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3f8CIwreJoKRwHHRNXfc3DNWM71mKy3t5exrop26P5rHHY0mUqm1lVsbKWnnDQTlzxbGV59ZITZ8usdKDHBDQ2iK9F6vfUB0grpmGa91nasCvrC6\/WM5U8ZNsoPOE9M9PzwMr016N2kvY8ZRIAMURhHkVJtB4N1b2Bpu5pnaPicwDWxQ6W04JQ8TcOCpylEWZXqobIrxvvIA0g+9sasM6amltxQL1HJloG6A0S61Ub664U1cqXwJeQqFLw6oWZiOVL1dQX6EzeKferZKHeDeaIhnycb4A2x0HQsQCeYK1i4SkVrsGZl5S4CmlJcX39kfiyGmG6vNsWrwsoV0aS2zbZITV5hLyeNQJXk6oO4qPcEy6krNhbUDDnmsRSf+mf26wvePVfpj1F0ydqrPjgZcyx0Air4vlAmKn3EciYw3pqRbDuy154olvl5p64Tw2oXgVZxmjxWvQwbHYLisLJtn3Z1erc4TLEyQPLFDlfa9IoRQIRBxn3s3hz5EO6cIdL7SnhflkOSfmtg+STpJ7mDuwBNOvFH7Df6mCEHQoizA88oPitjjNQx26tuy9\/RlhBtotD8wCEuvYFBJYNXo7yH586+EGrAtsMHdMjMBGTmW1EP0pYu4h5mVmEjzY+b7cqJzPrmvGFWDaTX7swykGP8f9RDvrZ1aGXbyap2g\/+XkUhOyp5NR3LVU4mA6OdFUZE6ZSjHSHUKJkuqSKXu88WBlUhpFe8CYDRj1THd3C+ZeiJ6hQOxp\/OneL0GSvZhWzbU0RwtIapaJ1YRNV\/GmKqhngj13dv7gFeP1PxQkVqBn5UzWhs3PVbGkFwJegEx8Bfs6CxjxC94FLxZBY4KzlU12fwmw21399wcOVPJSIycKQTrJU\/XCfyUGcdG4CPAUruHEUp2w69ttsTJZJAYgfLtyFdgGHF5pD8aFCTRTWXUZmkMLguEcAgpH7arz8FKV0g1IaIZaI\/acyeYUakBLvrOgNvJAwxRDhfCCL7lXrLflPb6K0n63wbWe7K3WK\/Nr1VH5ZtSiyuXoAU+brZ7e\/P1urL8yJlyNmguU0F8zQL+3neFy\/RDo7GR4edOQVB5aJgPhJB2DwlbVUf8BTvhRuAkWnEQuKSJrCXOfGZj0urGeVRODLMN+\/FzwuAUeMFgVju77pzMCSEL8AhbZDAGeD\/kvT6IXh8q4y7jhFuOkGXOe7zM04DE5QBNnrQCWEjzjPYv2EATI2+fCIGFDRjQMQ0949gA67xUpQ8so+YTG2SCeeV2Hvk08KQOXiGH9Xqb3y\/kF3JMRTmfZ\/EBdWKdV7i0S2SrsSSt7vJorlZjqXZ8rKVw2BOOfXgFisj+cvAjhqHsOMy4dM+9zJo8C0mMV7yxCoWl50\/zFFhcyOUlq82BUFhzBOcBTLkGZJGFJi8GVfaWAKwt\/OOu7adA0JO+V3Q78Em1BlFpolCCcb4J8wEKCxktWMjotqu7NJZIzx\/c5UWyMONWt6JKccy8QJWFCW0dEdHY06d+BlF1s1L46aa2+ragMONrMcujPxlN0HqdvTAgHrcq7HOrUz2SfZS1Wz1dsaPhVFR9p0ni+GEzGo3EuZzj2iwehbIq4UdaKVJn5fJUboUTRwsnjm\/Q5aB2\/HT7oBQXe76F9TaF\/Eqzmt3aTfLdSgiJezzXmLTDxrjrmNVRDyoC3BFFsqVIi9l7cqLVVUZKnkDPfNH\/2xv0\/\/Yse\/DPF7ha5wGB3kLJIceT5K6ulvBwFTWzVF8OLrThEzNRFmcb4X57IPCTig7h\/EmS+\/BaCAJiZfT+jGhOvNL1RmLXzJFXvG4ofkHZnovYO4b4R8FcPNgsOveX1INUFULY+ka+5bP6+63ZI+bf3urlBjfM3t7fHsYwUSvP7fFNc56AhiFslCj8vCQPMjwyszm1LfOhucQvIKasK1iZdpN\/jaOF2W5+s15C\/IfOXswasen88ytuzHm6zKM2ALUqVGkhz0CxOlcW1xTnNwJUpyAS5ClOInAW8cOxpLEPsZ+KXyxxXCp+cioqfk4pS3xXVHYhl\/ogew9pXES+xd6OQDNdNL2nzwg3Y3m4WVV2JC6P9+l2tFmmcc\/zJ0lhrluJRPw8DaRQWVQgBz5jQBAppMDd3FMtoXDIZRk2SWg6iQKvYx+81nIEfwAR5QM7mmaj\/8BFlHuaxbNNWf8D20oV\/B4qvtcrvucVp6z\/ng2emIimk\/bC3bxXMYxaoo8nUpAIbPGcyHWeqWR3+i+sgqRE6PIKOJwO1LPk1ug4m10ZTHyBBwSWoaBTyvWwOXaYAacPZT6S93oB0GDKjG\/C8+ijbtLGK\/XxquBh1LL09433tVn1uNvSx92fD17p6zWHgYJgApqlXConXFrZew9qI21ErYzcfSSt7sec3f+Y5T74CJtF2U3fgwzwcWADkKsInaT++YnQ69dl4S\/XmZlZH4p6Z31WWyZVE6X+6m8wUOX164Jk3kNfQxzv4QzlQHmfAeW9DhSoMYd6eVSqgGi23pA\/02rhxsErK5DeLydk20ugUUyceEyel8zxoFuIq83He6sO2w0JIbBWwWVHDkfYJTdH5CNE3RYqZVrMk97N0fbQ\/2kfKgxdrriZmwHDG11a0WijjLMHoYVbqXcG3WpyrWpKSo13TBz\/xTNUTIst1dGTodUL\/Kwc9A\/1dGmh4\/h+y2oPNCwv9BlhQZ\/xkCH4sP8tX7sKYbWYEXC91ssLzCcH\/pHPpjjkr3zIxS8Axa9Z91W5crkYyzREiDcLaVd5qFbBMTClZw5vU4cl\/lIXcL8DvfrOjh4yUvGd06ufqPlA+9+BwPEECLu4koqsYUNodsiO3mVkcMhk5rB3rD9kIneY\/CnuxXnO+EH3nSp6Nwszszo\/RJe3N5JZxxlr2m7lY\/oEY\/rEjk6zqX5i6qR+YeSU9j+xQdUQEsk\/cZ2yPssFtLhgR1+yWS6yFq8o+cL6C1YpCIumBOdyRXtX9GiWmWJkLd3BVWb1qFey7kihrMb6Gcb6mR19y2b\/mY\/VC81vtP9ZLcMjIygEd2WbTofUA5P8lGqqQzf3aahOMa\/GRJuTCLLSWVRnS8DbMMxZwlBBKyGsHw60e3nWa3iRWXErj4LgQKhkQCAfQSexwiXlnMf2PQV3XJ1VuC5hC79XCKscABZT+bgoZK3j1wBAigtrBDPiM2M\/mETdheCwZupC+x3Dc5IHrEwU0N6vjIh8tVoeWS1uzQATlijQC1kvZCr1eg9BU6iDAm7myf7qKaa5v8Ov4BUORMBlWLQp\/b2uZQbsOih16zgKCSqKa0vANUkAS+jX5de8DGee97hEagShlg1VsBEm94Dgc+qJuYhWOvyd+I0L9RzPK1TKy3X0Bupt+UM5UJF5sXIuqohFi3cGQLJWoa\/IBoALH0vjlPNv8jEK+OEuJ\/l1tSRUqipqTNVXvsR8x8tVhYNbOoa0cAwpHMBwSXceAukyz8vCgauzd0D5JovG44AamY5uR7INnmtjp4oRClSslVgo7jZZVvHwbV68HuWpxH2A+DpysiuPMscPOuJuL7bZZCn5fIUCEpnqnl+bmZ1\/SE8V3LIoccbco+SS0an5mCEQOMIysTpoj\/kpEGe0Jx7EthW\/RcZtPd216pNTtOqE+jr0Ja38rXBZ1x3\/dDuJFqFIZZQps\/d+Y3hVtjzL9O7C8rwL60uUtvABEyWWYbvBsLn1Uu5c8YYvoGXYsS\/3MjzLbwgXDKQqXQ\/kq0oiiA18BBf7NA4ciFbiEbgW8qdxlDCHSxmCpF3S2ttQ+IJzBo4minBOsntVMqh86l1m2cY\/FZw7P\/3omLqfsqXf+9Tb+4319i5pMZ85jPlfNXclTGgSGcdchSNNwqDGgastqhhUl4Z099emD6nIasskzpR3CUqKmjK0PBgA2L8YXv2LVd2tpV+jZW0Ff+kbtz4C7CSOqZM4oUuNaCSC0mJnDFFcMk64IioYtpU6Z4aOWrLo6Sv4lkfuPtkWP6bVTb1zkocfaIkf8uqWbvldRFpbMkQN9tG\/2NOHn4shn3q\/sZrtm23GT6V7VTMEQbLbPSZhWYz8k+282UPS2L0Sf1F3GEvog\/v1lt41p9HQD2ju3gv26xqxOmelEhL2wizzuQg8OGoftHpb7uq0mLBuBMpotJ31vCv8Yyv5ReB6m7DxQbMCPfGMsRVYogkMkV6aqy1c6gemjJJotA9F6ECmSK7JRpU3gjebP5+VAP1PVsiH\/yez2q9BBw7rpW8E2E1vE98b0+IGyd\/LyKPMmW7bGJJT1SafaJWbhyC2PfXD5kRX+etwZkrSSI6ZNfYuf+bHSDD4VZQ4zSgxRG5l95ptvoKD0kbcr\/SpN1FyWPGgKC3MJ+0Eia3w6b98Y4M46P0MPZSi5LSTBOaiWo6o+wwwhAoMiQBDqCjmTzvP809yOiNWryirzvzqCZOl4lfVlWh7I3C6LjC8BVpIanhh6\/cfG0HG13MSpd22IPZmNPE5JdS\/LOKm\/hGPGNE\/c45FiHBgNi5IXtme+Z1lu3W9Fg+iBLT2O8vKVfYrmaU4qei9QgSoG0Nl20BqQuY7PBNpqW3Fj5UBogldpb74zjlhJIFMQ\/xL96ddEvUJw907ap5IoeKv+qs3dksTZ6DYOGNHf2VahTNQbPzF+mdst0whi+ySKk62xIoyhryIUnYXxfUX+NXxmKXra7S2BMrhimW4SMa6h4hNRrXI7XlI9MuamXZ3UZfX6T6povnHIna8qR8OncQy4FwZx8Y\/81\/bT+KNmIdl9Pkp\/CcRzxDX63vZk7Y6u29IESK47ryv1EYCr4f6ZWq3px8vP9yhqi\/8jmOsTIiS6NfdihXmRJ4T8pzSi6YT7V4vfCsV3KDR5e1+pDros1WB1LD5ZUH37Bio6TyUvsTsWZGYFtV87YSIflulKrvlurI6Z1V+B51gdtg\/7dc9Hq9\/RF61esov9ZhmP48ODlvb\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Not indexed until the first approved release.<\/p><div class=\"nrp-reader\"><nav class=\"nrp-rail\" aria-label=\"Contents of Synthetic Biology and Bioengineering 2026\"><p class=\"nf-ui-eyebrow\">Contents<\/p><ol class=\"nrp-toc\"><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Edition home<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/summary\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Executive summary<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/coupled-system\/\"><span class=\"nrp-toc-n\">1<\/span><span>Synthetic biology is a build capability and a governance test<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/findings\/\"><span class=\"nrp-toc-n\">2<\/span><span>Key findings<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-and-sectors\/\"><span class=\"nrp-toc-n\">3<\/span><span>Systems and sectors at baseline<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/risk-and-capability\/\"><span class=\"nrp-toc-n\">4<\/span><span>Risks and capability<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/scenario\/\"><span class=\"nrp-toc-n\">5<\/span><span>Design capability outpaces screening and oversight<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/lenses-and-readings\/\"><span class=\"nrp-toc-n\">6<\/span><span>Readings from the other desks<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/agenda\/\"><span class=\"nrp-toc-n\">7<\/span><span>The 2027 agenda<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-in-depth\/\"><span class=\"nrp-toc-n\">8<\/span><span>Systems in depth<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/methodology\/\" aria-current=\"page\"><span class=\"nrp-toc-n\">A<\/span><span>Methodology<\/span><\/a><ol class=\"nrp-toc-sub\"><li><a href=\"#nx-nrp-xt-04-ca-s1\">A.1 Methods<\/a><\/li><li><a href=\"#nx-nrp-xt-04-ca-s2\">A.2 Model card, Synthetic biology System Model v0<\/a><\/li><li><a href=\"#nx-nrp-xt-04-ca-s3\">A.3 The baseline evidence cut<\/a><\/li><li><a href=\"#nx-nrp-xt-04-ca-s4\">A.4 Evidence age and coverage<\/a><\/li><li><a href=\"#nx-nrp-xt-04-ca-s5\">A.5 Evidence cards, two anchor sources<\/a><\/li><li><a href=\"#nx-nrp-xt-04-ca-s6\">A.6 Publication acceptance record<\/a><\/li><li><a href=\"#nx-nrp-xt-04-ca-s7\">A.7 Status words<\/a><\/li><li><a href=\"#nx-nrp-xt-04-ca-s8\">A.8 How the edition is made, released and corrected<\/a><\/li><li><a