GCRI · Biotechnology and Biosecurity
Diagnostics and therapeutics
Diagnostics detect disease; therapeutics and vaccines prevent or treat it. Biotechnology has transformed both, from molecular tests to biologic medicines and platform vaccines. This topic, studied at Biotechnology and Biosecurity, a platform of The Global Centre for Risk and Innovation (GCRI), examines how health innovations are evaluated, how evidence of performance is generated and judged, and how access and supply shape their value in practice. It is research, not clinical guidance.
What experts ask.
- How is the accuracy of a diagnostic test established, and how does it vary by setting?
- How do clinical trials balance speed and reliability, especially in emergencies?
- How do platform technologies change the time needed to develop countermeasures?
- What determines whether innovations reach the people who need them?
- How is safety monitored once products are in wide use?
Environmental exposure in West Africa.
Daytime surface heat, population density and haze over West Africa, from NASA GIBS. Each layer carries its own date.
The interactive map needs JavaScript; the layer list and sources are below.
Layers 3
Environmental exposure, for this page
About this layer
- Evidence
- Observed (persistent cloud still leaves gaps)
- Source
- VIIRS NOAA-20 Level 3, 8-day (NASA LANCE)
- Provider
- NASA LANCE
- Licence
- NASA open data
- Vintage
- 8-day; Satellite 8-day composite; persistent cloud still leaves gaps
- Newest at build
- 2026-09-14
- Resolution
- about 1 km grid
- Uncertainty
- Satellite skin temperature of the ground over the 8 days ending on the date shown, a heat exposure indicator; not air temperature, heat index or a heat warning.
- Reached through
- gibs.earthdata.nasa.gov, only after you allow the live map
About this layer
- Evidence
- Estimated
- Source
- Gridded Population of the World v4.11 (NASA SEDAC (CIESIN, Columbia University))
- Provider
- NASA SEDAC (CIESIN, Columbia University)
- Licence
- CC BY 4.0
- Vintage
- null; Census-based estimate, static (2020)
- Resolution
- about 1 km grid
- Uncertainty
- Census-based estimate of people per square kilometre in 2020, shown as exposure context; not a count of people affected by any hazard.
- Reached through
- gibs.earthdata.nasa.gov, only after you allow the live map
About this layer
- Evidence
- Observed (clouds leave gaps)
- Source
- VIIRS NOAA-20 Deep Blue AOD (NASA LANCE)
- Provider
- NASA LANCE
- Licence
- NASA open data
- Vintage
- daily; Satellite retrieval; clouds leave gaps
- Newest at build
- 2026-10-14
- Resolution
- about 2 km grid
- Uncertainty
- Satellite measure of haze, smoke and dust through the whole air column on the day shown; an exposure indicator, not ground-level PM2.5, an air quality index or a health warning.
- Reached through
- gibs.earthdata.nasa.gov, only after you allow the live map
About this layer
- Evidence
- Observed (clouds leave gaps)
- Source
- MODIS Terra NDVI (NASA LANCE)
- Provider
- NASA LANCE
- Licence
- NASA open data
- Vintage
- daily; Satellite index; clouds leave gaps
- Newest at build
- 2026-10-13
- Resolution
- about 250 m grid
- Uncertainty
- Satellite greenness index over the 8 days to the date shown; an indicator of crop and pasture condition, not a yield estimate or a food security warning.
- Reached through
- gibs.earthdata.nasa.gov, only after you allow the live map
About this layer
- Evidence
- Observed (clouds leave gaps)
- Source
- OMI Aura (NASA GES DISC)
- Provider
- NASA GES DISC
- Licence
- NASA open data
- Vintage
- daily; Satellite retrieval; clouds leave gaps
- Newest at build
- 2026-10-10
- Resolution
- about 2 km grid
- Uncertainty
- Satellite column of nitrogen dioxide in the lower atmosphere on the day shown, mostly from combustion; not a ground-level concentration or a health warning.
- Reached through
- gibs.earthdata.nasa.gov, only after you allow the live map
About this layer
- Evidence
- Observed
- Source
- VIIRS NOAA-20 corrected reflectance (NASA LANCE)
- Provider
- NASA LANCE
- Licence
- NASA open data
- Vintage
- daily; Satellite image
- Newest at build
- 2026-10-14
- Resolution
- about 250 m grid
- Uncertainty
- Satellite image. Satellite or model raster as the provider publishes it. Clouds, swath gaps and retrieval error leave gaps and noise; values are indicators, not measurements at a place.
