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\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\"><style>#nxe-nr-gcri-editions-xt-04-systems-in-depth.nxe{display:block;box-sizing:border-box;max-width:1180px;margin:0 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Not indexed until the first approved release.<\/p><div class=\"nrp-reader\"><nav class=\"nrp-rail\" aria-label=\"Contents of Synthetic Biology and Bioengineering 2026\"><p class=\"nf-ui-eyebrow\">Contents<\/p><ol class=\"nrp-toc\"><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Edition home<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/summary\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Executive summary<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/coupled-system\/\"><span class=\"nrp-toc-n\">1<\/span><span>Synthetic biology is a build capability and a governance test<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/findings\/\"><span class=\"nrp-toc-n\">2<\/span><span>Key findings<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-and-sectors\/\"><span class=\"nrp-toc-n\">3<\/span><span>Systems and sectors at baseline<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/risk-and-capability\/\"><span class=\"nrp-toc-n\">4<\/span><span>Risks and capability<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/scenario\/\"><span class=\"nrp-toc-n\">5<\/span><span>Design capability outpaces screening and oversight<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/lenses-and-readings\/\"><span class=\"nrp-toc-n\">6<\/span><span>Readings from the other desks<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/agenda\/\"><span class=\"nrp-toc-n\">7<\/span><span>The 2027 agenda<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-in-depth\/\" aria-current=\"page\"><span class=\"nrp-toc-n\">8<\/span><span>Systems in depth<\/span><\/a><ol class=\"nrp-toc-sub\"><li><a href=\"#nx-nrp-xt-04-c8-s1\">8.1 Genome, circuit and protein design platforms<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c8-s2\">8.2 Energy, water and feedstock for biomanufacturing<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c8-s3\">8.3 DNA, instruments and manufacturing capacity<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c8-s4\">8.4 Economy, investment and workforce<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c8-s5\">8.5 Biosecurity and governance watch<\/a><\/li><\/ol><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/methodology\/\"><span class=\"nrp-toc-n\">A<\/span><span>Methodology<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/data\/\"><span class=\"nrp-toc-n\">B<\/span><span>Data appendix<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/references\/\"><span class=\"nrp-toc-n\">C<\/span><span>References and record<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/full\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Complete edition, for print<\/span><\/a><\/li><\/ol><div class=\"nrp-actions\"><a class=\"nf-ui-btn\" data-variant=\"secondary\" href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/full\/\"><svg class=\"nrp-i\" viewBox=\"0 0 24 24\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2\"\/><path d=\"M6 9V3a1 1 0 0 1 1-1h10a1 1 0 0 1 1 1v6\"\/><rect x=\"6\" y=\"14\" width=\"12\" height=\"8\" rx=\"1\"\/><\/svg>Print or save as PDF<\/a><\/div><\/nav><article class=\"nrp-flow\" aria-labelledby=\"nx-nrp-xt-04-c8-top\"><header class=\"nrp-chap-head\" id=\"nx-nrp-xt-04-c8-top\"><ul class=\"nrp-eyerow\"><li class=\"nf-ui-eyebrow\"><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/\">Synthetic Biology and Bioengineering 2026<\/a><\/li><li class=\"nf-ui-eyebrow\">Chapter 8<\/li><\/ul><span class=\"nrp-rule\" aria-hidden=\"true\"><\/span><h1 class=\"pp-hero-title\">Systems in depth<\/h1><p class=\"nrp-lede\">One section per system: its state at evidence close, its exposures and what the operational series will watch.<\/p><p class=\"nrp-chap-meta\"><span>10 min read<\/span><span>0 figures<\/span><span>5 tables<\/span><span>25 notes<\/span><span>NR-XTECH-SYNBIO-GLOBAL-2026-BASELINE<\/span><\/p><details class=\"nrp-toc-m\"><summary>Contents<\/summary><ol class=\"nrp-toc\"><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Edition home<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/summary\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Executive summary<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/coupled-system\/\"><span class=\"nrp-toc-n\">1<\/span><span>Synthetic biology is a build capability and a governance test<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/findings\/\"><span class=\"nrp-toc-n\">2<\/span><span>Key findings<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-and-sectors\/\"><span class=\"nrp-toc-n\">3<\/span><span>Systems and sectors at baseline<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/risk-and-capability\/\"><span class=\"nrp-toc-n\">4<\/span><span>Risks and capability<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/scenario\/\"><span class=\"nrp-toc-n\">5<\/span><span>Design capability outpaces screening and oversight<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/lenses-and-readings\/\"><span class=\"nrp-toc-n\">6<\/span><span>Readings from the other desks<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/agenda\/\"><span class=\"nrp-toc-n\">7<\/span><span>The 2027 agenda<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-in-depth\/\" aria-current=\"page\"><span class=\"nrp-toc-n\">8<\/span><span>Systems in depth<\/span><\/a><ol class=\"nrp-toc-sub\"><li><a href=\"#nx-nrp-xt-04-c8-s1\">8.1 Genome, circuit and protein design platforms<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c8-s2\">8.2 Energy, water and feedstock for biomanufacturing<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c8-s3\">8.3 DNA, instruments and manufacturing capacity<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c8-s4\">8.4 Economy, investment and workforce<\/a><\/li><li><a href=\"#nx-nrp-xt-04-c8-s5\">8.5 Biosecurity and governance watch<\/a><\/li><\/ol><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/methodology\/\"><span class=\"nrp-toc-n\">A<\/span><span>Methodology<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/data\/\"><span class=\"nrp-toc-n\">B<\/span><span>Data appendix<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/references\/\"><span class=\"nrp-toc-n\">C<\/span><span>References and record<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/full\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Complete edition, for print<\/span><\/a><\/li><\/ol><\/details><\/header><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c8-s1\" aria-labelledby=\"nx-nrp-xt-04-c8-s1-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c8-s1-h\"><span class=\"nrp-num\">8.1<\/span><span>Genome, circuit and protein design platforms<\/span><\/h2><p class=\"nrp-stand\">Biological design now spans whole genomes, genetic circuits and designed proteins. Evidence is strongest where peer review exists and weakest for industrial performance.<\/p><div class=\"pp-cells nrp-cells-3\"><div class=\"nrp-cell\"><span class=\"pp-metric\">57<\/span><span class=\"nrp-cell-u\">codons<\/span><p>Syn57 genetic code<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n2\" id=\"nx-nrp-xt-04-c8-r2\" aria-label=\"Note 2\">2<\/a><\/sup><\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">60<\/span><span class=\"nrp-cell-u\">circuits<\/span><p>built by one design tool, 2016<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n6\" id=\"nx-nrp-xt-04-c8-r6\" aria-label=\"Note 6\">6<\/a><\/sup><\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">6.5<\/span><span class=\"nrp-cell-u\">chromosomes<\/span><p>synthetic yeast in one strain<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n4\" id=\"nx-nrp-xt-04-c8-r4\" aria-label=\"Note 4\">4<\/a><\/sup><\/p><\/div><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-c8-tab1\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 8.1<\/span><span class=\"nrp-tbl-t\">State at baseline<\/span><\/caption><thead><tr><th scope=\"col\">Component<\/th><th scope=\"col\">State<\/th><th scope=\"col\">Evidence<\/th><th scope=\"col\">Status<\/th><\/tr><\/thead><tbody><tr><td>Recoded bacterial genomes<\/td><td>a 57-codon code reported in 2025; 61 codons in 2019<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n1\" id=\"nx-nrp-xt-04-c8-r1\" aria-label=\"Note 1\">1<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n2\" aria-label=\"Note 2\">2<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n3\" id=\"nx-nrp-xt-04-c8-r3\" aria-label=\"Note 3\">3<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>Synthetic yeast<\/td><td>six and a half chromosomes combined in one strain<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n4\" aria-label=\"Note 4\">4<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n43\" id=\"nx-nrp-xt-04-c8-r43\" aria-label=\"Note 43\">43<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>Circuit design software<\/td><td>45 of 60 circuits worked in every output state<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n6\" aria-label=\"Note 6\">6<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>Protein design software<\/td><td>generative binder design tested by structure<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n7\" id=\"nx-nrp-xt-04-c8-r7\" aria-label=\"Note 7\">7<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-split\"><div><h3 class=\"nrp-h3\">Couplings<\/h3><ul class=\"nrp-list\"><li>AIC \u2192 BIO design tools<\/li><li>DAT \u2192 BIO sequence data<\/li><li>FIN \u2192 BIO funding<\/li><\/ul><\/div><div><h3 class=\"nrp-h3\">Evidence to bind in 2027<\/h3><ul class=\"nrp-list\"><li>industrial performance of engineered strains<\/li><li>cost of genome synthesis<\/li><\/ul><\/div><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">WHAT TO WATCH<\/p><p>Replication and viral-resistance tests; completion of the synthetic yeast genome; new design benchmarks.<\/p><\/aside><h3 class=\"nrp-h3\">Related editions<\/h3><ul class=\"nrp-chips\"><li class=\"nf-ui-chip\">GLB Global Systems<\/li><li class=\"nf-ui-chip\">GS-04 Health and One Health<\/li><li class=\"nf-ui-chip\">GS-03 Food and Agrifood Systems<\/li><li class=\"nf-ui-chip\">XT-05 Genomics and Gene Editing<\/li><li class=\"nf-ui-chip\">SR-08 Health Security, One Health and Biosecurity<\/li><li class=\"nf-ui-chip\">XT-01 Artificial Intelligence and Agentic Systems<\/li><\/ul><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">boundary<\/p><p>This chapter describes published results. It endorses no laboratory or company and forecasts no capability date.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c8-s2\" aria-labelledby=\"nx-nrp-xt-04-c8-s2-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c8-s2-h\"><span class=\"nrp-num\">8.2<\/span><span>Energy, water and feedstock for biomanufacturing<\/span><\/h2><p class=\"nrp-stand\">Fermentation and cell-free production need energy, process water and sugar or other feedstock. No source read counts them on a common basis.