td=\"Systematic searching for early signs of potentially important developments, threats and opportunities at the margins of current thinking.\" data-ts=\"NRS-C1\" data-tr=\"draft\" data-tg=\"https:\/\/globalriskforum.com\/glossary\/horizon-scanning\/\" data-tgl=\"Global Risks Forum glossary\">horizon scanning<\/a> and action plan<\/td><\/tr><tr><td>Cartagena Protocol<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n35\" id=\"nx-nrp-xt-04-c6-r35\" aria-label=\"Note 35\">35<\/a><\/sup><\/td><td>CBD parties<\/td><td>global<\/td><td>IN FORCE<\/td><td>living modified organisms<\/td><\/tr><tr><td>Biological Weapons Convention<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n34\" id=\"nx-nrp-xt-04-c6-r34\" aria-label=\"Note 34\">34<\/a><\/sup><\/td><td>States Parties<\/td><td>global<\/td><td>IN FORCE<\/td><td>prohibition<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-split\"><div><h3 class=\"nrp-h3\">Changed since 2024<\/h3><ul class=\"nrp-list\"><li>The EU proposed a Biotech Act on 16 December 2025<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n22\" aria-label=\"Note 22\">22<\/a><\/sup><\/li><li>The OECD published its anticipatory governance paper on 21 May 2026<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n18\" id=\"nx-nrp-xt-04-c6-r18\" aria-label=\"Note 18\">18<\/a><\/sup><\/li><li>The US executive order of May 2025 set a 90-day deadline for a revised screening framework<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n26\" aria-label=\"Note 26\">26<\/a><\/sup><\/li><\/ul><\/div><div><h3 class=\"nrp-h3\">To watch in 2027<\/h3><ul class=\"nrp-list\"><li>The EU second Biotech Act, expected in the third quarter of 2026<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n29\" id=\"nx-nrp-xt-04-c6-r29\" aria-label=\"Note 29\">29<\/a><\/sup><\/li><li>The CBD thematic action plan for COP-17<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n20\" aria-label=\"Note 20\">20<\/a><\/sup><\/li><li>Any replacement US screening framework<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n25\" aria-label=\"Note 25\">25<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n27\" id=\"nx-nrp-xt-04-c6-r27\" aria-label=\"Note 27\">27<\/a><\/sup><\/li><\/ul><\/div><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">evidence<\/p><p>Status is read from the issuing body on the retrieval date. Instruments open for signature or awaiting ratification are labelled as such; a change in status opens a review task for every finding that relies on the instrument.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c6-s8\" aria-labelledby=\"nx-nrp-xt-04-c6-s8-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c6-s8-h\"><span class=\"nrp-num\">6.8<\/span><span>Risk Academy reading: literature and evidence review, science and assessments<\/span><\/h2><p class=\"nrp-stand\">The review behind this edition covers synthetic biology assessments, peer-reviewed science and the institutional reports that bind its findings. Systematic reviews for each agenda item begin in 2027.<\/p><h3 class=\"nrp-h3\">Review protocol<\/h3><dl class=\"nrp-dl\"><dt>Question<\/dt><dd>What does the published evidence establish about synthetic biology and bioengineering as infrastructure and its couplings?<\/dd><dt>Sources searched<\/dt><dd>peer-reviewed journals; regulator and agency pages; policy papers; company filings<\/dd><dt>Window<\/dt><dd>releases available at evidence close, 30 September 2026<\/dd><dt>Selection<\/dt><dd>sources that bind or contextualise a finding in this edition<\/dd><dt>Next step<\/dt><dd>systematic reviews for agenda items 01 to 05 in 2027<\/dd><\/dl><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-c6-tab5\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 6.5<\/span><span class=\"nrp-tbl-t\">Peer-reviewed science<\/span><\/caption><thead><tr><th scope=\"col\">Reference<\/th><th scope=\"col\">Type<\/th><th scope=\"col\">Year<\/th><th scope=\"col\">Role<\/th><th scope=\"col\">Used for<\/th><\/tr><\/thead><tbody><tr><td>Robertson et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n1\" id=\"nx-nrp-xt-04-c6-r1\" aria-label=\"Note 1\">1<\/a><\/sup><\/td><td>journal article<\/td><td>2025<\/td><td>supports<\/td><td>recoded genome<\/td><\/tr><tr><td>Fredens et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n3\" id=\"nx-nrp-xt-04-c6-r3\" aria-label=\"Note 3\">3<\/a><\/sup><\/td><td>journal article<\/td><td>2019<\/td><td>supports<\/td><td>recoded genome<\/td><\/tr><tr><td>Sc2.0 consortium paper<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n4\" id=\"nx-nrp-xt-04-c6-r4\" aria-label=\"Note 4\">4<\/a><\/sup><\/td><td>journal