Quadruple helix collaborations create innovation through interactive processes in which different groups of actors contribute with their knowledge due to their function in society. Such collaborations formalize the role of civil society and this creates a more transparent innovation process based on the principles of responsible research and innovation. In addition they could be more adapted to the needs of the twenty-first century, as knowledge is increasingly created in cross-sectoral collaborations and is not limited to one field of knowledge. More perspectives are therefore needed to understand the present unfolding innovation process through a different lens. Innovation processes thereby become more open through the belief that different stakeholders in society jointly and actively are part of creating new ways of innovating.