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3f8CIwreJoKRwHHRNXfc3DNWM71mKy3t5exrop26P5rHHY0mUqm1lVsbKWnnDQTlzxbGV59ZITZ8usdKDHBDQ2iK9F6vfUB0grpmGa91nasCvrC6\/WM5U8ZNsoPOE9M9PzwMr016N2kvY8ZRIAMURhHkVJtB4N1b2Bpu5pnaPicwDWxQ6W04JQ8TcOCpylEWZXqobIrxvvIA0g+9sasM6amltxQL1HJloG6A0S61Ub664U1cqXwJeQqFLw6oWZiOVL1dQX6EzeKferZKHeDeaIhnycb4A2x0HQsQCeYK1i4SkVrsGZl5S4CmlJcX39kfiyGmG6vNsWrwsoV0aS2zbZITV5hLyeNQJXk6oO4qPcEy6krNhbUDDnmsRSf+mf26wvePVfpj1F0ydqrPjgZcyx0Air4vlAmKn3EciYw3pqRbDuy154olvl5p64Tw2oXgVZxmjxWvQwbHYLisLJtn3Z1erc4TLEyQPLFDlfa9IoRQIRBxn3s3hz5EO6cIdL7SnhflkOSfmtg+STpJ7mDuwBNOvFH7Df6mCEHQoizA88oPitjjNQx26tuy9\/RlhBtotD8wCEuvYFBJYNXo7yH586+EGrAtsMHdMjMBGTmW1EP0pYu4h5mVmEjzY+b7cqJzPrmvGFWDaTX7swykGP8f9RDvrZ1aGXbyap2g\/+XkUhOyp5NR3LVU4mA6OdFUZE6ZSjHSHUKJkuqSKXu88WBlUhpFe8CYDRj1THd3C+ZeiJ6hQOxp\/OneL0GSvZhWzbU0RwtIapaJ1YRNV\/GmKqhngj13dv7gFeP1PxQkVqBn5UzWhs3PVbGkFwJegEx8Bfs6CxjxC94FLxZBY4KzlU12fwmw21399wcOVPJSIycKQTrJU\/XCfyUGcdG4CPAUruHEUp2w69ttsTJZJAYgfLtyFdgGHF5pD8aFCTRTWXUZmkMLguEcAgpH7arz8FKV0g1IaIZaI\/acyeYUakBLvrOgNvJAwxRDhfCCL7lXrLflPb6K0n63wbWe7K3WK\/Nr1VH5ZtSiyuXoAU+brZ7e\/P1urL8yJlyNmguU0F8zQL+3neFy\/RDo7GR4edOQVB5aJgPhJB2DwlbVUf8BTvhRuAkWnEQuKSJrCXOfGZj0urGeVRODLMN+\/FzwuAUeMFgVju77pzMCSEL8AhbZDAGeD\/kvT6IXh8q4y7jhFuOkGXOe7zM04DE5QBNnrQCWEjzjPYv2EATI2+fCIGFDRjQMQ0949gA67xUpQ8so+YTG2SCeeV2Hvk08KQOXiGH9Xqb3y\/kF3JMRTmfZ\/EBdWKdV7i0S2SrsSSt7vJorlZjqXZ8rKVw2BOOfXgFisj+cvAjhqHsOMy4dM+9zJo8C0mMV7yxCoWl50\/zFFhcyOUlq82BUFhzBOcBTLkGZJGFJi8GVfaWAKwt\/OOu7adA0JO+V3Q78Em1BlFpolCCcb4J8wEKCxktWMjotqu7NJZIzx\/c5UWyMONWt6JKccy8QJWFCW0dEdHY06d+BlF1s1L46aa2+ragMONrMcujPxlN0HqdvTAgHrcq7HOrUz2SfZS1Wz1dsaPhVFR9p0ni+GEzGo3EuZzj2iwehbIq4UdaKVJn5fJUboUTRwsnjm\/Q5aB2\/HT7oBQXe76F9TaF\/Eqzmt3aTfLdSgiJezzXmLTDxrjrmNVRDyoC3BFFsqVIi9l7cqLVVUZKnkDPfNH\/2xv0\/\/Yse\/DPF7ha5wGB3kLJIceT5K6ulvBwFTWzVF8OLrThEzNRFmcb4X57IPCTig7h\/EmS+\/BaCAJiZfT+jGhOvNL1RmLXzJFXvG4ofkHZnovYO4b4R8FcPNgsOveX1INUFULY+ka+5bP6+63ZI+bf3urlBjfM3t7fHsYwUSvP7fFNc56AhiFslCj8vCQPMjwyszm1LfOhucQvIKasK1iZdpN\/jaOF2W5+s15C\/IfOXswasen88ytuzHm6zKM2ALUqVGkhz0CxOlcW1xTnNwJUpyAS5ClOInAW8cOxpLEPsZ+KXyxxXCp+cioqfk4pS3xXVHYhl\/ogew9pXES+xd6OQDNdNL2nzwg3Y3m4WVV2JC6P9+l2tFmmcc\/zJ0lhrluJRPw8DaRQWVQgBz5jQBAppMDd3FMtoXDIZRk2SWg6iQKvYx+81nIEfwAR5QM7mmaj\/8BFlHuaxbNNWf8D20oV\/B4qvtcrvucVp6z\/ng2emIimk\/bC3bxXMYxaoo8nUpAIbPGcyHWeqWR3+i+sgqRE6PIKOJwO1LPk1ug4m10ZTHyBBwSWoaBTyvWwOXaYAacPZT6S93oB0GDKjG\/C8+ijbtLGK\/XxquBh1LL09433tVn1uNvSx92fD17p6zWHgYJgApqlXConXFrZew9qI21ErYzcfSSt7sec3f+Y5T74CJtF2U3fgwzwcWADkKsInaT++YnQ69dl4S\/XmZlZH4p6Z31WWyZVE6X+6m8wUOX164Jk3kNfQxzv4QzlQHmfAeW9DhSoMYd6eVSqgGi23pA\/02rhxsErK5DeLydk20ugUUyceEyel8zxoFuIq83He6sO2w0JIbBWwWVHDkfYJTdH5CNE3RYqZVrMk97N0fbQ\/2kfKgxdrriZmwHDG11a0WijjLMHoYVbqXcG3WpyrWpKSo13TBz\/xTNUTIst1dGTodUL\/Kwc9A\/1dGmh4\/h+y2oPNCwv9BlhQZ\/xkCH4sP8tX7sKYbWYEXC91ssLzCcH\/pHPpjjkr3zIxS8Axa9Z91W5crkYyzREiDcLaVd5qFbBMTClZw5vU4cl\/lIXcL8DvfrOjh4yUvGd06ufqPlA+9+BwPEECLu4koqsYUNodsiO3mVkcMhk5rB3rD9kIneY\/CnuxXnO+EH3nSp6Nwszszo\/RJe3N5JZxxlr2m7lY\/oEY\/rEjk6zqX5i6qR+YeSU9j+xQdUQEsk\/cZ2yPssFtLhgR1+yWS6yFq8o+cL6C1YpCIumBOdyRXtX9GiWmWJkLd3BVWb1qFey7kihrMb6Gcb6mR19y2b\/mY\/VC81vtP9ZLcMjIygEd2WbTofUA5P8lGqqQzf3aahOMa\/GRJuTCLLSWVRnS8DbMMxZwlBBKyGsHw60e3nWa3iRWXErj4LgQKhkQCAfQSexwiXlnMf2PQV3XJ1VuC5hC79XCKscABZT+bgoZK3j1wBAigtrBDPiM2M\/mETdheCwZupC+x3Dc5IHrEwU0N6vjIh8tVoeWS1uzQATlijQC1kvZCr1eg9BU6iDAm7myf7qKaa5v8Ov4BUORMBlWLQp\/b2uZQbsOih16zgKCSqKa0vANUkAS+jX5de8DGee97hEagShlg1VsBEm94Dgc+qJuYhWOvyd+I0L9RzPK1TKy3X0Bupt+UM5UJF5sXIuqohFi3cGQLJWoa\/IBoALH0vjlPNv8jEK+OEuJ\/l1tSRUqipqTNVXvsR8x8tVhYNbOoa0cAwpHMBwSXceAukyz8vCgauzd0D5JovG44AamY5uR7INnmtjp4oRClSslVgo7jZZVvHwbV68HuWpxH2A+DpysiuPMscPOuJuL7bZZCn5fIUCEpnqnl+bmZ1\/SE8V3LIoccbco+SS0an5mCEQOMIysTpoj\/kpEGe0Jx7EthW\/RcZtPd216pNTtOqE+jr0Ja38rXBZ1x3\/dDuJFqFIZZQps\/d+Y3hVtjzL9O7C8rwL60uUtvABEyWWYbvBsLn1Uu5c8YYvoGXYsS\/3MjzLbwgXDKQqXQ\/kq0oiiA18BBf7NA4ciFbiEbgW8qdxlDCHSxmCpF3S2ttQ+IJzBo4minBOsntVMqh86l1m2cY\/FZw7P\/3omLqfsqXf+9Tb+4319i5pMZ85jPlfNXclTGgSGcdchSNNwqDGgastqhhUl4Z099emD6nIasskzpR3CUqKmjK0PBgA2L8YXv2LVd2tpV+jZW0Ff+kbtz4C7CSOqZM4oUuNaCSC0mJnDFFcMk64IioYtpU6Z4aOWrLo6Sv4lkfuPtkWP6bVTb1zkocfaIkf8uqWbvldRFpbMkQN9tG\/2NOHn4shn3q\/sZrtm23GT6V7VTMEQbLbPSZhWYz8k+282UPS2L0Sf1F3GEvog\/v1lt41p9HQD2ju3gv26xqxOmelEhL2wizzuQg8OGoftHpb7uq0mLBuBMpotJ31vCv8Yyv5ReB6m7DxQbMCPfGMsRVYogkMkV6aqy1c6gemjJJotA9F6ECmSK7JRpU3gjebP5+VAP1PVsiH\/yez2q9BBw7rpW8E2E1vE98b0+IGyd\/LyKPMmW7bGJJT1SafaJWbhyC2PfXD5kRX+etwZkrSSI6ZNfYuf+bHSDD4VZQ4zSgxRG5l95ptvoKD0kbcr\/SpN1FyWPGgKC3MJ+0Eia3w6b98Y4M46P0MPZSi5LSTBOaiWo6o+wwwhAoMiQBDqCjmTzvP809yOiNWryirzvzqCZOl4lfVlWh7I3C6LjC8BVpIanhh6\/cfG0HG13MSpd22IPZmNPE5JdS\/LOKm\/hGPGNE\/c45FiHBgNi5IXtme+Z1lu3W9Fg+iBLT2O8vKVfYrmaU4qei9QgSoG0Nl20BqQuY7PBNpqW3Fj5UBogldpb74zjlhJIFMQ\/xL96ddEvUJw907ap5IoeKv+qs3dksTZ6DYOGNHf2VahTNQbPzF+mdst0whi+ySKk62xIoyhryIUnYXxfUX+NXxmKXra7S2BMrhimW4SMa6h4hNRrXI7XlI9MuamXZ3UZfX6T6povnHIna8qR8OncQy4FwZx8Y\/81\/bT+KNmIdl9Pkp\/CcRzxDX63vZk7Y6u29IESK47ryv1EYCr4f6ZWq3px8vP9yhqi\/8jmOsTIiS6NfdihXmRJ4T8pzSi6YT7V4vfCsV3KDR5e1+pDros1WB1LD5ZUH37Bio6TyUvsTsWZGYFtV87YSIflulKrvlurI6Z1V+B51gdtg\/7dc9Hq9\/RF61esov9ZhmP48ODlvb\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Not indexed until the first approved release.<\/p><div class=\"nrp-reader\"><nav class=\"nrp-rail\" aria-label=\"Contents of Genomics and Gene Editing 2026\"><p class=\"nf-ui-eyebrow\">Contents<\/p><ol class=\"nrp-toc\"><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Edition home<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/summary\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Executive summary<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/coupled-system\/\"><span class=\"nrp-toc-n\">1<\/span><span>Genomics is data infrastructure and a therapeutic frontier<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/findings\/\"><span class=\"nrp-toc-n\">2<\/span><span>Key findings<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/systems-and-sectors\/\"><span class=\"nrp-toc-n\">3<\/span><span>Systems and sectors at baseline<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/risk-and-capability\/\"><span class=\"nrp-toc-n\">4<\/span><span>Risks and capability<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/scenario\/\"><span class=\"nrp-toc-n\">5<\/span><span>Individualised editing outpaces delivery systems<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/lenses-and-readings\/\"><span class=\"nrp-toc-n\">6<\/span><span>Readings from the other desks<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/agenda\/\"><span class=\"nrp-toc-n\">7<\/span><span>The 2027 agenda<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/systems-in-depth\/\"><span class=\"nrp-toc-n\">8<\/span><span>Systems in depth<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/methodology\/\" aria-current=\"page\"><span class=\"nrp-toc-n\">A<\/span><span>Methodology<\/span><\/a><ol class=\"nrp-toc-sub\"><li><a href=\"#nx-nrp-xt-05-ca-s1\">A.1 Methods<\/a><\/li><li><a href=\"#nx-nrp-xt-05-ca-s2\">A.2 Model card, Genomics System Model v0<\/a><\/li><li><a href=\"#nx-nrp-xt-05-ca-s3\">A.3 The baseline evidence cut<\/a><\/li><li><a href=\"#nx-nrp-xt-05-ca-s4\">A.4 Evidence age and coverage<\/a><\/li><li><a href=\"#nx-nrp-xt-05-ca-s5\">A.5 Evidence cards, two anchor sources<\/a><\/li><li><a href=\"#nx-nrp-xt-05-ca-s6\">A.6 Publication acceptance record<\/a><\/li><li><a href=\"#nx-nrp-xt-05-ca-s7\">A.7 Status words<\/a><\/li><li><a href=\"#nx-nrp-xt-05-ca-s8\">A.8 