article<\/td><td>2023<\/td><td>supports<\/td><td>synthetic yeast<\/td><\/tr><tr><td>Gibson et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n5\" id=\"nx-nrp-xt-04-c6-r5\" aria-label=\"Note 5\">5<\/a><\/sup><\/td><td>journal article<\/td><td>2010<\/td><td>context<\/td><td>first synthetic cell<\/td><\/tr><tr><td>Nielsen et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n6\" id=\"nx-nrp-xt-04-c6-r6\" aria-label=\"Note 6\">6<\/a><\/sup><\/td><td>journal article<\/td><td>2016<\/td><td>supports<\/td><td>circuit design<\/td><\/tr><tr><td>Watson et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n7\" id=\"nx-nrp-xt-04-c6-r7\" aria-label=\"Note 7\">7<\/a><\/sup><\/td><td>journal article<\/td><td>2023<\/td><td>supports<\/td><td>protein design<\/td><\/tr><tr><td>Frangoul et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n8\" id=\"nx-nrp-xt-04-c6-r8\" aria-label=\"Note 8\">8<\/a><\/sup><\/td><td>journal article<\/td><td>2024<\/td><td>supports<\/td><td>cell therapy<\/td><\/tr><tr><td>Musunuru et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n10\" id=\"nx-nrp-xt-04-c6-r10\" aria-label=\"Note 10\">10<\/a><\/sup><\/td><td>journal article<\/td><td>2025<\/td><td>context<\/td><td>patient-specific therapy<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-c6-tab6\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 6.6<\/span><span class=\"nrp-tbl-t\">Foundational methods<\/span><\/caption><thead><tr><th scope=\"col\">Reference<\/th><th scope=\"col\">Issuer<\/th><th scope=\"col\">Year<\/th><th scope=\"col\">Role<\/th><th scope=\"col\">Used for<\/th><\/tr><\/thead><tbody><tr><td>Kyrou et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n11\" id=\"nx-nrp-xt-04-c6-r11\" aria-label=\"Note 11\">11<\/a><\/sup><\/td><td>journal article<\/td><td>2018<\/td><td>context<\/td><td>gene drive<\/td><\/tr><tr><td><a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-h101\" data-tc=\"NHS-1 tech.biotech.mirror-life\" data-tk=\"Frontier and exponential technology \u00b7 Biotechnology and synthetic biology\" data-td=\"Creation and escape of organisms built from mirror-image molecules, which could evade immune defences, predators and decay in people, animals and plants and spread unchecked through ecosystems.\" data-ts=\"NRS-H101\" data-tr=\"draft\" data-tx=\"https:\/\/risksindex.com\/hazards\/tech\/\" data-txl=\"Frontier and exponential technology\">Mirror life<\/a> policy forum<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n12\" id=\"nx-nrp-xt-04-c6-r12\" aria-label=\"Note 12\">12<\/a><\/sup><\/td><td>journal article<\/td><td>2024<\/td><td>context<\/td><td>risk discussion<\/td><\/tr><tr><td>Screening study<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n13\" id=\"nx-nrp-xt-04-c6-r13\" aria-label=\"Note 13\">13<\/a><\/sup><\/td><td>journal article<\/td><td>2025<\/td><td>supports<\/td><td>screening gaps<\/td><\/tr><tr><td>Jinek et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n38\" id=\"nx-nrp-xt-04-c6-r38\" aria-label=\"Note 38\">38<\/a><\/sup><\/td><td>journal article<\/td><td>2012<\/td><td>framework<\/td><td>CRISPR programmable cutting<\/td><\/tr><tr><td>Gibson et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n39\" id=\"nx-nrp-xt-04-c6-r39\" aria-label=\"Note 39\">39<\/a><\/sup><\/td><td>journal article<\/td><td>2009<\/td><td>framework<\/td><td>DNA assembly<\/td><\/tr><tr><td>Ro et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n40\" id=\"nx-nrp-xt-04-c6-r40\" aria-label=\"Note 40\">40<\/a><\/sup><\/td><td>journal article<\/td><td>2006<\/td><td>framework<\/td><td>engineered yeast production<\/td><\/tr><tr><td>Elowitz and Leibler<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n41\" id=\"nx-nrp-xt-04-c6-r41\" aria-label=\"Note 41\">41<\/a><\/sup><\/td><td>journal article<\/td><td>2000<\/td><td>framework<\/td><td>synthetic oscillator<\/td><\/tr><tr><td>Gardner, Cantor and Collins<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n42\" id=\"nx-nrp-xt-04-c6-r42\" aria-label=\"Note 42\">42<\/a><\/sup><\/td><td>journal article<\/td><td>2000<\/td><td>framework<\/td><td>genetic toggle switch<\/td><\/tr><tr><td>Richardson et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n43\" id=\"nx-nrp-xt-04-c6-r43\" aria-label=\"Note 43\">43<\/a><\/sup><\/td><td>journal article<\/td><td>2017<\/td><td>framework<\/td><td>synthetic yeast design<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-c6-tab7\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 6.7<\/span><span class=\"nrp-tbl-t\">Standards, policy and governance<\/span><\/caption><thead><tr><th scope=\"col\">Reference<\/th><th scope=\"col\">Issuer<\/th><th scope=\"col\">Year<\/th><th