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\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solid;border-color:inherit}#nxe-nr-gcri-editions-xt-05-agenda.nxe svg{display:none}#nxe-nr-gcri-editions-xt-05-agenda.nxe svg.nx-i{display:inline-block;width:18px;height:18px;vertical-align:-3px}#nxe-nr-gcri-editions-xt-05-agenda.nxe :where([role=\"tablist\"],[role=\"toolbar\"],[hidden],button,.nx-theme-toggle,.nx-live-slot){display:none}#nxe-nr-gcri-editions-xt-05-agenda.nxe img{max-width:100%;height:auto}<\/style><svg class=\"nx-defs\" aria-hidden=\"true\" focusable=\"false\" width=\"0\" height=\"0\"><defs><linearGradient id=\"nx-gi\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"1\"><stop offset=\"0\" class=\"nx-gi-a\"\/><stop offset=\"0.55\" class=\"nx-gi-b\"\/><stop offset=\"1\" class=\"nx-gi-c\"\/><\/linearGradient><linearGradient id=\"nx-giu\" gradientUnits=\"userSpaceOnUse\" x1=\"0\" y1=\"0\" x2=\"800\" y2=\"0\"><stop offset=\"0\" class=\"nx-gi-a\"\/><stop offset=\"0.55\" class=\"nx-gi-b\"\/><stop offset=\"1\" class=\"nx-gi-c\"\/><\/linearGradient><linearGradient id=\"nx-gp\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"1\"><stop offset=\"0\" class=\"nx-gp-a\"\/><stop offset=\"1\" class=\"nx-gp-b\"\/><\/linearGradient><\/defs><\/svg><div class=\"nrp\"><div class=\"nrp-wrap\"><p class=\"nrj-draft\" data-nrj-shared=\"draft\" role=\"note\"><strong>Draft, not yet released.<\/strong> In stewardship review. Not indexed until the first approved release.<\/p><div class=\"nrp-reader\"><nav class=\"nrp-rail\" aria-label=\"Contents of Genomics and Gene Editing 2026\"><p class=\"nf-ui-eyebrow\">Contents<\/p><ol class=\"nrp-toc\"><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Edition home<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/summary\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Executive summary<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/coupled-system\/\"><span class=\"nrp-toc-n\">1<\/span><span>Genomics is data infrastructure and a therapeutic frontier<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/findings\/\"><span class=\"nrp-toc-n\">2<\/span><span>Key findings<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/systems-and-sectors\/\"><span class=\"nrp-toc-n\">3<\/span><span>Systems and sectors at baseline<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/risk-and-capability\/\"><span class=\"nrp-toc-n\">4<\/span><span>Risks and capability<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/scenario\/\"><span class=\"nrp-toc-n\">5<\/span><span>Individualised editing outpaces delivery systems<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/lenses-and-readings\/\"><span class=\"nrp-toc-n\">6<\/span><span>Readings from the other desks<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/agenda\/\" aria-current=\"page\"><span class=\"nrp-toc-n\">7<\/span><span>The 2027 agenda<\/span><\/a><ol class=\"nrp-toc-sub\"><li><a href=\"#nx-nrp-xt-05-c7-s1\">7.1 Questions for the operational series<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c7-s2\">7.2 Portfolio proposed for the Q1 2027 alignment<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c7-s3\">7.3 The pathway<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c7-s4\">7.4 Universe 2027: evidence pack for the genomics candidate mission<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c7-s5\">7.5 Handoffs and routing<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c7-s6\">7.6 Feeds and signal register<\/a><\/li><\/ol><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/systems-in-depth\/\"><span class=\"nrp-toc-n\">8<\/span><span>Systems in depth<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/methodology\/\"><span class=\"nrp-toc-n\">A<\/span><span>Methodology<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/data\/\"><span class=\"nrp-toc-n\">B<\/span><span>Data appendix<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/references\/\"><span class=\"nrp-toc-n\">C<\/span><span>References and