- Reached through
- gibs.earthdata.nasa.gov, only after you allow the live map
Keyboard, with the map focused
Hold Ctrl or ⌘ and scroll to zoom
Latest available
NASA GIBS / EOSDIS · ASTER GDEM (METI, NASA) · Blue Marble (NASA) · © OpenStreetMap contributors (ODbL) · Natural Earth
Loading the latest NASA imagery.
Drag to move. Ctrl or ⌘ and scroll, pinch or the buttons to zoom; hover for the values under the pointer; reset returns to the region.
Environmental exposure, framed on West Africa.Satellite and model products as NASA publishes them, each with its own date. They are indicators, not assessments of any place.
Data: NASA GIBS · ASTER GDEM · Blue Marble · © OpenStreetMap contributors · Natural Earth · NASA EONET · ESA Copernicus Sentinel-5P TROPOMI · NASA JPL OPERA DIST-ALERTSources and licences
- We acknowledge the use of imagery provided by services from NASA’s Global Imagery Browse Services (GIBS), part of NASA’s Earth Science Data and Information System (ESDIS). Colours redrawn from the published colour map; values averaged into hexagonal cells where shown (modified). NASA open data
- We acknowledge the use of imagery provided by services from NASA’s Global Imagery Browse Services (GIBS), part of NASA’s Earth Science Data and Information System (ESDIS). Colours redrawn from the published colour map; values averaged into hexagonal cells where shown (modified). NASA open data
- VIIRS near-real-time products (flood, land surface temperature, snow cover, corrected reflectance), NASA LANCE; imagery via NASA GIBS. Colours redrawn from the published colour map; values averaged into hexagonal cells where shown (modified). NASA open data
- Center for International Earth Science Information Network (CIESIN), Columbia University. 2018. Gridded Population of the World, Version 4 (GPWv4): Population Density, Revision 11. NASA Socioeconomic Data and Applications Center (SEDAC). Licensed under CC BY 4.0. Colours redrawn from the published colour map; values averaged into hexagonal cells where shown (modified). doi:10.7927/H49C6VHW. CC BY 4.0
- MODIS and VIIRS atmosphere products, NASA LANCE and LAADS DAAC; imagery via NASA GIBS. Colours redrawn from the published colour map; values averaged into hexagonal cells where shown (modified). NASA open data
- MODIS land products (vegetation indices, gross primary production, land cover), NASA LP DAAC and LANCE; imagery via NASA GIBS. Colours redrawn from the published colour map; values averaged into hexagonal cells where shown (modified). NASA open data
- OMI nitrogen dioxide (Aura) and OMPS aerosol index (Suomi NPP), NASA; distributed by the NASA GES DISC; imagery via NASA GIBS. Colours redrawn from the published colour map; values averaged into hexagonal cells where shown (modified). NASA open data
- ASTER GDEM is a product of METI and NASA (ASTER Global Digital Elevation Model V003, NASA LP DAAC); imagery via NASA GIBS. Colours redrawn from the published colour map; values averaged into hexagonal cells where shown (modified). Cite as: NASA/METI/AIST/Japan Spacesystems and U.S./Japan ASTER Science Team (2019). ASTER Global Digital Elevation Model V003. doi:10.5067/ASTER/ASTGTM.003. NASA open data
- Made with Natural Earth. Free vector and raster map data @ naturalearthdata.com. Public domain
- © OpenStreetMap contributors (ODbL), via NASA GIBS (coastlines, boundaries, roads and place names). Colours redrawn from the published colour map; values averaged into hexagonal cells where shown (modified). ODbL
- Blue Marble, NASA Earth Observatory; imagery via NASA GIBS. Colours redrawn from the published colour map; values averaged into hexagonal cells where shown (modified). NASA open data
- Context on the globe and flat map: coastlines, boundaries, roads and place names from NASA GIBS reference layers (OpenStreetMap data, ODbL, © OpenStreetMap contributors); Blue Marble imagery as an optional base; 3D terrain and the elevation read-out from the ASTER GDEM elevation colour index (5 m to 200 m classes, exaggerated for legibility). Boundaries are drawn as published and imply no position on any territory.