scope=\"col\">Role<\/th><th scope=\"col\">Used for<\/th><\/tr><\/thead><tbody><tr><td>US commission report, CRS note<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n14\" id=\"nx-nrp-xt-04-c6-r14\" aria-label=\"Note 14\">14<\/a><\/sup><\/td><td>Congressional Research Service<\/td><td>2025<\/td><td>supports<\/td><td>recommendations<\/td><\/tr><tr><td>OECD anticipatory governance<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n18\" aria-label=\"Note 18\">18<\/a><\/sup><\/td><td>OECD<\/td><td>2026<\/td><td>supports<\/td><td>governance<\/td><\/tr><tr><td>OECD technology assessment<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n19\" id=\"nx-nrp-xt-04-c6-r19\" aria-label=\"Note 19\">19<\/a><\/sup><\/td><td>OECD<\/td><td>2025<\/td><td>supports<\/td><td>convergence and risks<\/td><\/tr><tr><td>CBD synthetic biology page<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n20\" aria-label=\"Note 20\">20<\/a><\/sup><\/td><td>CBD secretariat<\/td><td>2026<\/td><td>supports<\/td><td>decisions<\/td><\/tr><tr><td>WHO framework<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n21\" aria-label=\"Note 21\">21<\/a><\/sup><\/td><td>WHO<\/td><td>2022<\/td><td>supports<\/td><td>dual-use guidance<\/td><\/tr><tr><td>Biodefense report<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n33\" id=\"nx-nrp-xt-04-c6-r33\" aria-label=\"Note 33\">33<\/a><\/sup><\/td><td>National Academies<\/td><td>2018<\/td><td>context<\/td><td>biodefence background<\/td><\/tr><tr><td>EU proposal summary<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n22\" aria-label=\"Note 22\">22<\/a><\/sup><\/td><td>law firm summary<\/td><td>2025<\/td><td>context<\/td><td>proposal content<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-c6-tab8\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 6.8<\/span><span class=\"nrp-tbl-t\">Industry, funding and field overviews<\/span><\/caption><thead><tr><th scope=\"col\">Reference<\/th><th scope=\"col\">Issuer<\/th><th scope=\"col\">Year<\/th><th scope=\"col\">Role<\/th><th scope=\"col\">Used for<\/th><\/tr><\/thead><tbody><tr><td>FAS commentary<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n15\" id=\"nx-nrp-xt-04-c6-r15\" aria-label=\"Note 15\">15<\/a><\/sup><\/td><td>Federation of American Scientists<\/td><td>2025<\/td><td>context<\/td><td>bioeconomy figures<\/td><\/tr><tr><td>Twist Bioscience filing<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n16\" aria-label=\"Note 16\">16<\/a><\/sup><\/td><td>company<\/td><td>2026<\/td><td>context<\/td><td><a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-c1\" data-tc=\"NRS-C1 weak-signal\" data-tk=\"Nexus risk vocabulary\" data-td=\"An early, fragmentary indication of a possible change that is not yet clearly recognised or understood.\" data-ts=\"NRS-C1\" data-tr=\"draft\">weak signal<\/a><\/td><\/tr><tr><td>Ginkgo Bioworks filing<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n17\" aria-label=\"Note 17\">17<\/a><\/sup><\/td><td>company<\/td><td>2026<\/td><td>context<\/td><td>weak signal<\/td><\/tr><tr><td>BioMADE page<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n23\" id=\"nx-nrp-xt-04-c6-r23\" aria-label=\"Note 23\">23<\/a><\/sup><\/td><td>institute<\/td><td>2020<\/td><td>context<\/td><td>infrastructure<\/td><\/tr><tr><td>Programme page<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n24\" aria-label=\"Note 24\">24<\/a><\/sup><\/td><td>US manufacturing programme<\/td><td>2024<\/td><td>supports<\/td><td>planning awards<\/td><\/tr><tr><td>Bio Revolution report<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n37\" id=\"nx-nrp-xt-04-c6-r37\" aria-label=\"Note 37\">37<\/a><\/sup><\/td><td>McKinsey<\/td><td>2020<\/td><td>context<\/td><td>economy<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-split\"><div><h3 class=\"nrp-h3\">Where the evidence agrees<\/h3><ul class=\"nrp-list\"><li>Whole-genome design and writing works at the scale of one organism<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n1\" aria-label=\"Note 1\">1<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n3\" aria-label=\"Note 3\">3<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n4\" aria-label=\"Note 4\">4<\/a><\/sup><\/li><li>Screening tools need updating for machine-designed sequences<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n13\" aria-label=\"Note 13\">13<\/a><\/sup><\/li><li>Governance is moving but implementation is uneven<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n14\" aria-label=\"Note 14\">14<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n18\" aria-label=\"Note 18\">18<\/a><\/sup><\/li><\/ul><\/div><div><h3 class=\"nrp-h3\">Where it is