record<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/full\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Complete edition, for print<\/span><\/a><\/li><\/ol><div class=\"nrp-actions\"><a class=\"nf-ui-btn\" data-variant=\"secondary\" href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/full\/\"><svg class=\"nrp-i\" viewBox=\"0 0 24 24\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2\"\/><path d=\"M6 9V3a1 1 0 0 1 1-1h10a1 1 0 0 1 1 1v6\"\/><rect x=\"6\" y=\"14\" width=\"12\" height=\"8\" rx=\"1\"\/><\/svg>Print or save as PDF<\/a><\/div><\/nav><article class=\"nrp-flow\" aria-labelledby=\"nx-nrp-xt-05-c7-top\"><header class=\"nrp-chap-head\" id=\"nx-nrp-xt-05-c7-top\"><ul class=\"nrp-eyerow\"><li class=\"nf-ui-eyebrow\"><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/\">Genomics and Gene Editing 2026<\/a><\/li><li class=\"nf-ui-eyebrow\">Chapter 7<\/li><\/ul><span class=\"nrp-rule\" aria-hidden=\"true\"><\/span><h1 class=\"pp-hero-title\">The 2027 agenda<\/h1><p class=\"nrp-lede\">Eight bounded questions open the 2027 genomics agenda. Each comes from a baseline finding, names the initiative that will carry it and the first output due in the 2027 genomics edition.<\/p><p class=\"nrp-chap-meta\"><span>5 min read<\/span><span>0 figures<\/span><span>6 tables<\/span><span>5 notes<\/span><span>NR-XTECH-GENOMICS-GLOBAL-2026-BASELINE<\/span><\/p><details class=\"nrp-toc-m\"><summary>Contents<\/summary><ol class=\"nrp-toc\"><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Edition home<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/summary\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Executive summary<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/coupled-system\/\"><span class=\"nrp-toc-n\">1<\/span><span>Genomics is data infrastructure and a therapeutic frontier<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/findings\/\"><span class=\"nrp-toc-n\">2<\/span><span>Key findings<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/systems-and-sectors\/\"><span class=\"nrp-toc-n\">3<\/span><span>Systems and sectors at baseline<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/risk-and-capability\/\"><span class=\"nrp-toc-n\">4<\/span><span>Risks and capability<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/scenario\/\"><span class=\"nrp-toc-n\">5<\/span><span>Individualised editing outpaces delivery systems<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/lenses-and-readings\/\"><span class=\"nrp-toc-n\">6<\/span><span>Readings from the other desks<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/agenda\/\" aria-current=\"page\"><span class=\"nrp-toc-n\">7<\/span><span>The 2027 agenda<\/span><\/a><ol class=\"nrp-toc-sub\"><li><a href=\"#nx-nrp-xt-05-c7-s1\">7.1 Questions for the operational series<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c7-s2\">7.2 Portfolio proposed for the Q1 2027 alignment<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c7-s3\">7.3 The pathway<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c7-s4\">7.4 Universe 2027: evidence pack for the genomics candidate mission<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c7-s5\">7.5 Handoffs and routing<\/a><\/li><li><a href=\"#nx-nrp-xt-05-c7-s6\">7.6 Feeds and signal register<\/a><\/li><\/ol><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/systems-in-depth\/\"><span class=\"nrp-toc-n\">8<\/span><span>Systems in depth<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/methodology\/\"><span class=\"nrp-toc-n\">A<\/span><span>Methodology<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/data\/\"><span class=\"nrp-toc-n\">B<\/span><span>Data appendix<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/references\/\"><span class=\"nrp-toc-n\">C<\/span><span>References and record<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/full\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Complete edition, for print<\/span><\/a><\/li><\/ol><\/details><\/header><section class=\"nrp-block\" id=\"nx-nrp-xt-05-c7-s1\" aria-labelledby=\"nx-nrp-xt-05-c7-s1-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-c7-s1-h\"><span class=\"nrp-num\">7.1<\/span><span>Questions for the operational series<\/span><\/h2><ol class=\"nrp-rows\"><li><span class=\"nrp-rows-i\">Q-01<\/span><p class=\"nrp-rows-t\">How many patients are treated with editing therapies, at what price, and where are the access gaps?