href=\"#nx-nrp-xt-04-ca-s9\">A.9 Glossary and abbreviations<\/a><\/li><li><a href=\"#nx-nrp-xt-04-ca-s10\">A.10 Technical annex<\/a><\/li><\/ol><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/data\/\"><span class=\"nrp-toc-n\">B<\/span><span>Data appendix<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/references\/\"><span class=\"nrp-toc-n\">C<\/span><span>References and record<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/full\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Complete edition, for print<\/span><\/a><\/li><\/ol><div class=\"nrp-actions\"><a class=\"nf-ui-btn\" data-variant=\"secondary\" href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/full\/\"><svg class=\"nrp-i\" viewBox=\"0 0 24 24\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2\"\/><path d=\"M6 9V3a1 1 0 0 1 1-1h10a1 1 0 0 1 1 1v6\"\/><rect x=\"6\" y=\"14\" width=\"12\" height=\"8\" rx=\"1\"\/><\/svg>Print or save as PDF<\/a><\/div><\/nav><article class=\"nrp-flow\" aria-labelledby=\"nx-nrp-xt-04-ca-top\"><header class=\"nrp-chap-head\" id=\"nx-nrp-xt-04-ca-top\"><ul class=\"nrp-eyerow\"><li class=\"nf-ui-eyebrow\"><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/\">Synthetic Biology and Bioengineering 2026<\/a><\/li><li class=\"nf-ui-eyebrow\">Annex A<\/li><\/ul><span class=\"nrp-rule\" aria-hidden=\"true\"><\/span><h1 class=\"pp-hero-title\">Methodology<\/h1><p class=\"nrp-lede\">How the edition was made: methods, the model card, the evidence cut and its age, the acceptance record and the glossary.<\/p><p class=\"nrp-chap-meta\"><span>14 min read<\/span><span>0 figures<\/span><span>13 tables<\/span><span>17 notes<\/span><span>NR-XTECH-SYNBIO-GLOBAL-2026-BASELINE<\/span><\/p><details class=\"nrp-toc-m\"><summary>Contents<\/summary><ol class=\"nrp-toc\"><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Edition home<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/summary\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Executive summary<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/coupled-system\/\"><span class=\"nrp-toc-n\">1<\/span><span>Synthetic biology is a build capability and a governance test<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/findings\/\"><span class=\"nrp-toc-n\">2<\/span><span>Key findings<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-and-sectors\/\"><span class=\"nrp-toc-n\">3<\/span><span>Systems and sectors at baseline<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/risk-and-capability\/\"><span class=\"nrp-toc-n\">4<\/span><span>Risks and capability<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/scenario\/\"><span class=\"nrp-toc-n\">5<\/span><span>Design capability outpaces screening and oversight<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/lenses-and-readings\/\"><span class=\"nrp-toc-n\">6<\/span><span>Readings from the other desks<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/agenda\/\"><span class=\"nrp-toc-n\">7<\/span><span>The 2027 agenda<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-in-depth\/\"><span class=\"nrp-toc-n\">8<\/span><span>Systems in depth<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/methodology\/\" aria-current=\"page\"><span class=\"nrp-toc-n\">A<\/span><span>Methodology<\/span><\/a><ol class=\"nrp-toc-sub\"><li><a href=\"#nx-nrp-xt-04-ca-s1\">A.1 Methods<\/a><\/li><li><a href=\"#nx-nrp-xt-04-ca-s2\">A.2 Model card, Synthetic biology System Model v0<\/a><\/li><li><a href=\"#nx-nrp-xt-04-ca-s3\">A.3 The baseline evidence cut<\/a><\/li><li><a href=\"#nx-nrp-xt-04-ca-s4\">A.4 Evidence age and coverage<\/a><\/li><li><a href=\"#nx-nrp-xt-04-ca-s5\">A.5 Evidence cards, two anchor sources<\/a><\/li><li><a href=\"#nx-nrp-xt-04-ca-s6\">A.6 Publication acceptance record<\/a><\/li><li><a href=\"#nx-nrp-xt-04-ca-s7\">A.7 Status words<\/a><\/li><li><a href=\"#nx-nrp-xt-04-ca-s8\">A.8 How the edition is made, released and corrected<\/a><\/li><li><a href=\"#nx-nrp-xt-04-ca-s9\">A.9 Glossary and abbreviations<\/a><\/li><li><a href=\"#nx-nrp-xt-04-ca-s10\">A.10 Technical annex<\/a><\/li><\/ol><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/data\/\"><span class=\"nrp-toc-n\">B<\/span><span>Data appendix<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/references\/\"><span class=\"nrp-toc-n\">C<\/span><span>References and record<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/full\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Complete edition, for print<\/span><\/a><\/li><\/ol><\/details><\/header><section class=\"nrp-block\" id=\"nx-nrp-xt-04-ca-s1\" aria-labelledby=\"nx-nrp-xt-04-ca-s1-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-ca-s1-h\"><span class=\"nrp-num\">A.1<\/span><span>Methods<\/span><\/h2><p class=\"nrp-stand\">The global baseline uses published values and four simple derivations. Each is shown in full so that any reader can reproduce it.<\/p><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-ca-tab1\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.1<\/span><span class=\"nrp-tbl-t\">Methods<\/span><\/caption><thead><tr><th scope=\"col\">No.<\/th><th scope=\"col\">Derivation<\/th><th scope=\"col\">Calculation<\/th><th scope=\"col\">Result<\/th><\/tr><\/thead><tbody><tr><td>(1)<\/td><td>Fall in codons from the standard code to Syn57<\/td><td>64 minus 57<\/td><td>7 codons<\/td><\/tr><tr><td>(2)<\/td><td>Growth in recoded codons, Syn57 against Syn61 (lower bound)<\/td><td>101,000 \u00f7 18,214<\/td><td>about 5.5 times<\/td><\/tr><tr><td>(3)<\/td><td>Change in Ginkgo Bioworks revenue, 2024 to 2025<\/td><td>(170.155 minus 227.043) \u00f7 227.043<\/td><td>about minus 25%<\/td><\/tr><tr><td>(4)<\/td><td>Share of Twist Bioscience third-quarter revenue from DNA synthesis and protein solutions<\/td><td>56.6 \u00f7 118.4<\/td><td>about 48%<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-ca-tab2\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.2<\/span><span class=\"nrp-tbl-t\">Coupling strength scale (matrix and model card)<\/span><\/caption><thead><tr><th scope=\"col\">Strength<\/th><th scope=\"col\">Definition<\/th><\/tr><\/thead><tbody><tr><td>STRONG<\/td><td>a disruption in the source system has historically changed the target system\u2019s service or output within one season, in more than one region<\/td><\/tr><tr><td>MODERATE<\/td><td>an effect is documented but buffered or slower<\/td><\/tr><tr><td>WEAK<\/td><td>an effect is plausible but not documented at global scale<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-ca-tab3\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.3<\/span><span class=\"nrp-tbl-t\">Status grammar<\/span><\/caption><thead><tr><th scope=\"col\">Label<\/th><th scope=\"col\">Rule<\/th><\/tr><\/thead><tbody><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><td>value as issued by its source, with year<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Inferred<\/span><\/td><td>reasoned from cited evidence; never a measurement<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Estimated<\/span><\/td><td>Nexus analytical value with stated method<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"caution\" aria-hidden=\"true\"><\/span>Scenario<\/span><\/td><td>conditional on stated assumptions<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Expert input<\/span><\/td><td>structured editorial judgement awaiting evidence<\/td><\/tr><\/tbody><\/table><\/div><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-ca-s2\" aria-labelledby=\"nx-nrp-xt-04-ca-s2-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-ca-s2-h\"><span