unsettled<\/h3><ul class=\"nrp-list\"><li>Whether screening practice and framework text keep pace with design tools<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n13\" aria-label=\"Note 13\">13<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n26\" aria-label=\"Note 26\">26<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n27\" aria-label=\"Note 27\">27<\/a><\/sup><\/li><li>How large the energy, water and feedstock footprint of manufacturing will be<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n24\" aria-label=\"Note 24\">24<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n37\" aria-label=\"Note 37\">37<\/a><\/sup><\/li><li>How company results map to the health of the sector<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n16\" aria-label=\"Note 16\">16<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n17\" aria-label=\"Note 17\">17<\/a><\/sup><\/li><\/ul><\/div><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">PREPRINTS<\/p><p>Three sources<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n24\" aria-label=\"Note 24\">24<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n25\" aria-label=\"Note 25\">25<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c6-n26\" aria-label=\"Note 26\">26<\/a><\/sup> are preprints and are labelled as not peer-reviewed. They contextualise findings; none binds a finding on its own.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c6-notes\" aria-labelledby=\"nx-nrp-xt-04-c6-notes-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c6-notes-h\"><span>Notes<\/span><\/h2><p class=\"nrp-note\">Numbers are the edition&#8217;s reference numbers, so a note reads the same in every chapter. The full list, with every source and its licence, is in Annex C. <a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/references\/\">Annex C, references<\/a><\/p><ol class=\"nrp-notes\"><li id=\"nx-nrp-xt-04-c6-n16\"><span class=\"nrp-notes-n\">16<\/span><span>Twist Bioscience Corporation (ed.), Form 8-K exhibit 99.1, results for the fiscal third quarter ended 30 June 2026 (company filing; revenue USD 118.4 million; nine months USD 332.8 million; fiscal 2026 guidance USD 456 to 457 million; company statements and guidance are weak evidence). US Securities and Exchange Commission, Washington. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r16\" aria-label=\"Back to the first call of note 16\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n17\"><span class=\"nrp-notes-n\">17<\/span><span>Ginkgo Bioworks Holdings, Inc. (ed.), Form 8-K exhibit 99.1, fourth quarter and full year 2025 results (company filing of 26 February 2026; revenue USD 170.155 million against USD 227.043 million; net loss USD 312.763 million; company statements are weak evidence). US Securities and Exchange Commission, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r17\" aria-label=\"Back to the first call of note 17\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n24\"><span class=\"nrp-notes-n\">24<\/span><span>US Manufacturing Program (ed.), Bioindustrial (programme topic page; Distributed Bioindustrial Manufacturing Program awards announced 10 July to 13 September 2024; 25 awards; USD 42 million cumulative). Manufacturing USA, Gaithersburg. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r24\" aria-label=\"Back to the first call of note 24\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n21\"><span class=\"nrp-notes-n\">21<\/span><span>World Health Organization (ed.), Global guidance framework for the responsible use of the life sciences: mitigating biorisks and governing <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-c1\" data-tc=\"NRS-C1 dual-use-research\" data-tk=\"Nexus risk vocabulary\" data-td=\"Legitimate research whose knowledge, methods or products could also be misused to cause serious harm.\" data-ts=\"NRS-C1\" data-tr=\"draft\">dual-use research<\/a> (publication page, 13 September 2022). WHO, Geneva. Observation year 2022. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r21\" aria-label=\"Back to the first call of note 21\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n25\"><span class=\"nrp-notes-n\">25<\/span><span>UNVERIFIED, not opened: Office of Science and Technology Policy (ed.), Framework for Nucleic Acid Synthesis Screening, April 2024, taken from search-result summaries; a fetch of the page was refused by the fetch tool. OSTP, Washington. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r25\" aria-label=\"Back to the first call of note 25\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n26\"><span class=\"nrp-notes-n\">26<\/span><span>UNVERIFIED, not opened: Executive Order 14292, Improving the Safety and Security of Biological Research, 5 May 2025 (90 days to revise or replace the framework), taken from search-result summaries; a fetch of an explainer page was refused by the fetch tool. The White House, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r26\" aria-label=\"Back to the first call of note 26\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n31\"><span class=\"nrp-notes-n\">31<\/span><span>UNVERIFIED, not opened: International Gene Synthesis Consortium (ed.), Harmonized Screening Protocol, cited from memory. IGSC. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r31\" aria-label=\"Back to the first call of note 31\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n32\"><span class=\"nrp-notes-n\">32<\/span><span>UNVERIFIED, not opened: UK Government (ed.), screening guidance on synthetic nucleic acids, 2024, cited from memory. Department for Science, Innovation and Technology, London. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r32\" aria-label=\"Back to the first call of note 32\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n36\"><span class=\"nrp-notes-n\">36<\/span><span>UNVERIFIED, not opened: International Organization for Standardization (ed.), ISO 20688-2, requirements for the production and quality control of synthesised gene fragments, genes and genome-scale constructs, cited from memory. ISO, Geneva. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r36\" aria-label=\"Back to the first call of note 36\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n22\"><span class=\"nrp-notes-n\">22<\/span><span>Baker McKenzie (ed.), EU Biotech Act unveiled: Commission proposal to turn Europe into a biotech powerhouse (law firm summary, 19 December 2025; proposal of 16 December 2025; health focus; investment pilot with the European Investment Bank Group; 12-month certificate extension; biodefence measures; second act expected in Q3 2026). Secondary source, not the Commission text. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r22\" aria-label=\"Back to the first call of note 22\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n28\"><span class=\"nrp-notes-n\">28<\/span><span>UNVERIFIED, not opened: European Commission (ed.), Proposal for a Biotech Act, COM(2025) 1022, 16 December 2025, taken from law firm and regulator summaries; the Commission page was not retrieved. European Commission, Brussels. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r28\" aria-label=\"Back to the first call of note 28\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n20\"><span class=\"nrp-notes-n\">20<\/span><span>Secretariat of the Convention on Biological Diversity (ed.), Synthetic biology (programme page; decisions X\/13 to 16\/21; AHTEG; <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-c1\" data-tc=\"NRS-C1 horizon-scanning\" data-tk=\"Nexus risk vocabulary\" data-td=\"Systematic searching for early signs of potentially important developments, threats and opportunities at the margins of current thinking.\" data-ts=\"NRS-C1\" data-tr=\"draft\" data-tg=\"https:\/\/globalriskforum.com\/glossary\/horizon-scanning\/\" data-tgl=\"Global Risks Forum glossary\">horizon scanning<\/a>; thematic action plan). CBD Secretariat, Montreal. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r20\" aria-label=\"Back to the first call of note 20\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n35\"><span class=\"nrp-notes-n\">35<\/span><span>UNVERIFIED, not opened: Cartagena Protocol on Biosafety to the Convention on Biological Diversity, 2000, cited from memory. CBD Secretariat, Montreal. Observation year 2000. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r35\" aria-label=\"Back to the first call of note 35\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n34\"><span class=\"nrp-notes-n\">34<\/span><span>UNVERIFIED, not opened: Convention on the Prohibition of the Development, Production and Stockpiling of Bacteriological (Biological) and Toxin Weapons and on their Destruction, 1972, cited from memory. United Nations, Geneva. Observation year 1972. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r34\" aria-label=\"Back to the first call of note 34\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n18\"><span class=\"nrp-notes-n\">18<\/span><span>OECD (ed.), Anticipatory governance for responsible innovation in synthetic biology, OECD Science, Technology and Industry Policy Papers No. 193, 21 May 2026 (record read via a bibliographic database; abstract only). OECD Publishing, Paris. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r18\" aria-label=\"Back to the first call of note 18\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n29\"><span class=\"nrp-notes-n\">29<\/span><span>UNVERIFIED, not opened: European Parliament (ed.), Legislative train entry for the European Biotech Act II (second act expected in the third quarter of 2026), taken from a search-result summary; the page returned no content. European Parliament, Brussels. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r29\" aria-label=\"Back to the first call of note 29\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n27\"><span class=\"nrp-notes-n\">27<\/span><span>UNVERIFIED, not opened: Congressional Research Service (ed.), report on artificial intelligence and biosecurity risks (reported in July 2026 as unable to determine whether the 2024 framework or the 2025 policy had been revised), taken from a trade news summary. Library of Congress, Washington. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r27\" aria-label=\"Back to the first call of note 27\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n1\"><span class=\"nrp-notes-n\">1<\/span><span>Robertson, W.E. et al., Escherichia coli with a 57-codon genetic code, Science 390 (6771), eady4368, published 23 October 2025 (record read via PubMed, PMID 40743368; the record gives a 4 megabase synthetic genome and six replaced sense codons). American Association for the Advancement of Science, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r1\" aria-label=\"Back to the first call of note 1\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n3\"><span class=\"nrp-notes-n\">3<\/span><span>Fredens, J. et al., Total synthesis of Escherichia coli with a recoded genome, Nature 569 (7757), 514 to 518, 2019 (record read via Europe PMC: 18,214 codons recoded; 61-codon genome). Springer Nature, London. Observation year 2019. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r3\" aria-label=\"Back to the first call of note 3\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n4\"><span class=\"nrp-notes-n\">4<\/span><span>Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions, Cell 186 (24), 5220 to 5236, 2023 (record read via Europe PMC: 6.5 synthetic chromosomes in one strain; over half of the Sc2.0 genome). Cell Press, Cambridge, Massachusetts. Observation year 2023. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r4\" aria-label=\"Back to the first call of note 4\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n5\"><span class=\"nrp-notes-n\">5<\/span><span>Gibson, D.G. et al., Creation of a bacterial cell controlled by a chemically synthesised genome, Science 329 (5987), 52 to 56, 2010 (record read via Europe PMC: 1.08 million base pair genome). American Association for the Advancement of Science, Washington. Observation year 2010. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r5\" aria-label=\"Back to the first call of note 5\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n6\"><span class=\"nrp-notes-n\">6<\/span><span>Nielsen, A.A.K. et al., Genetic circuit design automation, Science 352 (6281), 2016 (record read via Europe PMC: 60 circuits; 45 correct in all output states; 92% of output states as predicted). American Association for the Advancement of Science, Washington. Observation year 2016. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r6\" aria-label=\"Back to the first call of note 6\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n7\"><span class=\"nrp-notes-n\">7<\/span><span>Watson, J.L. et al., De novo design of protein structure and function with RFdiffusion, Nature 620, 1089 to 1100, 2023 (record read via Europe PMC). Springer Nature, London. Observation year 2023. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r7\" aria-label=\"Back to the first call of note 7\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n8\"><span class=\"nrp-notes-n\">8<\/span><span>Frangoul, H. et al., Exagamglogene autotemcel for severe sickle cell disease, New England Journal of Medicine 390 (18), 1649 to 1662, 2024 (record read via Europe PMC: 44 treated; 29 of 30 evaluable free of severe crises for 12 months; median follow-up 19.3 months). Massachusetts Medical Society, Waltham. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r8\" aria-label=\"Back to the first call of note 8\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n10\"><span class=\"nrp-notes-n\">10<\/span><span>Musunuru, K. et al., Patient-specific in vivo gene editing to treat a rare genetic disease, New England Journal of Medicine 392 (22), 2235 to 2243, 2025 (record read via Europe PMC: one infant; two infusions at about 7 and 8 months). Massachusetts Medical Society, Waltham. