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\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\"><style>#nxe-nr-gcri-editions-xt-05-coupled-system.nxe{display:block;box-sizing:border-box;max-width:1180px;margin:0 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8px;text-align:left;vertical-align:top;border-bottom:1px solid;border-color:inherit}#nxe-nr-gcri-editions-xt-05-coupled-system.nxe svg{display:none}#nxe-nr-gcri-editions-xt-05-coupled-system.nxe svg.nx-i{display:inline-block;width:18px;height:18px;vertical-align:-3px}#nxe-nr-gcri-editions-xt-05-coupled-system.nxe :where([role=\"tablist\"],[role=\"toolbar\"],[hidden],button,.nx-theme-toggle,.nx-live-slot){display:none}#nxe-nr-gcri-editions-xt-05-coupled-system.nxe img{max-width:100%;height:auto}<\/style><svg class=\"nx-defs\" aria-hidden=\"true\" focusable=\"false\" width=\"0\" height=\"0\"><defs><linearGradient id=\"nx-gi\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"1\"><stop offset=\"0\" class=\"nx-gi-a\"\/><stop offset=\"0.55\" class=\"nx-gi-b\"\/><stop offset=\"1\" class=\"nx-gi-c\"\/><\/linearGradient><linearGradient id=\"nx-giu\" gradientUnits=\"userSpaceOnUse\" x1=\"0\" y1=\"0\" x2=\"800\" y2=\"0\"><stop offset=\"0\" class=\"nx-gi-a\"\/><stop offset=\"0.55\" class=\"nx-gi-b\"\/><stop offset=\"1\" class=\"nx-gi-c\"\/><\/linearGradient><linearGradient id=\"nx-gp\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"1\"><stop offset=\"0\" class=\"nx-gp-a\"\/><stop offset=\"1\" class=\"nx-gp-b\"\/><\/linearGradient><\/defs><\/svg><div class=\"nrp\"><div class=\"nrp-wrap\"><p class=\"nrj-draft\" data-nrj-shared=\"draft\" role=\"note\"><strong>Draft, not yet released.<\/strong> In stewardship review. Not indexed until the first approved release.<\/p><div class=\"nrp-reader\"><nav class=\"nrp-rail\" aria-label=\"Contents of Genomics and Gene Editing 2026\"><p class=\"nf-ui-eyebrow\">Contents<\/p><ol class=\"nrp-toc\"><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Edition home<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/summary\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Executive summary<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/coupled-system\/\" aria-current=\"page\"><span class=\"nrp-toc-n\">1<\/span><span>Genomics is data infrastructure and a therapeutic frontier<\/span><\/a><ol class=\"nrp-toc-sub\"><li><a href=\"#nx-nrp-xt-05-c1-s1\">1.1 The questions this part answers<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c1-s2\">1.2 The argument<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c1-s3\">1.3 Twenty couplings between five systems<\/a><\/li><\/ol><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/findings\/\"><span class=\"nrp-toc-n\">2<\/span><span>Key findings<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/systems-and-sectors\/\"><span class=\"nrp-toc-n\">3<\/span><span>Systems and sectors at baseline<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/risk-and-capability\/\"><span class=\"nrp-toc-n\">4<\/span><span>Risks and capability<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/scenario\/\"><span class=\"nrp-toc-n\">5<\/span><span>Individualised editing outpaces delivery systems<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/lenses-and-readings\/\"><span class=\"nrp-toc-n\">6<\/span><span>Readings from the other desks<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/agenda\/\"><span class=\"nrp-toc-n\">7<\/span><span>The 2027 agenda<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/systems-in-depth\/\"><span class=\"nrp-toc-n\">8<\/span><span>Systems in depth<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/methodology\/\"><span class=\"nrp-toc-n\">A<\/span><span>Methodology<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/data\/\"><span class=\"nrp-toc-n\">B<\/span><span>Data appendix<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/references\/\"><span class=\"nrp-toc-n\">C<\/span><span>References and record<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/full\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Complete edition, for print<\/span><\/a><\/li><\/ol><div class=\"nrp-actions\"><a class=\"nf-ui-btn\" data-variant=\"secondary\" href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/full\/\"><svg class=\"nrp-i\" viewBox=\"0 0 24 24\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2\"\/><path d=\"M6 9V3a1 1 0 0 1 1-1h10a1 1 0 0 1 1 1v6\"\/><rect x=\"6\" y=\"14\" width=\"12\" height=\"8\" rx=\"1\"\/><\/svg>Print or save as PDF<\/a><\/div><\/nav><article class=\"nrp-flow\" aria-labelledby=\"nx-nrp-xt-05-c1-top\"><header class=\"nrp-chap-head\" id=\"nx-nrp-xt-05-c1-top\"><ul class=\"nrp-eyerow\"><li class=\"nf-ui-eyebrow\"><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/\">Genomics and Gene Editing 2026<\/a><\/li><li class=\"nf-ui-eyebrow\">Chapter 1<\/li><\/ul><span class=\"nrp-rule\" aria-hidden=\"true\"><\/span><h1 class=\"pp-hero-title\">Genomics is data infrastructure and a therapeutic frontier<\/h1><p class=\"nrp-lede\">Part I describes systems and their couplings. It ranks no country or operator and assesses no authority.