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\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svg{display:none}#nxe-nr-gcri-editions-xt-04-data.nxe svg.nx-i{display:inline-block;width:18px;height:18px;vertical-align:-3px}#nxe-nr-gcri-editions-xt-04-data.nxe :where([role=\"tablist\"],[role=\"toolbar\"],[hidden],button,.nx-theme-toggle,.nx-live-slot){display:none}#nxe-nr-gcri-editions-xt-04-data.nxe img{max-width:100%;height:auto}<\/style><svg class=\"nx-defs\" aria-hidden=\"true\" focusable=\"false\" width=\"0\" height=\"0\"><defs><linearGradient id=\"nx-gi\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"1\"><stop offset=\"0\" class=\"nx-gi-a\"\/><stop offset=\"0.55\" class=\"nx-gi-b\"\/><stop offset=\"1\" class=\"nx-gi-c\"\/><\/linearGradient><linearGradient id=\"nx-giu\" gradientUnits=\"userSpaceOnUse\" x1=\"0\" y1=\"0\" x2=\"800\" y2=\"0\"><stop offset=\"0\" class=\"nx-gi-a\"\/><stop offset=\"0.55\" class=\"nx-gi-b\"\/><stop offset=\"1\" class=\"nx-gi-c\"\/><\/linearGradient><linearGradient id=\"nx-gp\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"1\"><stop offset=\"0\" class=\"nx-gp-a\"\/><stop offset=\"1\" class=\"nx-gp-b\"\/><\/linearGradient><\/defs><\/svg><div class=\"nrp\"><div class=\"nrp-wrap\"><p class=\"nrj-draft\" data-nrj-shared=\"draft\" role=\"note\"><strong>Draft, not yet released.<\/strong> In stewardship review. Not indexed until the first approved release.<\/p><div class=\"nrp-reader\"><nav class=\"nrp-rail\" aria-label=\"Contents of Synthetic Biology and Bioengineering 2026\"><p class=\"nf-ui-eyebrow\">Contents<\/p><ol class=\"nrp-toc\"><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Edition home<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/summary\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Executive summary<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/coupled-system\/\"><span class=\"nrp-toc-n\">1<\/span><span>Synthetic biology is a build capability and a governance test<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/findings\/\"><span class=\"nrp-toc-n\">2<\/span><span>Key findings<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-and-sectors\/\"><span class=\"nrp-toc-n\">3<\/span><span>Systems and sectors at baseline<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/risk-and-capability\/\"><span class=\"nrp-toc-n\">4<\/span><span>Risks and capability<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/scenario\/\"><span class=\"nrp-toc-n\">5<\/span><span>Design capability outpaces screening and oversight<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/lenses-and-readings\/\"><span class=\"nrp-toc-n\">6<\/span><span>Readings from the other desks<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/agenda\/\"><span class=\"nrp-toc-n\">7<\/span><span>The 2027 agenda<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-in-depth\/\"><span class=\"nrp-toc-n\">8<\/span><span>Systems in depth<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/methodology\/\"><span class=\"nrp-toc-n\">A<\/span><span>Methodology<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/data\/\" aria-current=\"page\"><span class=\"nrp-toc-n\">B<\/span><span>Data appendix<\/span><\/a><ol class=\"nrp-toc-sub\"><li><a href=\"#nx-nrp-xt-04-cb-s1\">B.1 The indicator set<\/a><\/li><li><a href=\"#nx-nrp-xt-04-cb-s2\">B.2 Global source register<\/a><\/li><li><a href=\"#nx-nrp-xt-04-cb-s3\">B.3 Regional reading, synthetic biology across ten clusters<\/a><\/li><li><a href=\"#nx-nrp-xt-04-cb-s4\">B.4 Cluster card: DNA synthesis and screening chain<\/a><\/li><li><a href=\"#nx-nrp-xt-04-cb-s5\">B.5 How countries appear in the synthetic biology edition<\/a><\/li><li><a href=\"#nx-nrp-xt-04-cb-s6\">B.6 Licences<\/a><\/li><li><a href=\"#nx-nrp-xt-04-cb-s7\">B.7 Formats and provenance<\/a><\/li><\/ol><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/references\/\"><span class=\"nrp-toc-n\">C<\/span><span>References and record<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/full\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Complete edition, for print<\/span><\/a><\/li><\/ol><div class=\"nrp-actions\"><a class=\"nf-ui-btn\" data-variant=\"secondary\" href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/full\/\"><svg class=\"nrp-i\" viewBox=\"0 0 24 24\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2\"\/><path d=\"M6 9V3a1 1 0 0 1 1-1h10a1 1 0 0 1 1 1v6\"\/><rect x=\"6\" y=\"14\" width=\"12\" height=\"8\" rx=\"1\"\/><\/svg>Print or save as PDF<\/a><\/div><\/nav><article class=\"nrp-flow\" aria-labelledby=\"nx-nrp-xt-04-cb-top\"><header class=\"nrp-chap-head\" id=\"nx-nrp-xt-04-cb-top\"><ul class=\"nrp-eyerow\"><li class=\"nf-ui-eyebrow\"><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/\">Synthetic Biology and Bioengineering 2026<\/a><\/li><li class=\"nf-ui-eyebrow\">Annex B<\/li><\/ul><span class=\"nrp-rule\" aria-hidden=\"true\"><\/span><h1 class=\"pp-hero-title\">Data appendix<\/h1><p class=\"nrp-lede\">The indicator set with its sources, the source registers, the licences of every kind of material and the formats of the edition.<\/p><p class=\"nrp-chap-meta\"><span>11 min read<\/span><span>0 figures<\/span><span>8 tables<\/span><span>22 notes<\/span><span>NR-XTECH-SYNBIO-GLOBAL-2026-BASELINE<\/span><\/p><details class=\"nrp-toc-m\"><summary>Contents<\/summary><ol class=\"nrp-toc\"><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Edition home<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/summary\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Executive summary<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/coupled-system\/\"><span class=\"nrp-toc-n\">1<\/span><span>Synthetic biology is a build capability and a governance test<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/findings\/\"><span class=\"nrp-toc-n\">2<\/span><span>Key findings<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-and-sectors\/\"><span class=\"nrp-toc-n\">3<\/span><span>Systems and sectors at baseline<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/risk-and-capability\/\"><span class=\"nrp-toc-n\">4<\/span><span>Risks and capability<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/scenario\/\"><span class=\"nrp-toc-n\">5<\/span><span>Design capability outpaces screening and oversight<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/lenses-and-readings\/\"><span class=\"nrp-toc-n\">6<\/span><span>Readings from the other desks<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/agenda\/\"><span class=\"nrp-toc-n\">7<\/span><span>The 2027 agenda<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/systems-in-depth\/\"><span class=\"nrp-toc-n\">8<\/span><span>Systems in depth<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/methodology\/\"><span class=\"nrp-toc-n\">A<\/span><span>Methodology<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/data\/\" aria-current=\"page\"><span