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r10\" aria-label=\"Back to the first call of note 10\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n11\"><span class=\"nrp-notes-n\">11<\/span><span>Kyrou, K. et al., A CRISPR-Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes, Nature Biotechnology 36, 1062 to 1066, 2018 (record read via Europe PMC; laboratory cages only). Springer Nature, London. Observation year 2018. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r11\" aria-label=\"Back to the first call of note 11\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n12\"><span class=\"nrp-notes-n\">12<\/span><span>Confronting risks of <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-h101\" data-tc=\"NHS-1 tech.biotech.mirror-life\" data-tk=\"Frontier and exponential technology \u00b7 Biotechnology and synthetic biology\" data-td=\"Creation and escape of organisms built from mirror-image molecules, which could evade immune defences, predators and decay in people, animals and plants and spread unchecked through ecosystems.\" data-ts=\"NRS-H101\" data-tr=\"draft\" data-tx=\"https:\/\/risksindex.com\/hazards\/tech\/\" data-txl=\"Frontier and exponential technology\">mirror life<\/a>, Science 386, 1351 to 1353, 2024 (record read via Europe PMC; the record gives only a one-line abstract calling for broad discussion). American Association for the Advancement of Science, Washington. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r12\" aria-label=\"Back to the first call of note 12\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n13\"><span class=\"nrp-notes-n\">13<\/span><span>Strengthening nucleic acid biosecurity screening against generative protein design tools, Science 390 (6768), 82 to 87, 2025 (record read via Europe PMC; abstract only; no method detail used). American Association for the Advancement of Science, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r13\" aria-label=\"Back to the first call of note 13\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n38\"><span class=\"nrp-notes-n\">38<\/span><span>UNVERIFIED, not opened: Jinek, M. et al., A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity, Science 337, 816 to 821, 2012, cited from memory. Observation year 2012. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r38\" aria-label=\"Back to the first call of note 38\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n39\"><span class=\"nrp-notes-n\">39<\/span><span>UNVERIFIED, not opened: Gibson, D.G. et al., Enzymatic assembly of DNA molecules up to several hundred kilobases, Nature Methods 6, 343 to 345, 2009, cited from memory. Observation year 2009. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r39\" aria-label=\"Back to the first call of note 39\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n40\"><span class=\"nrp-notes-n\">40<\/span><span>UNVERIFIED, not opened: Ro, D.-K. et al., Production of the antimalarial drug precursor artemisinic acid in engineered yeast, Nature 440, 940 to 943, 2006, cited from memory. Observation year 2006. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r40\" aria-label=\"Back to the first call of note 40\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n41\"><span class=\"nrp-notes-n\">41<\/span><span>UNVERIFIED, not opened: Elowitz, M.B. and Leibler, S., A synthetic oscillatory network of transcriptional regulators, Nature 403, 335 to 338, 2000, cited from memory. Observation year 2000. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r41\" aria-label=\"Back to the first call of note 41\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n42\"><span class=\"nrp-notes-n\">42<\/span><span>UNVERIFIED, not opened: Gardner, T.S., Cantor, C.R. and Collins, J.J., <a class=\"nx-link\" href=\"https:\/\/nexustandards.com\/cities\/construction-and-real-estate\/\">Construction<\/a> of a genetic toggle switch in Escherichia coli, Nature 403, 339 to 342, 2000, cited from memory. Observation year 2000. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r42\" aria-label=\"Back to the first call of note 42\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n43\"><span class=\"nrp-notes-n\">43<\/span><span>UNVERIFIED, not opened: Richardson, S.M. et al., Design of a synthetic yeast genome, Science 355, 1040 to 1044, 2017, cited from memory. Observation year 2017. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r43\" aria-label=\"Back to the first call of note 43\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n14\"><span class=\"nrp-notes-n\">14<\/span><span>Congressional Research Service (ed.), National Security Commission on Emerging Biotechnology: Final Report and Options for Congress, CRS Insight IN12546, 17 April 2025 (report of 8 April 2025; 49 recommendations; at least USD 15 billion over five years; National Biotechnology Coordination Office). Library of Congress, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r14\" aria-label=\"Back to the first call of note 14\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n19\"><span class=\"nrp-notes-n\">19<\/span><span>OECD (ed.), Synthetic biology, AI and automation: a forward-looking technology assessment, OECD Science, Technology and Industry Policy Papers No. 187, 4 December 2025 (record read via a bibliographic database; abstract only). OECD Publishing, Paris. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r19\" aria-label=\"Back to the first call of note 19\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n33\"><span class=\"nrp-notes-n\">33<\/span><span>UNVERIFIED, not opened: National Academies of Sciences, Engineering, and Medicine (eds.), Biodefense in the Age of Synthetic Biology, 2018, cited from memory; a fetch returned an unrelated page. National Academies Press, Washington. Observation year 2018. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r33\" aria-label=\"Back to the first call of note 33\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n15\"><span class=\"nrp-notes-n\">15<\/span><span>Federation of American Scientists (ed.), Translating Vision into Action: FAS commentary on the NSCEB final report (commentary page; six pillars; cites over USD 210 billion of US GDP and over 640,000 jobs for the bioeconomy; secondary and advocacy-leaning source). Federation of American Scientists, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r15\" aria-label=\"Back to the first call of note 15\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n23\"><span class=\"nrp-notes-n\">23<\/span><span>BioMADE (ed.), DoD approves USD 87 million for newest bioindustrial manufacturing innovation institute (news page; seven years; the page shows Oct 20 and a 2023 footer, the press release is dated 2020 in search listings). BioMADE, Saint Paul. Observation year 2020. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r23\" aria-label=\"Back to the first call of note 23\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c6-n37\"><span class=\"nrp-notes-n\">37<\/span><span>UNVERIFIED, not opened: McKinsey Global Institute (ed.), The Bio Revolution: Innovations transforming economies, societies, and our lives, May 2020, cited from memory; the fetch returned a service error and no figure is used. McKinsey and Company, New York. Observation year 2020. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c6-r37\" aria-label=\"Back to the first call of note 37\">back<\/a><\/span><\/li><\/ol><\/section><section class=\"nrp-block nrp-noprint\" id=\"nx-nrp-xt-04-c6-cite\" aria-labelledby=\"nx-nrp-xt-04-c6-cite-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c6-cite-h\"><span>Cite this chapter<\/span><\/h2><pre class=\"nrp-pre\">Valadbaygi, S. (Ed.). (2026). Chapter 6: Readings from the other desks. In Exponential Technology Report 2026: Synthetic Biology and Bioengineering (Baseline Edition 2026, Report No. NR-XTECH-SYNBIO-GLOBAL-2026-BASELINE) [Draft under review]. The Global Centre for Risk and Innovation (GCRI).<\/pre><p class=\"nrp-note\">Every citation form of the whole report, BibTeX and RIS included, is on the edition home. <a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/#nx-nrp-xt-04-land-cite\">Cite this report<\/a><\/p><\/section><nav class=\"nrp-pager\" aria-label=\"Previous and next\"><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/scenario\/\" rel=\"prev\"><span class=\"nf-ui-eyebrow\">Previous \u00b7 Chapter 5<\/span><span class=\"nrp-pager-t\">Design capability outpaces screening and oversight<\/span><\/a><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/agenda\/\" rel=\"next\"><span class=\"nf-ui-eyebrow\">Next \u00b7 Chapter 7<\/span><span class=\"nrp-pager-t\">The 2027 agenda<\/span><\/a><\/nav><\/article><\/div><\/div><\/div><div class=\"nrp-noprint\"><section id=\"nx-sec-nr-gateway\" class=\"nx-section\" data-hue=\"systemic\" data-tone=\"alt\" aria-labelledby=\"nx-nr-gateway-h\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">Reports<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Contribute<\/span><\/div><h2 id=\"nx-nr-gateway-h\" class=\"nx-section-title\">Send evidence or a correction on Synthetic Biology and Bioengineering.<\/h2><p class=\"nx-lede\">Reports is the Consortium&#8217;s quarterly publication, written by six desks. 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