<\/p><p class=\"nrp-chap-meta\"><span>8 min read<\/span><span>2 figures<\/span><span>1 table<\/span><span>22 notes<\/span><span>NR-XTECH-GENOMICS-GLOBAL-2026-BASELINE<\/span><\/p><details class=\"nrp-toc-m\"><summary>Contents<\/summary><ol class=\"nrp-toc\"><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Edition home<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/summary\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Executive summary<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/coupled-system\/\" aria-current=\"page\"><span class=\"nrp-toc-n\">1<\/span><span>Genomics is data infrastructure and a therapeutic frontier<\/span><\/a><ol class=\"nrp-toc-sub\"><li><a href=\"#nx-nrp-xt-05-c1-s1\">1.1 The questions this part answers<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c1-s2\">1.2 The argument<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c1-s3\">1.3 Twenty couplings between five systems<\/a><\/li><\/ol><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/findings\/\"><span class=\"nrp-toc-n\">2<\/span><span>Key findings<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/systems-and-sectors\/\"><span class=\"nrp-toc-n\">3<\/span><span>Systems and sectors at baseline<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/risk-and-capability\/\"><span class=\"nrp-toc-n\">4<\/span><span>Risks and capability<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/scenario\/\"><span class=\"nrp-toc-n\">5<\/span><span>Individualised editing outpaces delivery systems<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/lenses-and-readings\/\"><span class=\"nrp-toc-n\">6<\/span><span>Readings from the other desks<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/agenda\/\"><span class=\"nrp-toc-n\">7<\/span><span>The 2027 agenda<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/systems-in-depth\/\"><span class=\"nrp-toc-n\">8<\/span><span>Systems in depth<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/methodology\/\"><span class=\"nrp-toc-n\">A<\/span><span>Methodology<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/data\/\"><span class=\"nrp-toc-n\">B<\/span><span>Data appendix<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/references\/\"><span class=\"nrp-toc-n\">C<\/span><span>References and record<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/full\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Complete edition, for print<\/span><\/a><\/li><\/ol><\/details><\/header><section class=\"nrp-block\" id=\"nx-nrp-xt-05-c1-s1\" aria-labelledby=\"nx-nrp-xt-05-c1-s1-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-c1-s1-h\"><span class=\"nrp-num\">1.1<\/span><span>The questions this part answers<\/span><\/h2><h3 class=\"nrp-h3\">Key questions<\/h3><ul class=\"nrp-list\"><li>Where is genomics risk concentrated?<\/li><li>Which couplings carry genomics shocks into other <a class=\"nx-link nx-term\" href=\"https:\/\/docs.therisk.global\/organization\/systems\" data-tc=\"Systems\" data-tk=\"Nexus Standards\" data-td=\"The twenty Nexus systems, NXS-CMD to NXS-LAB\">systems<\/a>?<\/li><li>Which genomics capabilities hold under compound stress?<\/li><li>What must 2027 evidence measure first?<\/li><\/ul><h3 class=\"nrp-h3\">In this part<\/h3><ul class=\"nrp-chips\"><li class=\"nf-ui-chip\">Narrative<\/li><li class=\"nf-ui-chip\">Headline finding<\/li><li class=\"nf-ui-chip\">Lead figure<\/li><li class=\"nf-ui-chip\">Five footprint and governance chapters<\/li><li class=\"nf-ui-chip\">Twelve-domain reading<\/li><li class=\"nf-ui-chip\">Sector screens<\/li><li class=\"nf-ui-chip\">Dependency matrix<\/li><li class=\"nf-ui-chip\">Risk objects<\/li><li class=\"nf-ui-chip\">Capability ladder<\/li><li class=\"nf-ui-chip\">Scenario<\/li><li class=\"nf-ui-chip\">Three lenses<\/li><li class=\"nf-ui-chip\">Portfolio<\/li><\/ul><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-c1-s2\" aria-labelledby=\"nx-nrp-xt-05-c1-s2-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-c1-s2-h\"><span class=\"nrp-num\">1.2<\/span><span>The argument<\/span><\/h2><div class=\"nrp-prose\"><p>Genomics is often told as a story of falling cost. The 2026 evidence reads it as two things at once: a data and hardware infrastructure of sequencers, reference genomes and biobanks, and a therapeutic technology whose first products now reach patients<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n11\" id=\"nx-nrp-xt-05-c1-r11\" aria-label=\"Note 11\">11<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n16\" id=\"nx-nrp-xt-05-c1-r16\" aria-label=\"Note 16\">16<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n1\" id=\"nx-nrp-xt-05-c1-r1\" aria-label=\"Note 1\">1<\/a><\/sup>.