class=\"nrp-num\">A.2<\/span><span>Model card, Synthetic biology System Model v0<\/span><\/h2><dl class=\"nrp-dl\"><dt>Model ID<\/dt><dd>MDL-XT04-SYNBIO \u00b7 v0.1<\/dd><dt>Purpose<\/dt><dd>represent synthetic biology as a build capability and manufacturing base coupled to health, food, energy, feedstock, finance, workforce and biosecurity<\/dd><dt>Family<\/dt><dd>graph-based system of <a class=\"nx-link nx-term\" href=\"https:\/\/docs.therisk.global\/organization\/systems\" data-tc=\"Systems\" data-tk=\"Nexus Standards\" data-td=\"The twenty Nexus systems, NXS-CMD to NXS-LAB\">systems<\/a><\/dd><dt>Inputs<\/dt><dd>the cited sources of this edition; no proprietary data<\/dd><dt>Method<\/dt><dd>expert-specified coupling strengths (STRONG \u00b7 MODERATE \u00b7 WEAK) from assessments and analogue events<\/dd><dt>Validation<\/dt><dd>none yet, first validation against federation evidence in 2027<\/dd><dt>Uncertainty<\/dt><dd>qualitative; strengths are hypotheses, not measurements<\/dd><dt>Domain of validity<\/dt><dd>global scale; not for asset-, site- or country-level use<\/dd><dt>Reproducibility<\/dt><dd>strength table and sources published in this edition<\/dd><\/dl><div class=\"pp-cells nrp-cells-3\"><div class=\"nrp-cell\"><span class=\"pp-metric\">20<\/span><span class=\"nrp-cell-u\">couplings<\/span><p>typed in v0<\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">0<\/span><span class=\"nrp-cell-u\">strong<\/span><p>documented within one season<\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">1<\/span><span class=\"nrp-cell-u\">moderate<\/span><p>documented, buffered<\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">19<\/span><span class=\"nrp-cell-u\">weak<\/span><p>plausible, undocumented<\/p><\/div><\/div><div class=\"nrp-split\"><div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">SUITABLE FOR<\/p><p>framing the 2027 agenda; choosing which couplings to measure first; explaining the three readings of synthetic biology as capability, manufacturing base and governance test.<\/p><\/aside><\/div><div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">NOT SUITABLE FOR<\/p><p>quantitative loss estimates, country comparisons or rankings, operational decisions, or any claim about a specific asset.<\/p><\/aside><\/div><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">VERSIONING<\/p><p>Models are immutable by version. A change to any coupling, rule or weight produces v0.2 with its own card and correction note.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-ca-s3\" aria-labelledby=\"nx-nrp-xt-04-ca-s3-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-ca-s3-h\"><span class=\"nrp-num\">A.3<\/span><span>The baseline evidence cut<\/span><\/h2><p class=\"nrp-stand\">Every Nexus edition is published from a frozen evidence cut. The global baseline cut is documentary: it pins the exact edition of every source cited. Federation cuts begin with the first national Foundry cuts in 2027.<\/p><dl class=\"nrp-dl\"><dt>Cut ID<\/dt><dd>DC-XTECH-SYNBIO-GLOBAL-2026-B0<\/dd><dt>Type<\/dt><dd>baseline documentary cut<\/dd><dt>Resolution policy<\/dt><dd>pinned \u00b7 as of 30 September 2026<\/dd><dt>Sources pinned<\/dt><dd>44 cited sources, each at the edition and access date in the references<\/dd><dt>Model runs<\/dt><dd>none at baseline, analytical values are stated with their method<\/dd><dt>Digest<\/dt><dd>computed at <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-h5\" data-tc=\"NHS-1 atmo.thermal.hard-freeze\" data-tk=\"Atmosphere and weather \u00b7 Thermal extremes\" data-td=\"Air temperature falling well below freezing for hours, killing crops, bursting pipes and stopping water flow.\" data-ts=\"NRS-H5\" data-tr=\"draft\" data-tx=\"https:\/\/risksindex.com\/hazards\/atmo\/\" data-txl=\"Atmosphere and weather\">freeze<\/a> and recorded in the publication record<\/dd><dt>Supersedes<\/dt><dd>nothing, first cut of the series<\/dd><dt>Superseded by<\/dt><dd>the 2027 synthetic biology annual cut<\/dd><\/dl><h3 class=\"nrp-h3\">Lineage<\/h3><ol class=\"nrp-rows\"><li><span class=\"nrp-rows-i\">01<\/span><p class=\"nrp-rows-x\">source edition<\/p><\/li><li><span class=\"nrp-rows-i\">02<\/span><p class=\"nrp-rows-x\">pinned citation<\/p><\/li><li><span class=\"nrp-rows-i\">03<\/span><p class=\"nrp-rows-x\">finding<\/p><\/li><li><span class=\"nrp-rows-i\">04<\/span><p class=\"nrp-rows-x\">page<\/p><\/li><li><span class=\"nrp-rows-i\">05<\/span><p class=\"nrp-rows-x\">publication record<\/p><\/li><\/ol><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-ca-tab4\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.4<\/span><span class=\"nrp-tbl-t\">From the baseline cut to the federation cut<\/span><\/caption><thead><tr><th scope=\"col\">Element<\/th><th scope=\"col\">Baseline 2026<\/th><th scope=\"col\">2027 global annual<\/th><\/tr><\/thead><tbody><tr><td>Sources<\/td><td>cited global publications, pinned by edition<\/td><td>national, regional and sector cuts through one graph<\/td><\/tr><tr><td>Analysis<\/td><td>stated methods and editorial estimates<\/td><td>typed analysis specifications<\/td><\/tr><tr><td>Models<\/td><td>Synthetic biology System Model v0 specification<\/td><td>model runs with receipts<\/td><\/tr><tr><td>Findings<\/td><td>twelve baseline findings<\/td><td>findings re-bound to federation evidence<\/td><\/tr><tr><td>Review<\/td><td>five passes scheduled<\/td><td>five passes on the exact digest<\/td><\/tr><\/tbody><\/table><\/div><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-ca-s4\" aria-labelledby=\"nx-nrp-xt-04-ca-s4-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-ca-s4-h\"><span class=\"nrp-num\">A.4<\/span><span>Evidence age and coverage<\/span><\/h2><p class=\"nrp-stand\">A 2026 global edition rests on evidence observed in many different years. This page shows each time base, so that no single year label hides older evidence.<\/p><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-ca-tab5\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.5<\/span><span class=\"nrp-tbl-t\">Evidence age and coverage<\/span><\/caption><thead><tr><th scope=\"col\">Indicator<\/th><th scope=\"col\">Observed<\/th><th scope=\"col\">Released<\/th><th scope=\"col\">Cadence<\/th><th scope=\"col\">Next release<\/th><\/tr><\/thead><tbody><tr><td>Recoded genome results<\/td><td>2019 to 2025<\/td><td>Nature 2019 \u00b7 Science Oct 2025<\/td><td>one-off<\/td><td>follow-up papers<\/td><\/tr><tr><td>Synthetic yeast<\/td><td>2023<\/td><td>Cell Dec 2023<\/td><td>one-off<\/td><td>completion papers<\/td><\/tr><tr><td>Screening study<\/td><td>2025<\/td><td>Science Oct 2025<\/td><td>one-off<\/td><td>follow-up studies<\/td><\/tr><tr><td>US commission report<\/td><td>2025<\/td><td>Apr 2025<\/td><td>one-off<\/td><td>legislation<\/td><\/tr><tr><td>US screening framework<\/td><td>2024 \u00b7 2025 order<\/td><td>Apr 2024 \u00b7 May 2025<\/td><td>periodic<\/td><td>replacement text<\/td><\/tr><tr><td>EU Biotech Act<\/td><td>2025<\/td><td>Dec 2025<\/td><td>periodic<\/td><td>second act<\/td><\/tr><tr><td>OECD governance paper<\/td><td>2026<\/td><td>May 2026<\/td><td>one-off<\/td><td>next policy paper<\/td><\/tr><tr><td>Company results<\/td><td>2025 to 2026<\/td><td>Feb 2026 \u00b7 Aug 2026<\/td><td>quarterly<\/td><td>next earnings<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-ca-tab6\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.6<\/span><span