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\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JV+iOKbLnthVmZP3VovmfhLEBxHOPohWMwxNGRfKxRucIOXmEkFfxl+WyvhNdet0+V3rV\/0rP9GkfaL1ocCbbo3y3T\/utD5dBW3TOdDtNV+L4u8gmTgfPXIMq+PGRFXIqxHZDr06SmUX1zq7J9kLqNapdEjEaaSZO2NUYQS4wgLVGdSOoDhJNTxXsZBK\/Ge5oFUpPY7cIoywuDwHTtDFqRGSQKqOhM+hyJTxG5Aqacor1qc0XhG0Frmzl7zb5lcmlFF6yG6LcMgMAvRnm1upxXq9vcZqWbK2+sHFbXdN9YUpdNkfRKUZNub2SM2FP6cJu7zUcqqrokrzEKqlKwup1bwve6RW6dbkmrFXHsX7Ic9V3y4UyQRwk+CeB4Xq64+A2dxHs0Mxl6s\/+xJDYoF9JRpzV18q9NWMMgo9UOlJlpzkQFdKX3aQzb1Il8RKMklPOVQNospy7ZHaO3onbpLkqpFgDDIdIjhCRhFLXsocAq3dcoCb485AVA+BmgAGAGYSZJdKs+oVJ2cctEFTUnBooieyLa6YgoDcZoTipF4E\/aL0gOWzBalOolk5zWGBQQUXgDqVZq7aJVaxcBMW7CpKCvdqR0tJBuSV+bb+8L1qoxKRBjiqCuwtoxTmp5P0YFxDwp7Em8kiKetfjsMnkw5LF8V3teWuI7o96dzldkkS0pjkgQj4On5Bd7UeGeCFdwMgHmAUQrbiqhjeXASgljNZl6R5YstktBHkdvVMQVl6hEhFPjBWE1TC8CcAdP5+JTHU+ArAGYEOVRAL88FOm5kSYpyiWgRhTykHaMOzyNajmhZjC4+DAwTmnF6aLv0100CJy6EgKtK2OuaJKAt6hehzDN0PQxmuQ7jWTrk5m+\/v1WDmuH2bv3HzCF\/lf4UaiwLrBoLmdeJGZe+HEGSQCDLw9FdoEPLz+QiVAg\/klY07ETQyUMHWF8VmFxvsmkPHfeiV+j4OWa+1kaxwYt47P2QGz+L9Kzjlz9tF+wX9S8VOm75kLjCc8eJCj0hiJE0yP736CRx2mh6PKp+6u8P0J0sxTwywN69fPhRRyhTaXlGM+MDqonFlwQsoyL3+DE2prZhlsgv36L4DvKmPkGNfRR+\/\/+X+0fEezZ58OCT4XY+G5WpvRWiLLYXas7V09fgHSdYK8o0tOotZ9vIbUIuwHziELn0pJKKEbGPWQApRH78gCKGOSl4yIwDhe0qjsLWVjnjbThAejMzswmNqarFfCJje0A\/bUTG69N9Dci77K5vSHx8tJdCPJEs+mgqTzRKCO0803hhtEHYqUoJ494KM5rmM7kZm1MVvk6NWdJz8iMx+bt+bwUQ9OdH4onU+gQDWeAWnWmgFIMeCsLFIaXzwLFYBU2gQwle1WNaO3gF+UYhVn8bocApB5c9+ZGZJbJbC+TGBvNTd8FNQ+eNj75q8k++cOjjMteSCm75gHjK0OodkeQP33lkx5qv7RCDBZXzq0viwKjgKcz0sCga+9ySnKsRzyBjydTX4bZonQ7QOxJNb3q9lywpiysWZiJCPFZHOWcigeHaiUcbNIHmsoPad\/ArVBN3tluJlhaASkmbYg0+6J2tubUsKwZ8X4I0+0wWzTftmG2mBORMTQEiJ22nHGk2jU\/LyL\/lQ6LwA2f+xEiN\/ZZLk96DuNw3oOOEY9ZH2tWvoZjY77NdTkpUQ7dekBELgmV\/wRrS3CduUgJd2RHeh5jvDRWxC2PyKrkWwzDgoQO1oLigMfxcsNE3nbpszpfWCzuedHcC1GEo3+lvpdOVtgUJYp5IBthrBBDSXbLbvYEe6rQpjiYBHPYVhTPs2XpFSNnRm5fA7nMkbmvm6lve5zh59CpyiwBm6L4zjxV5yYkafGEr\/b\/oH+yWDC3Fygiv1pybMtqGX5\/5KlUiHaHta9ZgDJBbGU6mU4MuHMcoLpUamwo32E2dRUSwTENRPk66msHSestNriRUDbb7Z3Y4Kv4SrfufaX\/aITkb5BeCMnCdFMs0jEbRXo4xB2BJFisNRUHOyvL10PDr9qfkupaI\/VGruB8hiBD2eWqYjftKIsVHx8uKNOjLEEt0bcJlL295p9WVQfOp1blmmm\/VItX4gNLgu5QxUAAFHEVKOsS1p4CQj6sKdTYdv2hqi4qBU++nI0h44kZwLxolSUSBxRNVRYir\/wZE\/fgGXRAk8EzBMWTpTNgLb5JLdfXOOKiFRhdmEzXhg+yoDdyoImOCKKM3CnYR\/ZySpqoAab+EKXuxw1szLaDtZjVv+6Rm5t2RReXGety8hcWdGg5+Cut5VBvSq8zO2tTHxWOWju0LzRXReIFFtgftUQWhrAdBC0KgfntkhdR+GnUwjd27DU8WLxDmDSUhSqnZaDaM5pcCiYMYQZjFXHSrD3th0t438lP9PuTcG7WKDxLbrWRhvk6\/6wc1UZICqOx7nh0iSSRgVlgIrdXI4vayAH\/fvy8ji08ZKssPFSN\/pXFBCbMl\/ghL01JDgdTRW4c1s9IrvtDeu1WDJYXa+lihb4IaUvfHowtblRhtobLF890CXJ4ryu+rtR3z0F9SOcD+ZB2FWr69rc2D4pM1mEZ\/\/Zk3yMMgAEhUuLvOjrjHL4nWnWdhzhZStPnmGwVu3MGi4mFmCvINcIWjLlhqDSDihJGCgryfSdzP3mjLDuJQwb914eX2ZwAsASLVHTE5cWdS38qnlbbTaClv7xNIF8zPg2rkLCSl1NC5vf9vHlGzv8rpzXVvzsw7Dm5hxfHxKUisCHt8o8AmGDZMGjW9wcNXxOsu8meApCJWjC\/G7jt1MkW69FqudOSsCuBru2ys9T+ohl3QrxzHBUz3gkrhoiueSK6utslQeY5gBbmnaDxQEIF7t9Ysfj2IJTmlwNxQHec\/L24EOuuW6qcCRlxfr4X39Ex4+\/CdvTB8t25jpELdXem48ZFuyPP0QfZLSzH0vl+p\/+7Xus4M8EYcvTdoCk95GsWbG3d6\/IVQdN2ZnYnOjOTWMT3k5H6ECQ4DrGqeIhaY5AEu0fLsdaW3zRGxe7RgvbSXtdtKGcy3D0uN0uwhHVrhkoX7h4t3145Zt2KsGz3uLSWzrLp4AjitDU8qk\/+CH0Iw+bXPinmiMIiN2HgUu0Z9C\/Z7nHlek5ZIpG0h3GaolDF0Am3gGpPUrTSu0fXW7sbq37wu2GiOrObrQ2otuXuEbq+vwmpNmv3CGwQeBuqzd49rsNg6a+pNmf3aIUAbunfIn1Xa+gMRAkafRk44cZlm5doHdehv2Wbrd2jE3o2tUC42d49gu3WC0O22dk9hjbcUM15kr6HII7RsLZnO2uz\/Wi5e3RXq5UneGTtHrfOxg689iN79+jbnhta7UfO7hGGcEuDkUYYhA1YActkm5doO7bAAWyzhVYaQGqdcLO9e7RdYHsW2+zsHhG6wGbIIwQFGtLxlhaFnbh5uXvc+tbaWbLN1u4x8FbAgmyzjVYVOI7LNjuk3jNgFwAvtLNarX22GS2yt7V9h23GOOY70GWb7d1j4MJNuGabnap+XtNcpBlEYwYbYK8A175EK+4C2+Lard2jBWzTdrl2G2HyOlg7XLuze3SdwPWbk5DneHHd0LMhYFoRIgcrGr9RKxrRtfyyDGTVaiP4HJeGLycLa22cVbOChxjkOYljXpo6+Z\/5vNksGAKVvrOhzs6Kev76ieqjmmtzQ9GkPyCmfhtqx\/0U5MXu0QErc7WlKRWagmd7G69Z\/NIy\/Oj6a4va7zA97B5N3wxMap+wwbWsfMm2oo5Nz\/RNSJHgw7HIMSoBC6x8\/sFy97i2bXcd8g8sdJZWlrviH9i4wipwNvwDhynqiR68wQM+N8AB1K2AWhEOh5vQWTGt+KB6oQuYVnv3iEjKesm0OrvHbQhNarTD+YznGTCjodbl7nGFRmNbrd2ja3kbCkVRq43JZAhMphWN5sGqCjpqBTAr52babGt1VADTiiiCxcwYtdq49PrGZXvAKxlsKRiCCzklDrBDm2tG45mu4zhsM9pAc2u63Nv27hGanrnhmtGQm8D3qMUAJdrYq5XJtOLlXIENYFotRDc3js\/2YO8evS2AFFVCrYisuyhnHEV6Y1AtqGVtuHa8pGuHPt243cLUyrF9rh0tq+OFK75\/vLDQphbWj9NLgMa1Qpvuh7Qvd4+Ov7JXkGtHiGqvvc2Ga0eXqQW21CqSdgcR4QBAatxjTK4UC1DojlrRmMAFFGKjVgtzBlvqikCtiIewApdCYdRKrhNAoRoSxMniIoxnm9Fuwi2gUBs3o+vEDZwAsM1oZd3A3kC2GW2ouTapBQ8jcpuEYeC6Ltu8RM3ApDAWN1uo2QVVBouqGWOsvbG5vvFebr2tRzNwaQYxzQ090w2pB\/kxu3i7R3\/LsAG+kYM3kCRg9xgE\/nZN846HDF0Uj54TbLYOzVPCgvC6ruXRyO4bfpaeEW30NtTd5BuXzAO4Wu06tGim8pTmIPJ3j9DeAp\/aViNC5N0Pgw2kWz2AAht2jxu42dAcQYH8WfHehq7HXLf4AWKJtp6z2vAPLEx5TLvVFSZJruABXnDbcyC94BcYG2Ga51FMeK814J8mFz+GIBNMFD8+fgZZKuLF0UN8agVrih++R2gb7BANyz\/zohTvtk3deOWjA0wFu0GGK9IMHCDmiCF9WMnjtDiiO3oN1uw0ARZTVsHKdRpkPMMU1a0jNBtQNLt8sCQsrNN6gGiauaGPUvmA3BXmuvWAXBem50hUZmtXvaZkvWAdgCDgZL1wHa7DFSvr8SwlkfWgDS3q56WsB4DnUBwQkfX8MLAoUY3IelyvWNZbusvN0mvLepbn+p45XtYLNkvPNQWy3gZsXWCzst7GXy1NTtYLNp5NMUlE1gOe7fmsrLcCngN8VtYzl65L3S2VrMcNXcl6W+gDuGzJeg7YbgK7JetZS9elxqtkPcezwRa2ZL01WIbAEsp6wdbfhGJZz3O2HhTLepvADX0olPVc4HjUJUTLes7KNjdtWc\/brFcUY13JesHac9y2rLf1\/dUWtGW9cAv5ZgdJ0Ktg47dkvTCANli3ZL1wDbbUyaxkPYgkj7Al63kbC9h+S9ZbhUuXupwrWc\/fBj4MW7Le1vZ8aLVkvZW3XflhS9azQnfNid94lp7NyFGVrMdhdC3rcVhdy3rQh27gt2U9DrtrWY\/D8FLW43CzlPW2lr8KIC\/rQRguQ4eX9UIHrDYtWc+zlhvLE8l61srUq\/8Pi3tVsfpa3AuXoRXanLgX2Ah1eHFv7W8sijMuxT0HOOHKbYl7G7A1txtW3INruKEFYSLuYWq7bot70IEruBaIe5a39ClFSCPurRDLCQXiHtg49ioUiHvQ39BoTIl7HrQ3gBf3QgtC3+PFPd8NfIprrMQ93\/PcLS\/u2c4GOiEv7pnBita0leIeBKHlu7y4B9yA3oVS3FttgO8CXtyz7I3pery4t7QcSDEPpbgXeqEdrHhxL7T8gJIFKnEv3G6cLS\/uea5rWoAX99Ybm1ZnVuJe6MJtsGyJe9D1V9t1W9wLtptV0BL3gOm69rYl7rmO7S9DXtyDIQyoW70U93zHC6hjX4p72+Vm45u8uLcKV+bW58U927GWq7At7oVh6Pp+W9wLgyDcbNriXrjxbGpRa3EP2mtobdvinmc6Ls0nVOJe6IQr6jzV4l6wCXzqkq3FPc\/xPH\/VFvc23tahhbJK3HNNd7tet8Q9x1yuHF7cs72VtfFa4t5yu6QuplLcW0F\/61oCcW9ttcU9y7ch1UUl7tnhOvRWLXFvE\/pLSmlci3um71IzqcQ931nZttcW91zfoe62StyD4YZWylTiXrBd0YehEveAufSXfkvcW\/kmMIFA3Ft6rmeDtrgH3A1wHZG4x8lEtbi39f0lw9vX4p4dbsJt2BL3oLsNTbMt7gWrFWTaK3HP99dbirEoxT24hTC0BeKev\/EtzxGIe9vQ832RuBdagbUGt4h73C404h6wLWvZKe650AG20ynutSZKi3umubY8q0Pca60pJe6Z5haubaG4t\/HdwF4Kxb3WbrDi3tpzQ69L3Nvif1riHnQC3w8E4l4YhCZFQRpxL3T97dYTiHtws6Uv3kbc81crYHsCcQ8Jr5Y9c4JSQSrSP0XCP0XCP0XCP0XCP0XCP0XCP0XCP0XCP0XCP0XCP0XCP0XCP0XCH0UklKgthPb5\/ctDBt65tEitzKn2ismcWsp\/C6YFy4mLxYScF\/JTKGCGpJihaXAJYInEys4Ci6vfaRaElHWlqKKonYKxMHXsHQq\/oWIkQm\/7xyLvKBgN0\/DesfAbCkYqb4Xescp3FIyGbpreodALCsbBV1fvQPgNBSORy7B3KPKKgrEiH\/YOFE0MGWNHIfd170DkFRW0AvNaPWORF1r5hFbmT4oGXw4NvpxxcGtocGvGwe2hwe0ZB3eGBnfmGbziOnuGr15ZKBttOTzaUt1o1vBolrrR7OHRbHWjOcOjOQpGQ3xxLwFEL9yfu0o+vjx473fB3mqoO6BuNdQd8LYa6g5IWw11B4xFQ4FDdi+0QEPdCS3QUHdCCzTUndACDXUntCA2oJ6xyAuqRloOjbRUNZI1NJKlaiR7aCRb1UjO0EgqrjZK79UvojfvzcQGUiq2YUjKF2cEBavzhgHBr80IBlYcDoOBX5sRDKSiHIYCvTUjEF40YkO8aM7tOMARIBzgrBhBdLsjcIK8OCMoWI88DAh+bSYwkK9LPwToDQWEEnvb9I6E31ChgkP+PtxIPYm3Gx+hhbZaKUi9zQBDnIZuhIb8aKHZXCZwRkIKQH6EgSb8pTzcv\/eyOb8rEed\/72VwflcixP\/ey9r8rkR0\/72XqfldicD+ey8787sSXoZ4mXHD4BT8Nd6hRNW8bF77p00C4VrVgzE+dpofR+fGnZEUJEHHBWS5RPpYUTUXOks7Lhc4Nr\/79JyzIMPVu6M4LlcVKTFe4U4ri1X9A6IKZWNdWPx5VbUgqHyUFAtvDN36W4ry3ePm6SldACr5AcHu0YRLZ1laNVFjmdLFtGzLbVr9AofYW86WbjNO4LcU+VR67rJyp0FPshQgF07Lrz06cCtAxuLQDK3KrwS1enGAPBqBVYU+l40GNuivwCpwbWpMGMfIW2oTbinoSpfPdejZAQ1gekkKZNX2rCrTAWo+p\/EnTtCwonuGb6jMwCM0N9vKBwj3EecGIIkEVoBtJpHFm5XPNvu7xy1Af2wzihUFm9AL1YZr1vsIHeiHNr+PoRUuYcDuo7\/115W3DruPYAvW25DfRzt0bAfw+7j0l9CyuH104XpZuYgw++htPY8ZE+\/jGqzhZtXaRyt0QxqMch+B7a6WAb+P\/sb3g\/Y+ehsHWO19tMN1naKB2kew2biVXym1j3TML7WPBL77+2H\/udffba+nH9okM16jYrAy\/Bz1UHuyhh1wJu+Hl2tdrQRXAjInpzAdMVZ\/SXFcb3nydXY+7HhHjy3j5wENUH8+G34cnVCGSrBYUG941BtZlL8a3mJa5UptF+VPeLY+TCAurKqTr81nUVl3\/CA84s+Ljhpl06uj5cYliYwg9V+54hdMDRvbagrajc3lKo2dbPrUr61yhSWi0FU0lBb7q0\/BGlXCsqrqLGXZk+XE0erypGe\/PmhkSW1HYgJn7EFw7aqTjbhbnBSQqaHC8LxNtUfn\/LH\/w4iSAH5MzIZJgVSupi7RC3JsQtVD29UXmxoDqJRpXVQZf2mq1Gmu8oJLkoQbYxIu8IMR6y9LYQkjVVUZmY0gFUMUbEdZ\/ay\/\/kRfbbTqJUXzYqqWqJifioJp0iSC+mycouTlKy4Y3cx+oaDaad94bSGZoVmm0gH9OM1hoKqAK0U5OovTLy26DpNFEz63IScblpzg6q7cXSCoLmZuZqku1kxLccHb8tpFbArZlOPpRa+3J7ik9bfciMFnekFJgS9RHCBNKzpwxjE9QQN+nOM0IySGtITg90Vzm67kivEphnIxggHtKeGNU\/pO10rdaclRMVXN\/KZ2zUeOTtbRoY5QzbE5m\/4isEvTVLG6v0bB\/\/PlgXxHl84b8D8NsnzKui1gdspVdxrDA4gNWh5DRT3kz07HgrD89izLM+MQ1WJxhe9vK0XgMKUINnwpAozFakoRjNiPFmWaZUvmHaXalX4qa95jBeUqB45eQvXDCNewnc3datfhtL8pzDb\/WIKDOgMFfAefrdT7GqfDoMs\/7MIoQxq0YxQLKoaUFB8pNgnLhE+Z+lIfCiex24GwoCmMMuar2nxMxfwCXStNG\/rKX66O6HJ15HV2I6GZ+XCPhaIAqFxlEej3He\/IbsZWsBdbia3wj9FZcX0Z1OW1U7mBHy\/k5DovhjB4ob8GL9fyjDfqEvSS8c4UyiRqHYI9RELjXo8X1eOykq7Jq2nqBqLpUi2jYqGYJlclHPhzteHll48qf4SsbH6IUU8ZnMxf5pPxiPzaKxJdtnLr6OrprTLvZTvmwUjh5A9062GWuK4U9sFqrE1OZrdm1QFSHjr7ERVZxYXLc5DkbG1ta0xRcFH1dV53SC7VAPppBprauUwN6WY6Rk85aVqhJ35DcU1y7gDIqS\/JMZDtwytktajlkShVqF3KZPx0Xh0qWZBfkVXOOCMXeRh8eSiyS6drZDmg4R06AaNf6XoWJa9q0EGJ1rdEC0V9IfT4brrj5zMyfp5hWWJ8V40TlQ06X4Mc5TI6QyNPw\/bLuJX\/BW6sfpYm1I\/SRBfYQso3o+RttyQfUZFx431nbRCNblqOuyXrhTVKZMe1EPHNYI60ujjI6uIiq8vzSkiBh4w7w9cIqmdxiYve66PyeSMeb2qkHrT92s\/65F\/udh5EiQRkeiBSkfiKnjyn3fsRZvDpaOlHWz86+llPY\/0S60GsB4EeRodLBhel2IEwobn5ZYfE4yyucYT8bIrPGMoIemeo5W+H5+haskDlNY\/tk8joTjcIPQNbnoNTnQT3iPuSnEq5QqWBF+hRcr4U+q8F8LAJ5WUxlgzW5EopHeSrAWYwBkX0BicTmPr05vaC+rISlUVvMJB+setLE5lN0ABb58eQlxmK3ZKlQ72esfGPQVWTXzx2XZbTR2wrtJy2QstieWHXNAe4bRFr3BBeYj8jpLdphXEcnfMonzyV\/IJk7s8rdd04wuumNPOLZnC6FDAohYHSacpILieYRf4OaR4uKINZcjnl33WKmncdIe1QosvkAQFWzeS9x7nxYKFP6jgRk6RM9GDxDmGyb+O9LOBfCeMK\/OLLA4L24eXaUOBKpVENiQgIUSJMHvY3hAflEEttSTQSfccZL15rWVArgaeFU9NBSy9ZAj9zsUKAWZUPFtylaf6kiPsa4vFq8o30BqTMtsRNVE25ci0brQpp0Ve8hzSvQDsn1Cqv5hdWw66a+wGd320aDbE3k40JnSXkq3mdhIByqVphla4R7d7HuT71SvXKJjpedKf4gv2Q11ajucReg5qJ\/9CR4w+bTBYOPJ9Tmom5Yofnih2ZE3iCyUXkB0S8IstxCOH1Qew\/IVqj\/cKcvYXAhdKkHYYEvBEiHy2ya+Ga9i3ydoqSJwfZmHU0ONGL0wvgmm9Higxjki5gM5djJFQJH8caiWg0aYbHDZjXiMHnQm7DqmOsS\/UyE02guuZ9p9u3lmCfRKSZ5QAaOYmmxvNScYpddYRUvKWoUOOnyq2ojIKV74qVQge0rTOoWXk8xCTbP0L\/lSLZN\/DRSOwR4AuriG1k6slAe0WiyGjDID3PwdhCGolbu\/kaZzEzIzjyquRZn1GMzwRjTN1tcMmMEOTFQoVxpdzlUXYIqQGQFPTWffZK\/kVujCDKkUU+EB+l6mn3jpcid7VZSYrIXJy+w0AGrApVBHOn1F4iUwr1mG9Pk4UKmHr2PSo5hLb2nzAOcuPnp6uQCvTJMZMHjH5kOmaJ6Nio216duDaOZklRJ31uKhaNJWMzXfDRPahcNJXMMdihkL4FUe6rVGaMPyzmj3IwpNbueyoS0PiEFYUfZ5AEY3nRyQPeJOgz9KaOn5mRgCDoxMtRwkwF8WRpAQpYZo2fOGSeibUR9MLw63L+aGv2kfHYOANkA8TaiacVUh2IVGtqc6qQm1yX4wJ0GUqoy2C+rkj\/pkRCbTFD2KO3xUpgl97pBjbgUSp3ka1kuRgjcCk2Ue7p3D9YpVU3fNZInvtZGsceyCpzd3GMEqmV0H7N0hh+eSgAqnUgvMLaHJ\/oUhNuXfcy2oIrjFpQscaninRv3jMwbbjlmqMMiuUV54zm\/VQq6luLP+YOVDcaIfE5jKFfjNa+8PukXNOCE5wo1k\/iPluYjTXT5xgZO9t4zCqpzV5EXqpRwJQ6Swotl0Ld46CpfPI6nUEC4xYFNuX6U7yXZ+TIInIo6XfHqD1TGjO3jGcZiiY4H6+3u89ofgxO5yecRUS33Ld33d44548Fw92Qd1YuemdtvR31Nfo4fV\/zAhygyF+gxULx4myH11\/zVnRChaE0hM0gbpLL+FHmx1DvOgTonNCpHJE\/C16EpuPG84W4v1SE+JABb1+kF\/9Y+hPstDNIjM997VIlhV54qZ6jHOFuEiWHKz2uFyWHyT2\/pxkT7sVmJTHLKHxzXzPXRppFxIdPM\/fvURwb\/hEkaLXrV+SAQdM8xBF6ch0hY8RI2cXKGKRtMhQxSOBIQ2QrlEWU87My6F28Iobd\/BaM4RvALECfTyrKXlB87rTn9eT5oTxF2egJ0hZVPGGalTKZRDQj\/XJv5E9b1KBkekgesVzyZKHN5v0Q+xekl0MvtY6cD0+\/woRfUBETK165Dkyrl45PYtNy+yCXdmcKjFbOjGfThadBLc0Yhzf5DUMeYcl1dke6ZjzOlY7S\/itzooPBAeadmIhQqZlZaS5VexwQAKLsp106zLaP8xv0izQzYBhCv8C9GLkPYoT+5GVGcVTSM4akt1TT5He970hNuEzd+HmGXx4OaIGTMs1eOTt0zECWoTPvao6yoXACStg1EnJGlRsLXaRpcmW3kMJadu8s6bGCNIFXMcJISgD1CNHp2tyA01eHTvKr2l0K910uPT2CAiEUxsCDsZBZa4g3\/ohY\/SdjZf6ko38tNHQC4VMNSJS8LRZ08OUoqbFtDR3l4SJns7d6\/LJF94xSapikgZATZFkA7IIbRFkZnK4REatbd9cZp8B8sRasrrneAxKcxfIN7MPjvfzLhhiBticS2dkoOcIsKnpNmKNuBibYddjGeUenDYQ6lbmzJzxUNlVsOVKbOLpS\/XU4rZZI1RMdJPShwPGIDfZj700G6w2Ep4vRD6zqgdQctedjwKnbR9hEBW4FVpVtrscySQhWm512htlpyUnmBacPEukWWavWhjdroQbK7X9ugJE97zoMkuQ4SXodEbwzj9abQPAaXLtFL5UqfTLcIb52hrGwGIDFUGa5rREYUEsF0nBiBBj02GUARA03BmRKglkUdDAcjgjlszvdGgxXT9l4h95rVOCkGdVn3DnWwe6sPfUCUsjhQHKYFZEP4rbCpLbXISTaaSD5xHGhfCQPQ9OeXXiSXKATu0C2YIFWSnQJXTK\/ghDaciphcWVMfPTJmXKF1PmH6N4EbjTsCz3MXKlbpDzE7R6Fz7wEHIlWJKxNpAsbvXnqCWCU9tiRLTp0BnHrop0ccWFQgkBcZOpQMEoF16IlotM3x6VPzPMRZV8esiJGOasoKCf5W+yOaV48UV0u2G2jbkgsyv7bEypRfkkiPw2g4UVBtNMiVB6wkF1mRBhHqoINnGaYiThqnWT7BxKzOYVlya2aPQL2jYphyaU\/p1kxculX5k8sQ8DzhxscvtWm2IYzKstUh3CMhh2wcShYg+couYqwylhJ87y4+\/RSXNtxctK9E9Xma5QEXx5Q6sZaYKyychBrhbIx8Ko0gzCBNiVtaza7Jw5HKVNPAwhJNVHeNaWEzW5ga55VK5VevBgqAySAfpRHacJDw6xVCx7ydCaIQAFyWDxMjxtsYUN6yXzYjw62Qgw\/pQEkVx+iWnPkahSNCrIChsBXuXAZinJCiEr5qaK6TYc0eTI1U29ibQ3MXiw0E0e\/4i\/lJ9P8STfxfxSeng+Y+VHe3tIZNjMvAOJ8A4XL6sfgQgMvOv8K4MdZYF6qnE61F9HDw77biIicVxC1J\/8adyGOCdSrHQGM5Xx5b5qpo8TE8MtDgKthYj3X3GS9HDFK\/jlLD0g32myvan\/D3kHbk51jxHcQFVFyIMPpyrpFrEEwMAe+Rl8Gg4sPA+OUVtGYxrm2nk53jx9cZCxxgQRVHSMuXUgejZK2A5JxAh8LjdQy06IkjJKogN++\/d0r\/AwzcIJ59dNrkYriFIpLliyme47\/kaanIc4ZMkcReYv3Sy7OYn9b3JDJpmS5U\/BvTXRsqdVr4hCF6Vvavrebcb636lkCDG16Kc6XMYr9dojCpjZWOAPFrUbEYvXrQqaH+kRJJInPosdMRj9exb11vwfStkygyvyk0BoKNEZCxTmrapcb8vlkJB2uFdXayQ8wj38F0z32ZuHmocKXpRrkjYeeWElHeussh\/2spqcWjJKxehjOXaHvPrEW4lQ4Q6HWsxxAngDeHs2g4uJBzhq9zvpZ+t5KdNmKgxBnpvmeuSmxE0pE+2Z2ZUKi4yNu8KVxpGH7+vNVgWa+7AyRi\/wdnBv3C1N67YZcYdR6qxC3oetcqUNR99rRZsyBG3l7qYRPL\/Kja3mZ2fN5R0teGkg+ufDBofisEJMuNou29ms4NpK3z7YKGcyz\/uc073FFaBFne4asrDKJVRk8FiTBXc1mYC2pQw3IPA4DSsBD4fqk1pCiaMmG1qZnKFgC4iYimDw2erb85pUCIpgsIqFSuQ5If23fAQ75FIyhDuYrITI5jEMmNa3IFIcVy8ZS+5mZ3kKcarfj5enAwgJcW94S94tpRZzduDhNJJdyLOAk3xApULVgugaQ\/L4OjyVg93m7DASG0b4uPb5FjuyE2\/yBK80fOP38AadR4pUYluwmBgNh9D3uOpzv2GRAXt9uCk9G2K8j57TStLHQlmEmMbgMIqNf96DxsoWScnBevwuiIOXkzYym1Gjj01O1wwlGZN926DJjrJOXpTRDwvRqY2OY3TEJKqW24aZghdlSXqV+PpsUGkfJa65LgIZKzFzFKaTlgNLAdSiqeExmG5KRoMPlS5zSVBXFKqdxW0yu0LlXYWWHEiiC2QS01ipckgDigoIEyPprXd\/m2ZJwbKuXZWxSNdW85iWmcFeLo6uqDUdSUALebg+gWS72na7UM7lFT5f16wId0yla6Xt1FeYX786XzIT2j3EJHcg0o1BwzC7JbQxCB\/kaCod0bt3u+TXb2SXRuDox1mzpGIsM+K+i\/DhN0RhixmQ3XrDUUvPFRcN+LUPWUaaXhxeBTbFMPtx1+4hT8VbV4KaL8SB77c6XQGUtaVmOHYHDsNLYYQyaNs6MbbLGaavbmZnzCOaTzKnVUVySytFAicOA2BeBZupHR1lIUHQIg1HTmX7np4fxxP7WAJ9bLJv2rSXNuL1izqs7\/cIgBPOjAB6JFAnTtFCkFGa76rj3hszOP+A9g+ZleCC7VRBXSvwrIOav\/RPDA0yC7smWokHLCrznlDEmu\/GtxKXCLKVsPe8uHrw\/JFFy5tJVdICXXlSnpySgEbFpTPrVrpA5eTN7Bcl90FB7zt+Hyr9aMlFEN4dxKZjQ3ME54pF6QnSwAzy\/boqs+0JYxNE4BAwS3aI8FZAYkN5onO8BTxWLM1foTMd+zBjfIR4R2S0GPfarw1plxVIARZwMkBNTzH88rzpOiCRf38DVmfisJxBMDZ1gx6YzofXFoBWFxND4jhxSLg9wFK2KgGvLP0ro0M7o1VaWhPm8R\/B4mkdGDMEpij93QvngTo5ASVowJaW7+S9pByp4zr\/G0XVKClK5USvHt7ldzSga1mmjdBZqrIRkYgEsQBTn1zsrZfHYVQnvUcZklM8Gp2lC1mMiCoyrQt2qHbChcj5XtjikWq9oFDaq9Hg6qJn1ble5OZVbgLVNMFPE+bNjzVp6jhmqzslEH5W7ueRwoFTpfeb3RuUGfh23BN20Yr7FecbuYlRCC5OlLdhLCx+2X8hx+0WzGJctezFgprAFd+zGlLhji+gEUV8iQoEIgUFMkpWfed3MO6JYJi77i9yv2iC3FA2sIUudd8Y7eIOD+i5RRYEh05ot1oFZQ7Kt1Ey+Nr7YvQu2lBumVQKYLf48pKu1f5BCpl3JNN2mHrA9az00ai3vk9mSGpCooeQ9wyXoiP\/K+0W1KlFinaDhweIdwqTDAitzt+1V+VBKc7YFyvQnCi2sMSIG5xxiwoo\/KbM+45G14qhLdhBcRxz89pmb4qlaOdpXPRXpWXr6KCF9cfwOMSy3rUClAR2qeSG7HsGzf+2yJPbIuZLDlhcLQHGcF2TUbckGtxUNVwJOSZu7PZ3UjMLWbK\/L3PTkBi7fqT2rZHRr8HQuPjsqLnW60dyU\/Lr3CMyGzmjr3iL4Pk6uzeAZguKJ8LFRHOsls4rdQjCzulAYOomC0Ebrz3oS4gmtAd14IwVvqesiXJJNSOQN1y57UudxSYhhAK9CxeJsikCYZWk2pV6Z1eRmQRBXweimZT\/jemFXucJlHWi+DLN92w1KLuy6Oz0SOk1YtGVrHa0a7obFXPNWV46a9nwY+REEOCatXmHcgMlADD6pKHNHarodpmHRZq7dtZK9pNdubb4d5ZKBqFRsMVoMfjOnZ02AINAVlA8UVnaVEFuKGF45j4XsBGI1uaYnw\/Ub8pq4tgSoJmTwm1TZ3ivn\/0e0Mi0ii0SWb4PZpsj3yedB+1mfoR4eygFQMnZmvqdyVDEH+5yhXB5SB1mXcB+UkdGmR2qQAozTf992vlLgvaIrMluiEyJZ+ZQYXoGH\/DPgOaerK8vl\/2GsQl+fBbHF39Qlh6b9sBE\/TsrA6\/MMgGYmMQCXK1sh6D09NzCL02cr8AvWFSQxm9pHOdXsywP26cVYzGReV5cdvCM7eRkCUwJySJXtorhnxbuIOQNdIgsGEoxkfq9LOFjrki4QuozDgmwkvC6ZRkeXYo1K\/c30TtJLlsDPnFbM67KVVHTZSiO6dMkKllycY4AUeB+T+dBdlD\/tYpAcnkC20MmnS7ZYXFnrzI5VRYAMeIs9q5oQvTIZKgxHCAbACMEAECFYqFyYENBLpKFXatOgzhRh1enqSTpdyktnazjodOqKJvaf9srRRcZ3va1k12v7z6JVrwn7e\/A69MlCpOYF0VVtVYszCL6epwc9Y17uqtbtrex0SLlV6yaihFI0SWkmMP+7S1J0mddMMJZyHl4WV2FBRfwT46gjAZKuRY0FSvSVxBQYHjyCtwhNCD2R49CND07NqixBU9n91+f8RFYAnjwYBDB4uQryCvJpQkXJCbG2jElPMwNw2nN+IqmKaJiITM+D\/W0mDWU\/7vBgtPDHROUKpytskTGJy0SN2zTLMk+55l+8yDc8+EcEs6dnSzd1U18uNC8tjlwSatJTmKVUsUhTWD\/2fz6h9fpWpM2Lyz1H+r7NUTS4nfSUKmupvGpxAj+K0TWS9+06zY7mqk5mf6VVw1iTpZmagQIDTLX53uv5i2JB9jOmttee0bAFOEwvtcT5CI0stHRzWL3ygsYq6y3dKU8+c1RYIoRuJW35bOVDye\/Riyj5PXWAKjuwYZnf5AJ6D\/113WZITC8JLxWLPC7fvN1kJ1efUp6HqaP6r9wRENE09LekUzKpci7s1puX99bMOv\/2hS13W74fobjwe2dttHYqbtQ+UCe+MTe6TXKG8Q6SN3k91r4StxxIvspyl8djLyaK0jzseWaIS72MKBxKsSy3g+SuT5MXiqWaHRUJ7rROwGQZNYcx9ItrZRUE5zMEGYob2yH1EgqG2FNthEunCq9HJ3CoAiWoZuLKgq8s8lGY4o4UK2oIiYK6mum70DzKpaxCxbEUlefl8lRaylMsYttqqR0HUfxybbmn1w2fdYquVmh8nTWXE3BRJ8heC6JEGYRNPEsNhiLjGz8So8Js6zVITjQ+8cA8o1feg1QVZpWZBcRj4yS9zT2SI7XWp4CxNofqXDLH0Nhg2WTDXOXyJTF\/yyHI\/GMXvMytZzZ311JQK1yUz4TNQ9aKORDLE9YPEg1AucI7Aldycg\/iPYr+wJOonJTSD9n9GOv6iWHxL3nb83Mp4fn5Gy55pzoNI+lVOg\/Hb+gYK87D8duhKj7OcWAmLdsI3IbYgIPlD17iAC\/ddYDr5KMIeiERKJDX7kZGB4gMAtf+hMVEB0qu2Z6kd+0IDlvWyYtaGhR7903StKssU2TpjtPh7AWTQLbnr1xGvocXcXEJCS0DdZmeI\/\/1pby0TW3JMlTy1QX4kViGpbmS6lvI7Eo8rBgEzDl0XKMcF2Uj\/OshTD9KRJ0ySaJ7xeQT4s4AFNHvwI8zSAJawSOO5lOkk0EufdqvWRrDLw8F8B7aFifHlMxHa0QTPRHyE\/795B\/jxNBN7HBZtqvJWv9tYsdXw8hPpY66tsBHZYNe71CpxF6IXZ72uBNUXa7VBW7l+yGF6FqBACNuvVElI0um1RWqwUu2dVD0UEE8xIeSDvabum1TPX7RL3c7D4ZpBmV6IMWgVTL\/+UnbYaXE09HSj7Z+dPSzfon1NNbD6HDJ4ELEuZmyg+ERFlc+wYZst6UHFNBxaludKLT0XwvgYQnyZTFWwqkPp8LgtvxE2MwbMyyzeREHIpNHZmNmssWspkUYz5TcDq0SEQSbZMiE7RDUMJmloEB+EvPdskXthEnxxzIQk6dCM\/1T08eWwZHfE37Nu44qW0xltpo8JArTzO9ueBy6HOWm08+gDRS9plRjptpqKS0WorEAzZfxQrgmZXD1gFwxQ64kITSEkSf319+gpRaR0DSN87mqCVg\/9P0VgtN96iwh6aazztK0SjO2NZYSfOfCSnciFHQBpXkOPxqB88sIQYzTpwrXIYhy5MTc5OtQkL+zBEN7TiQKAsioidFFD2MZRJZMrXYndTiZZ2lp16d3ga1nfWf3h7dtdR7db5KrQtVQ2VoiJaa12Yilic7CxVI4LRxIFK4sj1CjxrIsR0KCbYd+jlIgadh\/4gkLcrrlvr3rNnbaZlzRyTsrnOJk7b4d9Q1SJk1HCOyhLXB\/V+N0Xw2g0iiIdrMAByiqDdRy2h9SplVX4CED3r5IL\/6xtKvstDNIjM99rf2QB1iBXsWQUaxgIDQyc75wtCCXGbeUk4fFcUx5T8oRs8MnTRUGCl0Hi\/SMRo5hiCEQie3vURwb\/hEVfSpZL3QhTgdD8SGIn2FS6x0N28FOKGblwYfozE5Dfo2MTrLbN1whmyrnIm5368al1gp5xOITKDT1UIfutqxlgpmXBgcZcOO3K7WNJt7I\/T3S3VHrMEQ7O7BKYtaH7NpG3nsm+ZPNLoVkhCIeVfWM0ViLPJaZF6YUSK1dwiyZyRh94QXmPXV80jqHyCuS8fWWW1aErrqzQk75fzltIVrcUUqAOfKI5ydhfaRW5SLUUEW7+ZcMreI\/IGj2KH9gyXewQW\/L51XVgnr2EdbjqdGtv6XoDibNshWf8hPSXvjj8XS4Cvh4fZU59lz+sGiI1u57qqnR+B0eJrPgPR5w5uJg+cnA\/k8E+3IYh3SuMmFBY5wL31gy6e+txUKsPuh4WQpY8R6UC0WxCVmKYk+flhszgIfGa7JEQ+TsD7J8avxJSRZ1mb3VZZSV+oz2MMcR3Xuo9dt0zckcFzSpttuKKewnis4PpQ1c9Xu683mXhdXuZTZlXu2+VySKZWOvSKolvArlMy7yeaQoGBlpogtEoelTv1do45\/xjOriGattu388Y40wiuIZkR8RSpEpJ6+2Hw\/VHLZkfDz2rToYzu2VJJTVOs9PRpIexh5h5pj1C\/32Qk1tlhHJ3uWuqG8yTse9lge6mFBXnu7GdYBKgFjVM2pVTBamsP6ebhBoDb7+fFUgNGIX8ON1Lm+\/MvseExezkff3k3F5u\/LhUBwsq0HJVE1IszJDBVpjpKVOzzCpJ8kZahTF2uQnPEqHSCdn67lOUVb+jWl547erkpI+uCvN43d5njNzBmXNHBVgh52RqMxeD1Resxb7O9bPrMH+Wnn8DlazbGl75dfs6x3qWAoGI3ERtbD88MtDtzPHYOmgWbx+CMS\/IsL00g33v1vW0nqYzq1dh6uZzDK7IPVzDfSXO6ZET7UyPBl8puJI9dZpl3g2BqQcIY5u8qzZuucP3XZ\/WogilCtH9Z7byQM5LqC5VxIPTE\/j+ZzmunwvCTwoSWDPd9oVS8AWZBQiEf+oqWB+keFXspG+j8tuJ17O7asV7nFDQUUFPMQhVVc77Zbt6A9xJa\/Xv65dj54teJKYqpj0dCneZAb6vtFrWUxCYQkh2mmW9hfNkVJZKMC0PPOvN90zashd3FbmC7zNLN5QZY4txtsyNEpK0XFCVHohOH15qMS7JjScAkeFPzkz2jHNoj9QXqmO8SprdJMHcU5o\/CzN8\/6Jp0Uh4Uh\/AkUWfeAqSC2XzWH9j7OQHPjaKtSawzPIULh4RQzrbObKbn4ytFbWYLi2i6vOUja7NbBATMcJ36viEPvyv0YeBVCiWmszcJVJfhdGWV4gu2QcXEXKT1OFy9Ip99MzVBJUVRtNGA83e2QeHoowKcwgX8+w8Wgab3GR30ldtofgOqWGMKu3HfcjVWh7ewK2EUYyxi8DoRBfJdlLiyI9iS0pqmZG0rOIr+j3LCoQMTqliArU0GXxvtN5oq3Ds6ZwOerSwFAzRiEZPXvZqmk5ZBHppN59Ni+RkznDyDsSAdnNAWv7IYq9E1tOjO0S0vLQzOs5wG1vJVaJUbod5YNy7uxl0hO1ju0pCgIJGVd4QNuRUHi35s0qEKTFGOadx6NNnViSZlaF1FqBTjtIC5qHjmCGots+u4LAlY9IywjTvUyUzF0gP1Sm3tXU4B12CE4oUCEIZGKzOY3qvBOjCPFRemJs3Cgj9p+Qy8s3qXRWE6SSoerRq4rJbNLSyNnaorxAFlnVKhTSr3O9MXEL7QXK+jEoig5BYJWGkik8pNzAlb1IlLVtUnCGKn9nellGqN\/poB2za5ecloQzXaec0vdIv42wk3VybjUS3iF9RatK7rgcFiJcmL73uLZuNwglj9J2g+HSsHJR8K2E6a3s6MUxShgUQb60Ktl2MjOxfHKDzl+BW00JCdJltmJLJDuVy7eMKD0qjqzYc5YUXO5FkIl9v2Nb1UCAjsUpOHcaKvxELEfq\/c+IJq7XIju7NgdmWZpdhfyERF6hSzbKqRNHXjC3wC\/aykI5B9gS8oz2q9Z02OOyZLaL5FHm126SPzLNkb241WtfhUcknSWqGR43YBEsBp9y26f4WKMujSpxzb0iiOWgLZiD6Y7275OmC3h0r9+LbbkQFVpcu2uZOovVye04R8swk3PzVoNKKMCZ53P6a9N9kxmrjgtSyV+giJPxZb74BHHCRNHsSy0be5OicIYCnVXOmW7E2fOlQyVzr9Ddrc23o5wTuNAt25zK9KOFpeFzZeBrLJVy+bF5oPCizUNDcKVoqZSE3y+PuC4laPaF86lK0jg+nZOIybHkMiYyriVL7S+asRzHg5GqYk+WzoC4UJ1kUeBkNVihhWL9JRPzFVKlBgQeYpLwKJUZq9yDsyRgq3KjqUu4hk\/N17L70vKfhkbxeYZXhQvdM0w1pybXneQq4cx5ohPYXUhNSZ6zdvo3G8loumu9HfWVg1PECXxHVlIHqoivZXouLL6RzFJdEddtnZO4ftGPpsWj2csGTcz9jWRMMgKO4wy45GeyYT6N3\/ToS0t+rNphV3BclLlWSnY3G2e3ojm7meKAtZ9bMcB7NfV289Muyp92MUgOTyBb6OTTJVssrmxg9o7VHIAMeIs9q0kQvTIZKgxHCAbACMEAECFYqFyYENBLpKFXag87vbyX9Cqnm16lOdMbnYzejtVZXHkFDN5fXvcyvcCIF0RXYbUcuWIQumT9Apnf65JaYF0yMFaX1HWx23GOATILfkyzDv8aRNmXh6yIH17qdIKT4Nsd07x4orpbCNMTGohTxOn6pmfv+k9RVhl5ZJ5Oxm\/Slh3UC\/yICiUd0epkqY78OM2hWsU08S+JTieY5dEbfKGsFmH0AYMmR2xtdXCokjbi5LVv73z22uDtOJhWQlUYNz8lQUpoAnZfRlxV6johMCTnc8\/w6kebF2s6hCXsuENneFY2XnXNUzxkxQ8u2iAIOfxaQloiQQ1HwWhL02H8m5TufAUz0pTplU1gMeOGILqzS9Liqdr8hQjn6nPtdiY3apktcXJ6Ucqjf3si6Y4YinCKkicXOero2NyJCYRm4ARg0zM3lY5x+ct1HPVpaaaGyBErrZGiilgU7zCnSk+koVM88dkPJWlRM3ZHKno1nXdQh3auOFSGcxYTzRA8a4Qn30R1m5emJT8wPHkwCGDwQo4kd2AXVGuYl3xeCxmI9snZ0GcpeDtqBnGlXuhrVJdA8kxNAHRUJqHp8rAQDpYrUlXYACmkp9tAcgWJhDrvDWxWakxEpf5Mr80+zHr0k\/qVktyK+goXxxiRka7bV+MULMQZ4uwVSRGn19dM06b0lmTLXd5oXaoUsqWXDIlEETnOCEKWsEuF6MotH3A3qNN1g1KcjIl4GMTCYLPSBn2TUEJ3LtfXCiWxsKU35TAXKhWEncMzJSM5Q1J2ArHaAfk6n9b08vZdfBpfyHO5VjwC3qe6\/o4wDEcx54lMtqNwnjiPCwu5I6zfWC2sdxD3SaO9WyE8+tAykWDbCEwC9RNkza58NNeM42nPk9VlA73nMP7KOv3OIJWgwRAFKQuMNca9xT0XkqnEZaKj7Zp18BTvCjMn8vRXH9AdaYZOQAyQbutasgDbrdLua8slLTDi0sT94iVND\/Dd2lNGhznxLeOn6ulQlTg6UvCrHREx0yLaiTNmi2XxDpLaIqe4oFk\/E2GZLRXI5LSdYhVBNfxP2i\/V6FS+YJWpYfn1Jd+PoCxERK03b+tpMgq3AFKuDmyEGNGuO6Zwf3HWFkp301ctGdM31Xc8Ln9Fnwfscmmcoo+nKNHy7ODpQnFAc82fdOrsLBRDFb91nVLijFRJIrimMJN8TL6MtRjfoiAeFOMW17seAQJSoweplLR4pDmcIrtFLwHpsroEI54A0u1iJ6D6BGBhaH7OfXUvThrT5dZlsOb5697FabsNtULPxOy0VODsOL5sPgZUyKC0cK5sopgQvGQdHljzsRy7GNQ5e2Zck5rnYPzNGJQhmmjOlLJaYdNer4qo9b0uksixBv\/zaWmuflrc73IVHyLMn+CJIWnT5KOxGoS5jzmrUe8gZoncWZgrmN3JSZUqUl21BOWVSjqux87vzb3V1rrdFQZyMdAS0V2Hx1UW7zC4sNzwsLl+wORrSiRBzS9xkdMFvHF2ilKbbu5Hx\/9L1ZRg03LdtYhjuQKK4yPLXsnnpqyuqaDYiDRMl\/gqKN9jtnOV35iLQI0PM71yh\/TaLwe2ki3PVIF4sDwhV1\/LGaxBpChdB7taVXKsERGFqkYcmR0Xz96\/5EqT4wqJa0XRlJxjsalWVCl+dKy6WlBq0xWyreuVO45Su1WPuZplHJgbwOy6EJxFO4aNvS96ZDR1ytG+WdEmMlMyzqdnnLa0LcF49IxTmRYVBceN8qqgF\/LHy8nVtymYDx1MemMNcz7OohvHFQMulmMWN6W1ks7pyqQOmpBPv7t2iHzgG065Q+Styd4w5\/RseNc2HtxYHZlL92srznRUzRRn8r2hcukdkv7SoN2QLcE7GMBHd6zeTvQ5VMyxgxNiE7dIJfbwFAsO5\/QsYi8UnIFz2pQp4ll9FZ3OXH7onHKVfK6jNneuutwtcEgpaFq92V0VWoYEnXs94TYiewJtoHRa6r86PcZQWj1B1l+TFsaUC2IKnPHklrrOkyBYGplo6KZz7DHRx\/C2Iug5mqbAas+B0y9EqroM2DHnSUSAxkjgG8wmVRAc4u+QkDOt2Fwr1eFMdVr6ZIImR4OYSWjliN5a8wgnKKhbXVGvKAlE1+foGvCN0GdZwnr0Sxl3SQwfuSi60+mxB2DThR5zVB7G4FFGyzbxERteW+pEbhK2OQvu9AfBVZs\/w8AksoQP\/phhIGzH7LvvHfq+76sH3UqiJnCmcmnf1J80Q+M9U29MjHiXG5737eJLtbfctZCWpaPMO1ZjRjH+eZXwp6fcO+3LXzU1XWhmjprVYgWS9HmvL5004ILNmCWlcIfy++JdwkR+YMwKlErdW5fgPmExNCHvDw3pYoi5NKUbsV2889U+w4Q4OdUtB2Yma9eYNVYr0A4QN+N4FYXQr+dhNjhXGS7tK+U9wV5frPJGXBueYSbyIoOFf1SXrK1\/Tsbh2gHVIHWdB6BJGigF1uwqO4HK3J59+m2UBJV1skKO3WIvHAaJ2r7gCohDc2Xyd2AH8Z6DnUeuDdQlBePzi069D5MDOMDgZUGkTGodm5tqBrBINseea8Ie2LBBsiCM9lm1OCoceEtXTag33twrdsYfWI7dEeRPdXohnEBerxO2L9g4+8VViZuHEn5wpuXAxRfKGVgzjkGqZ0e5L\/ZsGMMOz62o77WOXbLrqKzvjtPO+u5KO5WFeYe98dqZ3kCJ8X1g9EYanTXpC7Kw3SGei2iZ2a0jTrRzO2jK5fvF10jbN3OW5AujsFAcaX1fPwzGHs3pK\/HhNe\/gB0CBp2ToW+z3dPpQpYmcx6tt8gIUkS\/wPu+RzkWCuFBi5+5Skw1u24n3vJWfbD+jsHerzoJR1s+qTWhtUWWJyWEc7jSYBLVqs+dQldlA5ggzGkT0udcKK9TFzsGrGYbrvOHkUi0jOVBTFwc+RsPAxJ3w0nmWvquOvLlZQ5Cl73MJWi0G0Z1H\/09xo0I\/m3ZUlInDTGY6jFXacAVJc4aG6s2zPpO7IkUKsH3M3My0qWh+5Fn25SGGbxDVIG0bJF3l45dcPvZo\/v0SwYJmavrV60qMDd9xNooTT4nDYG5ZWWWh9ndk\/2+fJbvYMnmkeWB0LqUZiTkq0ot\/xO50tXw09VJ9i+B7rv2apTH88lAA7+GF+PQRiiTn1Edzp5iIk3sU6zw6y+jx9WWnu43gBKN4+fDHLw\/nGCQPL1zuSUF0TEsBPx2GGCRIcuGqTQxmTuRLcbIGqP4UkTNVkqqnIk5sr1RzUQ3VmQx1+oYg0Z7zA2P1veCj4uWkdp13aOgIdSep509R\/LkTBhgxASAW+ZohLLGmQ+cBxAFEcaw4BO\/sp1kCM0Yci\/zXzy71fO2xKPZjZGNfqKkvB0\/A5BkQFUcn\/JYY\/s5NGoR0f8+K1WekTh0xu9EbYY2dHhOhPt\/8pCqciVdHhtBMByV+E1m58HUa\/YEJYoU36YeyBOUIZNasbnKhoyJPu67aP92qumUVXUnVG7XE0ZUDFXfxdwxUPewNhb2+yWwPK66OWaihauZMwVouCnc\/WKBVsGBNwdUmfwrRpYLk8\/0IM0pbWLn8I3yiPhtpFqFNfYNZEfkgrp\/h44zT\/u4srshUnSBK5paOy\/sJX5IoBOAV9uABeaHmdRpZ4tlZScDwHESnRjR8NjcyfR3T4spOhNofbgLP7l7ejG6ck6uq8ORzovlR5qMwx062oWOb6hgefo6ODDSoa7pq8RIdCuGR4ABmYTqjcipGqQglALanQV1n7BxQzFfZgs7Db2mE9XGXJFDrzntOiJdFuQfTr5XkOcqNY1RUmzkSHyVYTTwilqRFCNQaUWGt6HPCHV97cldx+n6+3pREweqLjWTSNQz5YdzEGe5vLFkvtSJzVCI\/C+soMo5ndYxjbSqzOv0t2MVRxicRULWIF\/FaVQS4WoFtIKkDQBu8qd9py415Kt285rba1\/NSkhiJSPZgufz8jy8PeZGejboQXf7wMjCgdCW2Y1TVX\/OS6tOprs6WwOrTb3Wdtj+O1afXtPpUHP9Warc1MR9V4oy5wgtbXp\/IJQL9TMdxhB0udA5OmL01396HY\/3Ul7oYb9Cmy0hQCuBFh6G7ZbqiPKn6YjG0X1jO\/2fNWsyaTVZQdGfAzZEkNXcwuJLqPTx+Ar88xEir+0Anah0V2P03hBBEv8javiVQQk7PSUBMQJal7y+16EozCShHh0Cms\/vFd7HAJxNQR\/yNO5IQyddKZnve7UBYwOxaqyweHnqLrlFks\/La5PMiURe5Wta\/w4bxtSY+Avek2m1hyOvFXnTlO1qG04VFlJRAq5PVcIxylr4bmFk2lfT\/1aO9WrbCqASzS\/2hBoKaNeAyDYkAaVu\/sSOOSvCSD+PsIw\/lr96lKNKkbDhFEzOmdPT3ce3QRlI0GntCo+\/H0pqHG5gveCmqlkmqjkmz+vma+1kaxx7IKmCLY5Tsm9b+G0nar\/\/nJstGPea1hIReJN6XfI5xEVPqv17nH+Z4OXnXXkmtyvXRn9JPHUilwUppxMYZGgXw8jaGTb8Iyi5FOKNA+E4+jADCMzq\/yDBYXe5FeuaiIb20KNKTTPWTeqgBdQqjPPFADhGdaKpHMVBhOHFZiRJtSEOnruQIogx1t5BdrSOXDrTDjksSgfJMF+PlsDLNtiT4vLTgac9LjZfzGWY+yKH61KL1zFBm0RHqrnonRmUhlYUJMHyrM6zcIksXQD\/NAGGQLkkA8dbzj7qofYUqNWHCv6u7qXNfCpRSSmgWPf0yncsMyUDpQW5MA9p4\/ZTcr8K8oM1Be73Oh+vGh9hR2a7OKHVmZ4Qiz0T6mkrWpRiCzqSKSP3nF0\/EwcpcqDN4xvBqGDEsd3hXzT4qGwQocHvVwsGzTKXjdbH9cyU09gzF2ysKblSjSY6h9rM++Ze7nQfDNIMyPRAxWMzIT57TDgsvT0dLP9r6WU9j\/RLrcaQHsR4UehDoYQTjIIeFTqJVF8Is1rLD42EXihLkxVCrgL42cb5t+W5y7yptKc0aEIFNB3qUnC+FXta1K+VW\/dcCeFiv8bIYS\/ZrKqCQzMdQWOp0TJrW1aLry9RosBga0Jt6ooxDPPmnx8m\/hDGYDnHweh30LMH869TlbAwysDbDhLUZBubVp6A2yERF9elcf0riygxDNqhcbLJwZB5t+0rDKfOs9bPpwpMEgrDsSHMoJnfZyiCNc5axupFnq+UZvZ+BGYwhyjM9\/Qig4PYWp95Se21N\/zgdvgIUl1zOIF\/LlKOEitpfRO1E0NFtZUIq05\/Vjs+3V0YYqUUZSrk74NmpkL\/EC1GGIWNN6peHPAHn\/JgWKO6gmhW+xAOQH2EwHXeyGdOYK12TY\/o+eCeWkgtjhpFPU0QG19J4XPnxDJ4hKJ6QytsIo0IvGXtcjxoz9wtV+ZNKwOJoHGA4WoAVMwaoAknV+t1zpFRHjKdN3IXgrGa6AI5JiyrhdT7HwIetAvJMxW7u7JAGdgVQad32zCnWkptUZKSJLlieSih06xotKhkXg1GujrlibJYbZTELhaAL8Ir\/De3z9R0TzMXQCPPrUMkodfKPcYivQxoAlbQV3X83MhBKyiKVQ19Hp7EdUaXAZevpMrhlzsU6DOpZhosrMUyXCjflcnGrtNczpIsvR9CwOM0l1d3wXAOrGCe0zegQHBQvAMifMIjYdWXnH6H\/CoPFYvCIKeW0ekEhvNj7Vd5RH42UXNXEjMbQiEmqQ\/ZW84\/tcm\/2+HJvHQErMJFgY2F8HU8J1Bx9Jae+XENnKOjHyP0jPMGdhj3GtABkr5MXKwAFvFlcnD5aMZm8Lxe3iaPTeZsiGQ9kV4CXEP\/aKUHdoSo6Pw5qrmrUHFPrTylH4hUJ+k\/kXfm1Mhmc2EioWb0iQTnruYvL5S8uV26Iee9fNEAQ5cCLYSC+z6qnQ0WDRrPQ9b6Xv5Ag2gfhqZPpsD7OfPowFZ3uwiirq+DUZxFkRflv4UEkr8Ek6H5JCWxUgR4GNDTyAGBdrwgNwcbyrGSHbqiUNar2FftSC8kViIBsWYbRtlwNuxA\/2ShHk26bb++6jeMCJsNxAlHSCweVJbTD8XLy2G83qwH4IpmjrlR8iRgeLN4hTEZUJLxf2gCExMf0PbmOCi2Ttz1wJbXryi8gP0MfUZMiSneapf1FWwqSqAxp1BiXcmVmfAI1UWCf0gB+eTjEqYeOd3V1HDLg7dmkPWeQGJ9yIyow2xoydlsMhEbWlo+FE9S7UlJmBdOD8+2j7S85OgrYBF5uf+VMST+RMbsjwEqqDwRx0lK5SajeDxkoeqPjFR37arxYkC2Gl2spOd6aPuArMwyS7Bc3RGMvFSqSTq9fscYCa8OjgliaQZwurm\/QL9LMgGFYIZKR+yBGHDsBR2LMMljqCM7wy0MWJYeHl68karoDmE4sIGvXhlUGOq0cvxyVLqVeDS45AhEdula+P72AxLAoRB2ne2SRT9aoX3f8vSakFJ1kVwONMGYAPvXA+WM\/45FDBvjeBBF95Kc7eUQrHcRgmq+Wa4e6KDJMwj0Y59e+GDdhaktlDFIsGhv76SPH97CoE29StVSMpSMqVGdbTLFSa6x\/BIVid7Ru2LyrP9pbgeKo7WHQkcho8hb8kaan3phwYW4zZmn7CtFZi\/2AvVAKckrP0R07jlYrBnLSRzHZodZI0gJOL05jDRWnsQTuR0xJGu1nVmA0NBy8PSLx1A+jg6WOjdwmlncf+vjlIU7xKw8v7YzWrRpP5bKvcPaO9nag9hahWk0XZnZBlD1lRbwYBJ0aVXZQwTgwy9Ls4aUdTdyOIF5JnK8ogGM1OazjDivm84I\/XU+Z3a+5qusgQw+ujj7oo0X0P42mp8vFyJbQ8AzqsmVlz+N1lkxCmANNilsju75JuDsP5+lrb+Fs4BQxM3W37eNl3+j0qzaWHMEYdxRNb7E5Le+06WNm49TOW\/845N8nAYMWFLNhPeo9uN53J\/PMH2\/0bRU1ax1Lip\/mj28LZbvDJqe7DL\/l024SsR8be78I85vQpFoG7JKgqi9lhOSsKC+ufCHlN5iReHHDg0fwFqE9RPcRiJL23KfP7HQuPq8jLrb7uDggdL4CJNlfEBvXlTt3FJ1BhHnQkVhQY51bW1RK72bbziAfU2W3U6X6RAtXuWeJ\/MtlDm3kWV23iUKbHZrBvF4IaITx9twqUtbI07AYWSfBPn\/gQF5V+jdWzuiBvwWJoRoUsj\/f2XQVFS2fwSF3e3t1Z9ZrehRWfm35KzpT\/BVlFI7XVoaLeQh9HTpURg4VqfYGsyj8RDJzZwYILUiLQiaO6J2qDrUf9qjaD1m2SFtzdZcnQwJAgfqfUsBP7hg1XG+7oqRFbdRQZxQbluD6L16TDbngvfpGKKm6iMZKgiChBsMbHwVtdoc+7+cNv4wzOjJtOH1Pl6\/rCBlbmjiQeuGDcTcy\/Fete+H1lzNU4amcsuYrT1sp6ejj01GwSKhvM\/d3Jg1Y4uErEuFks8JKnqvtVnIDptcYKYPKZhH82hHkpkxCBhL+OSuaMY51o50Lp1OCUxU4MT1ZQiHx0zpsoyUnqopr6JVgw2x6Sk8uqIGR2+QcK\/viAtQ747EuhCi3\/FLOmtprL13220uXC\/k1ZAyjLY3dRiRV41ZO5ywbjN1Zqm6phuPT5XgqXQXzIKbW82bkRzmaWpnx93USfZlik2Vi6A8jvMQxbfULow8YCDIfW0tn7Wxs13Fbiq63d97Z8u3ItwRvx44CeMLcgbdoMOcwebHLs0P\/zv0MwuQ6ZvKTc8GF59siszABQcKlskikGggcKNQp4fJh\/rjWk\/q66RQ0qOb3nRN3TFtBmF4NA6Z\/ZstTnS0PplOz5aFfymXLIz2oz5YH065seSqT4jWjKE2KB1OlaesaKPm0ddPz1dXnUGG+OpjOkq9ukr\/H5BlMTXIH08lJ7tC6Tf7l9CR3MEUWslmz3MFUdZY7skPlapOVKydypzR3GADWP6E5S5O7\/IHS3OHVPE0\/BHOnuStxfig7nPmfPDdcuQx3yA0nHAnpD+IYBg8vurpOYV4gCQ71ysMvYZNCROK7ZYwjg\/+AGeNKwP7MGDdnxji0yN8hYxzF3P0AGeNg+mdWlR8rqwrZkRkdgcoB\/ibTkSD+R2k6EtJhfQ7UpCNhO\/2x0pFwsP346UhYgP\/G0pEgoH+EdCQwvTkdCdFhC8NAVDk9wnRSohLhxfQjJR8p51Xq44FffHnIYA4R5y88HGilpx+OrtQj7F6LWBrWstiwJ5m+0f6i2YsfJFNJNUnaOJoXwH9tG0ddZB01RSlL9nROEzk4ytQh6LsdcMVp+2KV75RqBKZGGIOCzzUiruFYrYqfpXmO6kZNHvP7BmsjAG4L1jY1Y2mZP0mlrB+WfdSHZluiKmwquU+JaGKYDkcTW3eNJv5fK4y42r17x8jC1DhnqQcHc2\/fGkA6OoyEv6lWrswajov3\/bFDfTHf7P\/NBZsRsL9i7cwMPodS5pzhdO\/TL6\/vFAFX2pmGzyWLDnMtAw5\/6wi1misETQpYQmnTpF8UpRjkoZgpeXsVFTPVCeRQuJQCq1n+PilovaVItFTlR8MwlUnwO12EJuTDpxW6iuCMislrx1VuvzEMfyiWbPKMMnDqqB9BbcV4hlsKDs1j\/eFaey7jZDHdOJtfeTZ\/pBlEAd09cVdtRTwJa40qJv\/CstVSRBPf7rku3UWIEpncC3A8GL9D85il0FANC3\/JvzygFmR5lfUHE3Ttp0kOk6Lp+1pr+x7+3XL\/amrag9RMdiTEXomvlZGex+lS20yttvKPI3WJ\/dbmRowZi3P7OyQhxrQtOcBrv1rJcr7HfZaetfRS4IuXc2gShvcqKTeCmGraVMTF7Sve4ukwHiYmqrHnMorHB8bxYDz\/ITNidJvX9j1YBQRV6QKDCBjFPCt03okPmqeoDBCiAPcOci7H\/M8c5FxO8W8gyBm5Knrxe61GMD4kTUuFF18bu2kMzjnStpaf7nSpFV6s+eCMXr\/S9wLjwdSpTJ6LX0ZQIZfX4qgXweI6Wsd8k\/Fx357vG8yKyAdx1VqkZ6k5FAHtAcDdu33pf+Vcjs5Z+ta2T7Vv5Jatw+FOtTWcda99wpyNxAn7TxaaXzkozBfEXOnT\/zZC89uq2CqjyQxh+VVMxixqboWh9Y2f7KxoMlNs9Q3uA9NjqzlGSJdjNXQV1Ol7xP6iiLOZYn+fk4+jEUYHUYQZyV00KBIg\/wa0JFJ23OnAs\/FXmEMeqKjUrZzYYWX9kqudSaTqmmCmRZGeRi3I9EmhgNtBx5b2FeyYnFRHroR6brUBTEFaqRJMDTEGdIaxZacCQlRb4XQpYLCQh+C5OPfWblAwQjuJmQqwT1dOnmq7ocw3Lxxfhr7EOvmPRf4LfJ98QHI4+YRyhjWfmjc8kATkU\/77QjqlGIFl8k8RaNeuEkjVsazdTriKQRIQW4ODKhwN7UlHuRhymvihqu\/ohyDLEEmxNXs6AGjvpbYI9dCaAe63BfvzajqcCDVvWSiJJTmmsaDIV+2k1F\/cR+Wcg7QYKM8l1TfeObZ\/sm8SdOj3643LY8kM1jmD\/UiElBj9NUn91zF4IkdAvfRDl\/kxoTC3oPPsFLaGqk3KHJlzi\/ptI0TvZOegU9l1Dt7IA9kM59UHZ5HOlraA4RTZJiNKWGVLiSnYgXiMSDFgrpnJdo9JRea32NpW6pSexLnSnG125xw3wuxLHYl8JLL4EHGTwQwJ0TVP4\/TaEoRW7mStTAVgfVR2fJKeKf2WMSvL5ed\/oKgVEKAwQIxC06LJ+\/rTcPBE\/nbQEYv\/s+6nAdTPGdRfvUDPwemsl15zV0YT\/T9gFoAE6A9\/LV6jJE8T7f\/4PMMshgckIz7o\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\"><style>#nxe-nr-gcri-editions-xt-05-lenses-and-readings.nxe{display:block;box-sizing:border-box;max-width:1180px;margin:0 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8px;text-align:left;vertical-align:top;border-bottom:1px solid;border-color:inherit}#nxe-nr-gcri-editions-xt-05-lenses-and-readings.nxe svg{display:none}#nxe-nr-gcri-editions-xt-05-lenses-and-readings.nxe svg.nx-i{display:inline-block;width:18px;height:18px;vertical-align:-3px}#nxe-nr-gcri-editions-xt-05-lenses-and-readings.nxe :where([role=\"tablist\"],[role=\"toolbar\"],[hidden],button,.nx-theme-toggle,.nx-live-slot){display:none}#nxe-nr-gcri-editions-xt-05-lenses-and-readings.nxe img{max-width:100%;height:auto}<\/style><svg class=\"nx-defs\" aria-hidden=\"true\" focusable=\"false\" width=\"0\" height=\"0\"><defs><linearGradient id=\"nx-gi\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"1\"><stop offset=\"0\" class=\"nx-gi-a\"\/><stop offset=\"0.55\" class=\"nx-gi-b\"\/><stop offset=\"1\" class=\"nx-gi-c\"\/><\/linearGradient><linearGradient id=\"nx-giu\" gradientUnits=\"userSpaceOnUse\" x1=\"0\" y1=\"0\" x2=\"800\" y2=\"0\"><stop offset=\"0\" class=\"nx-gi-a\"\/><stop offset=\"0.55\" class=\"nx-gi-b\"\/><stop offset=\"1\" class=\"nx-gi-c\"\/><\/linearGradient><linearGradient id=\"nx-gp\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"1\"><stop offset=\"0\" class=\"nx-gp-a\"\/><stop offset=\"1\" class=\"nx-gp-b\"\/><\/linearGradient><\/defs><\/svg><div class=\"nrp\"><div class=\"nrp-wrap\"><p class=\"nrj-draft\" data-nrj-shared=\"draft\" role=\"note\"><strong>Draft, not yet released.<\/strong> In stewardship review. Not indexed until the first approved release.<\/p><div class=\"nrp-reader\"><nav class=\"nrp-rail\" aria-label=\"Contents of Genomics and Gene Editing 2026\"><p class=\"nf-ui-eyebrow\">Contents<\/p><ol class=\"nrp-toc\"><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Edition home<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/summary\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Executive summary<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/coupled-system\/\"><span class=\"nrp-toc-n\">1<\/span><span>Genomics is data infrastructure and a therapeutic frontier<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/findings\/\"><span class=\"nrp-toc-n\">2<\/span><span>Key findings<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/systems-and-sectors\/\"><span class=\"nrp-toc-n\">3<\/span><span>Systems and sectors at baseline<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/risk-and-capability\/\"><span class=\"nrp-toc-n\">4<\/span><span>Risks and capability<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/scenario\/\"><span class=\"nrp-toc-n\">5<\/span><span>Individualised editing outpaces delivery systems<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/lenses-and-readings\/\" aria-current=\"page\"><span class=\"nrp-toc-n\">6<\/span><span>Readings from the other desks<\/span><\/a><ol class=\"nrp-toc-sub\"><li><a href=\"#nx-nrp-xt-05-c6-s1\">6.1 The other desks&#8217; editions of this subject<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c6-s2\">6.2 Three lenses<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c6-s3\">6.3 Standards, Academy and steward contributions<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c6-s4\">6.4 <abbr title=\"The Global Centre for Risk and Innovation\">GCRI<\/abbr> reading: the model card<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c6-s5\">6.5 