<\/p><p>The therapy evidence is strong for one family. In two phase 3 studies, 97% of evaluable sickle cell patients and 91% of evaluable thalassaemia patients met the primary end point<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n2\" id=\"nx-nrp-xt-05-c1-r2\" aria-label=\"Note 2\">2<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n3\" id=\"nx-nrp-xt-05-c1-r3\" aria-label=\"Note 3\">3<\/a><\/sup>. One infant received a patient-specific base editor in 2025<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n4\" id=\"nx-nrp-xt-05-c1-r4\" aria-label=\"Note 4\">4<\/a><\/sup>. These are results at short follow-up, not a settled safety record<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n9\" id=\"nx-nrp-xt-05-c1-r9\" aria-label=\"Note 9\">9<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n10\" id=\"nx-nrp-xt-05-c1-r10\" aria-label=\"Note 10\">10<\/a><\/sup>.<\/p><p>The data evidence is practical. A complete genome sequence of 3.055 billion base pairs exists<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n11\" aria-label=\"Note 11\">11<\/a><\/sup>, a draft pangenome adds 119 million base pairs<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n12\" id=\"nx-nrp-xt-05-c1-r12\" aria-label=\"Note 12\">12<\/a><\/sup>, and two biobanks hold hundreds of thousands of genomes<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n16\" aria-label=\"Note 16\">16<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n17\" id=\"nx-nrp-xt-05-c1-r17\" aria-label=\"Note 17\">17<\/a><\/sup>. Most genetic studies still rest on European ancestry<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n18\" id=\"nx-nrp-xt-05-c1-r18\" aria-label=\"Note 18\">18<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n19\" id=\"nx-nrp-xt-05-c1-r19\" aria-label=\"Note 19\">19<\/a><\/sup>.<\/p><p>The physical and legal base is the least measured part. Vendor pages claim low sequencing prices<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n14\" id=\"nx-nrp-xt-05-c1-r14\" aria-label=\"Note 14\">14<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n15\" id=\"nx-nrp-xt-05-c1-r15\" aria-label=\"Note 15\">15<\/a><\/sup>, the energy footprint of sequencing is unpublished, compute has a carbon footprint<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n21\" id=\"nx-nrp-xt-05-c1-r21\" aria-label=\"Note 21\">21<\/a><\/sup>, and trade rules changed sequencer supply in 2025<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n30\" id=\"nx-nrp-xt-05-c1-r30\" aria-label=\"Note 30\">30<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n31\" id=\"nx-nrp-xt-05-c1-r31\" aria-label=\"Note 31\">31<\/a><\/sup>.<\/p><\/div><figure class=\"nrp-fig\" id=\"nx-nrp-xt-05-c1-fig1\" aria-labelledby=\"nx-nrp-xt-05-c1-fig1-t\"><figcaption class=\"nrp-figcap\"><span class=\"nf-ui-eyebrow\">Figure 1.1<\/span><span class=\"nf-ui-title\" data-level=\"card\" id=\"nx-nrp-xt-05-c1-fig1-t\">How much sequence did the two reference releases add? Million base pairs<\/span><p class=\"nrp-fig-what\">Both releases added sequence to the earlier reference. The two figures are measured against the same earlier reference but with different methods, so they are not additive<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n11\" aria-label=\"Note 11\">11<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n12\" aria-label=\"Note 12\">12<\/a><\/sup>.<\/p><\/figcaption><div class=\"nrp-tblw\"><table class=\"nrp-tbl nrp-bars\"><thead><tr><th scope=\"col\">Item<\/th><th scope=\"col\"><span class=\"nrp-sr\">Bar, scaled to the largest value<\/span><\/th><th scope=\"col\">Value<\/th><\/tr><\/thead><tbody><tr><th scope=\"row\">T2T-CHM13 (2022): nearly 200 million base pairs of new sequence<\/th><td class=\"nrp-barc\"><svg class=\"nrp-svg nrp-barsvg\" viewBox=\"0 0 100 8\" preserveAspectRatio=\"none\" aria-hidden=\"true\" focusable=\"false\"><rect class=\"nrp-track\" x=\"0\" y=\"0\" width=\"100\" height=\"8\"\/><rect class=\"nrp-bar\" x=\"0\" y=\"0\" width=\"100.0\" height=\"8\"\/><\/svg><\/td><td class=\"nrp-mono\">200<\/td><\/tr><tr><th scope=\"row\">Draft pangenome (2023): 119 million base pairs of added polymorphic sequence<\/th><td class=\"nrp-barc\"><svg class=\"nrp-svg nrp-barsvg\" viewBox=\"0 0 100 8\" preserveAspectRatio=\"none\" aria-hidden=\"true\" focusable=\"false\"><rect class=\"nrp-track\" x=\"0\" y=\"0\" width=\"100\" height=\"8\"\/><rect class=\"nrp-bar\" x=\"0\" y=\"0\" width=\"59.5\" height=\"8\"\/><\/svg><\/td><td class=\"nrp-mono\">119<\/td><\/tr><\/tbody><\/table><\/div><p class=\"nrp-fig-src\">Source: as cited in the note to this figure. Year 2023.