class=\"nrp-tbl-t\">Coverage by system at baseline<\/span><\/caption><thead><tr><th scope=\"col\">System<\/th><th scope=\"col\">Coverage<\/th><th scope=\"col\">Thinnest dimension<\/th><\/tr><\/thead><tbody><tr><td>Build capability<\/td><td>GOOD<\/td><td>industrial-scale performance<\/td><\/tr><tr><td>Clinical<\/td><td>PARTIAL<\/td><td>long-term outcomes<\/td><\/tr><tr><td>Biosecurity<\/td><td>PARTIAL<\/td><td>screening coverage<\/td><\/tr><tr><td>Governance<\/td><td>PARTIAL<\/td><td>text of replacement US framework<\/td><\/tr><tr><td>Investment<\/td><td>THIN<\/td><td>common basis for public and private<\/td><\/tr><tr><td>Energy and feedstock<\/td><td>THIN<\/td><td>fermentation footprint<\/td><\/tr><tr><td>Capacity<\/td><td>THIN<\/td><td>biofoundry and plant counts<\/td><\/tr><tr><td>Skills<\/td><td>THIN<\/td><td>workforce numbers<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-ca-tab7\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.7<\/span><span class=\"nrp-tbl-t\">Designed empty states: what is not bound, what would fill it and why<\/span><\/caption><thead><tr><th scope=\"col\">Field<\/th><th scope=\"col\">Source that would fill it<\/th><th scope=\"col\">Blocker<\/th><\/tr><\/thead><tbody><tr><td>Energy, water and feedstock use of biomanufacturing at scale<\/td><td>producers, national laboratories, peer-reviewed life-cycle studies<\/td><td>not retrieved on a common basis; no study opened<\/td><\/tr><tr><td>DNA synthesis capacity and screening coverage by provider and country<\/td><td>providers, industry consortia, national agencies<\/td><td>no consolidated series found; screening pages not opened<\/td><\/tr><tr><td>Status and text of the US screening framework after the 2025 order<\/td><td>OSTP and White House publications<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-ca-n25\" id=\"nx-nrp-xt-04-ca-r25\" aria-label=\"Note 25\">25<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-ca-n26\" id=\"nx-nrp-xt-04-ca-r26\" aria-label=\"Note 26\">26<\/a><\/sup><\/td><td>a fetch of the framework page was refused by the tool; status taken from search summaries and a CRS note summary<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-ca-n27\" id=\"nx-nrp-xt-04-ca-r27\" aria-label=\"Note 27\">27<\/a><\/sup><\/td><\/tr><tr><td>European Commission text of the Biotech Act proposal<\/td><td>European Commission proposal COM(2025) 1022<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-ca-n28\" id=\"nx-nrp-xt-04-ca-r28\" aria-label=\"Note 28\">28<\/a><\/sup><\/td><td>primary page not retrieved; content taken from a law firm summary<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-ca-n22\" id=\"nx-nrp-xt-04-ca-r22\" aria-label=\"Note 22\">22<\/a><\/sup><\/td><\/tr><tr><td>Status of the EU second Biotech Act<\/td><td>European Commission, European Parliament legislative train<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-ca-n29\" id=\"nx-nrp-xt-04-ca-r29\" aria-label=\"Note 29\">29<\/a><\/sup><\/td><td>the page returned no content; timing is a Q3 2026 expectation from summaries<\/td><\/tr><tr><td>Public and private investment in synthetic biology on one basis<\/td><td>national statistics, OECD, industry surveys<\/td><td>not retrieved; only two company filings used<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-ca-n16\" id=\"nx-nrp-xt-04-ca-r16\" aria-label=\"Note 16\">16<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-ca-n17\" id=\"nx-nrp-xt-04-ca-r17\" aria-label=\"Note 17\">17<\/a><\/sup><\/td><\/tr><tr><td>Biofoundry and fermentation capacity by country<\/td><td>industry and trade statistics<\/td><td>not retrieved<\/td><\/tr><tr><td>Programme totals for the US distributed bioindustrial manufacturing awards after September 2024<\/td><td>US manufacturing programme pages<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-ca-n24\" id=\"nx-nrp-xt-04-ca-r24\" aria-label=\"Note 24\">24<\/a><\/sup><\/td><td>the page read lists totals to September 2024 only<\/td><\/tr><tr><td>Bioeconomy size from a primary statistical source<\/td><td>national accounts, OECD<\/td><td>only a secondary commentary figure read<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-ca-n15\" id=\"nx-nrp-xt-04-ca-r15\" aria-label=\"Note 15\">15<\/a><\/sup><\/td><\/tr><tr><td>Workforce size and skills gaps<\/td><td>national statistics, OECD, industry surveys<\/td><td>not retrieved; capability rung stays LISTED<\/td><\/tr><tr><td>Independent replication and viral-resistance tests of recoded strains<\/td><td>peer-reviewed papers<\/td><td>not found at evidence close<\/td><\/tr><tr><td>Long-term outcomes of engineered therapies<\/td><td>trial follow-up publications<\/td><td>only the cited trial and one case report read<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-ca-n8\" id=\"nx-nrp-xt-04-ca-r8\" aria-label=\"Note 8\">8<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-ca-n10\" id=\"nx-nrp-xt-04-ca-r10\" aria-label=\"Note 10\">10<\/a><\/sup><\/td><\/tr><tr><td><a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-h101\" data-tc=\"NHS-1 tech.biotech.mirror-life\" data-tk=\"Frontier and exponential technology \u00b7 Biotechnology and synthetic biology\" data-td=\"Creation and escape of organisms built from mirror-image molecules, which could evade immune defences, predators and decay in people, animals and plants and spread unchecked through ecosystems.\" data-ts=\"NRS-H101\" data-tr=\"draft\" data-tx=\"https:\/\/risksindex.com\/hazards\/tech\/\" data-txl=\"Frontier and exponential technology\">Mirror life<\/a> <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-c1\" data-tc=\"NRS-C1 risk-assessment\" data-tk=\"Nexus risk vocabulary\" data-td=\"The overall process of identifying, analysing and evaluating risk to inform decisions.\" data-ts=\"NRS-C1\" data-tr=\"draft\" data-tg=\"https:\/\/nexustandards.com\/glossary\/risk-assessment\/\" data-tgl=\"Nexus Standards glossary\">risk assessment<\/a> beyond the policy forum<\/td><td>peer-reviewed risk studies<\/td><td>only the forum abstract read<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-ca-n12\" id=\"nx-nrp-xt-04-ca-r12\" aria-label=\"Note 12\">12<\/a><\/sup><\/td><\/tr><tr><td>Capability rungs beyond guidance and planning<\/td><td>agencies, operators, laboratories<\/td><td>not reviewed<\/td><\/tr><\/tbody><\/table><\/div><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-ca-s5\" aria-labelledby=\"nx-nrp-xt-04-ca-s5-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-ca-s5-h\"><span class=\"nrp-num\">A.5<\/span><span>Evidence cards, two anchor sources<\/span><\/h2><div class=\"nrp-cards\"><article class=\"nf-ui-card nrp-card\"><p class=\"nf-ui-eyebrow\">Published in Science 390 (2025) by Robertson and colleagues; news page of 1 August 2025. One-off. Role: binds BLD-001. Coverage: one organism in one laboratory line.<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">EVD-XT04-001<\/h3><p>Escherichia coli with a 57-codon genetic code<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-ca-n1\" id=\"nx-nrp-xt-04-ca-r1\" aria-label=\"Note 1\">1<\/a><\/sup><\/p><\/article><article class=\"nf-ui-card nrp-card\"><p class=\"nf-ui-eyebrow\">Published in Science 390 (2025). One-off study. Role: binds SEC-005. Coverage: screening tools and open design software; no sequence detail is reproduced here.