<\/p><p class=\"nrp-rows-m\">INI-XT05-DLV-01 \u00b7 delivery and access; first output: treatment and price register.<\/p><\/li><li><span class=\"nrp-rows-i\">Q-02<\/span><p class=\"nrp-rows-t\">What energy, cooling and cold-chain load do sequencing and cell therapies carry?<\/p><p class=\"nrp-rows-m\">INI-XT05-ENE-02 \u00b7 footprint of genomics; first output: footprint estimates by activity.<\/p><\/li><li><span class=\"nrp-rows-i\">Q-03<\/span><p class=\"nrp-rows-t\">What do sequencing and therapy costs look like on an independent basis?<\/p><p class=\"nrp-rows-m\">INI-XT05-CST-03 \u00b7 cost on a common basis; first output: cost table.<\/p><\/li><li><span class=\"nrp-rows-i\">Q-04<\/span><p class=\"nrp-rows-t\">Which instruments, consumables and reagents are single points of failure?<\/p><p class=\"nrp-rows-m\">INI-XT05-SUP-04 \u00b7 sequencer supply; first output: dependence map.<\/p><\/li><li><span class=\"nrp-rows-i\">Q-05<\/span><p class=\"nrp-rows-t\">How balanced are genome datasets by ancestry on a common basis?<\/p><p class=\"nrp-rows-m\">INI-XT05-DIV-05 \u00b7 dataset balance; first output: ancestry table.<\/p><\/li><li><span class=\"nrp-rows-i\">Q-06<\/span><p class=\"nrp-rows-t\">Which national rules cover genetic data, somatic editing and heritable editing?<\/p><p class=\"nrp-rows-m\">To be admitted in 2027; first output: rule overlay.<\/p><\/li><li><span class=\"nrp-rows-i\">Q-07<\/span><p class=\"nrp-rows-t\">What workforce exists for genetic counselling, laboratory work and bioinformatics?<\/p><p class=\"nrp-rows-m\">To be admitted in 2027; first output: scoping note.<\/p><\/li><li><span class=\"nrp-rows-i\">Q-08<\/span><p class=\"nrp-rows-t\">Which readiness capabilities have been tested, and which are only planned?<\/p><p class=\"nrp-rows-m\">Readiness capability register; first output: rung evidence for 15 functions.<\/p><\/li><\/ol><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-c7-s2\" aria-labelledby=\"nx-nrp-xt-05-c7-s2-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-c7-s2-h\"><span class=\"nrp-num\">7.2<\/span><span>Portfolio proposed for the Q1 2027 alignment<\/span><\/h2><p class=\"nrp-stand\">Five initiatives and one <a class=\"nx-link\" href=\"https:\/\/docs.therisk.global\/organization\/programme\/universe\">Universe<\/a> mission candidate are proposed for the 2027 genomics portfolio. They are programme objects: no partner, funder or member is attached to them in this edition.<\/p><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-c7-tab1\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 7.1<\/span><span class=\"nrp-tbl-t\">Objects proposed for the first operational quarter<\/span><\/caption><thead><tr><th scope=\"col\">ID<\/th><th scope=\"col\">Object<\/th><th scope=\"col\">Kind<\/th><th scope=\"col\">Question<\/th><th scope=\"col\">State<\/th><\/tr><\/thead><tbody><tr><td><span class=\"nrp-mono\">INI-XT05-DLV-01<\/span><\/td><td>Delivery and access<\/td><td>Initiative<\/td><td>Q-01<\/td><td>PROPOSED<\/td><\/tr><tr><td><span class=\"nrp-mono\">INI-XT05-ENE-02<\/span><\/td><td>Footprint of genomics<\/td><td>Initiative<\/td><td>Q-02<\/td><td>PROPOSED<\/td><\/tr><tr><td><span class=\"nrp-mono\">INI-XT05-CST-03<\/span><\/td><td>Cost on a common basis<\/td><td>Initiative<\/td><td>Q-03<\/td><td>PROPOSED<\/td><\/tr><tr><td><span class=\"nrp-mono\">INI-XT05-SUP-04<\/span><\/td><td>Sequencer supply<\/td><td>Initiative<\/td><td>Q-04<\/td><td>PROPOSED<\/td><\/tr><tr><td><span class=\"nrp-mono\">INI-XT05-DIV-05<\/span><\/td><td>Dataset balance<\/td><td>Initiative<\/td><td>Q-05<\/td><td>PROPOSED<\/td><\/tr><tr><td><span