<\/p><p class=\"nrp-fig-src\">Figure ID FIG-XTECH-GENOMICS-GLOBAL-2026-BASELINE-01-003<\/p><\/figure><div class=\"pp-cells nrp-cells-3\"><div class=\"nrp-cell\"><span class=\"pp-metric\">3.055<\/span><span class=\"nrp-cell-u\">billion bp<\/span><p>T2T-CHM13 sequence, 2022<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n11\" aria-label=\"Note 11\">11<\/a><\/sup><\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">\u2248200<\/span><span class=\"nrp-cell-u\">million bp<\/span><p>new sequence in T2T-CHM13<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n11\" aria-label=\"Note 11\">11<\/a><\/sup><\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">119<\/span><span class=\"nrp-cell-u\">million bp<\/span><p>added in the draft pangenome<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n12\" aria-label=\"Note 12\">12<\/a><\/sup><\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">47<\/span><span class=\"nrp-cell-u\">assemblies<\/span><p>phased diploid assemblies in the draft pangenome<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n12\" aria-label=\"Note 12\">12<\/a><\/sup><\/p><\/div><\/div><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-c1-s3\" aria-labelledby=\"nx-nrp-xt-05-c1-s3-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-c1-s3-h\"><span class=\"nrp-num\">1.3<\/span><span>Twenty couplings between five systems<\/span><\/h2><p class=\"nrp-stand\">The genomics-centred matrix types the twenty couplings between the five core <a class=\"nx-link nx-term\" href=\"https:\/\/docs.therisk.global\/organization\/systems\" data-tc=\"Systems\" data-tk=\"Nexus Standards\" data-td=\"The twenty Nexus systems, NXS-CMD to NXS-LAB\">systems<\/a>, read for their genomics content. Strengths are Nexus estimates (ESTIMATED) from the cited evidence and analogue events; they set the graph that 2027 evidence will test.<\/p><figure class=\"nrp-fig\" id=\"nx-nrp-xt-05-c1-fig2\" aria-labelledby=\"nx-nrp-xt-05-c1-fig2-t\"><figcaption class=\"nrp-figcap\"><span class=\"nf-ui-eyebrow\">Figure 1.2<\/span><span class=\"nf-ui-title\" data-level=\"card\" id=\"nx-nrp-xt-05-c1-fig2-t\">Couplings between the five systems<\/span><p class=\"nrp-fig-what\">Each line is one coupling from one system to another, drawn by the strength the edition assigns. Strengths are Nexus estimates from the cited evidence and analogue events.<\/p><\/figcaption><svg class=\"nrp-svg nrp-ring\" viewBox=\"0 0 340 340\" role=\"img\" aria-label=\"Coupling ring: 20 typed couplings between water, energy, food, health and biodiversity. The matrix in the next table carries every value.\" data-nx-z=\"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\"><\/svg><ul class=\"nrp-legend\"><li><span class=\"nrp-key\" data-w=\"STRONG\"><\/span>Strong<\/li><li><span class=\"nrp-key\" data-w=\"MODERATE\"><\/span>Moderate<\/li><li><span class=\"nrp-key\" data-w=\"WEAK\"><\/span>Weak<\/li><\/ul><p class=\"nrp-fig-src\">Source: this edition&#8217;s coupling matrix (Table 1.1); status Estimated.<\/p><\/figure><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-c1-tab1\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 1.1<\/span><span class=\"nrp-tbl-t\">Coupling matrix: from the row system to the column system<\/span><\/caption><thead><tr><th scope=\"col\">From, to<\/th><th scope=\"col\">WAT<\/th><th scope=\"col\">ENE<\/th><th scope=\"col\">FOO<\/th><th scope=\"col\">HLT<\/th><th scope=\"col\">BIO<\/th><\/tr><\/thead><tbody><tr><td><b>WAT<\/b> Water<\/td><td><span aria-label=\"same system\">\u00b7<\/span><\/td><td>WEAK<br><span class=\"nrp-cell-u\">no documented link<\/span><\/td><td>WEAK<br><span class=\"nrp-cell-u\">no documented link<\/span><\/td><td>WEAK<br><span class=\"nrp-cell-u\">no documented link<\/span><\/td><td>WEAK<br><span class=\"nrp-cell-u\">no documented link<\/span><\/td><\/tr><tr><td><b>ENE<\/b> Energy<\/td><td>WEAK<br><span class=\"nrp-cell-u\">no documented link<\/span><\/td><td><span aria-label=\"same system\">\u00b7<\/span><\/td><td>WEAK<br><span class=\"nrp-cell-u\">no documented link<\/span><\/td><td>WEAK<br><span class=\"nrp-cell-u\">compute and cold chain power<\/span><\/td><td>WEAK<br><span class=\"nrp-cell-u\">no documented link<\/span><\/td><\/tr><tr><td><b>FOO<\/b> Food<\/td><td>WEAK<br><span class=\"nrp-cell-u\">no documented link<\/span><\/td><td>WEAK<br><span class=\"nrp-cell-u\">no documented link<\/span><\/td><td><span aria-label=\"same system\">\u00b7<\/span><\/td><td>WEAK<br><span class=\"nrp-cell-u\">no documented link<\/span><\/td><td>WEAK<br><span class=\"nrp-cell-u\">no documented link<\/span><\/td><\/tr><tr><td><b>HLT<\/b> Health<\/td><td>WEAK<br><span class=\"nrp-cell-u\">no documented link<\/span><\/td><td>WEAK<br><span class=\"nrp-cell-u\">clinic and laboratory