<\/p><div class=\"pp-cells nrp-cells-3\"><div class=\"nrp-cell\"><span class=\"pp-metric\">0<\/span><span class=\"nrp-cell-u\">figures<\/span><p>bound for energy, water and feedstock in this edition<\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">25<\/span><span class=\"nrp-cell-u\">awards<\/span><p>US planning awards for bioindustrial plants, 2024<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n24\" id=\"nx-nrp-xt-04-c8-r24\" aria-label=\"Note 24\">24<\/a><\/sup><\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">87<\/span><span class=\"nrp-cell-u\">USD million<\/span><p>US institute award over seven years<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n23\" id=\"nx-nrp-xt-04-c8-r23\" aria-label=\"Note 23\">23<\/a><\/sup><\/p><\/div><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-c8-tab2\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 8.2<\/span><span class=\"nrp-tbl-t\">State at baseline<\/span><\/caption><thead><tr><th scope=\"col\">Component<\/th><th scope=\"col\">State<\/th><th scope=\"col\">Evidence<\/th><th scope=\"col\">Status<\/th><\/tr><\/thead><tbody><tr><td>Process energy<\/td><td>not published on a common basis; no figure used<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n24\" aria-label=\"Note 24\">24<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Expert input<\/span><\/td><\/tr><tr><td>Process water<\/td><td>not published on a common basis; no figure used<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n24\" aria-label=\"Note 24\">24<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Expert input<\/span><\/td><\/tr><tr><td>Feedstock<\/td><td>demand not bound; economy-level reports not opened<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n37\" id=\"nx-nrp-xt-04-c8-r37\" aria-label=\"Note 37\">37<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Expert input<\/span><\/td><\/tr><tr><td>Siting and planning<\/td><td>US awards fund plant planning, not construction<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n24\" aria-label=\"Note 24\">24<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-split\"><div><h3 class=\"nrp-h3\">Couplings<\/h3><ul class=\"nrp-list\"><li>ENE \u2194 BIO process energy<\/li><li>WAT \u2192 BIO process water<\/li><li>FOO \u2192 BIO feedstock<\/li><\/ul><\/div><div><h3 class=\"nrp-h3\">Evidence to bind in 2027<\/h3><ul class=\"nrp-list\"><li>energy, water and feedstock per tonne of product<\/li><li>plant counts and utilisation<\/li><\/ul><\/div><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">WHAT TO WATCH<\/p><p>Life-cycle studies; plant announcements; programme follow-on awards.<\/p><\/aside><h3 class=\"nrp-h3\">Related editions<\/h3><ul class=\"nrp-chips\"><li class=\"nf-ui-chip\">GLB Global Systems<\/li><li class=\"nf-ui-chip\">GS-04 Health and One Health<\/li><li class=\"nf-ui-chip\">GS-03 Food and Agrifood Systems<\/li><li class=\"nf-ui-chip\">XT-05 Genomics and Gene Editing<\/li><li class=\"nf-ui-chip\">SR-08 Health Security, One Health and Biosecurity<\/li><li class=\"nf-ui-chip\">XT-01 Artificial Intelligence and Agentic Systems<\/li><\/ul><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">boundary<\/p><p>This chapter describes physical dependencies. It assesses no company or facility.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c8-s3\" aria-labelledby=\"nx-nrp-xt-04-c8-s3-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c8-s3-h\"><span class=\"nrp-num\">8.3<\/span><span>DNA, instruments and manufacturing capacity<\/span><\/h2><p class=\"nrp-stand\">The build base starts with synthesised DNA, instruments and reagents and ends in pilot and commercial plants. Public sources count programmes more than capacity.<\/p><div class=\"pp-cells nrp-cells-3\"><div class=\"nrp-cell\"><span class=\"pp-metric\">332.8<\/span><span class=\"nrp-cell-u\">USD million<\/span><p>Twist Bioscience revenue, nine months to 30 June 2026<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n16\" id=\"nx-nrp-xt-04-c8-r16\" aria-label=\"Note 16\">16<\/a><\/sup><\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">48<\/span><span class=\"nrp-cell-u\">%<\/span><p>share of Twist third-quarter revenue from DNA synthesis and protein solutions, derived<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n16\" aria-label=\"Note 16\">16<\/a><\/sup><\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">42<\/span><span class=\"nrp-cell-u\">USD million<\/span><p>US planning awards to September 2024<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n24\" aria-label=\"Note 24\">24<\/a><\/sup><\/p><\/div><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-c8-tab3\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 8.3<\/span><span class=\"nrp-tbl-t\">State at baseline<\/span><\/caption><thead><tr><th scope=\"col\">Component<\/th><th scope=\"col\">State<\/th><th scope=\"col\">Evidence<\/th><th scope=\"col\">Status<\/th><\/tr><\/thead><tbody><tr><td>DNA synthesis<\/td><td>one provider reports USD 56.6 million for the segment in one quarter<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n16\" aria-label=\"Note 16\">16<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>Instruments and reagents<\/td><td>dependence not documented in the sources read<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n36\" id=\"nx-nrp-xt-04-c8-r36\" aria-label=\"Note 36\">36<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Expert input<\/span><\/td><\/tr><tr><td>Institute<\/td><td>USD 87 million over seven years for a manufacturing institute<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n23\" aria-label=\"Note 23\">23<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>Plant capacity<\/td><td>not counted in the sources read<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n24\" aria-label=\"Note 24\">24<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Expert input<\/span><\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-split\"><div><h3 class=\"nrp-h3\">Couplings<\/h3><ul class=\"nrp-list\"><li>MIN \u2192 BIO reagents<\/li><li>TRD \u2192 BIO export controls<\/li><li>FIN \u2192 INF plants<\/li><\/ul><\/div><div><h3 class=\"nrp-h3\">Evidence to bind in 2027<\/h3><ul class=\"nrp-list\"><li>synthesis capacity by provider and country<\/li><li>instrument and reagent dependence<\/li><\/ul><\/div><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">WHAT TO WATCH<\/p><p>Company filings; programme awards; gene synthesis standards.