How the edition is made, released and corrected<\/a><\/li><li><a href=\"#nx-nrp-xt-05-ca-s9\">A.9 Glossary and abbreviations<\/a><\/li><li><a href=\"#nx-nrp-xt-05-ca-s10\">A.10 Technical annex<\/a><\/li><\/ol><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/data\/\"><span class=\"nrp-toc-n\">B<\/span><span>Data appendix<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/references\/\"><span class=\"nrp-toc-n\">C<\/span><span>References and record<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/full\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Complete edition, for print<\/span><\/a><\/li><\/ol><div class=\"nrp-actions\"><a class=\"nf-ui-btn\" data-variant=\"secondary\" href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/full\/\"><svg class=\"nrp-i\" viewBox=\"0 0 24 24\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2\"\/><path d=\"M6 9V3a1 1 0 0 1 1-1h10a1 1 0 0 1 1 1v6\"\/><rect x=\"6\" y=\"14\" width=\"12\" height=\"8\" rx=\"1\"\/><\/svg>Print or save as PDF<\/a><\/div><\/nav><article class=\"nrp-flow\" aria-labelledby=\"nx-nrp-xt-05-ca-top\"><header class=\"nrp-chap-head\" id=\"nx-nrp-xt-05-ca-top\"><ul class=\"nrp-eyerow\"><li class=\"nf-ui-eyebrow\"><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/\">Genomics and Gene Editing 2026<\/a><\/li><li class=\"nf-ui-eyebrow\">Annex A<\/li><\/ul><span class=\"nrp-rule\" aria-hidden=\"true\"><\/span><h1 class=\"pp-hero-title\">Methodology<\/h1><p class=\"nrp-lede\">How the edition was made: methods, the model card, the evidence cut and its age, the acceptance record and the glossary.<\/p><p class=\"nrp-chap-meta\"><span>14 min read<\/span><span>0 figures<\/span><span>13 tables<\/span><span>21 notes<\/span><span>NR-XTECH-GENOMICS-GLOBAL-2026-BASELINE<\/span><\/p><details class=\"nrp-toc-m\"><summary>Contents<\/summary><ol class=\"nrp-toc\"><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Edition home<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/summary\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Executive summary<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/coupled-system\/\"><span class=\"nrp-toc-n\">1<\/span><span>Genomics is data infrastructure and a therapeutic frontier<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/findings\/\"><span class=\"nrp-toc-n\">2<\/span><span>Key findings<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/systems-and-sectors\/\"><span class=\"nrp-toc-n\">3<\/span><span>Systems and sectors at baseline<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/risk-and-capability\/\"><span class=\"nrp-toc-n\">4<\/span><span>Risks and capability<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/scenario\/\"><span class=\"nrp-toc-n\">5<\/span><span>Individualised editing outpaces delivery systems<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/lenses-and-readings\/\"><span class=\"nrp-toc-n\">6<\/span><span>Readings from the other desks<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/agenda\/\"><span class=\"nrp-toc-n\">7<\/span><span>The 2027 agenda<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/systems-in-depth\/\"><span class=\"nrp-toc-n\">8<\/span><span>Systems in depth<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/methodology\/\" aria-current=\"page\"><span class=\"nrp-toc-n\">A<\/span><span>Methodology<\/span><\/a><ol class=\"nrp-toc-sub\"><li><a href=\"#nx-nrp-xt-05-ca-s1\">A.1 Methods<\/a><\/li><li><a href=\"#nx-nrp-xt-05-ca-s2\">A.2 Model card, Genomics System Model v0<\/a><\/li><li><a href=\"#nx-nrp-xt-05-ca-s3\">A.3 The baseline evidence cut<\/a><\/li><li><a href=\"#nx-nrp-xt-05-ca-s4\">A.4 Evidence age and coverage<\/a><\/li><li><a href=\"#nx-nrp-xt-05-ca-s5\">A.5 Evidence cards, two anchor sources<\/a><\/li><li><a href=\"#nx-nrp-xt-05-ca-s6\">A.6 Publication acceptance record<\/a><\/li><li><a href=\"#nx-nrp-xt-05-ca-s7\">A.7 Status words<\/a><\/li><li><a href=\"#nx-nrp-xt-05-ca-s8\">A.8 How the edition is made, released and corrected<\/a><\/li><li><a href=\"#nx-nrp-xt-05-ca-s9\">A.9 Glossary and abbreviations<\/a><\/li><li><a href=\"#nx-nrp-xt-05-ca-s10\">A.10 Technical annex<\/a><\/li><\/ol><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/data\/\"><span class=\"nrp-toc-n\">B<\/span><span>Data appendix<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/references\/\"><span class=\"nrp-toc-n\">C<\/span><span>References and record<\/span><\/a><\/li><li><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/full\/\"><span class=\"nrp-toc-n\">\u00b7<\/span><span>Complete edition, for print<\/span><\/a><\/li><\/ol><\/details><\/header><section class=\"nrp-block\" id=\"nx-nrp-xt-05-ca-s1\" aria-labelledby=\"nx-nrp-xt-05-ca-s1-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-ca-s1-h\"><span class=\"nrp-num\">A.1<\/span><span>Methods<\/span><\/h2><p class=\"nrp-stand\">The global baseline uses published values and four simple derivations. Each is shown in full so that any reader can reproduce it.<\/p><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-ca-tab1\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.1<\/span><span class=\"nrp-tbl-t\">Methods<\/span><\/caption><thead><tr><th scope=\"col\">No.<\/th><th scope=\"col\">Derivation<\/th><th scope=\"col\">Calculation<\/th><th scope=\"col\">Result<\/th><\/tr><\/thead><tbody><tr><td>(1)<\/td><td>Share of evaluable sickle cell patients free of crises<\/td><td>29 \u00f7 30<\/td><td>97%<\/td><\/tr><tr><td>(2)<\/td><td>Share of evaluable thalassaemia patients transfusion independent<\/td><td>32 \u00f7 35<\/td><td>91%<\/td><\/tr><tr><td>(3)<\/td><td>Year-on-year growth in Casgevy revenue, first quarter<\/td><td>42.9 \u00f7 14.2<\/td><td>about 3.0 times<\/td><\/tr><tr><td>(4)<\/td><td>Evaluable share of treated sickle cell patients<\/td><td>30 \u00f7 44<\/td><td>68%<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-ca-tab2\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.2<\/span><span class=\"nrp-tbl-t\">Coupling strength scale (matrix and model card)<\/span><\/caption><thead><tr><th scope=\"col\">Strength<\/th><th scope=\"col\">Definition<\/th><\/tr><\/thead><tbody><tr><td>STRONG<\/td><td>a disruption in the source system has historically changed the target system\u2019s service or output within one season, in more than one region<\/td><\/tr><tr><td>MODERATE<\/td><td>an effect is documented but buffered or slower<\/td><\/tr><tr><td>WEAK<\/td><td>an effect is plausible but not documented at global scale<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-ca-tab3\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.3<\/span><span class=\"nrp-tbl-t\">Status grammar<\/span><\/caption><thead><tr><th scope=\"col\">Label<\/th><th scope=\"col\">Rule<\/th><\/tr><\/thead><tbody><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><td>value as issued by its source, with year<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Inferred<\/span><\/td><td>reasoned from cited evidence; never a measurement<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Estimated<\/span><\/td><td>Nexus analytical value with stated method<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"caution\" aria-hidden=\"true\"><\/span>Scenario<\/span><\/td><td>conditional on stated assumptions<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Expert input<\/span><\/td><td>structured editorial judgement awaiting