class=\"nrp-toc-n\">B<\/span><span>Data appendix<\/span><\/a><ol class=\"nrp-toc-sub\"><li><a href=\"#nx-nrp-xt-04-cb-s1\">B.1 The indicator set<\/a><\/li><li><a href=\"#nx-nrp-xt-04-cb-s2\">B.2 Global source register<\/a><\/li><li><a href=\"#nx-nrp-xt-04-cb-s3\">B.3 Regional reading, synthetic biology across ten clusters<\/a><\/li><li><a href=\"#nx-nrp-xt-04-cb-s4\">B.4 Cluster card: DNA synthesis and screening chain<\/a><\/li><li><a href=\"#nx-nrp-xt-04-cb-s5\">B.5 How countries appear in the synthetic biology edition<\/a><\/li><li><a href=\"#nx-nrp-xt-04-cb-s6\">B.6 Licences<\/a><\/li><li><a href=\"#nx-nrp-xt-04-cb-s7\">B.7 Formats and provenance<\/a><\/li><\/ol><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/references\/\"><span class=\"nrp-toc-n\">C<\/span><span>References and record<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/full\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Complete edition, for print<\/span><\/a><\/li><\/ol><\/details><\/header><section class=\"nrp-block\" id=\"nx-nrp-xt-04-cb-s1\" aria-labelledby=\"nx-nrp-xt-04-cb-s1-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-cb-s1-h\"><span class=\"nrp-num\">B.1<\/span><span>The indicator set<\/span><\/h2><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-cb-tab1\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table B.1<\/span><span class=\"nrp-tbl-t\">Global baseline indicator set<\/span><\/caption><thead><tr><th scope=\"col\">Indicator<\/th><th scope=\"col\">Value<\/th><th scope=\"col\">Unit<\/th><th scope=\"col\">Year<\/th><th scope=\"col\">State<\/th><th scope=\"col\">Source<\/th><\/tr><\/thead><tbody><tr><td>Codons in the standard genetic code<\/td><td><span class=\"nrp-mono\">64<\/span><\/td><td>codons<\/td><td>2025<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n2\" id=\"nx-nrp-xt-04-cb-r2\" aria-label=\"Note 2\">2<\/a><\/sup><\/td><\/tr><tr><td>Codons in the Syn61 strain<\/td><td><span class=\"nrp-mono\">61<\/span><\/td><td>codons<\/td><td>2019<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n3\" id=\"nx-nrp-xt-04-cb-r3\" aria-label=\"Note 3\">3<\/a><\/sup><\/td><\/tr><tr><td>Codons in the Syn57 strain<\/td><td><span class=\"nrp-mono\">57<\/span><\/td><td>codons<\/td><td>2025<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n2\" aria-label=\"Note 2\">2<\/a><\/sup><\/td><\/tr><tr><td>Codons recoded in Syn61<\/td><td><span class=\"nrp-mono\">18,214<\/span><\/td><td>codons<\/td><td>2019<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n3\" aria-label=\"Note 3\">3<\/a><\/sup><\/td><\/tr><tr><td>Codons recoded in Syn57<\/td><td><span class=\"nrp-mono\">&gt;101,000<\/span><\/td><td>codons<\/td><td>2025<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n2\" aria-label=\"Note 2\">2<\/a><\/sup><\/td><\/tr><tr><td>Fragments in the Syn57 assembly<\/td><td><span class=\"nrp-mono\">38<\/span><\/td><td>fragments<\/td><td>2025<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n2\" aria-label=\"Note 2\">2<\/a><\/sup><\/td><\/tr><tr><td>Synthetic yeast chromosomes in one strain<\/td><td><span class=\"nrp-mono\">6.5<\/span><\/td><td>chromosomes<\/td><td>2023<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n4\" id=\"nx-nrp-xt-04-cb-r4\" aria-label=\"Note 4\">4<\/a><\/sup><\/td><\/tr><tr><td>Genome of the first synthetic cell<\/td><td><span class=\"nrp-mono\">1.08<\/span><\/td><td>million base pairs<\/td><td>2010<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n5\" id=\"nx-nrp-xt-04-cb-r5\" aria-label=\"Note 5\">5<\/a><\/sup><\/td><\/tr><tr><td>Genetic circuits built by one tool<\/td><td><span class=\"nrp-mono\">60<\/span><\/td><td>circuits<\/td><td>2016<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n6\" id=\"nx-nrp-xt-04-cb-r6\" aria-label=\"Note 6\">6<\/a><\/sup><\/td><\/tr><tr><td>Circuits correct in every output state<\/td><td><span class=\"nrp-mono\">45<\/span><\/td><td>circuits<\/td><td>2016<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n6\" aria-label=\"Note 6\">6<\/a><\/sup><\/td><\/tr><tr><td>Patients treated in the exa-cel phase 3 study<\/td><td><span class=\"nrp-mono\">44<\/span><\/td><td>patients<\/td><td>2024<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n8\" id=\"nx-nrp-xt-04-cb-r8\" aria-label=\"Note 8\">8<\/a><\/sup><\/td><\/tr><tr><td>Patients free of severe crises for 12 months<\/td><td><span class=\"nrp-mono\">29 of 30<\/span><\/td><td>evaluable patients<\/td><td>2024<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n8\" aria-label=\"Note 8\">8<\/a><\/sup><\/td><\/tr><tr><td>US commission recommendations<\/td><td><span class=\"nrp-mono\">49<\/span><\/td><td>recommendations<\/td><td>2025<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n14\" id=\"nx-nrp-xt-04-cb-r14\" aria-label=\"Note 14\">14<\/a><\/sup><\/td><\/tr><tr><td>US commission funding recommended, minimum<\/td><td><span class=\"nrp-mono\">15<\/span><\/td><td>USD billion over five years<\/td><td>2025<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"caution\" aria-hidden=\"true\"><\/span>Scenario<\/span><\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n14\" aria-label=\"Note 14\">14<\/a><\/sup><\/td><\/tr><tr><td>Twist Bioscience revenue, nine months to 30 June 2026<\/td><td><span class=\"nrp-mono\">332.8<\/span><\/td><td>USD million<\/td><td>2026<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n16\" id=\"nx-nrp-xt-04-cb-r16\" aria-label=\"Note 16\">16<\/a><\/sup><\/td><\/tr><tr><td>Twist Bioscience fiscal 2026 revenue guidance<\/td><td><span class=\"nrp-mono\">456 to 457<\/span><\/td><td>USD million<\/td><td>2026<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"caution\" aria-hidden=\"true\"><\/span>Scenario<\/span><\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n16\" aria-label=\"Note 16\">16<\/a><\/sup><\/td><\/tr><tr><td>Ginkgo Bioworks revenue<\/td><td><span class=\"nrp-mono\">170.2<\/span><\/td><td>USD million<\/td><td>2025<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n17\" id=\"nx-nrp-xt-04-cb-r17\" aria-label=\"Note 17\">17<\/a><\/sup><\/td><\/tr><tr><td>Ginkgo Bioworks net loss<\/td><td><span class=\"nrp-mono\">312.8<\/span><\/td><td>USD million<\/td><td>2025<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n17\" aria-label=\"Note 17\">17<\/a><\/sup><\/td><\/tr><tr><td>US planning awards for bioindustrial manufacturing, cumulative to September 2024<\/td><td><span class=\"nrp-mono\">25<\/span><\/td><td>awards<\/td><td>2024<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n24\" id=\"nx-nrp-xt-04-cb-r24\" aria-label=\"Note 24\">24<\/a><\/sup><\/td><\/tr><tr><td>Funding of those awards, cumulative to September 2024<\/td><td><span class=\"nrp-mono\">42<\/span><\/td><td>USD million<\/td><td>2024<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n24\" aria-label=\"Note 24\">24<\/a><\/sup><\/td><\/tr><tr><td>Award for the bioindustrial manufacturing