<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">EVD-XT04-002<\/h3><p>Strengthening nucleic acid biosecurity screening against generative protein design tools<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-ca-n13\" id=\"nx-nrp-xt-04-ca-r13\" aria-label=\"Note 13\">13<\/a><\/sup><\/p><\/article><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-ca-tab8\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.8<\/span><span class=\"nrp-tbl-t\">Quality dimensions at baseline<\/span><\/caption><thead><tr><th scope=\"col\">Dimension<\/th><th scope=\"col\">EVD-XT04-001<\/th><th scope=\"col\">EVD-XT04-002<\/th><\/tr><\/thead><tbody><tr><td>Completeness<\/td><td>one organism; about 4 million base pairs<\/td><td>a set of screening tools and design software<\/td><\/tr><tr><td>Timeliness<\/td><td>news page about 12 weeks before the journal date<\/td><td>journal publication in 2025<\/td><\/tr><tr><td>Revision<\/td><td>preprint and journal versions<\/td><td>patches reported after testing<\/td><\/tr><tr><td>Method transparency<\/td><td>methods published in the paper<\/td><td>details limited for security reasons<\/td><\/tr><tr><td>External validation<\/td><td>peer review<\/td><td>peer review<\/td><\/tr><\/tbody><\/table><\/div><h3 class=\"nrp-h3\">Evidence cards to follow in 2027<\/h3><ul class=\"nrp-list\"><li>Robertson et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-ca-n1\" aria-label=\"Note 1\">1<\/a><\/sup>: viral resistance and replication<\/li><li>Science screening study<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-ca-n13\" aria-label=\"Note 13\">13<\/a><\/sup>: follow-up on patches and coverage<\/li><li>US framework<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-ca-n25\" aria-label=\"Note 25\">25<\/a><\/sup>: replacement text<\/li><li>European Commission<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-ca-n28\" aria-label=\"Note 28\">28<\/a><\/sup>: proposal text<\/li><\/ul><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-ca-s6\" aria-labelledby=\"nx-nrp-xt-04-ca-s6-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-ca-s6-h\"><span class=\"nrp-num\">A.6<\/span><span>Publication acceptance record<\/span><\/h2><p class=\"nrp-stand\">Editorial self-check at evidence close. Every applicable item carries a disposition; the remaining items are review, approval and deposit.<\/p><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-ca-tab9\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.9<\/span><span class=\"nrp-tbl-t\">Publication acceptance record<\/span><\/caption><thead><tr><th scope=\"col\">Group<\/th><th scope=\"col\">Area<\/th><th scope=\"col\">Items<\/th><th scope=\"col\">Pass<\/th><th scope=\"col\">N\/A<\/th><th scope=\"col\">Pending<\/th><\/tr><\/thead><tbody><tr><td>D1<\/td><td>Identity and scope<\/td><td>8<\/td><td>8<\/td><td>0<\/td><td>0<\/td><\/tr><tr><td>D2<\/td><td>Source and data<\/td><td>12<\/td><td>9<\/td><td>1<\/td><td>2<\/td><\/tr><tr><td>D3<\/td><td>Analysis and models<\/td><td>12<\/td><td>3<\/td><td>8<\/td><td>1<\/td><\/tr><tr><td>D4<\/td><td>Findings and claims<\/td><td>9<\/td><td>8<\/td><td>0<\/td><td>1<\/td><\/tr><tr><td>D5<\/td><td>Figures, tables, maps<\/td><td>10<\/td><td>6<\/td><td>2<\/td><td>2<\/td><\/tr><tr><td>D6<\/td><td>Editorial and citations<\/td><td>10<\/td><td>8<\/td><td>0<\/td><td>2<\/td><\/tr><tr><td>D7<\/td><td>Review and approval<\/td><td>13<\/td><td>0<\/td><td>0<\/td><td>13<\/td><\/tr><tr><td>D8<\/td><td>Artefact and design<\/td><td>12<\/td><td>7<\/td><td>0<\/td><td>5<\/td><\/tr><tr><td>D9<\/td><td>Registry and release<\/td><td>9<\/td><td>0<\/td><td>0<\/td><td>9<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-split\"><div><h3 class=\"nrp-h3\">Publication gate<\/h3><dl class=\"nrp-dl\"><dt>Conditions met<\/dt><dd>14 of 23 at evidence close<\/dd><dt>Blocking problems<\/dt><dd>none recorded<\/dd><dt>Open conditions<\/dt><dd>reviews, approval of the exact digest, deposit, registry pointer<\/dd><\/dl><\/div><div><h3 class=\"nrp-h3\">Not applicable at baseline<\/h3><dl class=\"nrp-dl\"><dt>Model runs<\/dt><dd>first runs in Q1 2027<\/dd><dt>Maps<\/dt><dd>plates in Q2 2027<\/dd><dt>Waivers<\/dt><dd>none<\/dd><\/dl><\/div><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">evidence<\/p><p>Dispositions are recorded item by item in the machine-readable checklist. A FAIL on any item blocks release.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-ca-s7\" aria-labelledby=\"nx-nrp-xt-04-ca-s7-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-ca-s7-h\"><span class=\"nrp-num\">A.7<\/span><span>Status words<\/span><\/h2><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-ca-tab10\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.10<\/span><span class=\"nrp-tbl-t\">The status every value carries<\/span><\/caption><thead><tr><th scope=\"col\">Status<\/th><th scope=\"col\">What it means<\/th><\/tr><\/thead><tbody><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"positive\" aria-hidden=\"true\"><\/span>Observed<\/span><\/td><td>Measured directly and published by the source.<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><td>Published statistics of an official or institutional source.<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Declared<\/span><\/td><td>Stated by the body concerned; not independently measured.<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Estimated<\/span><\/td><td>A Nexus estimate from cited evidence, with its method in Annex A.<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Modelled<\/span><\/td><td>Produced by a stated model from cited inputs.<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Inferred<\/span><\/td><td>Reasoned from cited evidence; not measured.<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"caution\" aria-hidden=\"true\"><\/span>Forecast<\/span><\/td><td>A projection by the cited source.<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"caution\" aria-hidden=\"true\"><\/span>Simulated<\/span><\/td><td>A simulation result under stated assumptions.<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"caution\" aria-hidden=\"true\"><\/span>Scenario<\/span><\/td><td>A conditional statement under stated assumptions; never a prediction.<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Expert input<\/span><\/td><td>Expert judgement, recorded with its basis.<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"caution\" aria-hidden=\"true\"><\/span>Candidate<\/span><\/td><td>Proposed for a later edition; not yet evidence.<\/td><\/tr><\/tbody><tfoot><tr><td colspan=\"2\">Evidence-quality levels (EQL 1 to 5) grade the source behind a value; they are not a score of the subject.<\/td><\/tr><\/tfoot><\/table><\/div><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-ca-s8\" aria-labelledby=\"nx-nrp-xt-04-ca-s8-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-ca-s8-h\"><span class=\"nrp-num\">A.8<\/span><span>How the edition is made, released and corrected<\/span><\/h2><p class=\"nx-p\">Every edition is built from a sealed evidence cut, reviewed under three keys, signed and deposited before any site shows it as published; corrections go to <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/\" data-tc=\"Nexus Standards\" data-tk=\"Nexus Standards\" data-td=\"The foundation standards\">Nexus Standards<\/a> as change proposals and feed the next cut.