evidence<\/td><\/tr><\/tbody><\/table><\/div><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-ca-s2\" aria-labelledby=\"nx-nrp-xt-05-ca-s2-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-ca-s2-h\"><span class=\"nrp-num\">A.2<\/span><span>Model card, Genomics System Model v0<\/span><\/h2><dl class=\"nrp-dl\"><dt>Model ID<\/dt><dd>MDL-XT05-GENOMICS \u00b7 v0.1<\/dd><dt>Purpose<\/dt><dd>represent genomics and gene editing as infrastructure coupled to health, compute and energy, trade and supply, finance, workforce and data protection<\/dd><dt>Family<\/dt><dd>graph-based system of <a class=\"nx-link nx-term\" href=\"https:\/\/docs.therisk.global\/organization\/systems\" data-tc=\"Systems\" data-tk=\"Nexus Standards\" data-td=\"The twenty Nexus systems, NXS-CMD to NXS-LAB\">systems<\/a><\/dd><dt>Inputs<\/dt><dd>the cited sources of this edition; no proprietary data<\/dd><dt>Method<\/dt><dd>expert-specified coupling strengths (STRONG \u00b7 MODERATE \u00b7 WEAK) from assessments and analogue events<\/dd><dt>Validation<\/dt><dd>none yet, first validation against federation evidence in 2027<\/dd><dt>Uncertainty<\/dt><dd>qualitative; strengths are hypotheses, not measurements<\/dd><dt>Domain of validity<\/dt><dd>global scale; not for asset-, site- or country-level use<\/dd><dt>Reproducibility<\/dt><dd>strength table and sources published in this edition<\/dd><\/dl><div class=\"pp-cells nrp-cells-3\"><div class=\"nrp-cell\"><span class=\"pp-metric\">20<\/span><span class=\"nrp-cell-u\">couplings<\/span><p>typed in v0<\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">0<\/span><span class=\"nrp-cell-u\">strong<\/span><p>documented within one season<\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">3<\/span><span class=\"nrp-cell-u\">moderate<\/span><p>documented, buffered<\/p><\/div><div class=\"nrp-cell\"><span class=\"pp-metric\">17<\/span><span class=\"nrp-cell-u\">weak<\/span><p>plausible, undocumented<\/p><\/div><\/div><div class=\"nrp-split\"><div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">SUITABLE FOR<\/p><p>framing the 2027 agenda; choosing which couplings to measure first; explaining the two readings of genomics as data infrastructure and as a therapeutic frontier.<\/p><\/aside><\/div><div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">NOT SUITABLE FOR<\/p><p>quantitative loss estimates, country comparisons or rankings, operational decisions, or any claim about a specific asset.<\/p><\/aside><\/div><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">VERSIONING<\/p><p>Models are immutable by version. A change to any coupling, rule or weight produces v0.2 with its own card and correction note.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-ca-s3\" aria-labelledby=\"nx-nrp-xt-05-ca-s3-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-ca-s3-h\"><span class=\"nrp-num\">A.3<\/span><span>The baseline evidence cut<\/span><\/h2><p class=\"nrp-stand\">Every Nexus edition is published from a frozen evidence cut. The global baseline cut is documentary: it pins the exact edition of every source cited. Federation cuts begin with the first national Foundry cuts in 2027.<\/p><dl class=\"nrp-dl\"><dt>Cut ID<\/dt><dd>DC-XTECH-GENOMICS-GLOBAL-2026-B0<\/dd><dt>Type<\/dt><dd>baseline documentary cut<\/dd><dt>Resolution policy<\/dt><dd>pinned \u00b7 as of 30 September 2026<\/dd><dt>Sources pinned<\/dt><dd>44 cited sources, each at the edition and access date in the references<\/dd><dt>Model runs<\/dt><dd>none at baseline, analytical values are stated with their method<\/dd><dt>Digest<\/dt><dd>computed at <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-h5\" data-tc=\"NHS-1 atmo.thermal.hard-freeze\" data-tk=\"Atmosphere and weather \u00b7 Thermal extremes\" data-td=\"Air temperature falling well below freezing for hours, killing crops, bursting pipes and stopping water flow.\" data-ts=\"NRS-H5\" data-tr=\"draft\" data-tx=\"https:\/\/risksindex.com\/hazards\/atmo\/\" data-txl=\"Atmosphere and weather\">freeze<\/a> and recorded in the publication record<\/dd><dt>Supersedes<\/dt><dd>nothing, first cut of the series<\/dd><dt>Superseded by<\/dt><dd>the 2027 genomics annual cut<\/dd><\/dl><h3 class=\"nrp-h3\">Lineage<\/h3><ol class=\"nrp-rows\"><li><span class=\"nrp-rows-i\">01<\/span><p class=\"nrp-rows-x\">source edition<\/p><\/li><li><span class=\"nrp-rows-i\">02<\/span><p class=\"nrp-rows-x\">pinned citation<\/p><\/li><li><span class=\"nrp-rows-i\">03<\/span><p class=\"nrp-rows-x\">finding<\/p><\/li><li><span class=\"nrp-rows-i\">04<\/span><p class=\"nrp-rows-x\">page<\/p><\/li><li><span class=\"nrp-rows-i\">05<\/span><p class=\"nrp-rows-x\">publication record<\/p><\/li><\/ol><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-ca-tab4\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.4<\/span><span class=\"nrp-tbl-t\">From the baseline cut to the federation cut<\/span><\/caption><thead><tr><th scope=\"col\">Element<\/th><th scope=\"col\">Baseline 2026<\/th><th scope=\"col\">2027 global annual<\/th><\/tr><\/thead><tbody><tr><td>Sources<\/td><td>cited global publications, pinned by edition<\/td><td>national, regional and sector cuts through one graph<\/td><\/tr><tr><td>Analysis<\/td><td>stated methods and editorial estimates<\/td><td>typed analysis specifications<\/td><\/tr><tr><td>Models<\/td><td>Genomics System Model v0 specification<\/td><td>model runs with receipts<\/td><\/tr><tr><td>Findings<\/td><td>twelve baseline findings<\/td><td>findings re-bound to federation evidence<\/td><\/tr><tr><td>Review<\/td><td>five passes scheduled<\/td><td>five passes on the exact digest<\/td><\/tr><\/tbody><\/table><\/div><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-ca-s4\" aria-labelledby=\"nx-nrp-xt-05-ca-s4-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-ca-s4-h\"><span class=\"nrp-num\">A.4<\/span><span>Evidence age and coverage<\/span><\/h2><p class=\"nrp-stand\">A 2026 global edition rests on evidence observed in many different years. This page shows each time base, so that no single year label hides older evidence.<\/p><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-ca-tab5\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.5<\/span><span class=\"nrp-tbl-t\">Evidence age and coverage<\/span><\/caption><thead><tr><th scope=\"col\">Indicator<\/th><th scope=\"col\">Observed<\/th><th scope=\"col\">Released<\/th><th scope=\"col\">Cadence<\/th><th scope=\"col\">Next release<\/th><\/tr><\/thead><tbody><tr><td>Phase 3 sickle cell and thalassaemia reports<\/td><td>2024<\/td><td>NEJM 2024<\/td><td>one-off<\/td><td>longer follow-up<\/td><\/tr><tr><td>FDA approval<\/td><td>2023<\/td><td>Dec 2023<\/td><td>one-off<\/td><td>paediatric label<\/td><\/tr><tr><td>Patient-specific base editing report<\/td><td>2025<\/td><td>NEJM 2025<\/td><td>one-off<\/td><td>follow-up<\/td><\/tr><tr><td>Reference genome and pangenome<\/td><td>2022 to 2023<\/td><td>Science 2022 \u00b7 Nature 2023<\/td><td>periodic<\/td><td>pangenome release 2<\/td><\/tr><tr><td>Biobank genome releases<\/td><td>2024 to 2025<\/td><td>Nature 2024 \u00b7 Nature 2025<\/td><td>periodic<\/td><td>next releases<\/td><\/tr><tr><td>Compute footprint studies<\/td><td>2021 to 2022<\/td><td>Adv Sci 2021 \u00b7 MBE 2022<\/td><td>one-off<\/td><td>new studies<\/td><\/tr><tr><td>Vertex company report<\/td><td>2026<\/td><td>page read 2026-11-03<\/td><td>quarterly<\/td><td>next quarterly