Global Risks Forum reading: editorial essays<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c6-s6\">6.6 Global Risks Alliance reading: 2027 genomics readiness pack<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c6-s7\">6.7 Nexus Standards reading: standards and regulatory watch<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c6-s8\">6.8 Risk Academy reading: literature and evidence review, science and assessments<\/a><\/li><\/ol><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/agenda\/\"><span class=\"nrp-toc-n\">7<\/span><span>The 2027 agenda<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/systems-in-depth\/\"><span class=\"nrp-toc-n\">8<\/span><span>Systems in depth<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/methodology\/\"><span class=\"nrp-toc-n\">A<\/span><span>Methodology<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/data\/\"><span class=\"nrp-toc-n\">B<\/span><span>Data appendix<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/references\/\"><span class=\"nrp-toc-n\">C<\/span><span>References and record<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/full\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Complete edition, for print<\/span><\/a><\/li><\/ol><div class=\"nrp-actions\"><a class=\"nf-ui-btn\" data-variant=\"secondary\" href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/full\/\"><svg class=\"nrp-i\" viewBox=\"0 0 24 24\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2\"\/><path d=\"M6 9V3a1 1 0 0 1 1-1h10a1 1 0 0 1 1 1v6\"\/><rect x=\"6\" y=\"14\" width=\"12\" height=\"8\" rx=\"1\"\/><\/svg>Print or save as PDF<\/a><\/div><\/nav><article class=\"nrp-flow\" aria-labelledby=\"nx-nrp-xt-05-c6-top\"><header class=\"nrp-chap-head\" id=\"nx-nrp-xt-05-c6-top\"><ul class=\"nrp-eyerow\"><li class=\"nf-ui-eyebrow\"><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/\">Genomics and Gene Editing 2026<\/a><\/li><li class=\"nf-ui-eyebrow\">Chapter 6<\/li><\/ul><span class=\"nrp-rule\" aria-hidden=\"true\"><\/span><h1 class=\"pp-hero-title\">Readings from the other desks<\/h1><p class=\"nrp-lede\">The genomics baseline is read through each steward\u2019s lens, then once as a whole. Each lens is a projection of reviewed findings, not a separate argument. The other desks&#8217; own editions of this subject are listed first, as cross-references, not copies.<\/p><p class=\"nrp-chap-meta\"><span>15 min read<\/span><span>0 figures<\/span><span>8 tables<\/span><span>36 notes<\/span><span>NR-XTECH-GENOMICS-GLOBAL-2026-BASELINE<\/span><\/p><details class=\"nrp-toc-m\"><summary>Contents<\/summary><ol class=\"nrp-toc\"><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Edition home<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/summary\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Executive summary<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/coupled-system\/\"><span class=\"nrp-toc-n\">1<\/span><span>Genomics is data infrastructure and a therapeutic frontier<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/findings\/\"><span class=\"nrp-toc-n\">2<\/span><span>Key findings<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/systems-and-sectors\/\"><span class=\"nrp-toc-n\">3<\/span><span>Systems and sectors at baseline<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/risk-and-capability\/\"><span class=\"nrp-toc-n\">4<\/span><span>Risks and capability<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/scenario\/\"><span class=\"nrp-toc-n\">5<\/span><span>Individualised editing outpaces delivery systems<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/lenses-and-readings\/\" aria-current=\"page\"><span class=\"nrp-toc-n\">6<\/span><span>Readings from the other desks<\/span><\/a><ol class=\"nrp-toc-sub\"><li><a href=\"#nx-nrp-xt-05-c6-s1\">6.1 The other desks&#8217; editions of this subject<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c6-s2\">6.2 Three lenses<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c6-s3\">6.3 Standards, Academy and steward contributions<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c6-s4\">6.4 GCRI reading: the model card<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c6-s5\">6.5 Global Risks Forum reading: editorial essays<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c6-s6\">6.6 Global Risks Alliance reading: 2027 genomics readiness pack<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c6-s7\">6.7 Nexus Standards reading: standards and regulatory watch<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c6-s8\">6.8 Risk Academy reading: literature and evidence review, science and assessments<\/a><\/li><\/ol><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/agenda\/\"><span class=\"nrp-toc-n\">7<\/span><span>The 2027 agenda<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/systems-in-depth\/\"><span class=\"nrp-toc-n\">8<\/span><span>Systems in depth<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/methodology\/\"><span class=\"nrp-toc-n\">A<\/span><span>Methodology<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/data\/\"><span class=\"nrp-toc-n\">B<\/span><span>Data appendix<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/references\/\"><span class=\"nrp-toc-n\">C<\/span><span>References and record<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/full\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Complete edition, for print<\/span><\/a><\/li><\/ol><\/details><\/header><section class=\"nrp-block\" id=\"nx-nrp-xt-05-c6-s1\" aria-labelledby=\"nx-nrp-xt-05-c6-s1-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-c6-s1-h\"><span class=\"nrp-num\">6.1<\/span><span>The other desks&#8217; editions of this subject<\/span><\/h2><p class=\"nrp-stand\">Federation: each desk writes its own edition for the subjects in its remit. Until a desk releases, its edition shows its frame and the reading this edition printed for it.<\/p><div class=\"nrp-tblw\"><table class=\"nrp-tbl\"><thead><tr><th scope=\"col\">Desk<\/th><th scope=\"col\">Edition<\/th><th scope=\"col\">State<\/th><th scope=\"col\">Identifier<\/th><\/tr><\/thead><tbody><tr data-host=\"true\"><th scope=\"row\">GCRI Systems Evidence<\/th><td>No edition of this subject at this desk in the 2026 Baseline cycle<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Not in this cycle<\/span><\/td><td class=\"nrp-mono\"><\/td><\/tr><tr><th scope=\"row\">GRF Public Deliberation<\/th><td>Outside this desk&#8217;s remit<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Not in remit<\/span><\/td><td class=\"nrp-mono\"><\/td><\/tr><tr><th scope=\"row\">GRA Capital Readiness<\/th><td>Outside this desk&#8217;s remit<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Not in remit<\/span><\/td><td class=\"nrp-mono\"><\/td><\/tr><tr><th scope=\"row\">Standards Progress<\/th><td>No edition of this subject at this desk in the 2026 Baseline cycle<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Not in this cycle<\/span><\/td><td class=\"nrp-mono\"><\/td><\/tr><tr><th scope=\"row\">Academy Capability<\/th><td>No edition of this subject at this desk in the 2026 Baseline cycle<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Not in this cycle<\/span><\/td><td class=\"nrp-mono\"><\/td><\/tr><tr><th scope=\"row\">Index Measurement<\/th><td>Outside this desk&#8217;s remit<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Not in remit<\/span><\/td><td class=\"nrp-mono\"><\/td><\/tr><\/tbody><\/table><\/div><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-c6-s2\" aria-labelledby=\"nx-nrp-xt-05-c6-s2-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-c6-s2-h\"><span class=\"nrp-num\">6.2<\/span><span>Three lenses<\/span><\/h2><p class=\"nrp-stand\">One edition, read by each steward. The lens of this site comes first.<\/p><div class=\"nrp-cards\" data-n=\"3\"><article class=\"nf-ui-card nrp-card\" data-host=\"true\"><p class=\"nf-ui-eyebrow\">GCRI \u00b7 KEY T<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">Technical Truth<\/h3><p>The evidence supports reading genomics as data infrastructure and as a therapeutic technology. Results are strong for one therapy family and for reference data, and the physical, cost and supply layers are thinly measured. Evidence is strongest for single peer-reviewed results, and weakest for energy, cost and treatment counts.<\/p><p class=\"nrp-note\">HLT-001 \u00b7 DAT-006 \u00b7 GOV-011 \u00b7 SYS-012<\/p><\/article><article class=\"nf-ui-card nrp-card\"><p class=\"nf-ui-eyebrow\">GRF \u00b7 KEY M<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">Public Meaning<\/h3><p>For most people the genomics story arrives as a cure headline, a data-privacy scare or a price. The baseline asks that public debate separate peer-reviewed results from company claims, and keep consent over genetic data in view.<\/p><p class=\"nrp-note\">HLT-001 \u00b7 HLT-004 \u00b7 DAT-007<\/p><\/article><article class=\"nf-ui-card nrp-card\"><p class=\"nf-ui-eyebrow\">GRA \u00b7 KEY F<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">Capital Meaning<\/h3><p>Readiness implications only. Revenue is small, access depends on cost and manufacturing capacity, and one-time prices raise payment questions<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n6\" id=\"nx-nrp-xt-05-c6-r6\" aria-label=\"Note 6\">6<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n7\" id=\"nx-nrp-xt-05-c6-r7\" aria-label=\"Note 7\">7<\/a><\/sup>. These show where finance-readiness evidence will matter. Nothing here is advice, a rating or an approval.<\/p><p class=\"nrp-note\">FIN-005 \u00b7 HLT-002<\/p><\/article><article class=\"nf-ui-card nrp-card\"><p class=\"nf-ui-eyebrow\">NEXUS<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">Synthesis<\/h3><p>Genomics is well described by single results and thinly measured as a system. The 2027 programme should count treatments, publish a comparable footprint and test the delivery pathway before more bespoke therapies reach patients.<\/p><p class=\"nrp-note\">SYS-012 \u00b7 Q-01 \u00b7 Q-02<\/p><\/article><\/div><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-c6-s3\" aria-labelledby=\"nx-nrp-xt-05-c6-s3-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-c6-s3-h\"><span class=\"nrp-num\">6.3<\/span><span>Standards, Academy and steward contributions<\/span><\/h2><p class=\"nrp-stand\">How the <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/\" data-tc=\"Nexus Standards\" data-tk=\"Nexus Standards\" data-td=\"The foundation standards\">Nexus Standards<\/a> drafts, the Risk Academy and the three stewards feed each quarterly edition for genomics. The standards are a preparatory working draft (2026) and are cited as drafts, never as adopted standards.<\/p><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-c6-tab1\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 6.1<\/span><span class=\"nrp-tbl-t\">The quarterly rhythm every edition follows<\/span><\/caption><thead><tr><th scope=\"col\">Quarter<\/th><th scope=\"col\">Edition<\/th><th scope=\"col\">Question<\/th><th scope=\"col\">Boundary<\/th><\/tr><\/thead><tbody><tr><td>Q1<\/td><td>State and Agenda<\/td><td>What matters this year, and what is the starting position?