class=\"nrp-mono\">MSN-XT05-2027-01<\/span><\/td><td>Delivery pathway Universe mission<\/td><td>Mission<\/td><td>Q-01<\/td><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"caution\" aria-hidden=\"true\"><\/span>Candidate<\/span><\/td><\/tr><\/tbody><\/table><\/div><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-c7-s3\" aria-labelledby=\"nx-nrp-xt-05-c7-s3-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-c7-s3-h\"><span class=\"nrp-num\">7.3<\/span><span>The pathway<\/span><\/h2><p class=\"nrp-stand\">The genomics edition reads national readiness chapters, the coupled sector reports on health and data, and the global edition through one governed evidence graph. At baseline the federation is designed; the global energy and lifeline editions are drafted. This page states what exists today and what comes next.<\/p><ol class=\"nrp-rows\"><li><span class=\"nrp-rows-i\">01<\/span><p class=\"nrp-rows-t\">National readiness chapters<\/p><p class=\"nrp-rows-x\">genomic medicine and data-protection readiness in each national edition<\/p><p class=\"nrp-rows-m\">IN PREPARATION \u00b7 national baselines<\/p><\/li><li><span class=\"nrp-rows-i\">02<\/span><p class=\"nrp-rows-t\">Sector couplings<\/p><p class=\"nrp-rows-x\">GS-04 health \u00b7 XT-04 biotechnology \u00b7 XT-10 cryptography<\/p><p class=\"nrp-rows-m\">GS-04 DRAFTED \u00b7 sector baselines<\/p><\/li><li><span class=\"nrp-rows-i\">03<\/span><p class=\"nrp-rows-t\">Technology system model<\/p><p class=\"nrp-rows-x\">sequencing, data, therapies, trade, workforce, governance<\/p><p class=\"nrp-rows-m\">v0 SPECIFIED \u00b7 v1 with federation evidence<\/p><\/li><li><span class=\"nrp-rows-i\">04<\/span><p class=\"nrp-rows-t\">Strategic links<\/p><p class=\"nrp-rows-x\">SR-02 lifeline <a class=\"nx-link nx-term\" href=\"https:\/\/docs.therisk.global\/organization\/systems\" data-tc=\"Systems\" data-tk=\"Nexus Standards\" data-td=\"The twenty Nexus systems, NXS-CMD to NXS-LAB\">systems<\/a> \u00b7 SR-13 strategic technology<\/p><p class=\"nrp-rows-m\">PLANNED \u00b7 strategic baselines<\/p><\/li><li><span class=\"nrp-rows-i\">05<\/span><p class=\"nrp-rows-t\">Universe<\/p><p class=\"nrp-rows-x\">annual proving environment<\/p><p class=\"nrp-rows-m\">CANDIDATE MISSION \u00b7 mandate in 2027<\/p><\/li><li><span class=\"nrp-rows-i\">06<\/span><p class=\"nrp-rows-t\">XT-05 report<\/p><p class=\"nrp-rows-x\">this series<\/p><p class=\"nrp-rows-m\">BASELINE DRAFT \u00b7 2027 annual edition<\/p><\/li><li><span class=\"nrp-rows-i\">07<\/span><p class=\"nrp-rows-t\">Evidence and correction<\/p><p class=\"nrp-rows-x\">one graph, many projections<\/p><p class=\"nrp-rows-m\">OPEN \u00b7 first correction cycle in 2027<\/p><\/li><\/ol><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-c7-s4\" aria-labelledby=\"nx-nrp-xt-05-c7-s4-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-c7-s4-h\"><span class=\"nrp-num\">7.4<\/span><span>Universe 2027: evidence pack for the genomics candidate mission<\/span><\/h2><ol class=\"nrp-rows\"><li><span class=\"nrp-rows-i\">01<\/span><p class=\"nrp-rows-x\">Mandate<\/p><\/li><li><span class=\"nrp-rows-i\">02<\/span><p class=\"nrp-rows-x\">Core Build \u00b7 1 month<\/p><\/li><li><span class=\"nrp-rows-i\">03<\/span><p class=\"nrp-rows-x\">Action \u00b7 1 week<\/p><\/li><li><span class=\"nrp-rows-i\">04<\/span><p class=\"nrp-rows-x\">Evidence seal<\/p><\/li><li><span class=\"nrp-rows-i\">05<\/span><p class=\"nrp-rows-x\">Portfolio correction<\/p><\/li><li><span class=\"nrp-rows-i\">06<\/span><p class=\"nrp-rows-x\">Next mandate<\/p><\/li><\/ol><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-c7-tab2\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 7.2<\/span><span class=\"nrp-tbl-t\">Universe 2027: evidence pack for the genomics candidate mission<\/span><\/caption><thead><tr><th scope=\"col\">Item<\/th><th scope=\"col\">Record<\/th><th scope=\"col\">State<\/th><th scope=\"col\">Timing<\/th><\/tr><\/thead><tbody><tr><td>F1<\/td><td>Annual mandate record<\/td><td>PLANNED<\/td><td>after the Q2 2027 