report<\/td><\/tr><tr><td>Illumina trade events<\/td><td>2025<\/td><td>Feb to Nov 2025<\/td><td>per event<\/td><td>current status<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-ca-tab6\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.6<\/span><span class=\"nrp-tbl-t\">Coverage by system at baseline<\/span><\/caption><thead><tr><th scope=\"col\">System<\/th><th scope=\"col\">Coverage<\/th><th scope=\"col\">Thinnest dimension<\/th><\/tr><\/thead><tbody><tr><td>Therapies<\/td><td>PARTIAL<\/td><td>treatment counts and prices<\/td><\/tr><tr><td>Data resources<\/td><td>GOOD<\/td><td>ancestry balance on a common basis<\/td><\/tr><tr><td>Governance<\/td><td>PARTIAL<\/td><td>national rule texts<\/td><\/tr><tr><td>Finance<\/td><td>THIN<\/td><td>payer and price data<\/td><\/tr><tr><td>Energy<\/td><td>THIN<\/td><td>sequencing and cold-chain energy<\/td><\/tr><tr><td>Supply<\/td><td>THIN<\/td><td>consumables and reagents<\/td><\/tr><tr><td>Skills<\/td><td>THIN<\/td><td>workforce beyond counselling<\/td><\/tr><tr><td>Agriculture and environment<\/td><td>THIN<\/td><td>edited crop and animal data<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-ca-tab7\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.7<\/span><span class=\"nrp-tbl-t\">Designed empty states: what is not bound, what would fill it and why<\/span><\/caption><thead><tr><th scope=\"col\">Field<\/th><th scope=\"col\">Source that would fill it<\/th><th scope=\"col\">Blocker<\/th><\/tr><\/thead><tbody><tr><td>Energy and cooling use of sequencing laboratories and cell-therapy cold chains<\/td><td>laboratories, manufacturers, peer-reviewed footprint studies<\/td><td>not retrieved; only compute footprints were read<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n21\" id=\"nx-nrp-xt-05-ca-r21\" aria-label=\"Note 21\">21<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n22\" id=\"nx-nrp-xt-05-ca-r22\" aria-label=\"Note 22\">22<\/a><\/sup><\/td><\/tr><tr><td>NHGRI cost per genome series values<\/td><td>NHGRI sequencing cost data table<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n13\" id=\"nx-nrp-xt-05-ca-r13\" aria-label=\"Note 13\">13<\/a><\/sup><\/td><td>the page shows graphs and a linked Excel table; the values were not read<\/td><\/tr><tr><td>Independent cost per genome at scale<\/td><td>service providers, national laboratories, published cost studies<\/td><td>only vendor list prices were read, and the Ultima page shows both USD 60 and USD 80<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n15\" id=\"nx-nrp-xt-05-ca-r15\" aria-label=\"Note 15\">15<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n40\" id=\"nx-nrp-xt-05-ca-r40\" aria-label=\"Note 40\">40<\/a><\/sup><\/td><\/tr><tr><td>Patients treated with editing therapies, by country<\/td><td>company reports, treatment centre registries, regulators<\/td><td>the first quarter 2026 report gave no counts<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n6\" id=\"nx-nrp-xt-05-ca-r6\" aria-label=\"Note 6\">6<\/a><\/sup>; full-year figures come from a search summary<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n35\" id=\"nx-nrp-xt-05-ca-r35\" aria-label=\"Note 35\">35<\/a><\/sup><\/td><\/tr><tr><td>Prices paid for editing therapies<\/td><td>payers, health technology assessment bodies, company reports<\/td><td>not retrieved<\/td><\/tr><tr><td>Number of people with a sequenced genome worldwide<\/td><td>national programmes, vendors, published tallies<\/td><td>no consolidated series found<\/td><\/tr><tr><td>Ancestry balance of genome datasets on a common basis<\/td><td>cohort papers and diversity monitors<\/td><td>two cohorts and two commentaries read<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n16\" id=\"nx-nrp-xt-05-ca-r16\" aria-label=\"Note 16\">16<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n17\" id=\"nx-nrp-xt-05-ca-r17\" aria-label=\"Note 17\">17<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n18\" id=\"nx-nrp-xt-05-ca-r18\" aria-label=\"Note 18\">18<\/a><\/sup><sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n19\" id=\"nx-nrp-xt-05-ca-r19\" aria-label=\"Note 19\">19<\/a><\/sup><\/td><\/tr><tr><td>Sequencer fleet and consumable supply by country<\/td><td>trade statistics, vendor filings<\/td><td>not retrieved; only trade events were read<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n31\" id=\"nx-nrp-xt-05-ca-r31\" aria-label=\"Note 31\">31<\/a><\/sup><\/td><\/tr><tr><td>Text of Regulation (EU) 2026\/1388 from the Official Journal<\/td><td>Official Journal of the European Union<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n36\" id=\"nx-nrp-xt-05-ca-r36\" aria-label=\"Note 36\">36<\/a><\/sup><\/td><td>not opened; dates and structure come from search summaries<\/td><\/tr><tr><td>FDA draft guidance on the plausible mechanism pathway<\/td><td>FDA guidance page<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n37\" id=\"nx-nrp-xt-05-ca-r37\" aria-label=\"Note 37\">37<\/a><\/sup><\/td><td>not opened; the November 2025 report was read<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n5\" id=\"nx-nrp-xt-05-ca-r5\" aria-label=\"Note 5\">5<\/a><\/sup><\/td><\/tr><tr><td>Date and terms on which the FDA lifted the 2025 clinical holds<\/td><td>company and FDA notices<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n39\" id=\"nx-nrp-xt-05-ca-r39\" aria-label=\"Note 39\">39<\/a><\/sup><\/td><td>search summaries only; sources differ on dates<\/td><\/tr><tr><td>National rules on genetic data, somatic editing and heritable editing<\/td><td>statutes and regulators<\/td><td>not retrieved; the Oviedo text was not opened<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n41\" id=\"nx-nrp-xt-05-ca-r41\" aria-label=\"Note 41\">41<\/a><\/sup><\/td><\/tr><tr><td>Genomics workforce beyond genetic counsellors<\/td><td>national statistics, surveys<\/td><td>not retrieved; only counsellor figures were read<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n33\" id=\"nx-nrp-xt-05-ca-r33\" aria-label=\"Note 33\">33<\/a><\/sup><\/td><\/tr><tr><td>Capability rungs beyond approvals and planning<\/td><td>agencies, clinics, laboratories<\/td><td>not reviewed<\/td><\/tr><\/tbody><\/table><\/div><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-ca-s5\" aria-labelledby=\"nx-nrp-xt-05-ca-s5-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-ca-s5-h\"><span class=\"nrp-num\">A.5<\/span><span>Evidence cards, two anchor sources<\/span><\/h2><div class=\"nrp-cards\"><article class=\"nf-ui-card nrp-card\"><p class=\"nf-ui-eyebrow\">Published in the New England Journal of Medicine in 2024 by Frangoul and colleagues. Phase 3 single-group study. Role: binds HLT-001. Coverage: patients 12 to 35 years of age.<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">EVD-XT05-001<\/h3><p>Exagamglogene autotemcel for severe sickle cell disease<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n2\" id=\"nx-nrp-xt-05-ca-r2\" aria-label=\"Note 2\">2<\/a><\/sup><\/p><\/article><article class=\"nf-ui-card nrp-card\"><p class=\"nf-ui-eyebrow\">Published in Science in 2022 by the Telomere-to-Telomere Consortium. One-off assembly. Role: binds DAT-006. Coverage: one human cell line genome.