- Live events: NASA Earth Observatory Natural Event Tracker (EONET); events are indicative and keep their original source links.
- Observed (EO): ESA Copernicus Sentinel-5P TROPOMI (contains modified Copernicus Sentinel data 2026). We acknowledge the use of imagery provided by services from NASA’s Global Imagery Browse Services (GIBS), part of NASA’s Earth Science Data and Information System (ESDIS).
- Observed (EO): NASA JPL OPERA DIST-ALERT (contains modified Copernicus Sentinel data 2026). We acknowledge the use of imagery provided by services from NASA’s Global Imagery Browse Services (GIBS), part of NASA’s Earth Science Data and Information System (ESDIS).
- NASA GIBS: We acknowledge the use of imagery provided by services from NASA’s Global Imagery Browse Services (GIBS), part of NASA’s Earth Science Data and Information System (ESDIS).
- Air quality forecast, 5 days, PM2.5 (CAMS via Open-Meteo): Contains modified Copernicus Atmosphere Monitoring Service information 2026.
- Past year, daily temperature (ERA5 via Open-Meteo): Contains modified Copernicus Climate Change Service information 2026.
- Weather data by Open-Meteo.com (https://open-meteo.com/), licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/).
- Optional layers (14 sources in the layer list: live, forecast, observed and context) print their provider credit on the map and here when switched on; forecasts are model output and derived indices are estimates.
Layers and dates
- Land surface temperature, day, 8-day composite: VIIRS NOAA-20 Level 3, 8-day, NASA LANCE · 14 Sep 2026
- Population density, 2020: Population: CIESIN, Columbia University, Gridded Population of the World v4.11 (2018), NASA SEDAC, CC BY 4.0 · static
- Aerosol optical depth, daily: VIIRS NOAA-20 Deep Blue AOD, NASA LANCE · 13 Oct 2026
- Vegetation greenness (NDVI), rolling 8 days: MODIS Terra NDVI, NASA LANCE · 13 Oct 2026
- Nitrogen dioxide, lower atmosphere column: OMI Aura, NASA GES DISC · 10 Oct 2026
- True colour: VIIRS NOAA-20 corrected reflectance, NASA LANCE · 13 Oct 2026
Countermeasures protect health and depend on other domains.
Countermeasure studies are designed for the Strategic Systems series. The WHO R&D Blueprint and the Essential Medicines List (24th list, 2025) frame priorities; GCRI approves no product.
- Access and supply studies.
- Evaluations of diagnostic deployment.
Oversight and capacity register.
The screen a team would use to follow this subject: its measures, states and decisions. Names are examples and values are illustrative.
Oversight and capacity register
Diagnostics and therapeutics · National committee · Review year 3
- Institutions with a committee, %83Watch
- Staff trained, %87Normal
- Reviews completed40this year
- Incident reports filed5Info
Institutional oversight
| Institution A | Active | Q2 | 84 | Current |
| Research campus | Active | Q1 | 61 | Audit due |
| Biomanufacturing site | Forming | none | 67 | Support |
| Diagnostic network | Active | Q3 | 88 | Current |
Scope note
- Covers
- governance, training, review capacity
- Excludes
- technical methods and agents
- Authority
- national oversight body
- Label
- SURVEY
Drivers and dynamics.
A diagnostic test’s usefulness depends on its sensitivity and specificity and on how common the condition is in the population tested, so the same test can perform differently in different settings. Therapeutics and vaccines are evaluated through staged trials, with regulators weighing evidence of benefit against risk. Emergency procedures can accelerate this process, at the cost of more uncertainty at the time of decision.
Platform technologies, which can be adapted to new targets, have shortened development times for some countermeasures. Yet value in practice depends on manufacturing, distribution, affordability and trust. Surveillance after approval detects rare adverse effects that trials are too small to find. Population health questions are studied at Health Nexus.
Model diagnostics and therapeutics as a system. Run the cascade.
Assembled from the Nexus Standards area profile Biological hazard standards: the hazards it names, the systems and sectors that carry the loss, the controls that dampen it and the data that observe it. Choose the components, pick an initiating hazard and step through the cascade. The Map view places the run on an example geography with open data. Every coupling weight is a stated assumption you can change. A teaching model, not a forecast, an assessment or a certification. To model a place of your own choosing, open the full System Builder.
