Health is not only a medical condition—it is a systems-level outcome shaped by environmental exposure, digital access, socioeconomic status, governance quality, infrastructure equity, and cross-border risks. In an era defined by pandemics, aging populations, health misinformation, antimicrobial resistance, climate-sensitive diseases, and algorithmic discrimination, siloed health systems are insufficient. Health risks are converging across human, animal, environmental, and digital systems. Traditional top-down health interventions—while critical—often fail to anticipate emerging threats, adapt to local realities, or coordinate across domains. The Nexus Ecosystem addresses these limitations by providing an open, secure, and interoperable platform that supports health forecasting, risk stratification, early warning, participatory policy design, and anticipatory financing at multiple levels—from urban clinics and refugee camps to national health ministries and global public health networks