<\/p><h3 class=\"nf-ui-title\" data-level=\"card\">EVD-XT05-002<\/h3><p>The complete sequence of a human genome<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n11\" id=\"nx-nrp-xt-05-ca-r11\" aria-label=\"Note 11\">11<\/a><\/sup><\/p><\/article><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-ca-tab8\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.8<\/span><span class=\"nrp-tbl-t\">Quality dimensions at baseline<\/span><\/caption><thead><tr><th scope=\"col\">Dimension<\/th><th scope=\"col\">EVD-XT05-001<\/th><th scope=\"col\">EVD-XT05-002<\/th><\/tr><\/thead><tbody><tr><td>Completeness<\/td><td>one disease; 30 evaluable patients<\/td><td>one genome; all chromosomes except Y gapless<\/td><\/tr><tr><td>Timeliness<\/td><td>interim analysis at median 19.3 months<\/td><td>single release in 2022<\/td><\/tr><tr><td>Revision<\/td><td>follow-up reports expected<\/td><td>pangenome release builds on it<\/td><\/tr><tr><td>Method transparency<\/td><td>methods and end points published<\/td><td>assembly methods published<\/td><\/tr><tr><td>External validation<\/td><td>peer review<\/td><td>peer review<\/td><\/tr><\/tbody><\/table><\/div><h3 class=\"nrp-h3\">Evidence cards to follow in 2027<\/h3><ul class=\"nrp-list\"><li>Frangoul<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n2\" aria-label=\"Note 2\">2<\/a><\/sup>: follow-up beyond the median 19.3 months<\/li><li>Vertex<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n6\" aria-label=\"Note 6\">6<\/a><\/sup>: counts of patients treated<\/li><li>FDA<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n37\" aria-label=\"Note 37\">37<\/a><\/sup>: draft guidance text<\/li><li>Official Journal<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n36\" aria-label=\"Note 36\">36<\/a><\/sup>: regulation text<\/li><\/ul><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-ca-s6\" aria-labelledby=\"nx-nrp-xt-05-ca-s6-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-ca-s6-h\"><span class=\"nrp-num\">A.6<\/span><span>Publication acceptance record<\/span><\/h2><p class=\"nrp-stand\">Editorial self-check at evidence close. Every applicable item carries a disposition; the remaining items are review, approval and deposit.<\/p><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-ca-tab9\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.9<\/span><span class=\"nrp-tbl-t\">Publication acceptance record<\/span><\/caption><thead><tr><th scope=\"col\">Group<\/th><th scope=\"col\">Area<\/th><th scope=\"col\">Items<\/th><th scope=\"col\">Pass<\/th><th scope=\"col\">N\/A<\/th><th scope=\"col\">Pending<\/th><\/tr><\/thead><tbody><tr><td>D1<\/td><td>Identity and scope<\/td><td>8<\/td><td>8<\/td><td>0<\/td><td>0<\/td><\/tr><tr><td>D2<\/td><td>Source and data<\/td><td>12<\/td><td>9<\/td><td>1<\/td><td>2<\/td><\/tr><tr><td>D3<\/td><td>Analysis and models<\/td><td>12<\/td><td>3<\/td><td>8<\/td><td>1<\/td><\/tr><tr><td>D4<\/td><td>Findings and claims<\/td><td>9<\/td><td>8<\/td><td>0<\/td><td>1<\/td><\/tr><tr><td>D5<\/td><td>Figures, tables, maps<\/td><td>10<\/td><td>6<\/td><td>2<\/td><td>2<\/td><\/tr><tr><td>D6<\/td><td>Editorial and citations<\/td><td>10<\/td><td>8<\/td><td>0<\/td><td>2<\/td><\/tr><tr><td>D7<\/td><td>Review and approval<\/td><td>13<\/td><td>0<\/td><td>0<\/td><td>13<\/td><\/tr><tr><td>D8<\/td><td>Artefact and design<\/td><td>12<\/td><td>7<\/td><td>0<\/td><td>5<\/td><\/tr><tr><td>D9<\/td><td>Registry and release<\/td><td>9<\/td><td>0<\/td><td>0<\/td><td>9<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-split\"><div><h3 class=\"nrp-h3\">Publication gate<\/h3><dl class=\"nrp-dl\"><dt>Conditions met<\/dt><dd>14 of 23 at evidence close<\/dd><dt>Blocking problems<\/dt><dd>none recorded<\/dd><dt>Open conditions<\/dt><dd>reviews, approval of the exact digest, deposit, registry pointer<\/dd><\/dl><\/div><div><h3 class=\"nrp-h3\">Not applicable at baseline<\/h3><dl class=\"nrp-dl\"><dt>Model runs<\/dt><dd>first runs in Q1 2027<\/dd><dt>Maps<\/dt><dd>plates in Q2 2027<\/dd><dt>Waivers<\/dt><dd>none<\/dd><\/dl><\/div><\/div><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">evidence<\/p><p>Dispositions are recorded item by item in the machine-readable checklist. A FAIL on any item blocks release.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-ca-s7\" aria-labelledby=\"nx-nrp-xt-05-ca-s7-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-ca-s7-h\"><span class=\"nrp-num\">A.7<\/span><span>Status words<\/span><\/h2><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-ca-tab10\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.10<\/span><span class=\"nrp-tbl-t\">The status every value carries<\/span><\/caption><thead><tr><th scope=\"col\">Status<\/th><th scope=\"col\">What it means<\/th><\/tr><\/thead><tbody><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"positive\" aria-hidden=\"true\"><\/span>Observed<\/span><\/td><td>Measured directly and published by the source.<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Reported<\/span><\/td><td>Published statistics of an official or institutional source.<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"info\" aria-hidden=\"true\"><\/span>Declared<\/span><\/td><td>Stated by the body concerned; not independently measured.<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Estimated<\/span><\/td><td>A Nexus estimate from cited evidence, with its method in Annex A.<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Modelled<\/span><\/td><td>Produced by a stated model from cited inputs.<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Inferred<\/span><\/td><td>Reasoned from cited evidence; not measured.<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"caution\" aria-hidden=\"true\"><\/span>Forecast<\/span><\/td><td>A projection by the cited source.<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"caution\" aria-hidden=\"true\"><\/span>Simulated<\/span><\/td><td>A simulation result under stated assumptions.<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"caution\" aria-hidden=\"true\"><\/span>Scenario<\/span><\/td><td>A conditional statement under stated assumptions; never a prediction.<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"neutral\" aria-hidden=\"true\"><\/span>Expert input<\/span><\/td><td>Expert judgement, recorded with its basis.<\/td><\/tr><tr><td><span class=\"nrp-st\"><span class=\"nf-ui-dot\" data-tone=\"caution\" aria-hidden=\"true\"><\/span>Candidate<\/span><\/td><td>Proposed for a later edition; not yet evidence.<\/td><\/tr><\/tbody><tfoot><tr><td colspan=\"2\">Evidence-quality levels (EQL 1 to 5) grade the source behind a value; they are not a score of the subject.<\/td><\/tr><\/tfoot><\/table><\/div><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-ca-s8\" aria-labelledby=\"nx-nrp-xt-05-ca-s8-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-ca-s8-h\"><span class=\"nrp-num\">A.8<\/span><span>How the edition is made, released and corrected<\/span><\/h2><p class=\"nx-p\">Every edition is built from a sealed evidence cut, reviewed under three keys, signed and deposited before any site shows it as published; corrections go to <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/\" data-tc=\"Nexus Standards\" data-tk=\"Nexus Standards\" data-td=\"The foundation standards\">Nexus Standards<\/a> as change proposals and feed the next cut.