alignment<\/td><\/tr><tr><td>F2<\/td><td>Core Build record<\/td><td>PLANNED<\/td><td>one month before the exercise<\/td><\/tr><tr><td>F3<\/td><td>Exercise evidence<\/td><td>PLANNED<\/td><td>during the Action week<\/td><\/tr><tr><td>F4<\/td><td>Decision packets<\/td><td>PLANNED<\/td><td>exercise state only<\/td><\/tr><tr><td>F5<\/td><td>Proof receipts<\/td><td>PLANNED<\/td><td>scoped to each recorded check<\/td><\/tr><tr><td>F6<\/td><td>After-action report<\/td><td>PLANNED<\/td><td>within one quarter<\/td><\/tr><tr><td>F7<\/td><td>Upgrade docket<\/td><td>PLANNED<\/td><td>routed to the Portfolio<\/td><\/tr><tr><td>F8<\/td><td>Portfolio renewal<\/td><td>PLANNED<\/td><td>2027 global annual edition<\/td><\/tr><tr><td>F9<\/td><td>Public synthesis<\/td><td>PLANNED<\/td><td>public-safe extracts only<\/td><\/tr><\/tbody><\/table><\/div><h3 class=\"nrp-h3\">Mission<\/h3><dl class=\"nrp-dl\"><dt>ID<\/dt><dd>MSN-XT05-2027-01 \u00b7 Delivery pathway Universe mission<\/dd><dt>Role spine<\/dt><dd>Leadership sponsor \u00b7 Institutional anchor \u00b7 Mission lead: drawn from national pathways<\/dd><dt>Receiving actors<\/dt><dd>to be identified with the mandate<\/dd><\/dl><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">boundary<\/p><p>Simulation success is not deployment approval; demonstration is not certification; finance readiness is not financing secured.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-c7-s5\" aria-labelledby=\"nx-nrp-xt-05-c7-s5-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-c7-s5-h\"><span class=\"nrp-num\">7.5<\/span><span>Handoffs and routing<\/span><\/h2><p class=\"nrp-stand\">Where the baseline\u2019s findings go next. A handoff routes a finding for awareness, review or work; it transfers no authority.<\/p><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-c7-tab3\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 7.3<\/span><span class=\"nrp-tbl-t\">Handoffs and routing<\/span><\/caption><thead><tr><th scope=\"col\">Finding<\/th><th scope=\"col\">Routed to<\/th><th scope=\"col\">Purpose<\/th><th scope=\"col\">Class<\/th><\/tr><\/thead><tbody><tr><td>HLT-001 \u00b7 sickle cell therapy<\/td><td>INI-XT05-DLV-01<\/td><td>delivery and access<\/td><td>PUBLIC<\/td><\/tr><tr><td>HLT-004 \u00b7 safety event<\/td><td>INI-XT05-DLV-01<\/td><td>delivery and access<\/td><td>PUBLIC<\/td><\/tr><tr><td>DAT-007 \u00b7 biobanks<\/td><td>INI-XT05-DIV-05<\/td><td>dataset balance<\/td><td>PUBLIC<\/td><\/tr><tr><td>INF-008 \u00b7 vendor claims<\/td><td>INI-XT05-CST-03<\/td><td>cost on a common basis<\/td><td>PUBLIC<\/td><\/tr><tr><td>ENE-009 \u00b7 compute footprint<\/td><td>INI-XT05-ENE-02 \u00b7 key F review<\/td><td>footprint of genomics<\/td><td>PUBLIC<\/td><\/tr><tr><td>TRD-010 \u00b7 trade<\/td><td>INI-XT05-SUP-04<\/td><td>sequencer supply<\/td><td>PUBLIC<\/td><\/tr><tr><td>GOV-011 \u00b7 approval and governance<\/td><td>regional consortia<\/td><td>rule overlay<\/td><td>PUBLIC<\/td><\/tr><tr><td>SYS-012 \u00b7 compound pathway<\/td><td>MSN-XT05-2027-01<\/td><td>Universe candidate<\/td><td>CONSORTIUM<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-c7-tab4\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 7.4<\/span><span class=\"nrp-tbl-t\">Routing rules by publication class<\/span><\/caption><thead><tr><th scope=\"col\">Class<\/th><th scope=\"col\">Where it goes<\/th><th scope=\"col\">Who can see it<\/th><\/tr><\/thead><tbody><tr><td>PUBLIC<\/td><td>the published edition and its evidence bundle<\/td><td>anyone<\/td><\/tr><tr><td>CONSORTIUM<\/td><td>governed rooms of the federation<\/td><td>consortium members under agreement<\/td><\/tr><tr><td>CONTROLLED<\/td><td>need-to-know channels<\/td><td>named competent actors only<\/td><\/tr><\/tbody><\/table><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">CODES ARE NOT JOINS<\/p><p>Series codes in this edition (XT-05 and its relatives) are <a class=\"nx-link\" href=\"https:\/\/docs.therisk.global\/organization\/programme\/reports\">Reports<\/a> codes. Codes in other indices can look alike. This edition makes no join on a code alone: a join needs a registry record that names both subjects.