institute<\/td><td><span class=\"nrp-mono\">87<\/span><\/td><td>USD million over seven years<\/td><td>2020<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><td><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n23\" id=\"nx-nrp-xt-04-cb-r23\" aria-label=\"Note 23\">23<\/a><\/sup><\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-actions nrp-noprint\"><a class=\"nf-ui-btn\" data-variant=\"secondary\" href=\"data:text\/csv;charset=utf-8,Indicator%2CValue%2CUnit%2CYear%2CState%2CSource%0ACodons%20in%20the%20standard%20genetic%20code%2C64%2Ccodons%2C2025%2CREPORTED%2C%5B2%5D%0ACodons%20in%20the%20Syn61%20strain%2C61%2Ccodons%2C2019%2CREPORTED%2C%5B3%5D%0ACodons%20in%20the%20Syn57%20strain%2C57%2Ccodons%2C2025%2CREPORTED%2C%5B2%5D%0ACodons%20recoded%20in%20Syn61%2C%2218%2C214%22%2Ccodons%2C2019%2CREPORTED%2C%5B3%5D%0ACodons%20recoded%20in%20Syn57%2C%22%3E101%2C000%22%2Ccodons%2C2025%2CREPORTED%2C%5B2%5D%0AFragments%20in%20the%20Syn57%20assembly%2C38%2Cfragments%2C2025%2CREPORTED%2C%5B2%5D%0ASynthetic%20yeast%20chromosomes%20in%20one%20strain%2C6.5%2Cchromosomes%2C2023%2CREPORTED%2C%5B4%5D%0AGenome%20of%20the%20first%20synthetic%20cell%2C1.08%2Cmillion%20base%20pairs%2C2010%2CREPORTED%2C%5B5%5D%0AGenetic%20circuits%20built%20by%20one%20tool%2C60%2Ccircuits%2C2016%2CREPORTED%2C%5B6%5D%0ACircuits%20correct%20in%20every%20output%20state%2C45%2Ccircuits%2C2016%2CREPORTED%2C%5B6%5D%0APatients%20treated%20in%20the%20exa-cel%20phase%203%20study%2C44%2Cpatients%2C2024%2CREPORTED%2C%5B8%5D%0APatients%20free%20of%20severe%20crises%20for%2012%20months%2C29%20of%2030%2Cevaluable%20patients%2C2024%2CREPORTED%2C%5B8%5D%0AUS%20commission%20recommendations%2C49%2Crecommendations%2C2025%2CREPORTED%2C%5B14%5D%0A%22US%20commission%20funding%20recommended%2C%20minimum%22%2C15%2CUSD%20billion%20over%20five%20years%2C2025%2CSCENARIO%2C%5B14%5D%0A%22Twist%20Bioscience%20revenue%2C%20nine%20months%20to%2030%20June%202026%22%2C332.8%2CUSD%20million%2C2026%2CREPORTED%2C%5B16%5D%0ATwist%20Bioscience%20fiscal%202026%20revenue%20guidance%2C456%20to%20457%2CUSD%20million%2C2026%2CSCENARIO%2C%5B16%5D%0AGinkgo%20Bioworks%20revenue%2C170.2%2CUSD%20million%2C2025%2CREPORTED%2C%5B17%5D%0AGinkgo%20Bioworks%20net%20loss%2C312.8%2CUSD%20million%2C2025%2CREPORTED%2C%5B17%5D%0A%22US%20planning%20awards%20for%20bioindustrial%20manufacturing%2C%20cumulative%20to%20September%202024%22%2C25%2Cawards%2C2024%2CREPORTED%2C%5B24%5D%0A%22Funding%20of%20those%20awards%2C%20cumulative%20to%20September%202024%22%2C42%2CUSD%20million%2C2024%2CREPORTED%2C%5B24%5D%0AAward%20for%20the%20bioindustrial%20manufacturing%20institute%2C87%2CUSD%20million%20over%20seven%20years%2C2020%2CREPORTED%2C%5B23%5D%0A\" download=\"NR-XTECH-SYNBIO-GLOBAL-2026-BASELINE-indicators.csv\"><svg class=\"nrp-i\" viewBox=\"0 0 24 24\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M12 15V3\"\/><path d=\"M21 15v4a2 2 0 0 1-2 2H5a2 2 0 0 1-2-2v-4\"\/><path d=\"m7 10 5 5 5-5\"\/><\/svg>Indicators, CSV<\/a><a class=\"nf-ui-btn\" data-variant=\"secondary\" href=\"data:application\/json;charset=utf-8,%7B%0A%20%22edition%22%3A%20%22NR-XTECH-SYNBIO-GLOBAL-2026-BASELINE%22%2C%0A%20%22title%22%3A%20%22Exponential%20Technology%20Report%202026%3A%20Synthetic%20Biology%20and%20Bioengineering%22%2C%0A%20%22status%22%3A%20%22Draft%20under%20stewardship%20review%3B%20not%20yet%20released%22%2C%0A%20%22licence%22%3A%20%22CC-BY-4.0%20for%20the%20edition%20table%3B%20each%20value%20keeps%20its%20source's%20licence%22%2C%0A%20%22columns%22%3A%20%5B%0A%20%20%22Indicator%22%2C%0A%20%20%22Value%22%2C%0A%20%20%22Unit%22%2C%0A%20%20%22Year%22%2C%0A%20%20%22State%22%2C%0A%20%20%22Source%22%0A%20%5D%2C%0A%20%22rows%22%3A%20%5B%0A%20%20%5B%0A%20%20%20%22Codons%20in%20the%20standard%20genetic%20code%22%2C%0A%20%20%20%2264%22%2C%0A%20%20%20%22codons%22%2C%0A%20%20%20%222025%22%2C%0A%20%20%20%22REPORTED%22%2C%0A%20%20%20%22%5B2%5D%22%0A%20%20%5D%2C%0A%20%20%5B%0A%20%20%20%22Codons%20in%20the%20Syn61%20strain%22%2C%0A%20%20%20%2261%22%2C%0A%20%20%20%22codons%22%2C%0A%20%20%20%222019%22%2C%0A%20%20%20%22REPORTED%22%2C%0A%20%20%20%22%5B3%5D%22%0A%20%20%5D%2C%0A%20%20%5B%0A%20%20%20%22Codons%20in%20the%20Syn57%20strain%22%2C%0A%20%20%20%2257%22%2C%0A%20%20%20%22codons%22%2C%0A%20%20%20%222025%22%2C%0A%20%20%20%22REPORTED%22%2C%0A%20%20%20%22%5B2%5D%22%0A%20%20%5D%2C%0A%20%20%5B%0A%20%20%20%22Codons%20recoded%20in%20Syn61%22%2C%0A%20%20%20%2218%2C214%22%2C%0A%20%20%20%22codons%22%2C%0A%20%20%20%222019%22%2C%0A%20%20%20%22REPORTED%22%2C%0A%20%20%20%22%5B3%5D%22%0A%20%20%5D%2C%0A%20%20%5B%0A%20%20%20%22Codons%20recoded%20in%20Syn57%22%2C%0A%20%20%20%22%3E101%2C000%22%2C%0A%20%20%20%22codons%22%2C%0A%20%20%20%222025%22%2C%0A%20%20%20%22REPORTED%22%2C%0A%20%20%20%22%5B2%5D%22%0A%20%20%5D%2C%0A%20%20%5B%0A%20%20%20%22Fragments%20in%20the%20Syn57%20assembly%22%2C%0A%20%20%20%2238%22%2C%0A%20%20%20%22fragments%22%2C%0A%20%20%20%222025%22%2C%0A%20%20%20%22REPORTED%22%2C%0A%20%20%20%22%5B2%5D%22%0A%20%20%5D%2C%0A%20%20%5B%0A%20%20%20%22Synthetic%20yeast%20chromosomes%20in%20one%20strain%22%2C%0A%20%20%20%226.5%22%2C%0A%20%20%20%22chromosomes%22%2C%0A%20%20%20%222023%22%2C%0A%20%20%20%22REPORTED%22%2C%0A%20%20%20%22%5B4%5D%22%0A%20%20%5D%2C%0A%20%20%5B%0A%20%20%20%22Genome%20of%20the%20first%20synthetic%20cell%22%2C%0A%20%20%20%221.08%22%2C%0A%20%20%20%22million%20base%20pairs%22%2C%0A%20%20%20%222010%22%2C%0A%20%20%20%22REPORTED%22%2C%0A%20%20%20%22%5B5%5D%22%0A%20%20%5D%2C%0A%20%20%5B%0A%20%20%20%22Genetic%20circuits%20built%20by%20one%20tool%22%2C%0A%20%20%20%2260%22%2C%0A%20%20%20%22circuits%22%2C%0A%20%20%20%222016%22%2C%0A%20%20%20%22REPORTED%22%2C%0A%20%20%20%22%5B6%5D%22%0A%20%20%5D%2C%0A%20%20%5B%0A%20%20%20%22Circuits%20correct%20in%20every%20output%20state%22%2C%0A%20%20%20%2245%22%2C%0A%20%20%20%22circuits%22%2C%0A%20%20%20%222016%22%2C%0A%20%20%20%22REPORTED%22%2C%0A%20%20%20%22%5B6%5D%22%0A%20%20%5D%2C%0A%20%20%5B%0A%20%20%20%22Patients%20treated%20in%20the%20exa-cel%20phase%203%20study%22%2C%0A%20%20%20%2244%22%2C%0A%20%20%20%22patients%22%2C%0A%20%20%20%222024%22%2C%0A%20%20%20%22REPORTED%22%2C%0A%20%20%20%22%5B8%5D%22%0A%20%20%5D%2C%0A%20%20%5B%0A%20%20%20%22Patients%20free%20of%20severe%20crises%20for%2012%20months%22%2C%0A%20%20%20%2229%20of%2030%22%2C%0A%20%20%20%22evaluable%20patients%22%2C%0A%20%20%20%222024%22%2C%0A%20%20%20%22REPORTED%22%2C%0A%20%20%20%22%5B8%5D%22%0A%20%20%5D%2C%0A%20%20%5B%0A%20%20%20%22US%20commission%20recommendations%22%2C%0A%20%20%20%2249%22%2C%0A%20%20%20%22recommendations%22%2C%0A%20%20%20%222025%22%2C%0A%20%20%20%22REPORTED%22%2C%0A%20%20%20%22%5B14%5D%22%0A%20%20%5D%2C%0A%20%20%5B%0A%20%20%20%22US%20commission%20funding%20recommended%2C%20minimum%22%2C%0A%20%20%20%2215%22%2C%0A%20%20%20%22USD%20billion%20over%20five%20years%22%2C%0A%20%20%20%222025%22%2C%0A%20%20%20%22SCENARIO%22%2C%0A%20%20%20%22%5B14%5D%22%0A%20%20%5D%2C%0A%20%20%5B%0