<\/p><\/aside><h3 class=\"nrp-h3\">Related editions<\/h3><ul class=\"nrp-chips\"><li class=\"nf-ui-chip\">GLB Global Systems<\/li><li class=\"nf-ui-chip\">GS-04 Health and One Health<\/li><li class=\"nf-ui-chip\">GS-03 Food and Agrifood Systems<\/li><li class=\"nf-ui-chip\">XT-05 Genomics and Gene Editing<\/li><li class=\"nf-ui-chip\">SR-08 Health Security, One Health and Biosecurity<\/li><li class=\"nf-ui-chip\">XT-01 Artificial Intelligence and Agentic Systems<\/li><\/ul><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">boundary<\/p><p>This chapter describes supply dependencies in public sources. It assesses no company, state or export-control decision.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c8-s4\" aria-labelledby=\"nx-nrp-xt-04-c8-s4-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c8-s4-h\"><span class=\"nrp-num\">8.4<\/span><span>Economy, investment and workforce<\/span><\/h2><p class=\"nrp-stand\">Company results are mixed and the sector has no common investment series. Workforce numbers are the thinnest part of the evidence.<\/p><div class=\"pp-cells nrp-cells-3\"><div class=\"nrp-cell\"><span class=\"pp-metric\">170.2<\/span><span class=\"nrp-cell-u\">USD million<\/span><p>Ginkgo Bioworks revenue, 2025<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n17\" id=\"nx-nrp-xt-04-c8-r17\" aria-label=\"Note 17\">17<\/a><\/sup><\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">227.0<\/span><span class=\"nrp-cell-u\">USD million<\/span><p>Ginkgo Bioworks revenue, 2024<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n17\" aria-label=\"Note 17\">17<\/a><\/sup><\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">15<\/span><span class=\"nrp-cell-u\">USD billion<\/span><p>minimum funding recommended by a US commission<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n14\" id=\"nx-nrp-xt-04-c8-r14\" aria-label=\"Note 14\">14<\/a><\/sup><\/p><\/div><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-c8-tab4\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 8.4<\/span><span class=\"nrp-tbl-t\">State at baseline<\/span><\/caption><thead><tr><th scope=\"col\">Component<\/th><th scope=\"col\">State<\/th><th scope=\"col\">Evidence<\/th><th scope=\"col\">Status<\/th><\/tr><\/thead><tbody><tr><td>Company revenue<\/td><td>Ginkgo fell about 25% in 2025; Twist guided to USD 456 to 457 million for fiscal 2026<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n16\" aria-label=\"Note 16\">16<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n17\" aria-label=\"Note 17\">17<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>Public programmes<\/td><td>US commission recommends at least USD 15 billion over five years; a recommendation<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n14\" aria-label=\"Note 14\">14<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>Bioeconomy size<\/td><td>commentary cites over USD 210 billion of US GDP; secondary figure<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n15\" id=\"nx-nrp-xt-04-c8-r15\" aria-label=\"Note 15\">15<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>Workforce<\/td><td>skills gaps reported in policy; no figure bound<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n14\" aria-label=\"Note 14\">14<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Expert input<\/span><\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-split\"><div><h3 class=\"nrp-h3\">Couplings<\/h3><ul class=\"nrp-list\"><li>FIN \u2192 BIO scale-up<\/li><li>HLT \u2192 BIO clinical demand<\/li><li>FIN \u2192 INF plants<\/li><\/ul><\/div><div><h3 class=\"nrp-h3\">Evidence to bind in 2027<\/h3><ul class=\"nrp-list\"><li>investment on a common basis<\/li><li>workforce size and skills gaps<\/li><\/ul><\/div><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">WHAT TO WATCH<\/p><p>The next earnings releases; national strategy updates; EU second Biotech Act funding provisions.<\/p><\/aside><h3 class=\"nrp-h3\">Related editions<\/h3><ul class=\"nrp-chips\"><li class=\"nf-ui-chip\">GLB Global Systems<\/li><li class=\"nf-ui-chip\">GS-04 Health and One Health<\/li><li class=\"nf-ui-chip\">GS-03 Food and Agrifood Systems<\/li><li class=\"nf-ui-chip\">XT-05 Genomics and Gene Editing<\/li><li class=\"nf-ui-chip\">SR-08 Health Security, One Health and Biosecurity<\/li><li class=\"nf-ui-chip\">XT-01 Artificial Intelligence and Agentic Systems<\/li><\/ul><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">boundary<\/p><p>This chapter describes company and public figures as reported. It gives no investment advice and endorses no company.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c8-s5\" aria-labelledby=\"nx-nrp-xt-04-c8-s5-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c8-s5-h\"><span class=\"nrp-num\">8.5<\/span><span>Biosecurity and governance watch<\/span><\/h2><p class=\"nrp-stand\">The nearest governance test is whether screening and oversight keep pace with design tools. Frameworks exist, and their status and implementation differ by jurisdiction.