<\/p><\/aside><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">boundary<\/p><p>Handoffs carry findings to Nexus programme objects and steward reviews. States and organisations receive public editions as published; nothing here instructs them.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-c7-s6\" aria-labelledby=\"nx-nrp-xt-05-c7-s6-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-c7-s6-h\"><span class=\"nrp-num\">7.6<\/span><span>Feeds and signal register<\/span><\/h2><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-c7-tab5\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 7.5<\/span><span class=\"nrp-tbl-t\">Feeds watched from 2027<\/span><\/caption><thead><tr><th scope=\"col\">Feed<\/th><th scope=\"col\">Producer<\/th><th scope=\"col\">Latency<\/th><th scope=\"col\">Feeds into<\/th><\/tr><\/thead><tbody><tr><td>Journals and preprints on editing and safety<\/td><td>peer review and preprints<\/td><td>continuous<\/td><td>HLT-001<\/td><\/tr><tr><td>FDA approvals and guidance<\/td><td>FDA<\/td><td>per release<\/td><td>GOV-011<\/td><\/tr><tr><td>Biobank data releases<\/td><td>biobanks<\/td><td>per release<\/td><td>DAT-007<\/td><\/tr><tr><td>Company results and announcements<\/td><td>companies<\/td><td>quarterly<\/td><td>FIN-005<\/td><\/tr><tr><td>Trade and procurement notices<\/td><td>agencies and ministries<\/td><td>per event<\/td><td>TRD-010<\/td><\/tr><tr><td>Employment projections<\/td><td>BLS<\/td><td>annual<\/td><td>FIN-005<\/td><\/tr><tr><td>Clinical hold and safety notices<\/td><td>companies and FDA<\/td><td>per event<\/td><td>HLT-004<\/td><\/tr><\/tbody><\/table><\/div><h3 class=\"nrp-h3\">Escalation routes<\/h3><ul class=\"nrp-chips\"><li class=\"nf-ui-chip\">none \u00b7 keep monitoring<\/li><li class=\"nf-ui-chip\">research question<\/li><li class=\"nf-ui-chip\">project<\/li><li class=\"nf-ui-chip\">risk object<\/li><li class=\"nf-ui-chip\">annual publication<\/li><li class=\"nf-ui-chip\">signal report<\/li><\/ul><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-c7-tab6\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table 7.6<\/span><span class=\"nrp-tbl-t\">Signals at baseline<\/span><\/caption><thead><tr><th scope=\"col\">ID<\/th><th scope=\"col\">Signal<\/th><th scope=\"col\">Corroboration<\/th><th scope=\"col\">Systems<\/th><th scope=\"col\">Route<\/th><\/tr><\/thead><tbody><tr><td>SIG-XT05-001<\/td><td>Phase 3 exa-cel results<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c7-n2\" id=\"nx-nrp-xt-05-c7-r2\" aria-label=\"Note 2\">2<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c7-n3\" id=\"nx-nrp-xt-05-c7-r3\" aria-label=\"Note 3\">3<\/a><\/sup><\/td><td>CORROBORATED<\/td><td>HLT<\/td><td>research question Q-01<\/td><\/tr><tr><td>SIG-XT05-002<\/td><td>Clinical hold on in vivo editing trials, October 2025<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c7-n9\" id=\"nx-nrp-xt-05-c7-r9\" aria-label=\"Note 9\">9<\/a><\/sup><\/td><td>PARTIAL<\/td><td>HLT<\/td><td>research question Q-01<\/td><\/tr><tr><td>SIG-XT05-003<\/td><td>Vendor price claims for sequencing<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c7-n14\" id=\"nx-nrp-xt-05-c7-r14\" aria-label=\"Note 14\">14<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-c7-n15\" id=\"nx-nrp-xt-05-c7-r15\" aria-label=\"Note 15\">15<\/a><\/sup><\/td><td>PARTIAL<\/td><td>INF<\/td><td>initiative Q-03<\/td><\/tr><\/tbody><\/table><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">boundary<\/p><p>A signal is not a warning. Signal records never substitute for official alerting or early-warning authorities, and they bypass no publication control.