<\/td><td>observed baseline stays distinct from planned work<\/td><\/tr><tr><td>Q2<\/td><td>Evidence and Build<\/td><td>What new evidence and capability exist?<\/td><td>a configured capability is not a validated result<\/td><\/tr><tr><td>Q3<\/td><td><a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-c1\" data-tc=\"NRS-C1 stress-test\" data-tk=\"Nexus risk vocabulary\" data-td=\"An assessment of how a system, portfolio or institution would perform under severe but plausible adverse scenarios, to find weaknesses before they are revealed by events.\" data-ts=\"NRS-C1\" data-tr=\"draft\">Stress Test<\/a> and Readiness<\/td><td>What do scenarios and tests show?<\/td><td>simulated loss or performance is not observed impact<\/td><\/tr><tr><td>Q4<\/td><td>Annual Synthesis and Renewal<\/td><td>What changed in the year, and what renews?<\/td><td>release follows review, not event publicity deadlines<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-c6-tab2\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 6.2<\/span><span class=\"nrp-tbl-t\">Who contributes what each quarter<\/span><\/caption><thead><tr><th scope=\"col\">Steward or body<\/th><th scope=\"col\">Role<\/th><th scope=\"col\">Contribution route<\/th><\/tr><\/thead><tbody><tr><td>The Global Centre for Risk and Innovation (GCRI Canada)<\/td><td>Lead Institution and Consortium Secretariat; publisher of record; technical truth (key T)<\/td><td>science and practice communities \u00b7 GCRI gateway<\/td><\/tr><tr><td>The Global Risks Forum (GRF)<\/td><td>leadership, dialogue and the <a class=\"nx-link\" href=\"https:\/\/docs.therisk.global\/organization\/programme\/universe\">Universe<\/a> programme; public meaning (key M)<\/td><td>policy, Universe and national adoption \u00b7 GRF gateway<\/td><\/tr><tr><td>The Global Risks Alliance (GRA)<\/td><td>finance, insurance and development readiness; capital meaning (key F)<\/td><td>finance and insurance \u00b7 GRA gateway<\/td><\/tr><tr><td>Nexus Standards<\/td><td>preparatory drafts on vocabulary, hazards, indicators and methods<\/td><td>Standards site \u00b7 working groups HAZ, IND, MTH, FIN, AI<\/td><\/tr><tr><td>Risk Academy<\/td><td>learning pathways tied to the agenda questions<\/td><td>Academy gateway \u00b7 learning by review<\/td><\/tr><tr><td>Nexus Standards and Academy<\/td><td>technology chapter inputs: GCRI evidence, NXS standards, RA capability<\/td><td>technology editorial board<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-split\"><div><h3 class=\"nrp-h3\">Standards drafts used in this edition<\/h3><ul class=\"nrp-list\"><li>Risk vocabulary NRS-C1 (424 terms) for terms in the glossary<\/li><li>Hazard atlas NHS-1 1.1.0 (905 hazards in 120 families) for risk objects<\/li><li>Seven risk classes: global, catastrophic, existential, emerging, planetary, exponential, frontier-tech<\/li><\/ul><\/div><div><h3 class=\"nrp-h3\">Standards calendar to watch<\/h3><ul class=\"nrp-list\"><li>Founding calls from 20 October 2026; working groups meet from 5 November 2026<\/li><li>Inaugural Global Standards Council session, 12 January 2027<\/li><li>Quarterly reviews in March, June, September and December, aligned with each edition<\/li><\/ul><\/div><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">boundary<\/p><p>Nothing here certifies. A Nexus attestation records an evaluation under a mandate; it confers no certification, endorsement or approval. Adoption of any standard is a decision of the competent standards body.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-c6-s4\" aria-labelledby=\"nx-nrp-xt-05-c6-s4-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-c6-s4-h\"><span class=\"nrp-num\">6.4<\/span><span>GCRI reading: the model card<\/span><\/h2><p class=\"nrp-p\">GCRI&#8217;s reading of this edition is its model card: what the national model is, what it computes and where it stops. It is printed in full in Annex A, with the methods it belongs to. <a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/methodology\/\">Annex A, methodology<\/a><\/p><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-c6-s5\" aria-labelledby=\"nx-nrp-xt-05-c6-s5-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-c6-s5-h\"><span class=\"nrp-num\">6.5<\/span><span>Global Risks Forum reading: editorial essays<\/span><\/h2><p class=\"nrp-stand\">Four signed essays by the <a class=\"nx-link\" href=\"https:\/\/docs.therisk.global\/organization\/programme\/reports\">Reports<\/a> editorial team set out the positions this edition takes. They are interpretation, labelled as such; the evidence they draw on is in the findings register.<\/p><div class=\"nrp-cards\"><article class=\"nf-ui-card nrp-card\"><p class=\"nf-ui-eyebrow\">Genomics is a data and hardware build-out and a therapeutic frontier. The first is large and measurable; the second is real for one product family and early for the rest. Keeping them apart avoids both hype and complacency.<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">EDITORIAL ESSAY \u00b7 01<\/h3><p>Two stories, one technology<\/p><\/article><article class=\"nf-ui-card nrp-card\"><p class=\"nf-ui-eyebrow\">A peer-reviewed phase 3 report, a company revenue line and a vendor price page carry different weight. This edition labels each and asks for a common basis before costs are compared.<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">EDITORIAL ESSAY \u00b7 02<\/h3><p>Separate results, claims and prices<\/p><\/article><article class=\"nf-ui-card nrp-card\"><p class=\"nf-ui-eyebrow\">Compute, cold chains and instruments are rarely counted. A published footprint would show whether scale is limited by energy, supply or money.<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">EDITORIAL ESSAY \u00b7 03<\/h3><p>The footprint is the blind spot<\/p><\/article><article class=\"nf-ui-card nrp-card\"><p class=\"nf-ui-eyebrow\">Therapies exist for a few patients. Whether they reach people in low-income settings depends on cost, manufacturing and clinics, which analyses are only starting to model.<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">EDITORIAL ESSAY \u00b7 04<\/h3><p>Access is the open question<\/p><\/article><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">boundary<\/p><p>Essays are signed views of the editorial team. Contributed articles from regional consortia, national pathways and invited experts begin with the 2027 global edition, each with its own review route and disclosures.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-c6-s6\" aria-labelledby=\"nx-nrp-xt-05-c6-s6-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-c6-s6-h\"><span class=\"nrp-num\">6.6<\/span><span>Global Risks Alliance reading: 2027 genomics readiness pack<\/span><\/h2><p class=\"nrp-stand\">The registers that open the 2027 global cycle. At baseline each is initialised from this edition.<\/p><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-c6-tab3\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 6.3<\/span><span class=\"nrp-tbl-t\">2027 genomics readiness pack<\/span><\/caption><thead><tr><th scope=\"col\">Item<\/th><th scope=\"col\">Register<\/th><th scope=\"col\">State at baseline<\/th><th scope=\"col\">First 2027 entry<\/th><\/tr><\/thead><tbody><tr><td>E1<\/td><td>Genomics risk state delta<\/td><td>baseline set by this edition<\/td><td>changes against the baseline<\/td><\/tr><tr><td>E2<\/td><td>WEFH+B state delta<\/td><td>five global system readings set<\/td><td>indicator updates and freshness<\/td><\/tr><tr><td>E3<\/td><td>Agenda and Portfolio movement<\/td><td>eight agenda items \u00b7 6 proposed objects<\/td><td>admission decisions<\/td><\/tr><tr><td>E4<\/td><td>Federation delivery register<\/td><td>national chapters in preparation<\/td><td>national chapters<\/td><\/tr><tr><td>E5<\/td><td>Consortium capability register<\/td><td>national consortia forming<\/td><td>first contributions<\/td><\/tr><tr><td>E6<\/td><td>Leadership questions and challenges<\/td><td>none yet<\/td><td>first challenge log<\/td><\/tr><tr><td>E7<\/td><td>Foundry technical state<\/td><td>national environments prepared<\/td><td>first federation cut<\/td><\/tr><tr><td>E8<\/td><td>Publication candidates<\/td><td>twelve findings carried forward<\/td><td>PUBLISH \u00b7 HOLD dispositions<\/td><\/tr><tr><td>E9<\/td><td>Universe readiness<\/td><td>one candidate mission<\/td><td>admission and role spine<\/td><\/tr><tr><td>E10<\/td><td>Correction register<\/td><td>none<\/td><td>first federation-wide cycle<\/td><\/tr><\/tbody><\/table><\/div><h3 class=\"nrp-h3\">Publication dispositions<\/h3><ul class=\"nrp-chips\"><li class=\"nf-ui-chip\">Publish<\/li><li class=\"nf-ui-chip\">Hold<\/li><li class=\"nf-ui-chip\">Needs evidence<\/li><li class=\"nf-ui-chip\">Restricted<\/li><li class=\"nf-ui-chip\">Superseded<\/li><\/ul><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">boundary<\/p><p>Programme progress is not real-world risk improvement. These registers record the work of the Nexus programme; they report on no state or organisation.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-c6-s7\" aria-labelledby=\"nx-nrp-xt-05-c6-s7-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-c6-s7-h\"><span class=\"nrp-num\">6.7<\/span><span>Nexus Standards reading: standards and regulatory watch<\/span><\/h2><p class=\"nrp-stand\">Instruments and published guidance that shape the <a class=\"nx-link nx-term\" href=\"https:\/\/docs.therisk.global\/organization\/systems\" data-tc=\"Systems\" data-tk=\"Nexus Standards\" data-td=\"The twenty Nexus systems, NXS-CMD to NXS-LAB\">systems<\/a> in this edition, by status on the retrieval date. The edition assesses no one\u2019s compliance.