<\/p><div class=\"pp-cells nrp-cells-3\"><div class=\"nrp-cell\"><span class=\"pp-metric\">49<\/span><span class=\"nrp-cell-u\">recommendations<\/span><p>US commission report, 2025<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n14\" aria-label=\"Note 14\">14<\/a><\/sup><\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">90<\/span><span class=\"nrp-cell-u\">days<\/span><p>deadline in the 2025 order for a revised screening framework<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n26\" id=\"nx-nrp-xt-04-c8-r26\" aria-label=\"Note 26\">26<\/a><\/sup><\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">2022<\/span><span class=\"nrp-cell-u\">framework<\/span><p>WHO global guidance on dual-use life sciences<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n21\" id=\"nx-nrp-xt-04-c8-r21\" aria-label=\"Note 21\">21<\/a><\/sup><\/p><\/div><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-c8-tab5\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 8.5<\/span><span class=\"nrp-tbl-t\">State at baseline<\/span><\/caption><thead><tr><th scope=\"col\">Component<\/th><th scope=\"col\">State<\/th><th scope=\"col\">Evidence<\/th><th scope=\"col\">Status<\/th><\/tr><\/thead><tbody><tr><td>Screening<\/td><td>a 2025 study found tools often missed redesigned sequences; patches helped<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n13\" id=\"nx-nrp-xt-04-c8-r13\" aria-label=\"Note 13\">13<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>US framework<\/td><td>2024 framework; 2025 order; current status unclear in sources read<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n25\" id=\"nx-nrp-xt-04-c8-r25\" aria-label=\"Note 25\">25<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n26\" aria-label=\"Note 26\">26<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n27\" id=\"nx-nrp-xt-04-c8-r27\" aria-label=\"Note 27\">27<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>EU<\/td><td>Biotech Act proposal of 16 December 2025 with biodefence measures<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n22\" id=\"nx-nrp-xt-04-c8-r22\" aria-label=\"Note 22\">22<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n28\" id=\"nx-nrp-xt-04-c8-r28\" aria-label=\"Note 28\">28<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><tr><td>Global<\/td><td>WHO guidance, CBD decisions, OECD papers, Cartagena Protocol<\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n18\" id=\"nx-nrp-xt-04-c8-r18\" aria-label=\"Note 18\">18<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n20\" id=\"nx-nrp-xt-04-c8-r20\" aria-label=\"Note 20\">20<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n21\" aria-label=\"Note 21\">21<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-c8-n35\" id=\"nx-nrp-xt-04-c8-r35\" aria-label=\"Note 35\">35<\/a><\/sup><\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-split\"><div><h3 class=\"nrp-h3\">Couplings<\/h3><ul class=\"nrp-list\"><li>DAT \u2192 BIO sequence data<\/li><li>GOV \u2192 SEC screening rules<\/li><li>GOV \u2192 TRD export controls<\/li><\/ul><\/div><div><h3 class=\"nrp-h3\">Evidence to bind in 2027<\/h3><ul class=\"nrp-list\"><li>screening coverage by provider<\/li><li>text of the current US framework<\/li><\/ul><\/div><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">WHAT TO WATCH<\/p><p>A replacement US framework; EU second act; CBD action plan for COP-17; follow-up screening studies.<\/p><\/aside><h3 class=\"nrp-h3\">Related editions<\/h3><ul class=\"nrp-chips\"><li class=\"nf-ui-chip\">GLB Global Systems<\/li><li class=\"nf-ui-chip\">GS-04 Health and One Health<\/li><li class=\"nf-ui-chip\">GS-03 Food and Agrifood Systems<\/li><li class=\"nf-ui-chip\">XT-05 Genomics and Gene Editing<\/li><li class=\"nf-ui-chip\">SR-08 Health Security, One Health and Biosecurity<\/li><li class=\"nf-ui-chip\">XT-01 Artificial Intelligence and Agentic Systems<\/li><\/ul><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">boundary<\/p><p>This chapter describes policy in public sources. It confers no certification on any product or provider and assesses no government or company.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-c8-notes\" aria-labelledby=\"nx-nrp-xt-04-c8-notes-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c8-notes-h\"><span>Notes<\/span><\/h2><p class=\"nrp-note\">Numbers are the edition&#8217;s reference numbers, so a note reads the same in every chapter. The full list, with every source and its licence, is in Annex C. <a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/references\/\">Annex C, references<\/a><\/p><ol class=\"nrp-notes\"><li id=\"nx-nrp-xt-04-c8-n2\"><span class=\"nrp-notes-n\">2<\/span><span>MRC Laboratory of Molecular Biology (ed.), Syn57 represents a new chapter in the genetic code of life (news page, 1 August 2025; over 101,000 codons recoded; 64 to 57 codons; genome of about 4 megabases built from 38 fragments of about 100 kilobases). MRC Laboratory of Molecular Biology, Cambridge. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r2\" aria-label=\"Back to the first call of note 2\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c8-n6\"><span class=\"nrp-notes-n\">6<\/span><span>Nielsen, A.A.K. et al., Genetic circuit design automation, Science 352 (6281), 2016 (record read via Europe PMC: 60 circuits; 45 correct in all output states; 92% of output states as predicted). American Association for the Advancement of Science, Washington. Observation year 2016. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r6\" aria-label=\"Back to the first call of note 6\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c8-n4\"><span class=\"nrp-notes-n\">4<\/span><span>Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions, Cell 186 (24), 5220 to 5236, 2023 (record read via Europe PMC: 6.5 synthetic chromosomes in one strain; over half of the Sc2.0 genome). Cell Press, Cambridge, Massachusetts. Observation year 2023. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r4\" aria-label=\"Back to the first call of note 4\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c8-n1\"><span class=\"nrp-notes-n\">1<\/span><span>Robertson, W.E. et al., Escherichia coli with a 57-codon genetic code, Science 390 (6771), eady4368, published 23 October 2025 (record read via PubMed, PMID 40743368; the record gives a 4 megabase synthetic genome and six replaced sense codons). American Association for the Advancement of Science, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r1\" aria-label=\"Back to the first call of note 1\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c8-n3\"><span class=\"nrp-notes-n\">3<\/span><span>Fredens, J. et al., Total synthesis of Escherichia coli with a recoded genome, Nature 569 (7757), 514 to 518, 2019 (record read via Europe PMC: 18,214 codons recoded; 61-codon genome). Springer Nature, London. Observation year 2019. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r3\" aria-label=\"Back to the first call of note 3\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c8-n43\"><span class=\"nrp-notes-n\">43<\/span><span>UNVERIFIED, not opened: Richardson, S.M. et al., Design of a synthetic yeast genome, Science 355, 1040 to 1044, 2017, cited from memory. Observation year 2017. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r43\" aria-label=\"Back to the first call of note 43\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c8-n7\"><span class=\"nrp-notes-n\">7<\/span><span>Watson, J.L. et al., De novo design of protein structure and function with RFdiffusion, Nature 620, 1089 to 1100, 2023 (record read via Europe PMC). Springer Nature, London. Observation year 2023. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r7\" aria-label=\"Back to the first call of note 7\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c8-n24\"><span class=\"nrp-notes-n\">24<\/span><span>US Manufacturing Program (ed.), Bioindustrial (programme topic page; Distributed Bioindustrial Manufacturing Program awards announced 10 July to 13 September 2024; 25 awards; USD 42 million cumulative). Manufacturing USA, Gaithersburg. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r24\" aria-label=\"Back to the first call of note 24\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c8-n23\"><span class=\"nrp-notes-n\">23<\/span><span>BioMADE (ed.), DoD approves USD 87 million for newest bioindustrial manufacturing innovation institute (news page; seven years; the page shows Oct 20 and a 2023 footer, the press release is dated 2020 in search listings). BioMADE, Saint Paul. Observation year 2020. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r23\" aria-label=\"Back to the first call of note 23\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c8-n37\"><span class=\"nrp-notes-n\">37<\/span><span>UNVERIFIED, not opened: McKinsey Global Institute (ed.), The Bio Revolution: Innovations transforming economies, societies, and our lives, May 2020, cited from memory; the fetch returned a service error and no figure is used. McKinsey and Company, New York. Observation year 2020. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r37\" aria-label=\"Back to the first call of note 37\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c8-n16\"><span class=\"nrp-notes-n\">16<\/span><span>Twist Bioscience Corporation (ed.), Form 8-K exhibit 99.1, results for the fiscal third quarter ended 30 June 2026 (company filing; revenue USD 118.4 million; nine months USD 332.8 million; fiscal 2026 guidance USD 456 to 457 million; company statements and guidance are weak evidence). US Securities and Exchange Commission, Washington. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r16\" aria-label=\"Back to the first call of note 16\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c8-n36\"><span class=\"nrp-notes-n\">36<\/span><span>UNVERIFIED, not opened: International Organization for Standardization (ed.), ISO 20688-2, requirements for the production and quality control of synthesised gene fragments, genes and genome-scale constructs, cited from memory. ISO, Geneva. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r36\" aria-label=\"Back to the first call of note 36\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c8-n17\"><span class=\"nrp-notes-n\">17<\/span><span>Ginkgo Bioworks Holdings, Inc. (ed.), Form 8-K exhibit 99.1, fourth quarter and full year 2025 results (company filing of 26 February 2026; revenue USD 170.155 million against USD 227.043 million; net loss USD 312.763 million; company statements are weak evidence). US Securities and Exchange Commission, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r17\" aria-label=\"Back to the first call of note 17\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c8-n14\"><span class=\"nrp-notes-n\">14<\/span><span>Congressional Research Service (ed.), National Security Commission on Emerging Biotechnology: Final Report and Options for Congress, CRS Insight IN12546, 17 April 2025 (report of 8 April 2025; 49 recommendations; at least USD 15 billion over five years; National Biotechnology Coordination Office). Library of Congress, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r14\" aria-label=\"Back to the first call of note 14\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c8-n15\"><span class=\"nrp-notes-n\">15<\/span><span>Federation of American Scientists (ed.), Translating Vision into Action: FAS commentary on the NSCEB final report (commentary page; six pillars; cites over USD 210 billion of US GDP and over 640,000 jobs for the bioeconomy; secondary and advocacy-leaning source). Federation of American Scientists, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r15\" aria-label=\"Back to the first call of note 15\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c8-n26\"><span