A%20%20%20%22Twist%20Bioscience%20revenue%2C%20nine%20months%20to%2030%20June%202026%22%2C%0A%20%20%20%22332.8%22%2C%0A%20%20%20%22USD%20million%22%2C%0A%20%20%20%222026%22%2C%0A%20%20%20%22REPORTED%22%2C%0A%20%20%20%22%5B16%5D%22%0A%20%20%5D%2C%0A%20%20%5B%0A%20%20%20%22Twist%20Bioscience%20fiscal%202026%20revenue%20guidance%22%2C%0A%20%20%20%22456%20to%20457%22%2C%0A%20%20%20%22USD%20million%22%2C%0A%20%20%20%222026%22%2C%0A%20%20%20%22SCENARIO%22%2C%0A%20%20%20%22%5B16%5D%22%0A%20%20%5D%2C%0A%20%20%5B%0A%20%20%20%22Ginkgo%20Bioworks%20revenue%22%2C%0A%20%20%20%22170.2%22%2C%0A%20%20%20%22USD%20million%22%2C%0A%20%20%20%222025%22%2C%0A%20%20%20%22REPORTED%22%2C%0A%20%20%20%22%5B17%5D%22%0A%20%20%5D%2C%0A%20%20%5B%0A%20%20%20%22Ginkgo%20Bioworks%20net%20loss%22%2C%0A%20%20%20%22312.8%22%2C%0A%20%20%20%22USD%20million%22%2C%0A%20%20%20%222025%22%2C%0A%20%20%20%22REPORTED%22%2C%0A%20%20%20%22%5B17%5D%22%0A%20%20%5D%2C%0A%20%20%5B%0A%20%20%20%22US%20planning%20awards%20for%20bioindustrial%20manufacturing%2C%20cumulative%20to%20September%202024%22%2C%0A%20%20%20%2225%22%2C%0A%20%20%20%22awards%22%2C%0A%20%20%20%222024%22%2C%0A%20%20%20%22REPORTED%22%2C%0A%20%20%20%22%5B24%5D%22%0A%20%20%5D%2C%0A%20%20%5B%0A%20%20%20%22Funding%20of%20those%20awards%2C%20cumulative%20to%20September%202024%22%2C%0A%20%20%20%2242%22%2C%0A%20%20%20%22USD%20million%22%2C%0A%20%20%20%222024%22%2C%0A%20%20%20%22REPORTED%22%2C%0A%20%20%20%22%5B24%5D%22%0A%20%20%5D%2C%0A%20%20%5B%0A%20%20%20%22Award%20for%20the%20bioindustrial%20manufacturing%20institute%22%2C%0A%20%20%20%2287%22%2C%0A%20%20%20%22USD%20million%20over%20seven%20years%22%2C%0A%20%20%20%222020%22%2C%0A%20%20%20%22REPORTED%22%2C%0A%20%20%20%22%5B23%5D%22%0A%20%20%5D%0A%20%5D%0A%7D\" download=\"NR-XTECH-SYNBIO-GLOBAL-2026-BASELINE-indicators.json\"><svg class=\"nrp-i\" viewBox=\"0 0 24 24\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M12 15V3\"\/><path d=\"M21 15v4a2 2 0 0 1-2 2H5a2 2 0 0 1-2-2v-4\"\/><path d=\"m7 10 5 5 5-5\"\/><\/svg>Indicators, JSON<\/a><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">NOTES<\/p><p>Values are rounded as published. Plans, recommendations and guidance are labelled SCENARIO. Company values come from filings and are weak evidence of the sector. Unopened references carry an UNVERIFIED prefix and are listed in the notes. A machine-readable copy of this table is published with the evidence bundle at release.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-cb-s2\" aria-labelledby=\"nx-nrp-xt-04-cb-s2-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-cb-s2-h\"><span class=\"nrp-num\">B.2<\/span><span>Global source register<\/span><\/h2><p class=\"nrp-stand\">The governed source set behind this edition. Each source keeps its authority, coverage, cadence and role; categories describe origin, not truth.<\/p><h3 class=\"nrp-h3\">Domains bound by the register<\/h3><ul class=\"nrp-chips\"><li class=\"nf-ui-chip\">BLD<\/li><li class=\"nf-ui-chip\">SEC<\/li><li class=\"nf-ui-chip\">GOV<\/li><li class=\"nf-ui-chip\">FIN<\/li><li class=\"nf-ui-chip\">CLN<\/li><li class=\"nf-ui-chip\">ENE<\/li><li class=\"nf-ui-chip\">WAT<\/li><li class=\"nf-ui-chip\">FOO<\/li><li class=\"nf-ui-chip\">CLI<\/li><li class=\"nf-ui-chip\">MIN<\/li><\/ul><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-cb-tab3\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table B.3<\/span><span class=\"nrp-tbl-t\">Global source register<\/span><\/caption><thead><tr><th scope=\"col\">Source<\/th><th scope=\"col\">Category<\/th><th scope=\"col\">Coverage<\/th><th scope=\"col\">Period<\/th><th scope=\"col\">Cadence<\/th><th scope=\"col\">Role<\/th><\/tr><\/thead><tbody><tr><td>Robertson et al. in Science<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n1\" id=\"nx-nrp-xt-04-cb-r1\" aria-label=\"Note 1\">1<\/a><\/sup><\/td><td>peer-reviewed journal<\/td><td>one organism<\/td><td>2025<\/td><td>one-off<\/td><td>genomes<\/td><\/tr><tr><td>MRC Laboratory of Molecular Biology news<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n2\" aria-label=\"Note 2\">2<\/a><\/sup><\/td><td>research institute<\/td><td>one organism<\/td><td>2025<\/td><td>one-off<\/td><td>genomes<\/td><\/tr><tr><td>Cell paper on synthetic yeast<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n4\" aria-label=\"Note 4\">4<\/a><\/sup><\/td><td>peer-reviewed journal<\/td><td>one lineage<\/td><td>2023<\/td><td>one-off<\/td><td>genomes<\/td><\/tr><tr><td>Nielsen et al. in Science<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n6\" aria-label=\"Note 6\">6<\/a><\/sup><\/td><td>peer-reviewed journal<\/td><td>method<\/td><td>2016<\/td><td>one-off<\/td><td>design tools<\/td><\/tr><tr><td>Journal records for therapies<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n8\" aria-label=\"Note 8\">8<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n10\" id=\"nx-nrp-xt-04-cb-r10\" aria-label=\"Note 10\">10<\/a><\/sup><\/td><td>peer-reviewed journal<\/td><td>clinical<\/td><td>2024 and 2025<\/td><td>one-off<\/td><td>clinical<\/td><\/tr><tr><td>FDA announcement<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n9\" id=\"nx-nrp-xt-04-cb-r9\" aria-label=\"Note 9\">9<\/a><\/sup><\/td><td>national regulator<\/td><td>US<\/td><td>2023<\/td><td>one-off<\/td><td>clinical<\/td><\/tr><tr><td>Screening study in Science<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n13\" id=\"nx-nrp-xt-04-cb-r13\" aria-label=\"Note 13\">13<\/a><\/sup><\/td><td>peer-reviewed journal<\/td><td>method<\/td><td>2025<\/td><td>one-off<\/td><td>biosecurity<\/td><\/tr><tr><td>CRS note on the US commission<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n14\" aria-label=\"Note 14\">14<\/a><\/sup><\/td><td>legislative research service<\/td><td>US<\/td><td>2025<\/td><td>one-off<\/td><td>policy<\/td><\/tr><tr><td>OECD policy papers<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n18\" id=\"nx-nrp-xt-04-cb-r18\" aria-label=\"Note 18\">18<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n19\" id=\"nx-nrp-xt-04-cb-r19\" aria-label=\"Note 19\">19<\/a><\/sup><\/td><td>intergovernmental organisation<\/td><td>OECD members<\/td><td>2025 and 2026<\/td><td>periodic<\/td><td>governance<\/td><\/tr><tr><td>Company filings<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n16\" aria-label=\"Note 16\">16<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n17\" aria-label=\"Note 17\">17<\/a><\/sup><\/td><td>company filing<\/td><td>two firms<\/td><td>2025 and 2026<\/td><td>quarterly<\/td><td>investment<\/td><\/tr><\/tbody><\/table><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">FIXTURE PROHIBITION<\/p><p>No demonstration or reference-cartographic fixture is used as evidence in this edition. The publication gate checks every binding against this register.