The Quadruple Helix is an innovation and collaboration model with a citizen/end-user perspective. The model is useful in innovation processes where the citizens needs are central, as for example in health care and public e-services. Innovative processes often lack involvement of citizens and end-users. These process sometimes adopt a Triple Helix model, which is an innovation and collaboration model that describes the interaction between public sector, academia and industry. In the Triple Helix model, citizens/end-users are viewed as passive recipients, consumers or end- users who assimilate the products and services developed. Using the Quadruple Helix for end-users participation in the development of an innovation can lead to more successful, user-oriented, and human-centered innovations. The end-users will be more likely to accept and adopt the innovation. It will also have a greater social benefit at lower costs and improve empowerment of the citizens, who will increasingly experience trust towards the innovators and become an active part of the innovation system.