<\/p><div class=\"nx-table-wrap\"><table class=\"nx-table\" data-stack=\"true\"><thead><tr><th scope=\"col\">Step<\/th><th scope=\"col\">What happens<\/th><th scope=\"col\">Source<\/th><\/tr><\/thead><tbody><tr><td data-label=\"Step\">01 Evidence arrives from the pillars<\/td><td data-label=\"What happens\">Foundry seals observations and indicator series, <a class=\"nx-link\" href=\"https:\/\/docs.therisk.global\/organization\/programme\/universe\">Universe<\/a> hands over after-action and scenario findings, and contributions are screened at every gateway, including this site&#8217;s.<\/td><td data-label=\"Source\"><\/td><\/tr><tr><td data-label=\"Step\">02 The cut is sealed<\/td><td data-label=\"What happens\">On the cut date the evidence is pinned under one identifier, so anyone can rebuild the edition from exactly what it was built on.<\/td><td data-label=\"Source\"><\/td><\/tr><tr><td data-label=\"Step\">03 The edition is assembled<\/td><td data-label=\"What happens\">The edition is drafted from its template and content pack. Agents may draft; they never publish and never decide.<\/td><td data-label=\"Source\"><\/td><\/tr><tr><td data-label=\"Step\">04 The keys turn<\/td><td data-label=\"What happens\">At the publisher of record the truth key comes first: every value is checked against its source or stated method before the meaning and capital keys turn. No edition moves on until every key has been turned by a named steward.<\/td><td data-label=\"Source\"><\/td><\/tr><tr><td data-label=\"Step\">05 The gate opens<\/td><td data-label=\"What happens\">A named approver releases one exact digest of the edition; any change after this point is a new version, never a silent edit.<\/td><td data-label=\"Source\"><\/td><\/tr><tr><td data-label=\"Step\">06 Signed and deposited<\/td><td data-label=\"What happens\">The PDF, the web edition and the data bundle are signed together with a manifest and an RO-Crate description, and deposited on Zenodo with a concept and a version DOI.<\/td><td data-label=\"Source\"><\/td><\/tr><tr><td data-label=\"Step\">07 Published on its desk&#8217;s site<\/td><td data-label=\"What happens\">Only then does the edition show as published on its desk&#8217;s <a class=\"nx-link\" href=\"https:\/\/docs.therisk.global\/organization\/programme\/reports\">Reports<\/a> site, and the Collection lists it as a part.<\/td><td data-label=\"Source\"><\/td><\/tr><tr><td data-label=\"Step\">08 Corrections go to Standards<\/td><td data-label=\"What happens\">Method and correction findings go to Nexus Standards as change proposals; citations, corrections and new contributions feed the next evidence cut.<\/td><td data-label=\"Source\"><\/td><\/tr><\/tbody><\/table><\/div><p class=\"nx-note nx-mt-2\">A teaching model of the process, not a forecast and not a record of any run; dates and counts on this page come from the programme record. Sources: <a class=\"nx-link\" href=\"https:\/\/therisk.global\/nexus-reports\/governance\/\" rel=\"noopener\">Reports governance at GCRI Canada<\/a> (2026); Zenodo, repository of record for Reports deposits (2026).<\/p><p class=\"nrp-note\">Lifecycle, one state at a time: Draft, Computed, Evidence bound, Reviewed, Approved for release, Published, Corrected, Superseded. This edition is a draft.<\/p><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-ca-s9\" aria-labelledby=\"nx-nrp-xt-05-ca-s9-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-ca-s9-h\"><span class=\"nrp-num\">A.9<\/span><span>Glossary and abbreviations<\/span><\/h2><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-ca-tab11\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.11<\/span><span class=\"nrp-tbl-t\">Series terms<\/span><\/caption><thead><tr><th scope=\"col\">Term<\/th><th scope=\"col\">Meaning<\/th><\/tr><\/thead><tbody><tr><td>Baseline Edition<\/td><td>the inaugural annual edition that fixes the reference state for the series<\/td><\/tr><tr><td>WEFH+B<\/td><td>water, energy, food, health and biodiversity, the <a class=\"nx-link nx-term\" href=\"https:\/\/docs.therisk.global\/organization\/governance-in-operation\/national-nexus\" data-tc=\"National Nexus\" data-tk=\"Nexus Standards\" data-td=\"The national model: the NNC, the NLC and the NWG as its three participation pillars, with the National Desk, Model and Portfolio and the NSC as the standards function of the NNC (OR-13)\">national nexus<\/a> core<\/td><\/tr><tr><td>Coupling<\/td><td>a typed dependency through which one system transmits to another<\/td><\/tr><tr><td><a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-c1\" data-tc=\"NRS-C1 protection-gap\" data-tk=\"Nexus risk vocabulary\" data-td=\"The difference between total economic losses from hazards and the share covered by insurance or other pre-arranged protection, leaving households, firms and governments to absorb the rest.\" data-ts=\"NRS-C1\" data-tr=\"draft\" data-tg=\"https:\/\/globalriskalliance.com\/glossary\/protection-gap\/\" data-tgl=\"Global Risks Alliance glossary\">Protection gap<\/a><\/td><td>the share of losses not covered by insurance<\/td><\/tr><tr><td>Capability ladder<\/td><td>LISTED \u2192 EXISTS \u2192 ADEQUATE \u2192 TESTED \u2192 DEMONSTRATED<\/td><\/tr><tr><td>EQL<\/td><td>evidence-quality level, 1\u20135<\/td><\/tr><tr><td>Evidence cut<\/td><td>a frozen resolution of exact sources and versions<\/td><\/tr><tr><td>NNC \u00b7 NLC \u00b7 NWG<\/td><td>National Nexus Consortium \u00b7 National Leadership Council \u00b7 National Working Groups<\/td><\/tr><\/tbody><\/table><\/div><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-ca-tab12\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.12<\/span><span class=\"nrp-tbl-t\">Abbreviations used in this edition<\/span><\/caption><thead><tr><th scope=\"col\">Abbreviation<\/th><th scope=\"col\">Expansion<\/th><\/tr><\/thead><tbody><tr><td>bp<\/td><td>base pairs<\/td><\/tr><tr><td>CRISPR<\/td><td>clustered regularly interspaced short palindromic repeats<\/td><\/tr><tr><td>exa-cel<\/td><td>exagamglogene autotemcel<\/td><\/tr><tr><td>FDA<\/td><td>US Food and Drug Administration<\/td><\/tr><tr><td>GWAS<\/td><td>genome-wide association study<\/td><\/tr><tr><td>LNP<\/td><td>lipid nanoparticle<\/td><\/tr><tr><td>NDAA<\/td><td>National Defense Authorization Act<\/td><\/tr><tr><td>NEJM<\/td><td>New England Journal of Medicine<\/td><\/tr><tr><td>OMB<\/td><td>US Office of Management and Budget<\/td><\/tr><tr><td>T2T<\/td><td>Telomere-to-Telomere<\/td><\/tr><tr><td>TDT<\/td><td>transfusion-dependent beta-thalassaemia<\/td><\/tr><tr><td>WHO<\/td><td>World Health Organization<\/td><\/tr><\/tbody><\/table><\/div><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-ca-s10\" aria-labelledby=\"nx-nrp-xt-05-ca-s10-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-ca-s10-h\"><span class=\"nrp-num\">A.10<\/span><span>Technical annex<\/span><\/h2><div class=\"nrp-tblw\" id=\"nx-nrp-xt-05-ca-tab13\"><table class=\"nrp-tbl\"><caption><span class=\"nf-ui-eyebrow\">Table A.13<\/span><span class=\"nrp-tbl-t\">Technical annex<\/span><\/caption><thead><tr><th scope=\"col\">Item<\/th><th scope=\"col\">Annex<\/th><th scope=\"col\">Contents<\/th><th scope=\"col\">Status<\/th><\/tr><\/thead><tbody><tr><td>A.1<\/td><td>Indicator definitions<\/td><td>the global indicator set, with units and sources<\/td><td>IN THIS EDITION<\/td><\/tr><tr><td>A.2<\/td><td>Coupling strengths<\/td><td>the twenty-cell matrix and its rationale<\/td><td>IN THIS EDITION<\/td><\/tr><tr><td>A.3<\/td><td>Scenario specification<\/td><td>SCN-XT05-DLV-01 assumptions and signposts<\/td><td>IN THIS EDITION<\/td><\/tr><tr><td>A.4<\/td><td>Capability placements<\/td><td>rung evidence for fifteen