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-cb-s3\" aria-labelledby=\"nx-nrp-xt-04-cb-s3-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-cb-s3-h\"><span class=\"nrp-num\">B.3<\/span><span>Regional reading, synthetic biology across ten clusters<\/span><\/h2><p class=\"nrp-stand\">Regional plates follow with the regional editions. This page gives the regional reading of synthetic biology infrastructure and governance in table form and ranks no region.<\/p><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-cb-tab4\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table B.4<\/span><span class=\"nrp-tbl-t\">Regional reading, synthetic biology across ten clusters<\/span><\/caption><thead><tr><th scope=\"col\">Region<\/th><th scope=\"col\">Principal hazards<\/th><th scope=\"col\">Systems most exposed<\/th><th scope=\"col\">Baseline evidence<\/th><\/tr><\/thead><tbody><tr><td>North America<\/td><td>research laboratories; federal commission report; screening framework in flux<\/td><td>governance, manufacturing<\/td><td>CRS<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n14\" aria-label=\"Note 14\">14<\/a><\/sup>; programme page<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n24\" aria-label=\"Note 24\">24<\/a><\/sup><\/td><\/tr><tr><td>South America<\/td><td>early national programmes; CBD participation<\/td><td>governance<\/td><td>regional evidence (not bound)<\/td><\/tr><tr><td>Europe<\/td><td>Biotech Act proposal; research strength<\/td><td>governance, research<\/td><td>EU proposal summary<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n22\" id=\"nx-nrp-xt-04-cb-r22\" aria-label=\"Note 22\">22<\/a><\/sup>; OECD<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n18\" aria-label=\"Note 18\">18<\/a><\/sup><\/td><\/tr><tr><td>Eurasia<\/td><td>research programmes<\/td><td>research<\/td><td>regional evidence (not bound)<\/td><\/tr><tr><td>Middle East and North Africa<\/td><td>emerging programmes<\/td><td>governance<\/td><td>regional evidence (not bound)<\/td><\/tr><tr><td>Africa<\/td><td>skills and access; gene drive field programmes<\/td><td>workforce, release<\/td><td>Kyrou<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n11\" id=\"nx-nrp-xt-04-cb-r11\" aria-label=\"Note 11\">11<\/a><\/sup>; regional evidence (not bound)<\/td><\/tr><tr><td>South Asia<\/td><td>national mission programmes<\/td><td>research, skills<\/td><td>regional evidence (not bound)<\/td><\/tr><tr><td>East Asia<\/td><td>manufacturing and research programmes<\/td><td>manufacturing, research<\/td><td>regional evidence (not bound)<\/td><\/tr><tr><td>ASEAN<\/td><td>bioeconomy planning<\/td><td>governance, manufacturing<\/td><td>regional evidence (not bound)<\/td><\/tr><tr><td>Oceania-Pacific<\/td><td>research programmes; skills<\/td><td>research, workforce<\/td><td>regional evidence (not bound)<\/td><\/tr><\/tbody><\/table><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">MAP PLATES WITH THE REGIONAL EDITIONS<\/p><p>Each plate will carry its boundary source and version, projection, resolution, classification, uncertainty encoding and public-safe transform, with text and table alternatives.<\/p><\/aside><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">boundary<\/p><p>Regional readings summarise the cited evidence. They are not risk ratings of any region or country.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-cb-s4\" aria-labelledby=\"nx-nrp-xt-04-cb-s4-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-cb-s4-h\"><span class=\"nrp-num\">B.4<\/span><span>Cluster card: DNA synthesis and screening chain<\/span><\/h2><ul class=\"nrp-chips\"><li class=\"nf-ui-chip\">supply chain<\/li><li class=\"nf-ui-chip\">DNA synthesis<\/li><li class=\"nf-ui-chip\">screening<\/li><li class=\"nf-ui-chip\">oversight<\/li><\/ul><dl class=\"nrp-dl\"><dt>Systems in view<\/dt><dd>synthesis providers, design tools, sequence data, oversight bodies<\/dd><dt>Defining events<\/dt><dd>the 2025 screening study and the 2025 US executive order<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n13\" aria-label=\"Note 13\">13<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n26\" id=\"nx-nrp-xt-04-cb-r26\" aria-label=\"Note 26\">26<\/a><\/sup><\/dd><dt>Couplings<\/dt><dd>DAT \u2192 BIO sequence data; GOV \u2192 SEC frameworks<\/dd><dt>Capability evidence<\/dt><dd>industry and national guidance exists<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n31\" id=\"nx-nrp-xt-04-cb-r31\" aria-label=\"Note 31\">31<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-04-cb-n32\" id=\"nx-nrp-xt-04-cb-r32\" aria-label=\"Note 32\">32<\/a><\/sup><\/dd><dt>Gaps<\/dt><dd>coverage by provider; benchtop devices; compliance<\/dd><dt>Agenda items<\/dt><dd>Q-01 \u00b7 Q-03<\/dd><\/dl><div class=\"nrp-cards\"><article class=\"nf-ui-card nrp-card\"><p class=\"nf-ui-eyebrow\">Open machine-learning protein design software can produce variants that screening tools often missed [13].<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">TOOLS<\/h3><p>Open design software<\/p><\/article><article class=\"nf-ui-card nrp-card\"><p class=\"nf-ui-eyebrow\">The 2024 US framework and the 2025 order left the current text unclear in sources read [26] [27].<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">RULES<\/h3><p>A framework in flux<\/p><\/article><article class=\"nf-ui-card nrp-card\"><p class=\"nf-ui-eyebrow\">Patches improved detection in the study, and industry and national guidance exists, but coverage is not counted [13] [31] [32].<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">RESPONSE<\/h3><p>Patches and guidance<\/p><\/article><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">evidence<\/p><p>Cluster cards are generated for the major platform and supply clusters in 2027. The DNA synthesis and screening chain is shown first because a peer-reviewed test of it exists.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-cb-s5\" aria-labelledby=\"nx-nrp-xt-04-cb-s5-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-cb-s5-h\"><span class=\"nrp-num\">B.5<\/span><span>How countries appear in the synthetic biology edition<\/span><\/h2><p class=\"nrp-stand\">Countries enter the synthetic biology edition through the readiness chapters of their own national editions, on one card grammar. They are read against peer distributions and thresholds, never ranked.