<\/p><div class=\"nx-table-wrap\"><table class=\"nx-table\" data-stack=\"true\"><thead><tr><th scope=\"col\">Step<\/th><th scope=\"col\">What happens<\/th><th scope=\"col\">Source<\/th><\/tr><\/thead><tbody><tr><td data-label=\"Step\">01 Evidence arrives from the pillars<\/td><td data-label=\"What happens\">Foundry seals observations and indicator series, <a class=\"nx-link\" href=\"https:\/\/docs.therisk.global\/organization\/programme\/universe\">Universe<\/a> hands over after-action and scenario findings, and contributions are screened at every gateway, including this site&#8217;s.<\/td><td data-label=\"Source\"><\/td><\/tr><tr><td data-label=\"Step\">02 The cut is sealed<\/td><td data-label=\"What happens\">On the cut date the evidence is pinned under one identifier, so anyone can rebuild the edition from exactly what it was built on.<\/td><td data-label=\"Source\"><\/td><\/tr><tr><td data-label=\"Step\">03 The edition is assembled<\/td><td data-label=\"What happens\">The edition is drafted from its template and content pack. Agents may draft; they never publish and never decide.<\/td><td data-label=\"Source\"><\/td><\/tr><tr><td data-label=\"Step\">04 The keys turn<\/td><td data-label=\"What happens\">At the publisher of record the truth key comes first: every value is checked against its source or stated method before the meaning and capital keys turn. No edition moves on until every key has been turned by a named steward.<\/td><td data-label=\"Source\"><\/td><\/tr><tr><td data-label=\"Step\">05 The gate opens<\/td><td data-label=\"What happens\">A named approver releases one exact digest of the edition; any change after this point is a new version, never a silent edit.<\/td><td data-label=\"Source\"><\/td><\/tr><tr><td data-label=\"Step\">06 Signed and deposited<\/td><td data-label=\"What happens\">The PDF, the web edition and the data bundle are signed together with a manifest and an RO-Crate description, and deposited on Zenodo with a concept and a version DOI.<\/td><td data-label=\"Source\"><\/td><\/tr><tr><td data-label=\"Step\">07 Published on its desk&#8217;s site<\/td><td data-label=\"What happens\">Only then does the edition show as published on its desk&#8217;s <a class=\"nx-link\" href=\"https:\/\/docs.therisk.global\/organization\/programme\/reports\">Reports<\/a> site, and the Collection lists it as a part.<\/td><td data-label=\"Source\"><\/td><\/tr><tr><td data-label=\"Step\">08 Corrections go to Standards<\/td><td data-label=\"What happens\">Method and correction findings go to Nexus Standards as change proposals; citations, corrections and new contributions feed the next evidence cut.<\/td><td data-label=\"Source\"><\/td><\/tr><\/tbody><\/table><\/div><p class=\"nx-note nx-mt-2\">A teaching model of the process, not a forecast and not a record of any run; dates and counts on this page come from the programme record. Sources: <a class=\"nx-link\" href=\"https:\/\/therisk.global\/nexus-reports\/governance\/\" rel=\"noopener\">Reports governance at GCRI Canada<\/a> (2026); Zenodo, repository of record for Reports deposits (2026).<\/p><p class=\"nrp-note\">Lifecycle, one state at a time: Draft, Computed, Evidence bound, Reviewed, Approved for release, Published, Corrected, Superseded. This edition is a draft.<\/p><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-ca-s9\" aria-labelledby=\"nx-nrp-xt-04-ca-s9-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-ca-s9-h\"><span class=\"nrp-num\">A.9<\/span><span>Glossary and abbreviations<\/span><\/h2><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-ca-tab11\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.11<\/span><span class=\"nrp-tbl-t\">Series terms<\/span><\/caption><thead><tr><th scope=\"col\">Term<\/th><th scope=\"col\">Meaning<\/th><\/tr><\/thead><tbody><tr><td>Baseline Edition<\/td><td>the inaugural annual edition that fixes the reference state for the series<\/td><\/tr><tr><td>WEFH+B<\/td><td>water, energy, food, health and biodiversity, the <a class=\"nx-link nx-term\" href=\"https:\/\/docs.therisk.global\/organization\/governance-in-operation\/national-nexus\" data-tc=\"National Nexus\" data-tk=\"Nexus Standards\" data-td=\"The national model: the NNC, the NLC and the NWG as its three participation pillars, with the National Desk, Model and Portfolio and the NSC as the standards function of the NNC (OR-13)\">national nexus<\/a> core<\/td><\/tr><tr><td>Coupling<\/td><td>a typed dependency through which one system transmits to another<\/td><\/tr><tr><td><a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-c1\" data-tc=\"NRS-C1 protection-gap\" data-tk=\"Nexus risk vocabulary\" data-td=\"The difference between total economic losses from hazards and the share covered by insurance or other pre-arranged protection, leaving households, firms and governments to absorb the rest.\" data-ts=\"NRS-C1\" data-tr=\"draft\" data-tg=\"https:\/\/globalriskalliance.com\/glossary\/protection-gap\/\" data-tgl=\"Global Risks Alliance glossary\">Protection gap<\/a><\/td><td>the share of losses not covered by insurance<\/td><\/tr><tr><td>Capability ladder<\/td><td>LISTED \u2192 EXISTS \u2192 ADEQUATE \u2192 TESTED \u2192 DEMONSTRATED<\/td><\/tr><tr><td>EQL<\/td><td>evidence-quality level, 1\u20135<\/td><\/tr><tr><td>Evidence cut<\/td><td>a frozen resolution of exact sources and versions<\/td><\/tr><tr><td>NNC \u00b7 NLC \u00b7 NWG<\/td><td>National Nexus Consortium \u00b7 National Leadership Council \u00b7 National Working Groups<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-ca-tab12\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.12<\/span><span class=\"nrp-tbl-t\">Abbreviations used in this edition<\/span><\/caption><thead><tr><th scope=\"col\">Abbreviation<\/th><th scope=\"col\">Expansion<\/th><\/tr><\/thead><tbody><tr><td>AHTEG<\/td><td>Ad Hoc Technical Expert Group<\/td><\/tr><tr><td>BWC<\/td><td>Biological Weapons Convention<\/td><\/tr><tr><td>CBD<\/td><td>Convention on Biological Diversity<\/td><\/tr><tr><td>CRS<\/td><td>Congressional Research Service<\/td><\/tr><tr><td>DBIMP<\/td><td>Distributed Bioindustrial Manufacturing Program<\/td><\/tr><tr><td>EO<\/td><td>executive order<\/td><\/tr><tr><td>FDA<\/td><td>US Food and Drug Administration<\/td><\/tr><tr><td>IGSC<\/td><td>International Gene Synthesis Consortium<\/td><\/tr><tr><td>NSCEB<\/td><td>National Security Commission on Emerging Biotechnology<\/td><\/tr><tr><td>OECD<\/td><td>Organisation for Economic Co-operation and Development<\/td><\/tr><tr><td>OSTP<\/td><td>Office of Science and Technology Policy<\/td><\/tr><tr><td>SPC<\/td><td>supplementary protection certificate<\/td><\/tr><\/tbody><\/table><\/div><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-ca-s10\" aria-labelledby=\"nx-nrp-xt-04-ca-s10-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-ca-s10-h\"><span class=\"nrp-num\">A.10<\/span><span>Technical annex<\/span><\/h2><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-ca-tab13\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.13<\/span><span class=\"nrp-tbl-t\">Technical annex<\/span><\/caption><thead><tr><th scope=\"col\">Item<\/th><th scope=\"col\">Annex<\/th><th scope=\"col\">Contents<\/th><th scope=\"col\">Status<\/th><\/tr><\/thead><tbody><tr><td>A.1<\/td><td>Indicator definitions<\/td><td>the global indicator set, with units and sources<\/td><td>IN THIS EDITION<\/td><\/tr><tr><td>A.2<\/td><td>Coupling strengths<\/td><td>the twenty-cell matrix and its rationale<\/td><td>IN THIS EDITION<\/td><\/tr><tr><td>A.3<\/td><td>Scenario specification<\/td><td>SCN-XT04-DSG-01 assumptions and signposts<\/td><td>IN THIS EDITION<\/td><\/tr><tr><td>A.4<\/td><td>Capability placements<\/td><td>rung evidence for fifteen functions<\/td><td>IN THIS EDITION<\/td><\/tr><tr><td>A.5<\/td><td>Model