<\/p><ul class=\"nrp-chips\"><li class=\"nf-ui-chip\">IN FORCE<\/li><li class=\"nf-ui-chip\">PUBLISHED<\/li><li class=\"nf-ui-chip\">DRAFT<\/li><li class=\"nf-ui-chip\">PUBLISHED \u00b7 VOLUNTARY<\/li><\/ul><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-c6-tab4\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 6.4<\/span><span class=\"nrp-tbl-t\">Standards and regulatory watch<\/span><\/caption><thead><tr><th scope=\"col\">Instrument<\/th><th scope=\"col\">Body<\/th><th scope=\"col\">Scope<\/th><th scope=\"col\">Status<\/th><th scope=\"col\">Relevance<\/th><\/tr><\/thead><tbody><tr><td>FDA approval of Casgevy and Lyfgenia<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n1\" id=\"nx-nrp-xt-05-c6-r1\" aria-label=\"Note 1\">1<\/a><\/sup><\/td><td>FDA<\/td><td>US<\/td><td>PUBLISHED 2023<\/td><td>approval<\/td><\/tr><tr><td>Plausible mechanism pathway<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n5\" id=\"nx-nrp-xt-05-c6-r5\" aria-label=\"Note 5\">5<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n37\" id=\"nx-nrp-xt-05-c6-r37\" aria-label=\"Note 37\">37<\/a><\/sup><\/td><td>FDA<\/td><td>US<\/td><td>DRAFT 2026<\/td><td>bespoke therapies<\/td><\/tr><tr><td>Human genome editing framework<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n27\" id=\"nx-nrp-xt-05-c6-r27\" aria-label=\"Note 27\">27<\/a><\/sup><\/td><td>WHO<\/td><td>global<\/td><td>PUBLISHED \u00b7 VOLUNTARY<\/td><td>governance<\/td><\/tr><tr><td>Third Summit statement<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n28\" id=\"nx-nrp-xt-05-c6-r28\" aria-label=\"Note 28\">28<\/a><\/sup><\/td><td>organising committee<\/td><td>global<\/td><td>PUBLISHED 2023<\/td><td>heritable editing<\/td><\/tr><tr><td>Genetic Technology (Precision Breeding) Act 2023<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n29\" id=\"nx-nrp-xt-05-c6-r29\" aria-label=\"Note 29\">29<\/a><\/sup><\/td><td>UK Parliament<\/td><td>England<\/td><td>IN FORCE<\/td><td>plant editing<\/td><\/tr><tr><td>Regulation (EU) 2026\/1388<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n36\" id=\"nx-nrp-xt-05-c6-r36\" aria-label=\"Note 36\">36<\/a><\/sup><\/td><td>EU Parliament and Council<\/td><td>EU<\/td><td>PUBLISHED 2026<\/td><td>plant editing<\/td><\/tr><tr><td>BIOSECURE provisions in the FY2026 NDAA<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n30\" id=\"nx-nrp-xt-05-c6-r30\" aria-label=\"Note 30\">30<\/a><\/sup><\/td><td>US Congress<\/td><td>US<\/td><td>IN FORCE<\/td><td>procurement<\/td><\/tr><tr><td>Oviedo Convention<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n41\" id=\"nx-nrp-xt-05-c6-r41\" aria-label=\"Note 41\">41<\/a><\/sup><\/td><td>Council of Europe<\/td><td>Europe<\/td><td>IN FORCE<\/td><td>genome interventions<\/td><\/tr><tr><td>Genetic Information Nondiscrimination Act<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n44\" id=\"nx-nrp-xt-05-c6-r44\" aria-label=\"Note 44\">44<\/a><\/sup><\/td><td>US Congress<\/td><td>US<\/td><td>IN FORCE<\/td><td>data and employment<\/td><\/tr><tr><td>Heritable editing moratorium call<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n42\" id=\"nx-nrp-xt-05-c6-r42\" aria-label=\"Note 42\">42<\/a><\/sup><\/td><td>scientists<\/td><td>global<\/td><td>PUBLISHED 2019<\/td><td>moratorium<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-split\"><div><h3 class=\"nrp-h3\">Changed since 2024<\/h3><ul class=\"nrp-list\"><li>The EU adopted its regulation on plants from new genomic techniques in June 2026, to apply from July 2028<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n36\" aria-label=\"Note 36\">36<\/a><\/sup><\/li><li>The FDA described a plausible mechanism pathway and issued draft guidance in 2026<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n5\" aria-label=\"Note 5\">5<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n37\" aria-label=\"Note 37\">37<\/a><\/sup><\/li><li>The BIOSECURE provisions were enacted on 18 December 2025<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n30\" aria-label=\"Note 30\">30<\/a><\/sup><\/li><\/ul><\/div><div><h3 class=\"nrp-h3\">To watch in 2027<\/h3><ul class=\"nrp-list\"><li>The OMB list of biotechnology companies of concern due by 18 December 2026<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n30\" aria-label=\"Note 30\">30<\/a><\/sup><\/li><li>Final FDA guidance on the plausible mechanism pathway<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n37\" aria-label=\"Note 37\">37<\/a><\/sup><\/li><li>Application of the EU regulation on new genomic techniques from 2028<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n36\" aria-label=\"Note 36\">36<\/a><\/sup><\/li><\/ul><\/div><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">evidence<\/p><p>Status is read from the issuing body on the retrieval date. Instruments open for signature or awaiting ratification are labelled as such; a change in status opens a review task for every finding that relies on the instrument.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-c6-s8\" aria-labelledby=\"nx-nrp-xt-05-c6-s8-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-c6-s8-h\"><span class=\"nrp-num\">6.8<\/span><span>Risk Academy reading: literature and evidence review, science and assessments<\/span><\/h2><p class=\"nrp-stand\">The review behind this edition covers genomics assessments, peer-reviewed science and the institutional reports that bind its findings. Systematic reviews for each agenda item begin in 2027.<\/p><h3 class=\"nrp-h3\">Review protocol<\/h3><dl class=\"nrp-dl\"><dt>Question<\/dt><dd>What does the published evidence establish about genomics and gene editing as infrastructure and its couplings?<\/dd><dt>Sources searched<\/dt><dd>peer-reviewed journals and preprints; regulators and international bodies; statutes and statements; market, vendor and trade-press reports<\/dd><dt>Window<\/dt><dd>releases available at evidence close, 30 September 2026<\/dd><dt>Selection<\/dt><dd>sources that bind or contextualise a finding in this edition<\/dd><dt>Next step<\/dt><dd>systematic reviews for agenda items 01 to 05 in 2027<\/dd><\/dl><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-c6-tab5\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 6.5<\/span><span class=\"nrp-tbl-t\">Peer-reviewed science and preprints<\/span><\/caption><thead><tr><th scope=\"col\">Reference<\/th><th scope=\"col\">Type<\/th><th scope=\"col\">Year<\/th><th scope=\"col\">Role<\/th><th scope=\"col\">Used for<\/th><\/tr><\/thead><tbody><tr><td>Frangoul et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n2\" id=\"nx-nrp-xt-05-c6-r2\" aria-label=\"Note 2\">2<\/a><\/sup><\/td><td>journal article<\/td><td>2024<\/td><td>supports<\/td><td>sickle cell therapy<\/td><\/tr><tr><td>Locatelli et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n3\" id=\"nx-nrp-xt-05-c6-r3\" aria-label=\"Note 3\">3<\/a><\/sup><\/td><td>journal article<\/td><td>2024<\/td><td>supports<\/td><td>thalassaemia therapy<\/td><\/tr><tr><td>Musunuru et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n4\" id=\"nx-nrp-xt-05-c6-r4\" aria-label=\"Note 4\">4<\/a><\/sup><\/td><td>journal article<\/td><td>2025<\/td><td>supports<\/td><td>patient-specific editing<\/td><\/tr><tr><td>Lek et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n10\" id=\"nx-nrp-xt-05-c6-r10\" aria-label=\"Note 10\">10<\/a><\/sup><\/td><td>journal article<\/td><td>2023<\/td><td>context<\/td><td>safety event<\/td><\/tr><tr><td>Nurk et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n11\" id=\"nx-nrp-xt-05-c6-r11\" aria-label=\"Note 11\">11<\/a><\/sup><\/td><td>journal article<\/td><td>2022<\/td><td>supports<\/td><td>complete genome<\/td><\/tr><tr><td>Liao et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n12\" id=\"nx-nrp-xt-05-c6-r12\" aria-label=\"Note 12\">12<\/a><\/sup><\/td><td>journal article<\/td><td>2023<\/td><td>supports<\/td><td>pangenome<\/td><\/tr><tr><td>Jinek et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n24\" id=\"nx-nrp-xt-05-c6-r24\" aria-label=\"Note 24\">24<\/a><\/sup><\/td><td>journal article<\/td><td>2012<\/td><td>framework<\/td><td>programmable Cas9<\/td><\/tr><tr><td>Komor et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n25\" id=\"nx-nrp-xt-05-c6-r25\" aria-label=\"Note 25\">25<\/a><\/sup><\/td><td>journal article<\/td><td>2016<\/td><td>framework<\/td><td>base editing<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-c6-tab6\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 6.6<\/span><span class=\"nrp-tbl-t\">Clinical evidence and safety<\/span><\/caption><thead><tr><th scope=\"col\">Reference<\/th><th scope=\"col\">Issuer<\/th><th scope=\"col\">Year<\/th><th scope=\"col\">Role<\/th><th scope=\"col\">Used for<\/th><\/tr><\/thead><tbody><tr><td>Anzalone et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n26\" id=\"nx-nrp-xt-05-c6-r26\" aria-label=\"Note 26\">26<\/a><\/sup><\/td><td>journal article<\/td><td>2019<\/td><td>framework<\/td><td>prime editing<\/td><\/tr><tr><td>UK Biobank consortium<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n16\" id=\"nx-nrp-xt-05-c6-r16\" aria-label=\"Note 16\">16<\/a><\/sup><\/td><td>journal article<\/td><td>2025<\/td><td>supports<\/td><td>whole genomes<\/td><\/tr><tr><td>All of Us investigators<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n17\" id=\"nx-nrp-xt-05-c6-r17\" aria-label=\"Note 17\">17<\/a><\/sup><\/td><td>journal article<\/td><td>2024<\/td><td>supports<\/td><td>diverse cohort<\/td><\/tr><tr><td>Fatumo et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n18\" id=\"nx-nrp-xt-05-c6-r18\" aria-label=\"Note 18\">18<\/a><\/sup><\/td><td>journal article<\/td><td>2022<\/td><td>context<\/td><td>diversity roadmap<\/td><\/tr><tr><td>Sirugo, Williams and Tishkoff<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n19\" id=\"nx-nrp-xt-05-c6-r19\" aria-label=\"Note 19\">19<\/a><\/sup><\/td><td>journal article<\/td><td>2019<\/td><td>context<\/td><td>missing diversity<\/td><\/tr><tr><td>Stephens et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n20\" id=\"nx-nrp-xt-05-c6-r20\" aria-label=\"Note 20\">20<\/a><\/sup><\/td><td>journal article<\/td><td>2015<\/td><td>context<\/td><td>data growth<\/td><\/tr><tr><td>IHGSC<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n43\" id=\"nx-nrp-xt-05-c6-r43\" aria-label=\"Note 43\">43<\/a><\/sup><\/td><td>journal article<\/td><td>2001<\/td><td>framework<\/td><td>first draft sequence<\/td><\/tr><tr><td>Grealey et al.<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n21\" id=\"nx-nrp-xt-05-c6-r21\" aria-label=\"Note 21\">21<\/a><\/sup><\/td><td>journal article<\/td><td>2022<\/td><td>supports<\/td><td>compute footprint<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-c6-tab7\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 6.7<\/span><span class=\"nrp-tbl-t\">Standards, policy and governance<\/span><\/caption><thead><tr><th scope=\"col\">Reference<\/th><th scope=\"col\">Issuer<\/th><th scope=\"col\">Year<\/th><th scope=\"col\">Role<\/th><th scope=\"col\">Used for<\/th><\/tr><\/thead><tbody><tr><td>FDA approval notice<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n1\" aria-label=\"Note 1\">1<\/a><\/sup><\/td><td>FDA<\/td><td>2023<\/td><td>supports<\/td><td>approval<\/td><\/tr><tr><td>WHO framework<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n27\" aria-label=\"Note 27\">27<\/a><\/sup><\/td><td>WHO<\/td><td>2021<\/td><td>supports<\/td><td>governance<\/td><\/tr><tr><td>Third Summit statement<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n28\" aria-label=\"Note 28\">28<\/a><\/sup><\/td><td>organising committee<\/td><td>2023<\/td><td>supports<\/td><td>heritable editing<\/td><\/tr><tr><td>Precision Breeding Act<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n29\" aria-label=\"Note 29\">29<\/a><\/sup><\/td><td>UK Parliament<\/td><td>2023<\/td><td>supports<\/td><td>plant editing<\/td><\/tr><tr><td>Oviedo Convention<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n41\" aria-label=\"Note 41\">41<\/a><\/sup><\/td><td>Council of Europe<\/td><td>1997<\/td><td>context<\/td><td>genome interventions<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-c6-tab8\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 6.8<\/span><span class=\"nrp-tbl-t\">Supply, market and data overviews<\/span><\/caption><thead><tr><th scope=\"col\">Reference<\/th><th scope=\"col\">Issuer<\/th><th scope=\"col\">Year<\/th><th scope=\"col\">Role<\/th><th scope=\"col\">Used for<\/th><\/tr><\/thead><tbody><tr><td>Vertex first quarter report<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n6\" aria-label=\"Note 6\">6<\/a><\/sup><\/td><td>Vertex<\/td><td>2026<\/td><td>context<\/td><td>company revenue<\/td><\/tr><tr><td>Cost-effectiveness