<\/p><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-cb-tab5\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table B.5<\/span><span class=\"nrp-tbl-t\">How countries appear in the synthetic biology edition<\/span><\/caption><thead><tr><th scope=\"col\">Card field<\/th><th scope=\"col\">What it shows<\/th><th scope=\"col\">Source<\/th><\/tr><\/thead><tbody><tr><td>WEFH+B state<\/td><td>each core system against peer distribution bands<\/td><td>national edition<\/td><\/tr><tr><td>Couplings<\/td><td>the national dependency matrix<\/td><td>national edition<\/td><\/tr><tr><td>Risk objects<\/td><td>the national risk portfolio<\/td><td>national edition<\/td><\/tr><tr><td>Capability rungs<\/td><td>the national capability ladder<\/td><td>national edition<\/td><\/tr><tr><td>Evidence age<\/td><td>oldest and newest source dates<\/td><td>national source register<\/td><\/tr><\/tbody><\/table><\/div><h3 class=\"nrp-h3\">Editions in the 2026 Baseline programme<\/h3><div class=\"pp-cells nrp-cells-3\"><div class=\"nrp-cell\"><span class=\"pp-metric\">26<\/span><span class=\"nrp-cell-u\">national<\/span><p>countries and unions<\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">10<\/span><span class=\"nrp-cell-u\">regional<\/span><p>clusters<\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">16<\/span><span class=\"nrp-cell-u\">global<\/span><p>flagship and sector<\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">14<\/span><span class=\"nrp-cell-u\">strategic<\/span><p><a class=\"nx-link nx-term\" href=\"https:\/\/docs.therisk.global\/organization\/systems\" data-tc=\"Systems\" data-tk=\"Nexus Standards\" data-td=\"The twenty Nexus systems, NXS-CMD to NXS-LAB\">systems<\/a> reports<\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">20<\/span><span class=\"nrp-cell-u\">frontier<\/span><p>technology reports<\/p><\/div><\/div><h3 class=\"nrp-h3\">How to read a country card<\/h3><ul class=\"nrp-list\"><li>Each system is shown against the distribution of its peers, with thresholds where they exist<\/li><li>Couplings and risk objects come from the country\u2019s own national edition<\/li><li>Capability rungs record evidence, not a judgement of institutions<\/li><li>Evidence age is printed, so older national data are visible as such<\/li><\/ul><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-cb-tab6\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table B.6<\/span><span class=\"nrp-tbl-t\">National Baseline Editions in the 2026 programme<\/span><\/caption><thead><tr><th scope=\"col\">Wave<\/th><th scope=\"col\">Countries and unions<\/th><th scope=\"col\">State<\/th><\/tr><\/thead><tbody><tr><td>W0<\/td><td>Canada<\/td><td>ISSUED<\/td><\/tr><tr><td>W1<\/td><td>United States, United Kingdom, France, Germany, Italy, Japan, European Union, Switzerland<\/td><td>PLANNED<\/td><\/tr><tr><td>W2<\/td><td>Mexico, Brazil, Argentina, T\u00fcrkiye, Russian Federation, Saudi Arabia, United Arab Emirates, South Africa, Senegal, Kenya, African Union, India, China, Republic of Korea, Indonesia, Singapore, Australia<\/td><td>PLANNED<\/td><\/tr><\/tbody><\/table><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">boundary<\/p><p>External rankings, where cited, keep their own method and source. Nexus never converts them into a rating, and each country\u2019s ownership of its national edition is unaffected by its appearance here.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-cb-s6\" aria-labelledby=\"nx-nrp-xt-04-cb-s6-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-cb-s6-h\"><span class=\"nrp-num\">B.6<\/span><span>Licences<\/span><\/h2><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-cb-tab7\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table B.7<\/span><span class=\"nrp-tbl-t\">Licences of each kind of material<\/span><\/caption><thead><tr><th scope=\"col\">Material<\/th><th scope=\"col\">Licence<\/th><\/tr><\/thead><tbody><tr><td>Text<\/td><td>CC BY 4.0<\/td><\/tr><tr><td>Data<\/td><td>on the licence of each source; Nexus tables CC BY 4.0<\/td><\/tr><tr><td>Figures<\/td><td>Nexus figures CC BY 4.0; third-party as credited<\/td><\/tr><tr><td>Maps<\/td><td>boundary source and licence printed on each plate<\/td><\/tr><tr><td>Metadata<\/td><td>CC0 1.0, as Zenodo publishes it<\/td><\/tr><tr><td>Third-party data, figures and text<\/td><td>The source&#8217;s own licence, credited where it is used; never relicensed<\/td><\/tr><\/tbody><tfoot><tr><td colspan=\"2\">Nexus-authored text, tables and figures: CC BY 4.0 (SPDX CC-BY-4.0). Map plates print their boundary source and licence.<\/td><\/tr><\/tfoot><\/table><\/div><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-cb-s7\" aria-labelledby=\"nx-nrp-xt-04-cb-s7-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-cb-s7-h\"><span class=\"nrp-num\">B.7<\/span><span>Formats and provenance<\/span><\/h2><div class=\"nrp-tblw\" id=\"nx-nrp-xt-04-cb-tab8\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table B.8<\/span><span class=\"nrp-tbl-t\">This edition in every format<\/span><\/caption><thead><tr><th scope=\"col\">Format<\/th><th scope=\"col\">Kind<\/th><th scope=\"col\">State<\/th><th scope=\"col\">What it is<\/th><th scope=\"col\">Identifier<\/th><\/tr><\/thead><tbody><tr><td>Web edition<\/td><td><span class=\"nrp-mono\">HTML<\/span><\/td><td><span class=\"nx-nr-out-s\" data-state=\"here\">On this site<\/span><\/td><td>Draft in stewardship review; every value resolves to its source.<\/td><td><span class=\"nrp-mono\">NR-XTECH-SYNBIO-GLOBAL-2026-BASELINE-v1.0.0<\/span><\/td><\/tr><tr><td>Print edition<\/td><td><span class=\"nrp-mono\">PDF<\/span><\/td><td><span class=\"nx-nr-out-s\" data-state=\"release\">At release<\/span><\/td><td>A4 portrait \u00b7 screen, print and archival PDF, signed with the web edition at release.<\/td><td><span class=\"nrp-mono\">NR-XTECH-SYNBIO-GLOBAL-2026-BASELINE-v1.0.0<\/span><\/td><\/tr><tr><td>Indicator data<\/td><td><span class=\"nrp-mono\">CSV \u00b7 JSON<\/span><\/td><td><span class=\"nx-nr-out-s\" data-state=\"here\">On this site<\/span><\/td><td>21 indicators with unit, year, status and source; the machine-readable copy ships with the evidence bundle at release.<\/td><td><span class=\"nrp-mono\">NR-XTECH-SYNBIO-GLOBAL-2026-BASELINE data release v1<\/span><\/td><\/tr><tr><td>Figures<\/td><td><span class=\"nrp-mono\">SVG \u00b7 PNG<\/span><\/td><td><span class=\"nx-nr-out-s\" data-state=\"here\">On this site<\/span><\/td><td>4 on the web edition: headline figure, figure 1.3, coupling instrument, capability ladder.<\/td><td><span class=\"nrp-mono\">FIG-XTECH-SYNBIO-GLOBAL-2026-BASELINE-*<\/span><\/td><\/tr><tr><td>Slides<\/td><td><span class=\"nrp-mono\">PDF<\/span><\/td><td><span class=\"nx-nr-out-s\" data-state=\"none\">Not recorded<\/span><\/td><td>No slide deck is recorded for this edition.<\/td><td><span class=\"nrp-mono\"><\/span><\/td><\/tr><tr><td>Evidence brief<\/td><td><span class=\"nrp-mono\">HTML \u00b7 PDF<\/span><\/td><td><span class=\"nx-nr-out-s\" data-state=\"none\">Not recorded<\/span><\/td><td>No evidence brief is recorded for this edition.<\/td><td><span class=\"nrp-mono\"><\/span><\/td><\/tr><tr><td>Dataset with DOI<\/td><td><span class=\"nrp-mono\">DataCite<\/span><\/td><td><span class=\"nx-nr-out-s\" data-state=\"release\">At release<\/span><\/td><td>Concept and version DOI are minted at deposit; none is recorded yet.