functions<\/td><td>IN THIS EDITION<\/td><\/tr><tr><td>A.5<\/td><td>Model diagnostics<\/td><td>first runs and validation<\/td><td>2027<\/td><\/tr><tr><td>A.6<\/td><td>Sensitivity analyses<\/td><td>influence of coupling strengths<\/td><td>2027<\/td><\/tr><tr><td>A.7<\/td><td>Cluster notes<\/td><td>cards for the major sequencing and cell-therapy clusters<\/td><td>2027<\/td><\/tr><tr><td>A.8<\/td><td>Review statements<\/td><td>pass-by-pass review record<\/td><td>AT RELEASE<\/td><\/tr><\/tbody><\/table><\/div><h3 class=\"nrp-h3\">A.1 \u00b7 indicator definition: transfusion independence<\/h3><dl class=\"nrp-dl\"><dt>Construct<\/dt><dd>a weighted average haemoglobin level of 9 g per decilitre or higher without red-cell transfusion for at least 12 consecutive months<\/dd><dt>Unit<\/dt><dd>patients meeting the definition among evaluable patients<\/dd><dt>Method<\/dt><dd>prespecified interim analysis of an open-label single-group study<\/dd><dt>Source<\/dt><dd>New England Journal of Medicine 2024<sup class=\"nrp-fn\"><a href=\"#nx-nrp-xt-05-ca-n3\" id=\"nx-nrp-xt-05-ca-r3\" aria-label=\"Note 3\">3<\/a><\/sup><\/dd><dt>Uncertainty<\/dt><dd>95% <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-c1\" data-tc=\"NRS-C1 confidence-interval\" data-tk=\"Nexus risk vocabulary\" data-td=\"A range computed from data by a procedure that would contain the true value in a stated share of repeated samples.\" data-ts=\"NRS-C1\" data-tr=\"draft\">confidence interval<\/a> 77 to 98 for the 91% result<\/dd><dt>Known limits<\/dt><dd>interim analysis; short follow-up; no comparison arm<\/dd><\/dl><aside class=\"nrp-call\"><p class=\"nf-ui-eyebrow\">evidence<\/p><p>Annexes carry the same evidence, review and correction rules as the chapters and are versioned with the edition.<\/p><\/aside><\/section><section class=\"nrp-block\" id=\"nx-nrp-xt-05-ca-notes\" aria-labelledby=\"nx-nrp-xt-05-ca-notes-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-ca-notes-h\"><span>Notes<\/span><\/h2><p class=\"nrp-note\">Numbers are the edition&#8217;s reference numbers, so a note reads the same in every chapter. The full list, with every source and its licence, is in Annex C. <a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/references\/\">Annex C, references<\/a><\/p><ol class=\"nrp-notes\"><li id=\"nx-nrp-xt-05-ca-n21\"><span class=\"nrp-notes-n\">21<\/span><span>Grealey, J. et al., The Carbon Footprint of Bioinformatics, Molecular Biology and Evolution 2022 (abstract read through the Europe PMC record; a software upgrade cut one tool footprint by 73%). Oxford University Press, Oxford. Observation year 2022. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-ca-r21\" aria-label=\"Back to the first call of note 21\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-ca-n22\"><span class=\"nrp-notes-n\">22<\/span><span>Lannelongue, L., Grealey, J. and Inouye, M., Green Algorithms: Quantifying the Carbon Footprint of Computation, Advanced Science 2021 (abstract read through the Europe PMC record). Wiley, Weinheim. Observation year 2021. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-ca-r22\" aria-label=\"Back to the first call of note 22\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-ca-n13\"><span class=\"nrp-notes-n\">13<\/span><span>National Human Genome Research Institute (ed.), The Cost of Sequencing a Human Genome (fact sheet page; method notes read; the cost values sit in graphs and a linked table that were not read; page updated 16 May 2023). NHGRI, Bethesda. Observation year 2023. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-ca-r13\" aria-label=\"Back to the first call of note 13\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-ca-n15\"><span class=\"nrp-notes-n\">15<\/span><span>Ultima Genomics (ed.), germline genetics product page (vendor claim of a USD 60 genome at list price over 4 wafers on the UG200 series; the browser title reads USD 80; vendor evidence, weak). Ultima Genomics, Newark. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-ca-r15\" aria-label=\"Back to the first call of note 15\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-ca-n40\"><span class=\"nrp-notes-n\">40<\/span><span>UNVERIFIED, not opened: Ultima Genomics (ed.), UG 100 Solaris launch announcement of 24 February 2025 (USD 80 genome at list price), taken from search-result summaries; vendor evidence, weak. Ultima Genomics, Newark. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-ca-r40\" aria-label=\"Back to the first call of note 40\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-ca-n6\"><span class=\"nrp-notes-n\">6<\/span><span>Vertex Pharmaceuticals (ed.), Vertex Reports First Quarter 2026 Financial Results (company press release read through a wire page; Casgevy revenue USD 42.9 million against USD 14.2 million; pediatric submission completed; company statement, weak evidence). Vertex, Boston. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-ca-r6\" aria-label=\"Back to the first call of note 6\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-ca-n35\"><span class=\"nrp-notes-n\">35<\/span><span>UNVERIFIED, not opened: Vertex Pharmaceuticals (ed.), full-year 2025 results (Casgevy revenue USD 115.8 million in 2025 and USD 10 million in 2024), taken from search-result summaries. Vertex, Boston. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-ca-r35\" aria-label=\"Back to the first call of note 35\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-ca-n16\"><span class=\"nrp-notes-n\">16<\/span><span>UK Biobank Whole-Genome Sequencing Consortium, Whole-genome sequencing of 490,640 UK Biobank participants, Nature 2025 (abstract read through the Europe PMC record). Springer Nature, London. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-ca-r16\" aria-label=\"Back to the first call of note 16\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-ca-n17\"><span class=\"nrp-notes-n\">17<\/span><span>All of Us Research Program Genomics Investigators, Genomic data in the All of Us Research Program, Nature 2024 (abstract read through the Europe PMC record; 245,388 genomes; 77% from communities under-represented in research). Springer Nature, London. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-ca-r17\" aria-label=\"Back to the first call of note 17\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-ca-n18\"><span class=\"nrp-notes-n\">18<\/span><span>Fatumo, S. et al., A roadmap to increase diversity in genomic studies, Nature Medicine 2022 (abstract read through the Europe PMC record). Springer Nature, London. Observation year 2022. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-ca-r18\" aria-label=\"Back to the first call of note 18\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-ca-n19\"><span class=\"nrp-notes-n\">19<\/span><span>Sirugo, G., Williams, S.M. and Tishkoff, S.A., The Missing Diversity in Human Genetic Studies, Cell 2019 (abstract read through the Europe PMC record). Cell Press, Cambridge. Observation year 2019. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-ca-r19\" aria-label=\"Back to the first call of note 19\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-ca-n31\"><span class=\"nrp-notes-n\">31<\/span><span>MedTech Dive (ed.), China to lift Illumina <a class=\"nx-link nx-term\" href=\"https:\/\/nexustandards.com\/standards\/nrs\/#nrs-h60\" data-tc=\"NHS-1 sys.supply-chain.trade-restriction\" data-tk=\"Systemic and compound events \u00b7 Supply-chain and flow disruption\" data-td=\"Export bans, sanctions or embargoes that cut access to goods, energy or inputs.