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-c7-notes\" aria-labelledby=\"nx-nrp-xt-05-c7-notes-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-c7-notes-h\"><span>Notes<\/span><\/h2><p class=\"nrp-note\">Numbers are the edition&#8217;s reference numbers, so a note reads the same in every chapter. The full list, with every source and its licence, is in Annex C. <a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/references\/\">Annex C, references<\/a><\/p><ol class=\"nrp-notes\"><li id=\"nx-nrp-xt-05-c7-n2\"><span class=\"nrp-notes-n\">2<\/span><span>Frangoul, H. et al., Exagamglogene Autotemcel for Severe Sickle Cell Disease, New England Journal of Medicine 2024 (abstract read through the Europe PMC record; 44 treated, 30 evaluable, 29 free of crises for 12 months or more). Massachusetts Medical Society, Waltham. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c7-r2\" aria-label=\"Back to the first call of note 2\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c7-n3\"><span class=\"nrp-notes-n\">3<\/span><span>Locatelli, F. et al., Exagamglogene Autotemcel for Transfusion-Dependent beta-Thalassemia, New England Journal of Medicine 2024 (abstract read through the Europe PMC record; 52 treated, 35 evaluable, 32 transfusion independent). Massachusetts Medical Society, Waltham. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c7-r3\" aria-label=\"Back to the first call of note 3\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c7-n9\"><span class=\"nrp-notes-n\">9<\/span><span>BioSpace (ed.), Life-threatening liver toxicity triggers FDA <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-h5\" data-tc=\"NHS-1 atmo.thermal.hard-freeze\" data-tk=\"Atmosphere and weather \u00b7 Thermal extremes\" data-td=\"Air temperature falling well below freezing for hours, killing crops, bursting pipes and stopping water flow.\" data-ts=\"NRS-H5\" data-tr=\"draft\" data-tx=\"https:\/\/risksindex.com\/hazards\/atmo\/\" data-txl=\"Atmosphere and weather\">freeze<\/a> on two Intellia gene therapy studies (trade press, 30 October 2025; relays company disclosures; secondary report, weak evidence). BioSpace, Boston. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c7-r9\" aria-label=\"Back to the first call of note 9\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c7-n14\"><span class=\"nrp-notes-n\">14<\/span><span>Illumina (ed.), NovaSeq X Series product page (vendor claims: 16 to 21 Tb per run for NovaSeq X Plus, more than 128 genomes per run, run time about 14 to 48 hours; vendor evidence, weak). Illumina, San Diego. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c7-r14\" aria-label=\"Back to the first call of note 14\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-c7-n15\"><span class=\"nrp-notes-n\">15<\/span><span>Ultima Genomics (ed.), germline genetics product page (vendor claim of a USD 60 genome at list price over 4 wafers on the UG200 series; the browser title reads USD 80; vendor evidence, weak). Ultima Genomics, Newark. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-c7-r15\" aria-label=\"Back to the first call of note 15\">back<\/a><\/span><\/li><\/ol><\/section><section class=\"nrp-block nrp-noprint\" id=\"nx-nrp-xt-05-c7-cite\" aria-labelledby=\"nx-nrp-xt-05-c7-cite-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-c7-cite-h\"><span>Cite this chapter<\/span><\/h2><pre class=\"nrp-pre\">Valadbaygi, S. (Ed.). (2026). Chapter 7: The 2027 agenda. In Exponential Technology Report 2026: Genomics and Gene Editing (Baseline Edition 2026, Report No. NR-XTECH-GENOMICS-GLOBAL-2026-BASELINE) [Draft under review]. The Global Centre for Risk and Innovation (GCRI).<\/pre><p class=\"nrp-note\">Every citation form of the whole report, BibTeX and RIS included, is on the edition home. <a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/#nx-nrp-xt-05-land-cite\">Cite this report<\/a><\/p><\/section><nav class=\"nrp-pager\" aria-label=\"Previous and next\"><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/lenses-and-readings\/\" rel=\"prev\"><span class=\"nf-ui-eyebrow\">Previous \u00b7 Chapter 6<\/span><span class=\"nrp-pager-t\">Readings from the other desks<\/span><\/a><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/systems-in-depth\/\" rel=\"next\"><span class=\"nf-ui-eyebrow\">Next \u00b7 Chapter 8<\/span><span class=\"nrp-pager-t\">Systems in depth<\/span><\/a><\/nav><\/article><\/div><\/div><\/div><div class=\"nrp-noprint\"><section id=\"nx-sec-nr-gateway\" class=\"nx-section\" data-hue=\"systemic\" data-tone=\"alt\" aria-labelledby=\"nx-nr-gateway-h\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">Reports<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Contribute<\/span><\/div><h2 id=\"nx-nr-gateway-h\" class=\"nx-section-title\">Send evidence or a correction on Genomics and Gene Editing.