<\/td><td><span class=\"nrp-mono\"><\/span><\/td><\/tr><\/tbody><\/table><\/div><h3 class=\"nrp-h3\">Provenance<\/h3><dl class=\"nrp-dl\"><dt>Edition pack<\/dt><dd>The edition&#8217;s content pack (JSON), from which the print and web editions are built<\/dd><dt>Evidence cut<\/dt><dd>DC-XTECH-SYNBIO-GLOBAL-2026-B0, closed 30 September 2026<\/dd><dt>Reproducibility<\/dt><dd>sourced values cited; analytical values reproducible from stated parameters<\/dd><dt>Self-check<\/dt><dd>14 of 23 at evidence close; a fail on any item blocks release<\/dd><dt>Review<\/dt><dd>five passes scheduled before release (in Annex C)<\/dd><dt>Publisher of record<\/dt><dd>The Global Centre for Risk and Innovation (GCRI) for the Nexus Consortium<\/dd><dt>Corrections<\/dt><dd>Registry correction pathway; upheld corrections are published as notices with a new version<\/dd><\/dl><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-04-cb-notes\" aria-labelledby=\"nx-nrp-xt-04-cb-notes-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-cb-notes-h\"><span>Notes<\/span><\/h2><p class=\"nrp-note\">Numbers are the edition&#8217;s reference numbers, so a note reads the same in every chapter. The full list, with every source and its licence, is in Annex C. <a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/references\/\">Annex C, references<\/a><\/p><ol class=\"nrp-notes\"><li id=\"nx-nrp-xt-04-cb-n2\"><span class=\"nrp-notes-n\">2<\/span><span>MRC Laboratory of Molecular Biology (ed.), Syn57 represents a new chapter in the genetic code of life (news page, 1 August 2025; over 101,000 codons recoded; 64 to 57 codons; genome of about 4 megabases built from 38 fragments of about 100 kilobases). MRC Laboratory of Molecular Biology, Cambridge. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-cb-r2\" aria-label=\"Back to the first call of note 2\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-cb-n3\"><span class=\"nrp-notes-n\">3<\/span><span>Fredens, J. et al., Total synthesis of Escherichia coli with a recoded genome, Nature 569 (7757), 514 to 518, 2019 (record read via Europe PMC: 18,214 codons recoded; 61-codon genome). Springer Nature, London. Observation year 2019. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-cb-r3\" aria-label=\"Back to the first call of note 3\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-cb-n4\"><span class=\"nrp-notes-n\">4<\/span><span>Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions, Cell 186 (24), 5220 to 5236, 2023 (record read via Europe PMC: 6.5 synthetic chromosomes in one strain; over half of the Sc2.0 genome). Cell Press, Cambridge, Massachusetts. Observation year 2023. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-cb-r4\" aria-label=\"Back to the first call of note 4\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-cb-n5\"><span class=\"nrp-notes-n\">5<\/span><span>Gibson, D.G. et al., Creation of a bacterial cell controlled by a chemically synthesised genome, Science 329 (5987), 52 to 56, 2010 (record read via Europe PMC: 1.08 million base pair genome). American Association for the Advancement of Science, Washington. Observation year 2010. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-cb-r5\" aria-label=\"Back to the first call of note 5\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-cb-n6\"><span class=\"nrp-notes-n\">6<\/span><span>Nielsen, A.A.K. et al., Genetic circuit design automation, Science 352 (6281), 2016 (record read via Europe PMC: 60 circuits; 45 correct in all output states; 92% of output states as predicted). American Association for the Advancement of Science, Washington. Observation year 2016. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-cb-r6\" aria-label=\"Back to the first call of note 6\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-cb-n8\"><span class=\"nrp-notes-n\">8<\/span><span>Frangoul, H. et al., Exagamglogene autotemcel for severe sickle cell disease, New England Journal of Medicine 390 (18), 1649 to 1662, 2024 (record read via Europe PMC: 44 treated; 29 of 30 evaluable free of severe crises for 12 months; median follow-up 19.3 months). Massachusetts Medical Society, Waltham. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-cb-r8\" aria-label=\"Back to the first call of note 8\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-cb-n14\"><span class=\"nrp-notes-n\">14<\/span><span>Congressional Research Service (ed.), National Security Commission on Emerging Biotechnology: Final Report and Options for Congress, CRS Insight IN12546, 17 April 2025 (report of 8 April 2025; 49 recommendations; at least USD 15 billion over five years; National Biotechnology Coordination Office). Library of Congress, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-cb-r14\" aria-label=\"Back to the first call of note 14\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-cb-n16\"><span class=\"nrp-notes-n\">16<\/span><span>Twist Bioscience Corporation (ed.), Form 8-K exhibit 99.1, results for the fiscal third quarter ended 30 June 2026 (company filing; revenue USD 118.4 million; nine months USD 332.8 million; fiscal 2026 guidance USD 456 to 457 million; company statements and guidance are weak evidence). US Securities and Exchange Commission, Washington. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-cb-r16\" aria-label=\"Back to the first call of note 16\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-cb-n17\"><span class=\"nrp-notes-n\">17<\/span><span>Ginkgo Bioworks Holdings, Inc. (ed.), Form 8-K exhibit 99.1, fourth quarter and full year 2025 results (company filing of 26 February 2026; revenue USD 170.155 million against USD 227.043 million; net loss USD 312.763 million; company statements are weak evidence). US Securities and Exchange Commission, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-cb-r17\" aria-label=\"Back to the first call of note 17\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-cb-n24\"><span class=\"nrp-notes-n\">24<\/span><span>US Manufacturing Program (ed.), Bioindustrial (programme topic page; Distributed Bioindustrial Manufacturing Program awards announced 10 July to 13 September 2024; 25 awards; USD 42 million cumulative). Manufacturing USA, Gaithersburg. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-cb-r24\" aria-label=\"Back to the first call of note 24\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-cb-n23\"><span class=\"nrp-notes-n\">23<\/span><span>BioMADE (ed.), DoD approves USD 87 million for newest bioindustrial manufacturing innovation institute (news page; seven years; the page shows Oct 20 and a 2023 footer, the press release is dated 2020 in search listings). BioMADE, Saint Paul. Observation year 2020. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-cb-r23\" aria-label=\"Back to the first call of note 23\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-cb-n1\"><span class=\"nrp-notes-n\">1<\/span><span>Robertson, W.E. et al., Escherichia coli with a 57-codon genetic code, Science 390 (6771), eady4368, published 23 October 2025 (record read via PubMed, PMID 40743368; the record gives a 4 megabase synthetic genome and six replaced sense codons). American Association for the Advancement of Science, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-cb-r1\" aria-label=\"Back to the first call of note 1\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-cb-n10\"><span class=\"nrp-notes-n\">10<\/span><span>Musunuru, K. et al., Patient-specific in vivo gene editing to treat a rare genetic disease, New England Journal of Medicine 392 (22), 2235 to 2243, 2025 (record read via Europe PMC: one infant; two infusions at about 7 and 8 months). Massachusetts Medical Society, Waltham. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-cb-r10\" aria-label=\"Back to the first call of note 10\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-cb-n9\"><span class=\"nrp-notes-n\">9<\/span><span>US Food and Drug Administration (ed.), FDA approves first gene therapies to treat patients with sickle cell disease (press announcement, 8 December 2023; Casgevy and Lyfgenia; ages 12 and over; 29 of 31 evaluable Casgevy patients free of severe crises for at least 12 months). FDA, Silver Spring. Observation year 2023. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-cb-r9\" aria-label=\"Back to the first call of note 9\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-cb-n13\"><span class=\"nrp-notes-n\">13<\/span><span>Strengthening nucleic acid biosecurity screening against generative protein design tools, Science 390 (6768), 82 to 87, 2025 (record read via Europe PMC; abstract only; no method detail used). American Association for the Advancement of Science, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-cb-r13\" aria-label=\"Back to the first call of note 13\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-cb-n18\"><span class=\"nrp-notes-n\">18<\/span><span>OECD (ed.), Anticipatory governance for responsible innovation in synthetic biology, OECD Science, Technology and Industry Policy Papers No. 193, 21 May 2026 (record read via a bibliographic database; abstract only). OECD Publishing, Paris. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-cb-r18\" aria-label=\"Back to the first call of note 18\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-cb-n19\"><span class=\"nrp-notes-n\">19<\/span><span>OECD (ed.), Synthetic biology, AI and automation: a forward-looking technology assessment, OECD Science, Technology and Industry Policy Papers No. 187, 4 December 2025 (record read via a bibliographic database; abstract only). OECD Publishing, Paris. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-cb-r19\" aria-label=\"Back to the first call of note 19\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-cb-n22\"><span class=\"nrp-notes-n\">22<\/span><span>Baker McKenzie (ed.), EU Biotech Act unveiled: Commission proposal to turn Europe into a biotech powerhouse (law firm summary, 19 December 2025; proposal of 16 December 2025; health focus; investment pilot with the European Investment Bank Group; 12-month certificate extension; biodefence measures; second act expected in Q3 2026). Secondary source, not the Commission text. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-cb-r22\" aria-label=\"Back to the first call of note 22\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-cb-n11\"><span class=\"nrp-notes-n\">11<\/span><span>Kyrou, K. et al., A CRISPR-Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes, Nature Biotechnology 36, 1062 to 1066, 2018 (record read via Europe PMC; laboratory cages only). Springer Nature, London. Observation year 2018. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-cb-r11\" aria-label=\"Back to the first call of note 11\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-cb-n26\"><span class=\"nrp-notes-n\">26<\/span><span>UNVERIFIED, not opened: Executive Order 14292, Improving the Safety and Security of Biological Research, 5 May 2025 (90 days to revise or replace the framework), taken from search-result summaries; a fetch of an explainer page was refused by the fetch tool. The White House, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-cb-r26\" aria-label=\"Back to the first call of note 26\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-cb-n31\"><span class=\"nrp-notes-n\">31<\/span><span>UNVERIFIED, not opened: International Gene Synthesis Consortium (ed.), Harmonized Screening Protocol, cited from memory. IGSC. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-cb-r31\" aria-label=\"Back to the first call of note 31\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-04-cb-n32\"><span class=\"nrp-notes-n\">32<\/span><span>UNVERIFIED, not opened: UK Government (ed.), screening guidance on synthetic nucleic acids, 2024, cited from memory. Department for Science, Innovation and Technology, London. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-04-cb-r32\" aria-label=\"Back to the first call of note 32\">back<\/a><\/span><\/li><\/ol><\/section><section class=\"nrp-block nrp-noprint\" id=\"nx-nrp-xt-04-cb-cite\" aria-labelledby=\"nx-nrp-xt-04-cb-cite-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-04-cb-cite-h\"><span>Cite this annex<\/span><\/h2><pre class=\"nrp-pre\">Valadbaygi, S. (Ed.). (2026). Annex B: Data appendix. In Exponential Technology Report 2026: Synthetic Biology and Bioengineering (Baseline Edition 2026, Report No. NR-XTECH-SYNBIO-GLOBAL-2026-BASELINE) [Draft under review]. The Global Centre for Risk and Innovation (GCRI).<\/pre><p class=\"nrp-note\">Every citation form of the whole report, BibTeX and RIS included, is on the edition home. <a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/#nx-nrp-xt-04-land-cite\">Cite this report<\/a><\/p><\/section><nav class=\"nrp-pager\" aria-label=\"Previous and next\"><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/methodology\/\" rel=\"prev\"><span class=\"nf-ui-eyebrow\">Previous \u00b7 Annex A<\/span><span class=\"nrp-pager-t\">Methodology<\/span><\/a><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-04\/references\/\" rel=\"next\"><span class=\"nf-ui-eyebrow\">Next \u00b7 Annex C<\/span><span class=\"nrp-pager-t\">References and record<\/span><\/a><\/nav><\/article><\/div><\/div><\/div><div class=\"nrp-noprint\"><section id=\"nx-sec-nr-gateway\" class=\"nx-section\" data-hue=\"systemic\" data-tone=\"alt\" aria-labelledby=\"nx-nr-gateway-h\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">Reports<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Contribute<\/span><\/div><h2 id=\"nx-nr-gateway-h\" class=\"nx-section-title\">Send evidence or a correction on Synthetic Biology and Bioengineering.<\/h2><p class=\"nx-lede\"><a class=\"nx-link\" href=\"https:\/\/docs.therisk.global\/organization\/programme\/reports\">Reports<\/a> is the Consortium&#8217;s quarterly publication, written by six desks. 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