class=\"nrp-notes-n\">26<\/span><span>UNVERIFIED, not opened: Executive Order 14292, Improving the Safety and Security of Biological Research, 5 May 2025 (90 days to revise or replace the framework), taken from search-result summaries; a fetch of an explainer page was refused by the fetch tool. The White House, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r26\" aria-label=\"Back to the first call of note 26\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c8-n21\"><span class=\"nrp-notes-n\">21<\/span><span>World Health Organization (ed.), Global guidance framework for the responsible use of the life sciences: mitigating biorisks and governing <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-c1\" data-tc=\"NRS-C1 dual-use-research\" data-tk=\"Nexus risk vocabulary\" data-td=\"Legitimate research whose knowledge, methods or products could also be misused to cause serious harm.\" data-ts=\"NRS-C1\" data-tr=\"draft\">dual-use research<\/a> (publication page, 13 September 2022). WHO, Geneva. Observation year 2022. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r21\" aria-label=\"Back to the first call of note 21\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c8-n13\"><span class=\"nrp-notes-n\">13<\/span><span>Strengthening nucleic acid biosecurity screening against generative protein design tools, Science 390 (6768), 82 to 87, 2025 (record read via Europe PMC; abstract only; no method detail used). American Association for the Advancement of Science, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r13\" aria-label=\"Back to the first call of note 13\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c8-n25\"><span class=\"nrp-notes-n\">25<\/span><span>UNVERIFIED, not opened: Office of Science and Technology Policy (ed.), Framework for Nucleic Acid Synthesis Screening, April 2024, taken from search-result summaries; a fetch of the page was refused by the fetch tool. OSTP, Washington. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r25\" aria-label=\"Back to the first call of note 25\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c8-n27\"><span class=\"nrp-notes-n\">27<\/span><span>UNVERIFIED, not opened: Congressional Research Service (ed.), report on artificial intelligence and biosecurity risks (reported in July 2026 as unable to determine whether the 2024 framework or the 2025 policy had been revised), taken from a trade news summary. Library of Congress, Washington. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r27\" aria-label=\"Back to the first call of note 27\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c8-n22\"><span class=\"nrp-notes-n\">22<\/span><span>Baker McKenzie (ed.), EU Biotech Act unveiled: Commission proposal to turn Europe into a biotech powerhouse (law firm summary, 19 December 2025; proposal of 16 December 2025; health focus; investment pilot with the European Investment Bank Group; 12-month certificate extension; biodefence measures; second act expected in Q3 2026). Secondary source, not the Commission text. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r22\" aria-label=\"Back to the first call of note 22\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c8-n28\"><span class=\"nrp-notes-n\">28<\/span><span>UNVERIFIED, not opened: European Commission (ed.), Proposal for a Biotech Act, COM(2025) 1022, 16 December 2025, taken from law firm and regulator summaries; the Commission page was not retrieved. European Commission, Brussels. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r28\" aria-label=\"Back to the first call of note 28\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c8-n18\"><span class=\"nrp-notes-n\">18<\/span><span>OECD (ed.), Anticipatory governance for responsible innovation in synthetic biology, OECD Science, Technology and Industry Policy Papers No. 193, 21 May 2026 (record read via a bibliographic database; abstract only). OECD Publishing, Paris. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r18\" aria-label=\"Back to the first call of note 18\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c8-n20\"><span class=\"nrp-notes-n\">20<\/span><span>Secretariat of the Convention on Biological Diversity (ed.), Synthetic biology (programme page; decisions X\/13 to 16\/21; AHTEG; <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-c1\" data-tc=\"NRS-C1 horizon-scanning\" data-tk=\"Nexus risk vocabulary\" data-td=\"Systematic searching for early signs of potentially important developments, threats and opportunities at the margins of current thinking.\" data-ts=\"NRS-C1\" data-tr=\"draft\" data-tg=\"https:\/\/globalriskforum.com\/glossary\/horizon-scanning\/\" data-tgl=\"Global Risks Forum glossary\">horizon scanning<\/a>; thematic action plan). CBD Secretariat, Montreal. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r20\" aria-label=\"Back to the first call of note 20\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-c8-n35\"><span class=\"nrp-notes-n\">35<\/span><span>UNVERIFIED, not opened: Cartagena Protocol on Biosafety to the Convention on Biological Diversity, 2000, cited from memory. CBD Secretariat, Montreal. Observation year 2000. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-c8-r35\" aria-label=\"Back to the first call of note 35\">back<\/a><\/span><\/li><\/ol><\/section><section class=\"nrp-block nrp-noprint\" id=\"nx-nrp-xt-04-c8-cite\" aria-labelledby=\"nx-nrp-xt-04-c8-cite-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-c8-cite-h\"><span>Cite this chapter<\/span><\/h2><pre class=\"nrp-pre\">Valadbaygi, S. (Ed.). (2026). Chapter 8: Systems in depth. In Exponential Technology Report 2026: Synthetic Biology and Bioengineering (Baseline Edition 2026, Report No. NR-XTECH-SYNBIO-GLOBAL-2026-BASELINE) [Draft under review]. The Global Centre for Risk and Innovation (GCRI).