GCRI · 生物技术与生物安全
面向生物技术与生物安全的分子与生命科学
How molecular and life sciences is applied in Biotechnology and Biosecurity. Molecular and life sciences study the structure and function of living 系统 from genes and proteins to cells and organisms. They underpin the understanding of pathogens, resistance, toxicity and biological innovation.
What molecular and life sciences does here.
Molecular and life sciences study the structure and function of living 系统 from genes and proteins to cells and organisms. They underpin the understanding of pathogens, resistance, toxicity and biological innovation. In health and biosecurity and food and agriculture, life sciences support pathogen characterisation, 抗微生物药物耐药性 tracking and biosecurity assessment. They inform how biological threats might spread through health, agriculture and trade. The canonical description is on STEM Commons.
- 01
Methods used here
genome sequencing and assembly; phylogenetic analysis; functional assays; proteomics and metabolomics; cell and tissue culture; bioinformatic pipelines.
- 02
验证
Results are confirmed through biological replicates, independent laboratories and orthogonal assays. Reference standards and proficiency testing check analytical accuracy.
地点网络上的 SEIR 模型。
An outbreak seeded in one place spreads through a small-world network by the share of contacts people make elsewhere; play it to see the order of arrival and how the timing of measures moves the peak. Teaching model with stated illustrative values, not a prediction.
控制措施
- 基本再生数 R0
- 2.5
- 潜伏期
- 3.0 days
- 传染期
- 5.0 days
- 在其他地点发生的接触所占比例
- 8%
- 网络中的地点
- 24
- 措施开始于第几天
- 40
- 措施带来的接触减少
- 40%
- 模拟天数
- 240 days
读数
- 新增感染峰值
- 4.42 per 1,000 a day
- 峰值日
- 176
- 累计感染比例
- 56%
- 已覆盖地点
- 100%
- 采取措施后的再生数
- 1.50
数字、方法与来源
| 日 | 每 1,000 人新增感染 | 累计感染（%） |
|---|---|---|
| 0 | 0.00 | 0.0 |
| 17 | 0.03 | 0.0 |
| 34 | 0.31 | 0.2 |
| 51 | 0.92 | 1.4 |
| 68 | 1.56 | 3.5 |
| 85 | 2.11 | 6.7 |
| 102 | 2.39 | 10.5 |
| 119 | 2.61 | 14.8 |
| 136 | 3.12 | 19.6 |
| 153 | 3.87 | 25.6 |
| 170 | 4.38 | 32.7 |
| 187 | 4.30 | 40.2 |
| 204 | 3.65 | 47.0 |
| 221 | 2.56 | 52.2 |
| 238 | 1.45 | 55.6 |
方法
- SEIR 仓室 Kermack 和 McKendrick（1927），Proc. R. Soc. A 115
- 通过人口流动实现的集合种群耦合 Balcan and others (2009), PNAS 106
- 小世界网络 Watts and Strogatz (1998), Nature 393
- 传染病建模 Keeling and Rohani (2008), Princeton University Press
- 不确定性扇形图（参数蒙特卡罗） Spiegelhalter, Pearson and Short (2011), Visualising uncertainty about the future, Science 333
- 单因素敏感性（龙卷风图） Saltelli and others (2008), Global Sensitivity Analysis: The Primer, Wiley
数据
The model runs on the teaching values set by the controls. To calibrate it for a place, read it against these admitted layers and series, which this page’s map can draw:
- 城市 Natural Earth
- 机场 Natural Earth
- 主要道路 Natural Earth
贯穿六大支柱，由 Nexus Consortium 牵头
该方法使用的输入。
Datasets and records used by molecular and life sciences on this platform, with the role each plays and the label its values carry. Sources are listed in 来源登记册.
| 数据 | 角色 | 标签 |
|---|---|---|
| Sequencing instruments | 输入 | 观测 |
| Public sequence repositories | 输入 | 观测 |
| Biobanks | 输入 | 观测 |
| Laboratory assays | 输入 | 观测 |
| Structural biology instruments | 输入 | 观测 |
The model, the data and the uncertainty.
模型、其假设、数据和不确定性，以科学家或工程师会核查的形式呈现。结构遵循已发表的方法。所取数值仅为示意，不是研究发现。
不确定性区间
How far the outlook for molecular and life sciences for biotechnology and biosecurity could spread, shown as ranges rather than a single line.
- 中心估计值
- 集合的中位数
- 范围
- IPCC 校准用语中的“可能”和“很可能”
- 集合
- 明示成员、情景和初始条件
- 配合阅读
- 结果对每项输入的敏感性
结果如何核查。
Results are confirmed through biological replicates, independent laboratories and orthogonal assays. Reference standards and proficiency testing check analytical accuracy.
Laboratory findings do not always translate to organisms or populations. Sampling bias in sequence databases limits generalisation.
由谁维护该方法。
Biotechnology and Biosecurity stewards molecular and life sciences for the Consortium and reviews how it is applied across platforms.
问题与解答。
What are the limits of molecular and life sciences in this field?
结果如何核查？
本页面上的数值是真实的吗？
该方法还应用于何处？
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法律文件。
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