<\/h2><p class=\"nx-lede\">Reports is the Consortium&#8217;s quarterly publication, written by six desks. This page sits with the Global Centre for Risk and Innovation (GCRI) <a class=\"nx-link nx-term\" href=\"https:\/\/docs.therisk.global\/organization\/systems\" data-tc=\"Systems\" data-tk=\"Nexus Standards\" data-td=\"The twenty Nexus systems, NXS-CMD to NXS-LAB\">Systems<\/a> Evidence desk. What you know about this subject can become evidence, a case or a correction in the next edition, credited to you and published under CC BY 4.0 where it is your own work. Sent to the wrong desk, it is forwarded, not refused.<\/p><div class=\"nx-chips\"><span class=\"nx-chip\">GCRI Systems Evidence desk<\/span><span class=\"nx-chip\">Exponential Technology<\/span><\/div><\/div><div class=\"nx-section-body\"><ul class=\"nx-dest\"><li><a class=\"nx-dest-card\" href=\"https:\/\/therisk.global\/nexus-reports\/write-to-us\/contact\/\"><span class=\"nx-dest-top\"><span class=\"nx-dest-rel\">Email<\/span><span class=\"nx-dest-host\">Gateway GW-GCRI<\/span><\/span><span class=\"nx-dest-title\">Send it from this page<\/span><span class=\"nx-dest-why\">Evidence, a correction, a case, a method, a review, a translation or profile input. It arrives tagged with this page, so the editor who owns it receives it.<\/span><span class=\"nx-dest-go\" aria-hidden=\"true\"><svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/span><\/a><\/li><li><a class=\"nx-dest-card\" href=\"https:\/\/therisk.global\/nexus-reports\/open-science\/#nx-sec-zenodo\"><span class=\"nx-dest-top\"><span class=\"nx-dest-rel\">Zenodo<\/span><span class=\"nx-dest-host\">Open deposit<\/span><\/span><span class=\"nx-dest-title\">Deposit it and submit to the community<\/span><span class=\"nx-dest-why\">Publish your own record on Zenodo with your ORCID iD, then submit it to the Reports community there. Curators review it; the DOI stays yours.<\/span><span class=\"nx-dest-go\" aria-hidden=\"true\"><svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/span><\/a><\/li><li><a class=\"nx-dest-card\" href=\"https:\/\/therisk.global\/nexus-reports\/contribute\/#nx-sec-routing\"><span class=\"nx-dest-top\"><span class=\"nx-dest-rel\">Reports<\/span><span class=\"nx-dest-host\">GCRI<\/span><\/span><span class=\"nx-dest-title\">See which desk takes what you have<\/span><span class=\"nx-dest-why\">The routing table opens the contribution page: what you have, the desk that takes it, how each contribution is reviewed and credited, and the licence.<\/span><span class=\"nx-dest-go\" aria-hidden=\"true\"><svg class=\"nx-arrow\" viewBox=\"0 0 16 16\" aria-hidden=\"true\"><path d=\"M3 8h10M9 4l4 4-4 4\"\/><\/svg><\/span><\/a><\/li><\/ul><div class=\"nx-live-slot\" data-nxf-slot=\"contribute\" data-nxf-kind=\"workflow\" data-nxf-resource=\"nexus:\/\/gcri\/nexus-reports\/editions\/xt-05\/agenda#contribute\" data-nxf-title=\"Contribute evidence\" data-nxf-height=\"480\" hidden><\/div><p class=\"nx-note nx-mt-3\">Never send personal data, sensitive infrastructure detail or anything you have no right to share. A contribution is reviewed before use; sending it confers no authorship or editorial rights, and sponsorship never buys a finding.<\/p><\/div><\/div><\/section><\/div><p class=\"nx-note\" data-nr-rights=\"true\"><a class=\"nx-link\" rel=\"license\" href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY 4.0<\/a> Free to read. Text and figures: CC BY 4.0. Data: CC0 1.0. Authors keep copyright. 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