load<\/span><\/td><td>WEAK<br><span class=\"nrp-cell-u\">no documented link<\/span><\/td><td><span aria-label=\"same system\">\u00b7<\/span><\/td><td>MODERATE<br><span class=\"nrp-cell-u\">genome data and therapy outcomes<\/span><\/td><\/tr><tr><td><b>BIO<\/b> Biodiversity<\/td><td>WEAK<br><span class=\"nrp-cell-u\">no documented link<\/span><\/td><td>WEAK<br><span class=\"nrp-cell-u\">no documented link<\/span><\/td><td>MODERATE<br><span class=\"nrp-cell-u\">edited plants under new rules<\/span><\/td><td>MODERATE<br><span class=\"nrp-cell-u\">genome variation and disease<\/span><\/td><td><span aria-label=\"same system\">\u00b7<\/span><\/td><\/tr><\/tbody><tfoot><tr><td colspan=\"6\">Strength: strong, moderate or weak; a Nexus estimate (status Estimated) from cited evidence and analogue events. The scale is defined in Annex A.<\/td><\/tr><\/tfoot><\/table><\/div><h3 class=\"nrp-h3\">Transmission paths<\/h3><ol class=\"nrp-rows\"><li><span class=\"nrp-rows-i\">01<\/span><p class=\"nrp-rows-t\">DAT \u2192 HLT<\/p><p class=\"nrp-rows-x\">Reference genomes and biobanks inform diagnosis and therapy targets.<\/p><p class=\"nrp-rows-m\"><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Inferred<\/span> T2T, UK Biobank and All of Us<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n11\" aria-label=\"Note 11\">11<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n16\" aria-label=\"Note 16\">16<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n17\" aria-label=\"Note 17\">17<\/a><\/sup><\/p><\/li><li><span class=\"nrp-rows-i\">02<\/span><p class=\"nrp-rows-t\">TRD \u2192 INF<\/p><p class=\"nrp-rows-x\">Trade rules change sequencer supply.<\/p><p class=\"nrp-rows-m\"><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span> Illumina China bans and BIOSECURE<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n30\" aria-label=\"Note 30\">30<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n31\" aria-label=\"Note 31\">31<\/a><\/sup><\/p><\/li><li><span class=\"nrp-rows-i\">03<\/span><p class=\"nrp-rows-t\">FIN \u2192 HLT<\/p><p class=\"nrp-rows-x\">Payment and manufacturing capacity limit therapy access.<\/p><p class=\"nrp-rows-m\"><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span> cost-effectiveness analysis and company report<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n6\" id=\"nx-nrp-xt-05-c1-r6\" aria-label=\"Note 6\">6<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n7\" id=\"nx-nrp-xt-05-c1-r7\" aria-label=\"Note 7\">7<\/a><\/sup><\/p><\/li><li><span class=\"nrp-rows-i\">04<\/span><p class=\"nrp-rows-t\">ENE \u2192 INF<\/p><p class=\"nrp-rows-x\">Compute and cold chain power shape the cost of scale.<\/p><p class=\"nrp-rows-m\"><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Inferred<\/span> carbon footprint studies<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n21\" aria-label=\"Note 21\">21<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n22\" id=\"nx-nrp-xt-05-c1-r22\" aria-label=\"Note 22\">22<\/a><\/sup><\/p><\/li><li><span class=\"nrp-rows-i\">05<\/span><p class=\"nrp-rows-t\">GOV \u2192 HLT<\/p><p class=\"nrp-rows-x\">Approval pathways and heritable-editing limits set what reaches patients.<\/p><p class=\"nrp-rows-m\"><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span> FDA and Third Summit<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n1\" aria-label=\"Note 1\">1<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n5\" id=\"nx-nrp-xt-05-c1-r5\" aria-label=\"Note 5\">5<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c1-n28\" id=\"nx-nrp-xt-05-c1-r28\" aria-label=\"Note 28\">28<\/a><\/sup><\/p><\/li><\/ol><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-c1-notes\" aria-labelledby=\"nx-nrp-xt-05-c1-notes-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-c1-notes-h\"><span>Notes<\/span><\/h2><p class=\"nrp-note\">Numbers are the edition&#8217;s reference numbers, so a note reads the same in every chapter. The full list, with every source and its licence, is in Annex C. <a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/references\/\">Annex C, references<\/a><\/p><ol class=\"nrp-notes\"><li id=\"nx-nrp-xt-05-c1-n11\"><span class=\"nrp-notes-n\">11<\/span><span>Nurk, S. et al., The complete sequence of a human genome, Science 2022 (abstract read through the Europe PMC record; 3.055 billion base pairs; nearly 200 million base pairs of new sequence). American Association for the Advancement of Science, Washington. Observation year 2022. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c1-r11\" aria-label=\"Back to the first call of note 11\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c1-n16\"><span class=\"nrp-notes-n\">16<\/span><span>UK Biobank Whole-Genome Sequencing Consortium, Whole-genome sequencing of 490,640 UK Biobank participants, Nature 2025 (abstract read through the Europe PMC record). Springer Nature, London. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c1-r16\" aria-label=\"Back to the first call of note 16\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c1-n1\"><span class=\"nrp-notes-n\">1<\/span><span>US Food and Drug Administration (ed.), FDA approves first gene therapies to treat patients with sickle cell disease (press announcement, 8 December 2023; Casgevy uses CRISPR\/Cas9, Lyfgenia a lentiviral vector; patients 12 years and older). FDA, Silver Spring. Observation year 2023. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c1-r1\" aria-label=\"Back to the first call of note 1\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c1-n2\"><span class=\"nrp-notes-n\">2<\/span><span>Frangoul, H. et al., Exagamglogene Autotemcel for Severe Sickle Cell Disease, New England Journal of Medicine 2024 (abstract read through the Europe PMC record; 44 treated, 30 evaluable, 29 free of crises for 12 months or more). Massachusetts Medical Society, Waltham. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c1-r2\" aria-label=\"Back to the first call of note 2\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c1-n3\"><span class=\"nrp-notes-n\">3<\/span><span>Locatelli, F. et al., Exagamglogene Autotemcel for Transfusion-Dependent beta-Thalassemia, New England Journal of Medicine 2024 (abstract read through the Europe PMC record; 52 treated, 35 evaluable, 32 transfusion independent). Massachusetts Medical Society, Waltham. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c1-r3\" aria-label=\"Back to the first call of note 3\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c1-n4\"><span class=\"nrp-notes-n\">4<\/span><span>Musunuru, K. et al., Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease, New England Journal of Medicine 2025 (abstract read through the Europe PMC record; one infant, two infusions at about 7 and 8 months of age). Massachusetts Medical Society, Waltham. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c1-r4\" aria-label=\"Back to the first call of note 4\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c1-n9\"><span class=\"nrp-notes-n\">9<\/span><span>BioSpace (ed.), Life-threatening liver toxicity triggers FDA <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-h5\" data-tc=\"NHS-1 atmo.thermal.hard-freeze\" data-tk=\"Atmosphere and weather \u00b7 Thermal extremes\" data-td=\"Air temperature falling well below freezing for hours, killing crops, bursting pipes and stopping water flow.\" data-ts=\"NRS-H5\" data-tr=\"draft\" data-tx=\"https:\/\/risksindex.com\/hazards\/atmo\/\" data-txl=\"Atmosphere and weather\">freeze<\/a> on two Intellia gene therapy studies (trade press, 30 October 2025; relays company disclosures; secondary report, weak evidence). BioSpace, Boston. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c1-r9\" aria-label=\"Back to the first call of note 9\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c1-n10\"><span class=\"nrp-notes-n\">10<\/span><span>Lek, A. et al., Death after High-Dose rAAV9 Gene Therapy in a Patient with Duchenne Muscular Dystrophy, New England Journal of Medicine 2023 (abstract read through the Europe PMC record). Massachusetts Medical Society, Waltham. Observation year 2023. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c1-r10\" aria-label=\"Back to the first call of note 10\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c1-n12\"><span class=\"nrp-notes-n\">12<\/span><span>Liao, W.-W. et al. (Human Pangenome Reference Consortium), A draft human pangenome reference, Nature 2023 (abstract read through the Europe PMC record; 47 phased diploid assemblies; 119 million base pairs added). Springer Nature, London. Observation year 2023. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c1-r12\" aria-label=\"Back to the first call of note 12\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c1-n17\"><span class=\"nrp-notes-n\">17<\/span><span>All of Us Research Program Genomics Investigators, Genomic data in the All of Us Research Program, Nature 2024 (abstract read through the Europe PMC record; 245,388 genomes; 77% from communities under-represented in research). Springer Nature, London. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c1-r17\" aria-label=\"Back to the first call of note 17\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c1-n18\"><span class=\"nrp-notes-n\">18<\/span><span>Fatumo, S. et al., A roadmap to increase diversity in genomic studies, Nature Medicine 2022 (abstract read through the Europe PMC record). Springer Nature, London. Observation year 2022. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c1-r18\" aria-label=\"Back to the first call of note 18\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c1-n19\"><span class=\"nrp-notes-n\">19<\/span><span>Sirugo, G., Williams, S.M. and Tishkoff, S.A., The Missing Diversity in Human Genetic Studies, Cell 2019 (abstract read through the Europe PMC record). Cell Press, Cambridge. Observation year 2019. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c1-r19\" aria-label=\"Back to the first call of note 19\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c1-n14\"><span class=\"nrp-notes-n\">14<\/span><span>Illumina (ed.), NovaSeq X Series product page (vendor claims: 16 to 21 Tb per run for NovaSeq X Plus, more than 128 genomes per run, run time about 14 to 48 hours; vendor evidence, weak). Illumina, San Diego. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c1-r14\" aria-label=\"Back to the first call of note 14\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c1-n15\"><span class=\"nrp-notes-n\">15<\/span><span>Ultima Genomics (ed.), germline genetics product page (vendor claim of a USD 60 genome at list price over 4 wafers on the UG200 series; the browser title reads USD 80; vendor evidence, weak). Ultima Genomics, Newark. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c1-r15\" aria-label=\"Back to the first call of note 15\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c1-n21\"><span class=\"nrp-notes-n\">21<\/span><span>Grealey, J. et al., The Carbon Footprint of Bioinformatics, Molecular Biology and Evolution 2022 (abstract read through the Europe PMC record; a software upgrade cut one tool footprint by 73%). Oxford University Press, Oxford. Observation year 2022. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c1-r21\" aria-label=\"Back to the first call of note 21\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c1-n30\"><span class=\"nrp-notes-n\">30<\/span><span>Latham and Watkins (ed.), BIOSECURE Act becomes law, limiting grants with biotechnology companies of concern (law-firm summary; enacted 18 December 2025 in the FY2026 NDAA; OMB list due by 18 December 2026; secondary source of a statute). Latham and Watkins, Los Angeles. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c1-r30\" aria-label=\"Back to the first call of note 30\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c1-n31\"><span class=\"nrp-notes-n\">31<\/span><span>MedTech Dive (ed.), China to lift Illumina <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-h60\" data-tc=\"NHS-1 sys.supply-chain.trade-restriction\" data-tk=\"Systemic and compound events \u00b7 Supply-chain and flow disruption\" data-td=\"Export bans, sanctions or embargoes that cut access to goods, energy or inputs.\" data-ts=\"NRS-H60\" data-tr=\"draft\" data-tx=\"https:\/\/risksindex.com\/hazards\/sys\/\" data-txl=\"Systemic and compound events\">export ban<\/a> (trade press, November 2025; listing in February 2025, import ban in March 2025, lift on 10 November 2025, instrument sales in China down 54% in the third quarter; secondary report, weak evidence). Industry Dive, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c1-r31\" aria-label=\"Back to the first call of note 31\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c1-n6\"><span class=\"nrp-notes-n\">6<\/span><span>Vertex Pharmaceuticals (ed.), Vertex <a class=\"nx-link\" href=\"https:\/\/docs.therisk.global\/organization\/programme\/reports\">Reports<\/a> First Quarter 2026 Financial Results (company press release read through a wire page; Casgevy revenue USD 42.9 million against USD 14.2 million; pediatric submission completed; company statement, weak evidence). Vertex, Boston. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c1-r6\" aria-label=\"Back to the first call of note 6\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c1-n7\"><span class=\"nrp-notes-n\">7<\/span><span>Chetlapalli, K. et al., Haploidentical transplant, gene therapy, and standard care in sickle cell disease: a cost-effectiveness analysis, Blood 2026 (abstract read through the Europe PMC record; gene therapy access limited by cost and manufacturing capacity). American Society of Hematology, Washington. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c1-r7\" aria-label=\"Back to the first call of note 7\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c1-n22\"><span class=\"nrp-notes-n\">22<\/span><span>Lannelongue, L., Grealey, J. and Inouye, M., Green Algorithms: Quantifying the Carbon Footprint of Computation, Advanced Science 2021 (abstract read through the Europe PMC record). Wiley, Weinheim. Observation year 2021. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c1-r22\" aria-label=\"Back to the first call of note 22\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c1-n5\"><span class=\"nrp-notes-n\">5<\/span><span>Clinical Trials Arena (ed.), FDA unveils new pathway to usher bespoke therapies to market (trade press, 13 November 2025; describes the plausible mechanism pathway announced in a journal article by the FDA Commissioner and the CBER Director; secondary report, weak evidence). Clinical Trials Arena, London. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c1-r5\" aria-label=\"Back to the first call of note 5\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c1-n28\"><span class=\"nrp-notes-n\">28<\/span><span>Royal Society (ed.), Statement from the Organising Committee of the Third International Summit on Human Genome Editing (8 March 2023; convened by the Royal Society, the Academy of Medical Sciences, the US National Academies and The World Academy of Sciences). Royal Society, London. Observation year 2023. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c1-r28\" aria-label=\"Back to the first call of note 28\">back<\/a><\/span><\/li><\/ol><\/section><section class=\"nrp-block nrp-noprint\" id=\"nx-nrp-xt-05-c1-cite\" aria-labelledby=\"nx-nrp-xt-05-c1-cite-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-c1-cite-h\"><span>Cite this chapter<\/span><\/h2><pre class=\"nrp-pre\">Valadbaygi, S. (Ed.). (2026). Chapter 1: Genomics is data infrastructure and a therapeutic frontier. In Exponential Technology Report 2026: Genomics and Gene Editing (Baseline Edition 2026, Report No. NR-XTECH-GENOMICS-GLOBAL-2026-BASELINE) [Draft under review]. The Global Centre for Risk and Innovation (GCRI).<\/pre><p class=\"nrp-note\">Every citation form of the whole report, BibTeX and RIS included, is on the edition home. <a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/#nx-nrp-xt-05-land-cite\">Cite this report<\/a><\/p><\/section><nav class=\"nrp-pager\" aria-label=\"Previous and next\"><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/summary\/\" rel=\"prev\"><span class=\"nf-ui-eyebrow\">Previous \u00b7 Executive summary<\/span><span class=\"nrp-pager-t\">Executive summary<\/span><\/a><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/findings\/\" rel=\"next\"><span class=\"nf-ui-eyebrow\">Next \u00b7 Chapter 2<\/span><span class=\"nrp-pager-t\">Key findings<\/span><\/a><\/nav><\/article><\/div><\/div><\/div><div class=\"nrp-noprint\"><section id=\"nx-sec-nr-gateway\" class=\"nx-section\" data-hue=\"systemic\" data-tone=\"alt\" aria-labelledby=\"nx-nr-gateway-h\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">Reports<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Contribute<\/span><\/div><h2 id=\"nx-nr-gateway-h\" class=\"nx-section-title\">Send evidence or a correction on Genomics and Gene Editing.<\/h2><p class=\"nx-lede\">Reports is the Consortium&#8217;s quarterly publication, written by six desks. 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Published by GCRI Canada.<\/p><section class=\"nx-section nx-deeper-band\" aria-labelledby=\"nx-deeper-obal-nexus-reports-editions-xt-05-coupled-system-h\"><div class=\"nx-container\"><nav class=\"nx-deeper\" aria-labelledby=\"nx-deeper-obal-nexus-reports-editions-xt-05-coupled-system-h\" data-nx-deeper=\"3\" data-nx-resources=\"1 1 1\"><h2 class=\"nx-deeper-h\" id=\"nx-deeper-obal-nexus-reports-editions-xt-05-coupled-system-h\">Go deeper<\/h2><ul><li><a href=\"https:\/\/docs.therisk.global\/organization\/model\/scenarios\/urban-flood\" data-ext><span class=\"nx-deeper-k\">Documentation:<\/span> Urban flood<span class=\"nx-deeper-x\" aria-hidden=\"true\">\u2197<\/span><span class=\"nx-deeper-sr\"> (opens another site)<\/span><\/a><\/li><li><a href=\"https:\/\/risksacademy.com\/risk-science\/risk-information-standards\/\" data-ext><span class=\"nx-deeper-k\">Academy:<\/span> Risk information standards and interoperability<span class=\"nx-deeper-x\" aria-hidden=\"true\">\u2197<\/span><span class=\"nx-deeper-sr\"> (opens another site)<\/span><\/a><\/li><li><a href=\"https:\/\/nexustandards.com\/data\/identification-standards\/\" data-ext><span class=\"nx-deeper-k\">Standards:<\/span> Identification (the UNI)<span class=\"nx-deeper-x\" aria-hidden=\"true\">\u2197<\/span><span class=\"nx-deeper-sr\"> (opens another site)<\/span><\/a><\/li><\/ul><\/nav><\/div><\/section><\/div><\/div><script class=\"_iub_cs_skip\">window.__nxMount ? window.__nxMount(document.currentScript) : null;<\/script><style>@media print { @page { margin: 20mm 17mm 20mm 17mm; @top-left { content: \"Nexus Reports\"; font: 500 7.5pt \"IBM Plex Mono\", monospace; color: #4a4a4a; } @top-right { content: \"Genomics and Gene Editing 2026 \\0000b7  Chapter 1\"; font: 400 7.5pt \"IBM Plex Sans\", sans-serif; color: #4a4a4a; } @bottom-left { content: \"NR-XTECH-GENOMICS-GLOBAL-2026-BASELINE \\0000b7  Draft, not released\"; font: 400 7pt \"IBM Plex Mono\", monospace; color: #4a4a4a; } @bottom-center { content: \"CC BY 4.0. 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