<\/pre><p class=\"nrp-note\">Every citation form of the whole report, BibTeX and RIS included, is on the edition home. <a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/#nx-nrp-xt-04-land-cite\">Cite this report<\/a><\/p><\/section><nav class=\"nrp-pager\" aria-label=\"Previous and next\"><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/agenda\/\" rel=\"prev\"><span class=\"nf-ui-eyebrow\">Previous \u00b7 Chapter 7<\/span><span class=\"nrp-pager-t\">The 2027 agenda<\/span><\/a><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/methodology\/\" rel=\"next\"><span class=\"nf-ui-eyebrow\">Next \u00b7 Annex A<\/span><span class=\"nrp-pager-t\">Methodology<\/span><\/a><\/nav><\/article><\/div><\/div><\/div><div class=\"nrp-noprint\"><section id=\"nx-sec-nr-gateway\" class=\"nx-section\" data-hue=\"systemic\" data-tone=\"alt\" aria-labelledby=\"nx-nr-gateway-h\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">Reports<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Contribute<\/span><\/div><h2 id=\"nx-nr-gateway-h\" class=\"nx-section-title\">Send evidence or a correction on Synthetic Biology and Bioengineering.<\/h2><p class=\"nx-lede\"><a class=\"nx-link\" href=\"https:\/\/docs.therisk.global\/organization\/programme\/reports\">Reports<\/a> is the Consortium&#8217;s quarterly publication, written by six desks. This page sits with the Global Centre for Risk and Innovation (GCRI) <a class=\"nx-link nx-term\" href=\"https:\/\/docs.therisk.global\/organization\/systems\" data-tc=\"Systems\" data-tk=\"Nexus Standards\" data-td=\"The twenty Nexus systems, NXS-CMD to NXS-LAB\">Systems<\/a> Evidence desk. What you know about this subject can become evidence, a case or a correction in the next edition, credited to you and published under CC BY 4.0 where it is your own work. Sent to the wrong desk, it is forwarded, not refused.<\/p><div class=\"nx-chips\"><span class=\"nx-chip\">GCRI Systems Evidence desk<\/span><span class=\"nx-chip\">Exponential Technology<\/span><\/div><\/div><div class=\"nx-section-body\"><ul class=\"nx-dest\"><li><a class=\"nx-dest-card\" href=\"https:\/\/therisk.global\/nexus-reports\/write-to-us\/contact\/\"><span class=\"nx-dest-top\"><span class=\"nx-dest-rel\">Email<\/span><span class=\"nx-dest-host\">Gateway GW-GCRI<\/span><\/span><span class=\"nx-dest-title\">Send it from this page<\/span><span class=\"nx-dest-why\">Evidence, a correction, a case, a method, a review, a translation or profile input. It arrives tagged with this page, so the editor who owns it receives it.<\/span><span class=\"nx-dest-go\" aria-hidden=\"true\"><svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/span><\/a><\/li><li><a class=\"nx-dest-card\" href=\"https:\/\/therisk.global\/nexus-reports\/open-science\/#nx-sec-zenodo\"><span class=\"nx-dest-top\"><span class=\"nx-dest-rel\">Zenodo<\/span><span class=\"nx-dest-host\">Open deposit<\/span><\/span><span class=\"nx-dest-title\">Deposit it and submit to the community<\/span><span class=\"nx-dest-why\">Publish your own record on Zenodo with your ORCID iD, then submit it to the Reports community there. 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A contribution is reviewed before use; sending it confers no authorship or editorial rights, and sponsorship never buys a finding.<\/p><\/div><\/div><\/section><\/div><p class=\"nx-note\" data-nr-rights=\"true\"><a class=\"nx-link\" rel=\"license\" href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY 4.0<\/a> Free to read. Text and figures: CC BY 4.0. Data: CC0 1.0. Authors keep copyright. Published by GCRI Canada.<\/p><section class=\"nx-section nx-deeper-band\" aria-labelledby=\"nx-deeper-al-nexus-reports-editions-xt-04-systems-in-depth-h\"><div class=\"nx-container\"><nav class=\"nx-deeper\" aria-labelledby=\"nx-deeper-al-nexus-reports-editions-xt-04-systems-in-depth-h\" data-nx-deeper=\"3\" data-nx-resources=\"1 1 1\"><h2 class=\"nx-deeper-h\" id=\"nx-deeper-al-nexus-reports-editions-xt-04-systems-in-depth-h\">Go deeper<\/h2><ul><li><a href=\"https:\/\/docs.therisk.global\/organization\/model\/scenarios\/urban-flood\" data-ext><span class=\"nx-deeper-k\">Documentation:<\/span> Urban flood<span class=\"nx-deeper-x\" aria-hidden=\"true\">\u2197<\/span><span class=\"nx-deeper-sr\"> (opens another site)<\/span><\/a><\/li><li><a href=\"https:\/\/risksacademy.com\/risk-science\/risk-information-standards\/\" data-ext><span class=\"nx-deeper-k\">Academy:<\/span> Risk information standards and interoperability<span class=\"nx-deeper-x\" aria-hidden=\"true\">\u2197<\/span><span class=\"nx-deeper-sr\"> (opens another site)<\/span><\/a><\/li><li><a href=\"https:\/\/nexustandards.com\/data\/identification-standards\/\" data-ext><span class=\"nx-deeper-k\">Standards:<\/span> Identification (the UNI)<span class=\"nx-deeper-x\" aria-hidden=\"true\">\u2197<\/span><span class=\"nx-deeper-sr\"> (opens another site)<\/span><\/a><\/li><\/ul><\/nav><\/div><\/section><\/div><\/div><script class=\"_iub_cs_skip\">window.__nxMount ? window.__nxMount(document.currentScript) : null;<\/script><style>@media print { @page { margin: 20mm 17mm 20mm 17mm; @top-left { content: \"Nexus Reports\"; font: 500 7.5pt \"IBM Plex Mono\", monospace; color: #4a4a4a; } @top-right { content: \"Synthetic Biology and Bioengineering 2026 \\0000b7  Chapter 8\"; font: 400 7.5pt \"IBM Plex Sans\", sans-serif; color: #4a4a4a; } @bottom-left { content: \"NR-XTECH-SYNBIO-GLOBAL-2026-BASELINE \\0000b7  Draft, not released\"; font: 400 7pt \"IBM Plex Mono\", monospace; color: #4a4a4a; } @bottom-center { content: \"CC BY 4.0. 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