diagnostics<\/td><td>first runs and validation<\/td><td>2027<\/td><\/tr><tr><td>A.6<\/td><td>Sensitivity analyses<\/td><td>influence of coupling strengths<\/td><td>2027<\/td><\/tr><tr><td>A.7<\/td><td>Cluster notes<\/td><td>cards for the major platform, DNA supply and manufacturing clusters<\/td><td>2027<\/td><\/tr><tr><td>A.8<\/td><td>Review statements<\/td><td>pass-by-pass review record<\/td><td>AT RELEASE<\/td><\/tr><\/tbody><\/table><\/div><h3 class=\"nrp-h3\">A.1 \u00b7 indicator definition: codons recoded<\/h3><dl class=\"nrp-dl\"><dt>Construct<\/dt><dd>number of codon positions in a genome replaced by a synonymous codon<\/dd><dt>Unit<\/dt><dd>count of codons<\/dd><dt>Method<\/dt><dd>genome design, fragment synthesis and assembly<\/dd><dt>Source<\/dt><dd>Nature 569 (2019)<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-ca-n3\" id=\"nx-nrp-xt-04-ca-r3\" aria-label=\"Note 3\">3<\/a><\/sup>; Science 390 (2025) and the research institute news page<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-ca-n2\" id=\"nx-nrp-xt-04-ca-r2\" aria-label=\"Note 2\">2<\/a><\/sup><\/dd><dt>Uncertainty<\/dt><dd>the Syn57 count is stated as over 101,000, a lower bound<\/dd><dt>Known limits<\/dt><dd>counts may include sense codons and a stop codon; one lineage of organisms<\/dd><\/dl><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">evidence<\/p><p>Annexes carry the same evidence, review and correction rules as the chapters and are versioned with the edition.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-ca-notes\" aria-labelledby=\"nx-nrp-xt-04-ca-notes-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-ca-notes-h\"><span>Notes<\/span><\/h2><p class=\"nrp-note\">Numbers are the edition&#8217;s reference numbers, so a note reads the same in every chapter. The full list, with every source and its licence, is in Annex C. <a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/references\/\">Annex C, references<\/a><\/p><ol class=\"nrp-notes\"><li id=\"nx-nrp-xt-04-ca-n25\"><span class=\"nrp-notes-n\">25<\/span><span>UNVERIFIED, not opened: Office of Science and Technology Policy (ed.), Framework for Nucleic Acid Synthesis Screening, April 2024, taken from search-result summaries; a fetch of the page was refused by the fetch tool. OSTP, Washington. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-ca-r25\" aria-label=\"Back to the first call of note 25\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-ca-n26\"><span class=\"nrp-notes-n\">26<\/span><span>UNVERIFIED, not opened: Executive Order 14292, Improving the Safety and Security of Biological Research, 5 May 2025 (90 days to revise or replace the framework), taken from search-result summaries; a fetch of an explainer page was refused by the fetch tool. The White House, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-ca-r26\" aria-label=\"Back to the first call of note 26\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-ca-n27\"><span class=\"nrp-notes-n\">27<\/span><span>UNVERIFIED, not opened: Congressional Research Service (ed.), report on artificial intelligence and biosecurity risks (reported in July 2026 as unable to determine whether the 2024 framework or the 2025 policy had been revised), taken from a trade news summary. Library of Congress, Washington. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-ca-r27\" aria-label=\"Back to the first call of note 27\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-ca-n28\"><span class=\"nrp-notes-n\">28<\/span><span>UNVERIFIED, not opened: European Commission (ed.), Proposal for a Biotech Act, COM(2025) 1022, 16 December 2025, taken from law firm and regulator summaries; the Commission page was not retrieved. European Commission, Brussels. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-ca-r28\" aria-label=\"Back to the first call of note 28\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-ca-n22\"><span class=\"nrp-notes-n\">22<\/span><span>Baker McKenzie (ed.), EU Biotech Act unveiled: Commission proposal to turn Europe into a biotech powerhouse (law firm summary, 19 December 2025; proposal of 16 December 2025; health focus; investment pilot with the European Investment Bank Group; 12-month certificate extension; biodefence measures; second act expected in Q3 2026). Secondary source, not the Commission text. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-ca-r22\" aria-label=\"Back to the first call of note 22\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-ca-n29\"><span class=\"nrp-notes-n\">29<\/span><span>UNVERIFIED, not opened: European Parliament (ed.), Legislative train entry for the European Biotech Act II (second act expected in the third quarter of 2026), taken from a search-result summary; the page returned no content. European Parliament, Brussels. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-ca-r29\" aria-label=\"Back to the first call of note 29\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-ca-n16\"><span class=\"nrp-notes-n\">16<\/span><span>Twist Bioscience Corporation (ed.), Form 8-K exhibit 99.1, results for the fiscal third quarter ended 30 June 2026 (company filing; revenue USD 118.4 million; nine months USD 332.8 million; fiscal 2026 guidance USD 456 to 457 million; company statements and guidance are weak evidence). US Securities and Exchange Commission, Washington. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-ca-r16\" aria-label=\"Back to the first call of note 16\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-ca-n17\"><span class=\"nrp-notes-n\">17<\/span><span>Ginkgo Bioworks Holdings, Inc. (ed.), Form 8-K exhibit 99.1, fourth quarter and full year 2025 results (company filing of 26 February 2026; revenue USD 170.155 million against USD 227.043 million; net loss USD 312.763 million; company statements are weak evidence). US Securities and Exchange Commission, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-ca-r17\" aria-label=\"Back to the first call of note 17\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-ca-n24\"><span class=\"nrp-notes-n\">24<\/span><span>US Manufacturing Program (ed.), Bioindustrial (programme topic page; Distributed Bioindustrial Manufacturing Program awards announced 10 July to 13 September 2024; 25 awards; USD 42 million cumulative). Manufacturing USA, Gaithersburg. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-ca-r24\" aria-label=\"Back to the first call of note 24\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-ca-n15\"><span class=\"nrp-notes-n\">15<\/span><span>Federation of American Scientists (ed.), Translating Vision into Action: FAS commentary on the NSCEB final report (commentary page; six pillars; cites over USD 210 billion of US GDP and over 640,000 jobs for the bioeconomy; secondary and advocacy-leaning source). Federation of American Scientists, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-ca-r15\" aria-label=\"Back to the first call of note 15\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-ca-n8\"><span class=\"nrp-notes-n\">8<\/span><span>Frangoul, H. et al., Exagamglogene autotemcel for severe sickle cell disease, New England Journal of Medicine 390 (18), 1649 to 1662, 2024 (record read via Europe PMC: 44 treated; 29 of 30 evaluable free of severe crises for 12 months; median follow-up 19.3 months). Massachusetts Medical Society, Waltham. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-ca-r8\" aria-label=\"Back to the first call of note 8\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-ca-n10\"><span class=\"nrp-notes-n\">10<\/span><span>Musunuru, K. et al., Patient-specific in vivo gene editing to treat a rare genetic disease, New England Journal of Medicine 392 (22), 2235 to 2243, 2025 (record read via Europe PMC: one infant; two infusions at about 7 and 8 months). Massachusetts Medical Society, Waltham. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-ca-r10\" aria-label=\"Back to the first call of note 10\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-ca-n12\"><span class=\"nrp-notes-n\">12<\/span><span>Confronting risks of <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-h101\" data-tc=\"NHS-1 tech.biotech.mirror-life\" data-tk=\"Frontier and exponential technology \u00b7 Biotechnology and synthetic biology\" data-td=\"Creation and escape of organisms built from mirror-image molecules, which could evade immune defences, predators and decay in people, animals and plants and spread unchecked through ecosystems.\" data-ts=\"NRS-H101\" data-tr=\"draft\" data-tx=\"https:\/\/risksindex.com\/hazards\/tech\/\" data-txl=\"Frontier and exponential technology\">mirror life<\/a>, Science 386, 1351 to 1353, 2024 (record read via Europe PMC; the record gives only a one-line abstract calling for broad discussion). American Association for the Advancement of Science, Washington. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-ca-r12\" aria-label=\"Back to the first call of note 12\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-ca-n1\"><span class=\"nrp-notes-n\">1<\/span><span>Robertson, W.E. et al., Escherichia coli with a 57-codon genetic code, Science 390 (6771), eady4368, published 23 October 2025 (record read via PubMed, PMID 40743368; the record gives a 4 megabase synthetic genome and six replaced sense codons). American Association for the Advancement of Science, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-ca-r1\" aria-label=\"Back to the first call of note 1\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-ca-n13\"><span class=\"nrp-notes-n\">13<\/span><span>Strengthening nucleic acid biosecurity screening against generative protein design tools, Science 390 (6768), 82 to 87, 2025 (record read via Europe PMC; abstract only; no method detail used). American Association for the Advancement of Science, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-ca-r13\" aria-label=\"Back to the first call of note 13\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-ca-n3\"><span class=\"nrp-notes-n\">3<\/span><span>Fredens, J. et al., Total synthesis of Escherichia coli with a recoded genome, Nature 569 (7757), 514 to 518, 2019 (record read via Europe PMC: 18,214 codons recoded; 61-codon genome). Springer Nature, London. Observation year 2019. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-ca-r3\" aria-label=\"Back to the first call of note 3\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-ca-n2\"><span class=\"nrp-notes-n\">2<\/span><span>MRC Laboratory of Molecular Biology (ed.), Syn57 represents a new chapter in the genetic code of life (news page, 1 August 2025; over 101,000 codons recoded; 64 to 57 codons; genome of about 4 megabases built from 38 fragments of about 100 kilobases). MRC Laboratory of Molecular Biology, Cambridge. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-ca-r2\" aria-label=\"Back to the first call of note 2\">back<\/a><\/span><\/li><\/ol><\/section><section class=\"nrp-block nrp-noprint\" id=\"nx-nrp-xt-04-ca-cite\" aria-labelledby=\"nx-nrp-xt-04-ca-cite-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-ca-cite-h\"><span>Cite this annex<\/span><\/h2><pre class=\"nrp-pre\">Valadbaygi, S. (Ed.). (2026). Annex A: Methodology. In Exponential Technology Report 2026: Synthetic Biology and Bioengineering (Baseline Edition 2026, Report No. NR-XTECH-SYNBIO-GLOBAL-2026-BASELINE) [Draft under review]. The Global Centre for Risk and Innovation (GCRI).<\/pre><p class=\"nrp-note\">Every citation form of the whole report, BibTeX and RIS included, is on the edition home. <a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/#nx-nrp-xt-04-land-cite\">Cite this report<\/a><\/p><\/section><nav class=\"nrp-pager\" aria-label=\"Previous and next\"><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-in-depth\/\" rel=\"prev\"><span class=\"nf-ui-eyebrow\">Previous \u00b7 Chapter 8<\/span><span class=\"nrp-pager-t\">Systems in depth<\/span><\/a><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/data\/\" rel=\"next\"><span class=\"nf-ui-eyebrow\">Next \u00b7 Annex B<\/span><span class=\"nrp-pager-t\">Data appendix<\/span><\/a><\/nav><\/article><\/div><\/div><\/div><div class=\"nrp-noprint\"><section id=\"nx-sec-nr-gateway\" class=\"nx-section\" data-hue=\"systemic\" data-tone=\"alt\" aria-labelledby=\"nx-nr-gateway-h\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">Reports<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Contribute<\/span><\/div><h2 id=\"nx-nr-gateway-h\" class=\"nx-section-title\">Send evidence or a correction on Synthetic Biology and Bioengineering.<\/h2><p class=\"nx-lede\">Reports is the Consortium&#8217;s quarterly publication, written by six desks. This page sits with the Global Centre for Risk and Innovation (GCRI) <a class=\"nx-link nx-term\" href=\"https:\/\/docs.therisk.global\/organization\/systems\" data-tc=\"Systems\" data-tk=\"Nexus Standards\" data-td=\"The twenty Nexus systems, NXS-CMD to NXS-LAB\">Systems<\/a> Evidence desk. What you know about this subject can become evidence, a case or a correction in the next edition, credited to you and published under CC BY 4.0 where it is your own work. Sent to the wrong desk, it is forwarded, not refused.<\/p><div class=\"nx-chips\"><span class=\"nx-chip\">GCRI Systems Evidence desk<\/span><span class=\"nx-chip\">Exponential Technology<\/span><\/div><\/div><div class=\"nx-section-body\"><ul class=\"nx-dest\"><li><a class=\"nx-dest-card\" href=\"https:\/\/therisk.global\/nexus-reports\/write-to-us\/contact\/\"><span class=\"nx-dest-top\"><span class=\"nx-dest-rel\">Email<\/span><span class=\"nx-dest-host\">Gateway GW-GCRI<\/span><\/span><span class=\"nx-dest-title\">Send it from this page<\/span><span class=\"nx-dest-why\">Evidence, a correction, a case, a method, a review, a translation or profile input. It arrives tagged with this page, so the editor who owns it receives it.<\/span><span class=\"nx-dest-go\" aria-hidden=\"true\"><svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/span><\/a><\/li><li><a class=\"nx-dest-card\" href=\"https:\/\/therisk.global\/nexus-reports\/open-science\/#nx-sec-zenodo\"><span class=\"nx-dest-top\"><span class=\"nx-dest-rel\">Zenodo<\/span><span class=\"nx-dest-host\">Open deposit<\/span><\/span><span class=\"nx-dest-title\">Deposit it and submit to the community<\/span><span class=\"nx-dest-why\">Publish your own record on Zenodo with your ORCID iD, then submit it to the Reports community there. 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A contribution is reviewed before use; sending it confers no authorship or editorial rights, and sponsorship never buys a finding.<\/p><\/div><\/div><\/section><\/div><p class=\"nx-note\" data-nr-rights=\"true\"><a class=\"nx-link\" rel=\"license\" href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY 4.0<\/a> Free to read. Text and figures: CC BY 4.0. Data: CC0 1.0. Authors keep copyright. 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