\" data-ts=\"NRS-H60\" data-tr=\"draft\" data-tx=\"https:\/\/risksindex.com\/hazards\/sys\/\" data-txl=\"Systemic and compound events\">export ban<\/a> (trade press, November 2025; listing in February 2025, import ban in March 2025, lift on 10 November 2025, instrument sales in China down 54% in the third quarter; secondary report, weak evidence). Industry Dive, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-ca-r31\" aria-label=\"Back to the first call of note 31\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-ca-n36\"><span class=\"nrp-notes-n\">36<\/span><span>UNVERIFIED, not opened: European Parliament and Council, Regulation (EU) 2026\/1388 on plants obtained by certain new genomic techniques (adopted 17 June 2026, published 26 June 2026, applies from 17 July 2028), taken from search-result summaries that differ on some dates. Official Journal of the European Union, Luxembourg. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-ca-r36\" aria-label=\"Back to the first call of note 36\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-ca-n37\"><span class=\"nrp-notes-n\">37<\/span><span>UNVERIFIED, not opened: US Food and Drug Administration (ed.), draft guidance on the plausible mechanism framework for individualised therapies, February 2026, taken from search-result summaries. FDA, Silver Spring. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-ca-r37\" aria-label=\"Back to the first call of note 37\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-ca-n5\"><span class=\"nrp-notes-n\">5<\/span><span>Clinical Trials Arena (ed.), FDA unveils new pathway to usher bespoke therapies to market (trade press, 13 November 2025; describes the plausible mechanism pathway announced in a journal article by the FDA Commissioner and the CBER Director; secondary report, weak evidence). Clinical Trials Arena, London. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-ca-r5\" aria-label=\"Back to the first call of note 5\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-ca-n39\"><span class=\"nrp-notes-n\">39<\/span><span>UNVERIFIED, not opened: Intellia Therapeutics and trade press on the lifting of the 2025 clinical holds on the MAGNITUDE trials, taken from search-result summaries that differ on dates. Observation year 2026. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-ca-r39\" aria-label=\"Back to the first call of note 39\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-ca-n41\"><span class=\"nrp-notes-n\">41<\/span><span>UNVERIFIED, not opened: Council of Europe (ed.), Convention for the Protection of Human Rights and Dignity of the Human Being with regard to the Application of Biology and Medicine (Oviedo Convention), 1997, cited from memory; the page returned an access error. Council of Europe, Strasbourg. Observation year 1997. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-ca-r41\" aria-label=\"Back to the first call of note 41\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-ca-n33\"><span class=\"nrp-notes-n\">33<\/span><span>US Bureau of Labor Statistics (ed.), Occupational Outlook Handbook: Genetic Counselors (about 4,200 jobs in 2025; median pay USD 100,040 in May 2025; 10% growth projected 2025 to 2035). BLS, Washington. Observation year 2025. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-ca-r33\" aria-label=\"Back to the first call of note 33\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-ca-n2\"><span class=\"nrp-notes-n\">2<\/span><span>Frangoul, H. et al., Exagamglogene Autotemcel for Severe Sickle Cell Disease, New England Journal of Medicine 2024 (abstract read through the Europe PMC record; 44 treated, 30 evaluable, 29 free of crises for 12 months or more). Massachusetts Medical Society, Waltham. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-ca-r2\" aria-label=\"Back to the first call of note 2\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-ca-n11\"><span class=\"nrp-notes-n\">11<\/span><span>Nurk, S. et al., The complete sequence of a human genome, Science 2022 (abstract read through the Europe PMC record; 3.055 billion base pairs; nearly 200 million base pairs of new sequence). American Association for the Advancement of Science, Washington. Observation year 2022. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-ca-r11\" aria-label=\"Back to the first call of note 11\">back<\/a><\/span><\/li><li id=\"nx-nrp-xt-05-ca-n3\"><span class=\"nrp-notes-n\">3<\/span><span>Locatelli, F. et al., Exagamglogene Autotemcel for Transfusion-Dependent beta-Thalassemia, New England Journal of Medicine 2024 (abstract read through the Europe PMC record; 52 treated, 35 evaluable, 32 transfusion independent). Massachusetts Medical Society, Waltham. Observation year 2024. Accessed 2026-11-03.<a class=\"nrp-notes-back\" href=\"#nx-nrp-xt-05-ca-r3\" aria-label=\"Back to the first call of note 3\">back<\/a><\/span><\/li><\/ol><\/section><section class=\"nrp-block nrp-noprint\" id=\"nx-nrp-xt-05-ca-cite\" aria-labelledby=\"nx-nrp-xt-05-ca-cite-h\"><h2 class=\"nrp-h2\" id=\"nx-nrp-xt-05-ca-cite-h\"><span>Cite this annex<\/span><\/h2><pre class=\"nrp-pre\">Valadbaygi, S. (Ed.). (2026). Annex A: Methodology. In Exponential Technology Report 2026: Genomics and Gene Editing (Baseline Edition 2026, Report No. NR-XTECH-GENOMICS-GLOBAL-2026-BASELINE) [Draft under review]. The Global Centre for Risk and Innovation (GCRI).<\/pre><p class=\"nrp-note\">Every citation form of the whole report, BibTeX and RIS included, is on the edition home. <a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/#nx-nrp-xt-05-land-cite\">Cite this report<\/a><\/p><\/section><nav class=\"nrp-pager\" aria-label=\"Previous and next\"><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/systems-in-depth\/\" rel=\"prev\"><span class=\"nf-ui-eyebrow\">Previous \u00b7 Chapter 8<\/span><span class=\"nrp-pager-t\">Systems in depth<\/span><\/a><a href=\"https:\/\/therisk.global\/nexus-reports\/editions\/xt-05\/data\/\" rel=\"next\"><span class=\"nf-ui-eyebrow\">Next \u00b7 Annex B<\/span><span class=\"nrp-pager-t\">Data appendix<\/span><\/a><\/nav><\/article><\/div><\/div><\/div><div class=\"nrp-noprint\"><section id=\"nx-sec-nr-gateway\" class=\"nx-section\" data-hue=\"systemic\" data-tone=\"alt\" aria-labelledby=\"nx-nr-gateway-h\"><div class=\"nx-container\"><div class=\"nx-section-head\"><div class=\"nx-eyebrow-row\"><span class=\"nx-eyebrow\">Reports<\/span><span class=\"nx-rule\" aria-hidden=\"true\"><\/span><span class=\"nx-eyebrow\">Contribute<\/span><\/div><h2 id=\"nx-nr-gateway-h\" class=\"nx-section-title\">Send evidence or a correction on Genomics and Gene Editing.<\/h2><p class=\"nx-lede\">Reports is the Consortium&#8217;s quarterly publication, written by six desks. This page sits with the Global Centre for Risk and Innovation (GCRI) <a class=\"nx-link nx-term\" href=\"https:\/\/docs.therisk.global\/organization\/systems\" data-tc=\"Systems\" data-tk=\"Nexus Standards\" data-td=\"The twenty Nexus systems, NXS-CMD to NXS-LAB\">Systems<\/a> Evidence desk. What you know about this subject can become evidence, a case or a correction in the next edition, credited to you and published under CC BY 4.0 where it is your own work. 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