analysis<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n7\" aria-label=\"Note 7\">7<\/a><\/sup><\/td><td>Blood<\/td><td>2026<\/td><td>supports<\/td><td>cost and capacity<\/td><\/tr><tr><td>Illumina product page<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n14\" id=\"nx-nrp-xt-05-c6-r14\" aria-label=\"Note 14\">14<\/a><\/sup><\/td><td>Illumina<\/td><td>2026<\/td><td>context<\/td><td>vendor claim<\/td><\/tr><tr><td>Ultima product page<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n15\" id=\"nx-nrp-xt-05-c6-r15\" aria-label=\"Note 15\">15<\/a><\/sup><\/td><td>Ultima<\/td><td>2026<\/td><td>context<\/td><td>vendor claim<\/td><\/tr><tr><td>Employment projection<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n33\" id=\"nx-nrp-xt-05-c6-r33\" aria-label=\"Note 33\">33<\/a><\/sup><\/td><td>BLS<\/td><td>2025<\/td><td>supports<\/td><td>workforce<\/td><\/tr><tr><td>Generation Study<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n34\" id=\"nx-nrp-xt-05-c6-r34\" aria-label=\"Note 34\">34<\/a><\/sup><\/td><td>Genomics England<\/td><td>2026<\/td><td>context<\/td><td>newborn sequencing<\/td><\/tr><tr><td>Evo 2 preprint<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n23\" id=\"nx-nrp-xt-05-c6-r23\" aria-label=\"Note 23\">23<\/a><\/sup><\/td><td>bioRxiv<\/td><td>2025<\/td><td>context<\/td><td>genome model<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-split\"><div><h3 class=\"nrp-h3\">Where the evidence agrees<\/h3><ul class=\"nrp-list\"><li>Ex vivo editing met its primary end point in most evaluable patients at short follow-up<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n2\" aria-label=\"Note 2\">2<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n3\" aria-label=\"Note 3\">3<\/a><\/sup><\/li><li>Genomic datasets are large and still weighted to European ancestry<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n16\" aria-label=\"Note 16\">16<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n17\" aria-label=\"Note 17\">17<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n18\" aria-label=\"Note 18\">18<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n19\" aria-label=\"Note 19\">19<\/a><\/sup><\/li><li>Heritable editing is not currently acceptable<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n28\" aria-label=\"Note 28\">28<\/a><\/sup><\/li><\/ul><\/div><div><h3 class=\"nrp-h3\">Where it is unsettled<\/h3><ul class=\"nrp-list\"><li>Long-term safety of in vivo editing and high-dose delivery<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n9\" id=\"nx-nrp-xt-05-c6-r9\" aria-label=\"Note 9\">9<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n10\" aria-label=\"Note 10\">10<\/a><\/sup><\/li><li>Real sequencing and therapy costs on a common basis<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n14\" aria-label=\"Note 14\">14<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n15\" aria-label=\"Note 15\">15<\/a><\/sup><\/li><li>How much energy and cooling genomics needs at scale<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n21\" aria-label=\"Note 21\">21<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n22\" id=\"nx-nrp-xt-05-c6-r22\" aria-label=\"Note 22\">22<\/a><\/sup><\/li><\/ul><\/div><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">PREPRINTS<\/p><p>Three sources<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n24\" aria-label=\"Note 24\">24<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n25\" aria-label=\"Note 25\">25<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c6-n26\" aria-label=\"Note 26\">26<\/a><\/sup> are preprints and are labelled as not peer-reviewed. They contextualise findings; none binds a finding on its own.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-c6-notes\" aria-labelledby=\"nx-nrp-xt-05-c6-notes-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-c6-notes-h\"><span>Notes<\/span><\/h2><p class=\"nrp-note\">Numbers are the edition&#8217;s reference numbers, so a note reads the same in every chapter. The full list, with every source and its licence, is in Annex C. <a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/references\/\">Annex C, references<\/a><\/p><ol class=\"nrp-notes\"><li id=\"nx-nrp-xt-05-c6-n6\"><span class=\"nrp-notes-n\">6<\/span><span>Vertex Pharmaceuticals (ed.), Vertex Reports First Quarter 2026 Financial Results (company press release read through a wire page; Casgevy revenue USD 42.9 million against USD 14.2 million; pediatric submission completed; company statement, weak evidence). Vertex, Boston. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r6\" aria-label=\"Back to the first call of note 6\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n7\"><span class=\"nrp-notes-n\">7<\/span><span>Chetlapalli, K. et al., Haploidentical transplant, gene therapy, and standard care in sickle cell disease: a cost-effectiveness analysis, Blood 2026 (abstract read through the Europe PMC record; gene therapy access limited by cost and manufacturing capacity). American Society of Hematology, Washington. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r7\" aria-label=\"Back to the first call of note 7\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n1\"><span class=\"nrp-notes-n\">1<\/span><span>US Food and Drug Administration (ed.), FDA approves first gene therapies to treat patients with sickle cell disease (press announcement, 8 December 2023; Casgevy uses CRISPR\/Cas9, Lyfgenia a lentiviral vector; patients 12 years and older). FDA, Silver Spring. Observation year 2023. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r1\" aria-label=\"Back to the first call of note 1\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n5\"><span class=\"nrp-notes-n\">5<\/span><span>Clinical Trials Arena (ed.), FDA unveils new pathway to usher bespoke therapies to market (trade press, 13 November 2025; describes the plausible mechanism pathway announced in a journal article by the FDA Commissioner and the CBER Director; secondary report, weak evidence). Clinical Trials Arena, London. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r5\" aria-label=\"Back to the first call of note 5\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n37\"><span class=\"nrp-notes-n\">37<\/span><span>UNVERIFIED, not opened: US Food and Drug Administration (ed.), draft guidance on the plausible mechanism framework for individualised therapies, February 2026, taken from search-result summaries. FDA, Silver Spring. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r37\" aria-label=\"Back to the first call of note 37\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n27\"><span class=\"nrp-notes-n\">27<\/span><span>World Health Organization (ed.), Human genome editing: a framework for governance (technical document, 12 July 2021; companion recommendations published separately and not read). WHO, Geneva. Observation year 2021. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r27\" aria-label=\"Back to the first call of note 27\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n28\"><span class=\"nrp-notes-n\">28<\/span><span>Royal Society (ed.), Statement from the Organising Committee of the Third International Summit on Human Genome Editing (8 March 2023; convened by the Royal Society, the Academy of Medical Sciences, the US National Academies and The World Academy of Sciences). Royal Society, London. Observation year 2023. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r28\" aria-label=\"Back to the first call of note 28\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n29\"><span class=\"nrp-notes-n\">29<\/span><span>UK Parliament (ed.), Genetic Technology (Precision Breeding) Act 2023, 2023 c. 6 (contents page read; section texts not read). UK Parliament, London. Observation year 2023. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r29\" aria-label=\"Back to the first call of note 29\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n36\"><span class=\"nrp-notes-n\">36<\/span><span>UNVERIFIED, not opened: European Parliament and Council, Regulation (EU) 2026\/1388 on plants obtained by certain new genomic techniques (adopted 17 June 2026, published 26 June 2026, applies from 17 July 2028), taken from search-result summaries that differ on some dates. Official Journal of the European Union, Luxembourg. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r36\" aria-label=\"Back to the first call of note 36\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n30\"><span class=\"nrp-notes-n\">30<\/span><span>Latham and Watkins (ed.), BIOSECURE Act becomes law, limiting grants with biotechnology companies of concern (law-firm summary; enacted 18 December 2025 in the FY2026 NDAA; OMB list due by 18 December 2026; secondary source of a statute). Latham and Watkins, Los Angeles. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r30\" aria-label=\"Back to the first call of note 30\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n41\"><span class=\"nrp-notes-n\">41<\/span><span>UNVERIFIED, not opened: Council of Europe (ed.), Convention for the Protection of Human Rights and Dignity of the Human Being with regard to the Application of Biology and Medicine (Oviedo Convention), 1997, cited from memory; the page returned an access error. Council of Europe, Strasbourg. Observation year 1997. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r41\" aria-label=\"Back to the first call of note 41\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n44\"><span class=\"nrp-notes-n\">44<\/span><span>UNVERIFIED, not opened: Genetic Information Nondiscrimination Act of 2008, Public Law 110-233, United States Congress, cited from memory. Observation year 2008. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r44\" aria-label=\"Back to the first call of note 44\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n42\"><span class=\"nrp-notes-n\">42<\/span><span>UNVERIFIED, not opened: Lander, E.S. et al., Adopt a moratorium on heritable genome editing, Nature 567, 165 to 168, 2019, cited from memory. Observation year 2019. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r42\" aria-label=\"Back to the first call of note 42\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n2\"><span class=\"nrp-notes-n\">2<\/span><span>Frangoul, H. et al., Exagamglogene Autotemcel for Severe Sickle Cell Disease, New England Journal of Medicine 2024 (abstract read through the Europe PMC record; 44 treated, 30 evaluable, 29 free of crises for 12 months or more). Massachusetts Medical Society, Waltham. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r2\" aria-label=\"Back to the first call of note 2\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n3\"><span class=\"nrp-notes-n\">3<\/span><span>Locatelli, F. et al., Exagamglogene Autotemcel for Transfusion-Dependent beta-Thalassemia, New England Journal of Medicine 2024 (abstract read through the Europe PMC record; 52 treated, 35 evaluable, 32 transfusion independent). Massachusetts Medical Society, Waltham. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r3\" aria-label=\"Back to the first call of note 3\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n4\"><span class=\"nrp-notes-n\">4<\/span><span>Musunuru, K. et al., Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease, New England Journal of Medicine 2025 (abstract read through the Europe PMC record; one infant, two infusions at about 7 and 8 months of age). Massachusetts Medical Society, Waltham. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r4\" aria-label=\"Back to the first call of note 4\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n10\"><span class=\"nrp-notes-n\">10<\/span><span>Lek, A. et al., Death after High-Dose rAAV9 Gene Therapy in a Patient with Duchenne Muscular Dystrophy, New England Journal of Medicine 2023 (abstract read through the Europe PMC record). Massachusetts Medical Society, Waltham. Observation year 2023. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r10\" aria-label=\"Back to the first call of note 10\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n11\"><span class=\"nrp-notes-n\">11<\/span><span>Nurk, S. et al., The complete sequence of a human genome, Science 2022 (abstract read through the Europe PMC record; 3.055 billion base pairs; nearly 200 million base pairs of new sequence). American Association for the Advancement of Science, Washington. Observation year 2022. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r11\" aria-label=\"Back to the first call of note 11\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n12\"><span class=\"nrp-notes-n\">12<\/span><span>Liao, W.-W. et al. (Human Pangenome Reference Consortium), A draft human pangenome reference, Nature 2023 (abstract read through the Europe PMC record; 47 phased diploid assemblies; 119 million base pairs added). Springer Nature, London. Observation year 2023. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r12\" aria-label=\"Back to the first call of note 12\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n24\"><span class=\"nrp-notes-n\">24<\/span><span>Jinek, M. et al., A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity, Science 2012 (abstract read through the Europe PMC record). American Association for the Advancement of Science, Washington. Observation year 2012. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r24\" aria-label=\"Back to the first call of note 24\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n25\"><span class=\"nrp-notes-n\">25<\/span><span>Komor, A.C. et al., Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage, Nature 2016 (abstract read through the Europe PMC record). Springer Nature, London. Observation year 2016. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r25\" aria-label=\"Back to the first call of note 25\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n26\"><span class=\"nrp-notes-n\">26<\/span><span>Anzalone, A.V. et al., Search-and-replace genome editing without double-strand breaks or donor DNA, Nature 2019 (abstract read through the Europe PMC record). Springer Nature, London. Observation year 2019. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r26\" aria-label=\"Back to the first call of note 26\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n16\"><span class=\"nrp-notes-n\">16<\/span><span>UK Biobank Whole-Genome Sequencing Consortium, Whole-genome sequencing of 490,640 UK Biobank participants, Nature 2025 (abstract read through the Europe PMC record). Springer Nature, London. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r16\" aria-label=\"Back to the first call of note 16\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n17\"><span class=\"nrp-notes-n\">17<\/span><span>All of Us Research Program Genomics Investigators, Genomic data in the All of Us Research Program, Nature 2024 (abstract read through the Europe PMC record; 245,388 genomes; 77% from communities under-represented in research). Springer Nature, London. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r17\" aria-label=\"Back to the first call of note 17\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n18\"><span class=\"nrp-notes-n\">18<\/span><span>Fatumo, S. et al., A roadmap to increase diversity in genomic studies, Nature Medicine 2022 (abstract read through the Europe PMC record). Springer Nature, London. Observation year 2022. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r18\" aria-label=\"Back to the first call of note 18\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n19\"><span class=\"nrp-notes-n\">19<\/span><span>Sirugo, G., Williams, S.M. and Tishkoff, S.A., The Missing Diversity in Human Genetic Studies, Cell 2019 (abstract read through the Europe PMC record). Cell Press, Cambridge. Observation year 2019. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r19\" aria-label=\"Back to the first call of note 19\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n20\"><span class=\"nrp-notes-n\">20<\/span><span>Stephens, Z.D. et al., Big Data: Astronomical or Genomical?, PLOS Biology 2015 (abstract read through the Europe PMC record). Public Library of Science, San Francisco. Observation year 2015. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r20\" aria-label=\"Back to the first call of note 20\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n43\"><span class=\"nrp-notes-n\">43<\/span><span>UNVERIFIED, not opened: International Human Genome Sequencing Consortium, Initial sequencing and analysis of the human genome, Nature 409, 860 to 921, 2001, cited from memory. Observation year 2001. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r43\" aria-label=\"Back to the first call of note 43\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n21\"><span class=\"nrp-notes-n\">21<\/span><span>Grealey, J. et al., The Carbon Footprint of Bioinformatics, Molecular Biology and Evolution 2022 (abstract read through the Europe PMC record; a software upgrade cut one tool footprint by 73%). Oxford University Press, Oxford. Observation year 2022. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r21\" aria-label=\"Back to the first call of note 21\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n14\"><span class=\"nrp-notes-n\">14<\/span><span>Illumina (ed.), NovaSeq X Series product page (vendor claims: 16 to 21 Tb per run for NovaSeq X Plus, more than 128 genomes per run, run time about 14 to 48 hours; vendor evidence, weak). Illumina, San Diego. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r14\" aria-label=\"Back to the first call of note 14\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n15\"><span class=\"nrp-notes-n\">15<\/span><span>Ultima Genomics (ed.), germline genetics product page (vendor claim of a USD 60 genome at list price over 4 wafers on the UG200 series; the browser title reads USD 80; vendor evidence, weak). Ultima Genomics, Newark. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r15\" aria-label=\"Back to the first call of note 15\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n33\"><span class=\"nrp-notes-n\">33<\/span><span>US Bureau of Labor Statistics (ed.), Occupational Outlook Handbook: Genetic Counselors (about 4,200 jobs in 2025; median pay USD 100,040 in May 2025; 10% growth projected 2025 to 2035). BLS, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r33\" aria-label=\"Back to the first call of note 33\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n34\"><span class=\"nrp-notes-n\">34<\/span><span>Genomics England (ed.), Generation Study: newborn genome sequencing (initiative page; 100,000 babies; more than 200 conditions; recruitment progress not stated). Genomics England, London. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r34\" aria-label=\"Back to the first call of note 34\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n23\"><span class=\"nrp-notes-n\">23<\/span><span>Brixi, G. et al., Genome modelling and design across all domains of life with Evo 2, bioRxiv preprint 2025 (abstract read through the Europe PMC record; trained on 9.3 trillion base pairs; not peer reviewed at the time of reading). Cold Spring Harbor Laboratory, New York. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r23\" aria-label=\"Back to the first call of note 23\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n9\"><span class=\"nrp-notes-n\">9<\/span><span>BioSpace (ed.), Life-threatening liver toxicity triggers FDA <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-h5\" data-tc=\"NHS-1 atmo.thermal.hard-freeze\" data-tk=\"Atmosphere and weather \u00b7 Thermal extremes\" data-td=\"Air temperature falling well below freezing for hours, killing crops, bursting pipes and stopping water flow.\" data-ts=\"NRS-H5\" data-tr=\"draft\" data-tx=\"https:\/\/risksindex.com\/hazards\/atmo\/\" data-txl=\"Atmosphere and weather\">freeze<\/a> on two Intellia gene therapy studies (trade press, 30 October 2025; relays company disclosures; secondary report, weak evidence). BioSpace, Boston. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r9\" aria-label=\"Back to the first call of note 9\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c6-n22\"><span class=\"nrp-notes-n\">22<\/span><span>Lannelongue, L., Grealey, J. and Inouye, M., Green Algorithms: Quantifying the Carbon Footprint of Computation, Advanced Science 2021 (abstract read through the Europe PMC record). Wiley, Weinheim. Observation year 2021. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c6-r22\" aria-label=\"Back to the first call of note 22\">back<\/a><\/span><\/li><\/ol><\/section><section class=\"nrp-block nrp-noprint\" id=\"nx-nrp-xt-05-c6-cite\" aria-labelledby=\"nx-nrp-xt-05-c6-cite-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-c6-cite-h\"><span>Cite this chapter<\/span><\/h2><pre class=\"nrp-pre\">Valadbaygi, S. (Ed.). (2026). Chapter 6: Readings from the other desks. In Exponential Technology Report 2026: Genomics and Gene Editing (Baseline Edition 2026, Report No. NR-XTECH-GENOMICS-GLOBAL-2026-BASELINE) [Draft under review]. The Global Centre for Risk and Innovation (GCRI).<\/pre><p class=\"nrp-note\">Every citation form of the whole report, BibTeX and RIS included, is on the edition home. <a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/#nx-nrp-xt-05-land-cite\">Cite this report<\/a><\/p><\/section><nav class=\"nrp-pager\" aria-label=\"Previous and next\"><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/scenario\/\" rel=\"prev\"><span class=\"nf-ui-eyebrow\">Previous \u00b7 Chapter 5<\/span><span class=\"nrp-pager-t\">Individualised editing outpaces delivery systems<\/span><\/a><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/agenda\/\" rel=\"next\"><span class=\"nf-ui-eyebrow\">Next \u00b7 Chapter 7<\/span><span class=\"nrp-pager-t\">The 2027 agenda<\/span><\/a><\/nav><\/article><\/div><\/div><\/div><div class=\"nrp-noprint\"><section id=\"nx-sec-nr-gateway\" class=\"nx-section\" data-hue=\"systemic\" data-tone=\"alt\" aria-labelledby=\"nx-nr-gateway-h\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">Reports<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Contribute<\/span><\/div><h2 id=\"nx-nr-gateway-h\" class=\"nx-section-title\">Send evidence or a correction on Genomics and Gene Editing.<\/h2><p class=\"nx-lede\">Reports is the Consortium&#8217;s quarterly publication, written by six desks. 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