Hazards
Systems and couplings
- Biological hazard standards
- Health risk standards Cascade
- Food and agriculture risk standards Cascade
- Biodiversity and nature risk standards Common driver
- Health security and One Health Mechanism
Controls
NS-0Constitution and principlesNS-3Risk record UNIs (grammar, legacy crosswalk, allocation authority)NS-11Verification and monitoring (evidence, attestations, zero-trust conformance observation)NRS-H41Hazard family: Animal-to-human spillover (NHS-1 health.zoonotic)NRS-H44Hazard family: Plant disease and pests (NHS-1 health.plant-health)NRS-H43Hazard family: Livestock and aquaculture epizootics (NHS-1 health.animal-health)NRS-H35Hazard family: Airborne and respiratory infection (NHS-1 health.respiratory)NRS-H40Hazard family: Blood-borne and sexually transmitted infection (NHS-1 health.bloodborne)NRS-H60Hazard family: Supply-chain and flow disruption (NHS-1 sys.supply-chain)
Observation
- WHO Disease Outbreak News (listed for reference)
- WAHIS animal health events (listed for reference)
- GBIF occurrence API and downloads (listed for reference)
- International Health Regulations capacity and health emergency preparedness
- Proportion of countries adopting relevant national legislation and adequately resourcing the prevention or control of invasive alien species
Example geography
- West Africa: 59 hexagonal cells
- Night lights tonight, outages (VIIRS Day/Night Band), NASA GIBS
How it is studied.
- 01
Evidence synthesis
Systematic reviews and meta-analyses pool results across studies, with attention to bias.
- 02
Statistical evaluation
Methods from probability and statistics assess test accuracy, trial design and uncertainty.
- 03
Health technology assessment
Frameworks compare benefits, risks and costs, drawing on epidemiology and public health science.
- 04
Limits
Trials may not represent all populations, published evidence can be biased toward positive results, and performance in practice often differs from performance in trials.
How diagnostics and therapeutics is modelled, measured and tested.
The model, its assumptions, its data and its uncertainty, in the form a scientist or engineer would check. Structures follow published methods. The values drawn are illustrative, not findings.
System model
The couplings between the systems in diagnostics and therapeutics: signs of influence, a reinforcing and a balancing loop, and cross-links where stress jumps.
What it informs and who decides.
This evidence informs regulatory decisions, procurement and stockpiling, health technology assessment and preparedness planning. Regulators, health agencies and clinicians decide; GCRI is not a health-service provider or clinical authority. The insurance-sector reading of health innovation and pandemic risk is built by Insurance Nexus at The Global Risks Alliance (GRA). Related topics are biomanufacturing, biological threats and One Health impacts; methods sit on epidemiology and public health science and probability and statistics.
Published analysis on this topic is designed to carry a named subject reviewer, its references and the views of independent specialists, including biosafety professionals and those who disagree.
Where this page’s references lead.
The bodies and documents this page is read against. Status and editions change; each link goes to the issuing body.
Questions and answers.
Can the platform tell me which test or treatment to use?
Why can an accurate test give misleading results?
Are emergency approvals less reliable?
Who reviews coverage of this topic?
Contribute evidence from this page.
Reports is the Consortium’s quarterly publication. What you know about this subject can become evidence, a case or a correction in the next edition, credited to you and published under CC BY 4.0 where it is your own work.
- EmailGateway GW-GCRISend it from this pageEvidence, a correction, a case, a method, a review, a translation or profile input. It arrives tagged with this page, so the editor who owns it receives it.
- ZenodoOpen depositDeposit it and submit to the communityPublish your own record on Zenodo with your ORCID iD, then submit it to the Reports community there. Curators review it; the DOI stays yours.
- ReportsGCRISee every way to contributeThe contribution types, how each is reviewed, what credit you receive, the licence and what is never accepted.
Never send personal data, sensitive infrastructure detail or anything you have no right to share. A contribution is reviewed before use; sending it confers no authorship or editorial rights, and sponsorship never buys a finding.
Bring a method, a dataset or a question.
Information and enquiries are open today. An enquiry receives a reference and names the next step; applications, payments, compute allocations and registrations open only when their team, terms and review capacity exist.
Legal documents.
Maps, data and figures on this site are shown for context and general information. They are not advice, forecasts or warnings; the limits of the information are set out in the Disclaimers and Data Notices.